File:Intracellularpathogens.jpg

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Summary[edit | edit source]

Intracellular pathogens and the proteins/metabolites they express can directly interfere with human transcription, translation, and DNA repair processes. Source: Front. Pediatr., 04 December 2018 Proal A and Marshall T (2018) Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity. Front. Pediatr. 6:373. doi: 10.3389/fped.2018.00373 https://www.frontiersin.org/articles/10.3389/fped.2018.00373/full License: CC-BY (using CC-BY-4.0)

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metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

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current13:40, February 11, 2019Thumbnail for version as of 13:40, February 11, 2019765 × 420 (249 KB)Notjusttired (talk | contribs)Intracellular pathogens and the proteins/metabolites they express can directly interfere with human transcription, translation, and DNA repair processes. Source: Front. Pediatr., 04 December 2018 Proal A and Marshall T (2018) Myalgic Encephalomyeliti...

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