Sodium valproate

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Sodium valproate or valproic acid (VPA) is an anti-seizure medication licensed for epilepsy and as a mood stabilizer for bipolar disorder.[1][2][3] Sodium valproate is sometimes used off-label for nerve pain.[3]

Theory[edit | edit source]

Evidence[edit | edit source]

No sodium valproate clinical trials have been done with ME/CFS patients.

Clinicians[edit | edit source]

Risks and safety[edit | edit source]

Sodium valproate cannot be taken during pregnancy and effective contraception must be used due to the high risk of harm to the baby.[4]

Carnitine levels may be lowered by sodium valproate, taking L-carnitine or Acetyl-L-carnitine supplements is advised against.[5]

Costs and availability[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Valproic acid: medicine used for bipolar disorder, epilepsy and migraine". National Health Service. September 27, 2018. Retrieved December 28, 2023.
  2. "Valproic Acid (Oral Route) Side Effects - Mayo Clinic". Mayo Clinic. Retrieved December 28, 2023.
  3. 3.0 3.1 Rahman, Masum; Awosika, Ayoola O.; Nguyen, Hoang (2023). Valproic Acid. Treasure Island (FL): StatPearls Publishing. PMID 32644538.
  4. "Sodium valproate medicines and risks in pregnancy". Epilepsy Action. Retrieved December 28, 2023.
  5. Dechéne, Lucy (2015). "Review of Nutritional Supplements Used for ME/CFS/FM". Massachusetts ME/CFS & FM Association. Retrieved December 28, 2023.