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Haptoglobin (HP) is a hemoglobin-binding protein with immunomodulatory properties. Its gene harbors a common polymorphism with 2 different alleles: HP1 and HP2. Allele HP2 and genotype HP22 has been shown to be overrepresented in different immune diseases like Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) and type 1 diabetes, and has also been found to be more frequent in patients with irritable bowel disease (ulcerative colitis and Crohn's disease) than in healthy controls.[1]

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References[edit | edit source]

  1. The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease, Tim Vanuytsel, Séverine Vermeire, and Isabelle Cleynen, Tissue Barriers. 2013 Dec 1; 1(5): e27321.