File:KER-NK-cells.jpg

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KER expression on NK cells in PBMC from ME/CFS and MS patients and healthy controls. NK cells were identified in PBMC as CD3-CD56+ cells in flow cytometry (as shown in Figure 1). Subpopulations were characterised as A) KIR2 DL1- DS1+; B) KIR2DL1+DS1+; C) KIR2DL3+; D) KIR2 DS1-DL1+; E) KIR2DL2+DS2+; F) KIR2DL5+

Author: (or citation)[edit | edit source]

Cliff JM, King EC, Lee J-S, Sepúlveda N, Wolf A-S, Kingdon C, Bowman E, Dockrell HM, Nacul L, Lacerda E and Riley EM (2019) Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front. Immunol. 10:796. doi: 10.3389/fimmu.2019.00796

Supplementary Figure S4

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https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full

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myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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current13:11, June 27, 2020Thumbnail for version as of 13:11, June 27, 20201,125 × 955 (215 KB)Notjusttired (talk | contribs)==== Title: (or description) ==== KER expression on NK cells in PBMC from ME/CFS and MS patients and healthy controls. NK cells were identified in PBMC as CD3-CD56+ cells in flow cytometry (as shown in Figure 1). Subpopulations were characterised as A)...

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