MEpedia - User contributions [en]

Science Media Centre

2017-08-01T18:34:36Z

Seanko:not a government organisation

The '''Science Media Centre''' is an organisation formed in 2000 to encourage more accurate reporting of science in the media. When notable scientific papers are published, the Science Media Centre will often publish a page of "expert opinion" which journalists will then commonly re-purpose in their published work. The Science Media Centre has published a number of expert opinions on ME/CFS.<ref>[http://www.sciencemediacentre.org/?s=cfs/me&cat= Search results for (cfs/me)]</ref>

==Criticism==
The Science Media Centre has been criticized for being a "lobby group".<ref>[http://www.theguardian.com/science/2002/jun/02/gm.observersciencepages Lobby group 'led GM thriller critics']</ref>

Patients have criticised the Science Media Centre for focusing its output on psychological and psychiatric expert opinions on ME/CFS and the fact that they house the disease within their Mental Health section.<ref>[http://voicesfromtheshadowsfilm.co.uk/welcome/reflections/ Reflections on Voices from the Shadows]</ref><ref>[http://www.meactionuk.org.uk/The-Media-and-ME.htm The Media and ME]</ref>

It has also been criticised for bias toward corporate interests.<ref>[http://www.scidev.net/global/journalism/feature/uk-s-science-media-centre-lambasted-for-pushing-corporate-science.html UK’s Science Media Centre lambasted for pushing corporate science]</ref>

[[Fiona Fox]], director of the SMC, has debated a critic about the value of the SMC.<ref>[http://www.cjr.org/the_observatory/science_media_centers_the_pres.php Science media centers & the press, part 1]</ref>

Professor [[James Coyne]] has criticized the Science Media Centre for what he sees as lobbying against open-data in science.<ref>[https://jcoynester.wordpress.com/2016/01/31/further-insights-into-the-war-against-data-sharing-the-science-media-centres-letter-writing-campaign-to-uk-parliament/ Further insights into war against data sharing: Science Media Centre’s letter writing campaign to UK Parliament]</ref>

Professor [[Malcolm Hooper]] has criticized the Science Media Centre coverage of the disease.<ref>[http://www.meactionuk.org.uk/The-SMC-and-its-campaign-against-MECFS.pdf The Role of the Science Media Centre and the Insurance Industry in ME/CFS: the facts behind the fiction]</ref>

It was found upon investigation that the Science Media Centre were behind the media publicity blitz in 2011 of allegations of harassment of researchers by patients during the year when the [[PACE trial]] results were published and criticised. <ref>[https://web.archive.org/web/20160418232134/http://www.sciencemediacentre.org/wp-content/uploads/2013/03/Review-of-the-first-three-years-of-the-mental-health-research-function-at-the-Science-Media-Centre.pdf Supporting experts targeted by extremists]</ref> <ref>[https://web.archive.org/web/20140106032125/http://www.sciencemediacentre.org/wp-content/uploads/2011/10/SMC-Anniversary-Brochure.pdf Threats of Persecution]</ref>

==Notable people==
*[[Fiona Fox]] (Chief Executive)<ref>[http://www.sciencemediacentre.org/about-us/staff/ Staff]</ref>
*[[Edward Sykes]] (Senior Press Manager & Head of Mental Health and Neuroscience)
*[[Simon Wessely]] (Board of Trustees)<ref>[http://www.sciencemediacentre.org/about-us/governance/ Governance]</ref>

==Learn more==
*[https://en.wikipedia.org/wiki/Science_Media_Centre Wikipedia - Science Media Centre]

==See also==
*[[Sense About Science]]
*[[PACE trial]]
*[[UK CFS/ME Research Collaborative]]

==References==
<references>
</references>

[[Category:Organizations]] [[Category:UK Organizations‎]]

Creatine

2016-12-04T19:32:40Z

Seanko:typo + marked as a stub

{{stub}}
'''Creatine''' is a nitrogenous organic acid that helps supply [[energy]] to all [[cell]]s in the body, especially [[muscle]]. It increases the formation of [[ATP]]. It is produced from the [[amino acid]]s [[glycine]] and [[arginine]].

[[Category:Biochemistry and cell biology]] [[Category:Amino acids]] [[Category:Potential treatments]] [[Category:Supplements]]

Rich Van Konynenburg

2016-12-04T19:31:25Z

Seanko:marked as a stub

{{stub}}
==See also==

*[[Methylation cycle hypothesis]]

[[Category:Researchers]]
[[Category:USA researchers]]

Talk:Robert Naviaux

2016-11-24T20:15:48Z

Seanko:to do suggestions

To do:

more information on the Open Medicine metabolomics study & Dauer state
(by contrast there is a lot of biographical information)

[[Seanko]]

Robert Naviaux

2016-11-24T20:13:31Z

Seanko:link added

[[File:Robert Naviaux.png|thumb|Source: gordonmedical.com]]
'''Robert K. Naviaux,''' MD, PhD, is a Professor in Residence at the University of California, San Diego, California, USA. His work "has focused on the role of mitochondrial DNA replication, copy number regulation, DNA damage, and nucleotide signaling in development, aging, healing and regeneration in mitochondrial mechanisms of disease and development."<ref>http://profiles.ucsd.edu/robert.naviaux</ref> He was invited to join the [[Open Medicine Foundation]]'s research team in 2016, following a announcement that the [[ME/CFS Severely Ill, Big Data Study]] had a significant result in the area of [[mitochondria]].<ref>http://www.openmedicinefoundation.org/2016/02/10/welcome-dr-naviaux-to-our-team/</ref>

Dr. Naviaux directs the Robert Naviaux Laboratory at University of California, San Diego (UCSD) whose work is "divided into two groups: 1) Mitochondrial Mechanisms of Disease and Development, and 2) Evolutionary Systems Biology and Marine Metagenomics."<ref>http://med.ucsd.edu/divisions/med-genetics/research/Pages/Naviaux-Lab.aspx</ref> He is founder and co-director of the Mitochondrial and Metabolic Disease Center at UCSD, the co-founder and a former president of the Mitochondrial Medicine Society, as well as, a founding associate editor of the journal, ''Mitochondrion''.<ref>http://www.openmedicinefoundation.org/2016/02/10/welcome-dr-naviaux-to-our-team/</ref>

Dr. Naviaux "discovered the cause and created the diagnostic test for Alpers syndrome, a mitochondrial disease... [and] is the director of the first FDA-approved clinical trial to study suramin [an antiparasitic drug] as a treatment for autism."<ref>http://www.openmedicinefoundation.org/2016/02/10/welcome-dr-naviaux-to-our-team/</ref>

Currently, Dr. Naviaux is using his mitochrondria expertise, especially in metabolomics, to look for a biomarker and potential treatment for ME/CFS.<ref>http://www.healthrising.org/forums/threads/the-mitochondria-man-gets-his-money-and-the-uk-goes-mega-me-cfs-research-moving-forward.4360/</ref>

In May 2016, a study was launched, led by Dr. Naviaux and Dr. [[Ronald Davis]], in collaboration with Dr. [[Eric Gordon]], Dr. [[Paul Cheney]], and the Stanford Genome Technology Center in order "to validate earlier findings of a possible diagnostic signature for ME/CFS by measuring metabolites and to evaluate the contribution of genetics to the variation in observed metabolic signatures in this disease." The initial phase, with a total of 90 participants, has been completed and suggests "the mitochondria is in hypometabolism due to a chronic cell danger response state in ME/CFS patients."<ref>http://www.openmedicinefoundation.org/expanded-mecfs-metabolomics-study/</ref>

==Education==
*1994-1997 - Fellowship (Biochemical Genetics, mtDNA Replication), University of California, San Diego Medical Center, San Diego, CA
*1990-1994 - Postdoctorate (Retrovirology, Gene Therapy), The Salk Institute, La Jolla, CA
*1986-1990 - Internship and Residency, Internal Medicine, American Board of Internal Medicine (ABIM), Clinical Investigator Pathway, University of California, Davis
*1986, 1989 - M.D., Ph.D. (Genetics, Virology), Indiana University School of Medicine, Indianapolis, IN
*1981 - M.S. (Zoology), Indiana University, Bloomington, IN
*1979 - B.S. (Biological Sciences), University of California, Davis, CA
*1977-1978 - Undergraduate (Biochemistry), Georg August Universität, Göttingen, Germany

==Notable studies==
*2016, [http://www.pnas.org/content/early/2016/08/24/1607571113.long Metabolic features of chronic fatigue syndrome]<ref name="Naviaux, 2016"/>
*2014, [http://www.sciencedirect.com/science/article/pii/S1567724913002390 Metabolic features of the cell danger response]
*2008, [http://www.tandfonline.com/doi/pdf/10.4161/cbt.7.8.6741 Mitochondrial control of epigenetics]
*2004, [http://www.ncbi.nlm.nih.gov/pubmed/16120397 Developing a systematic approach to the diagnosis and classification of mitochondrial disease]

==Awards and Honors==
*2008, Hailey’s Wish Foundation - Hailey’s Hero Award, For Outstanding Research and Clinical Care of children with mitochondrial disease
*2007, Thomson ESI - Science Citation Index “Fast Moving Front Article”
*2007, United Mitochondrial Disease Foundation Mitochondrial Medicine - Best Abstract Award
*2002, Honored in a non-fiction book entitled, ''Anna’s Friends — Lessons Learned from a Short and Beautiful Life''

==Talks & interviews==
[http://youtu.be/1Sq2Os0mtrQ Youtube - Mitochondria and Autism (2011)]

==Articles==
*2016, [http://www.healthrising.org/blog/2016/05/19/mitochondria-man-gets-money-uk-goes-mega-chronic-fatigue-syndrome-research-moves-forward/ "Mitochondria Man Gets His Money and the UK Goes Mega: Chronic Fatigue Syndrome Research Moving Forward"]

==Online presence==
*[http://www.ncbi.nlm.nih.gov/pubmed/?term=Naviaux%20RK%5Bauth%5D PubMed for Robert Naviaux]
*[http://profiles.ucsd.edu/robert.naviaux University of California, San Diego Faculty Website]
*[https://www.youtube.com/results?search_query=%22Robert+Naviaux%22 YouTube talks for Robert Naviaux on autism]
*[http://www.healthrising.org/forums/threads/an-eye-on-the-mitochondria-man-robert-naviaux-and-chronic-fatigue-syndrome-me-cfs.4163/ Health Rising Forum for Robert Naviaux]

==Learn more==
*[http://naviauxlab.ucsd.edu Robert Naviaux Laboratory at UC San Diego]
*[http://www.nofone.org/#!significance-of-naviaux-2015-fragile-x/ctef The Significance of Reversing Autism-Like Features in Two Distinct Mouse Models With a Single Drug, Suramin]

==See also==
*[[Metabolomics]]
*[[Mitochondria]]

==References==
<references>
<ref name="Naviaux, 2016">
{{Citation
| last1 = Naviaux | first1 = Robert K | authorlink1 = Robert Naviaux
| last2 = Naviaux | first2 = Jane C. | authorlink2 =
| last3 = Lia | first3 = Kefeng | authorlink3 =
| last4 = Bright | first4 = A. Taylor | authorlink4 =
| last5 = Alaynicka | first5 = William A. | authorlink5 =
| last6 = Wang | first6 = Lin | authorlink6 =
| last7 = Baxter | first7 = Asha | authorlink7 =
| last8 = Nathan | first8 = Neil | authorlink8 =
| last9 = Anderson | first9 = Wayne | authorlink9 =
| last10 = Gordon | first10 = Eric | authorlink10 =
| title = Metabolic features of chronic fatigue syndrome
| journal = PNAS | volume = 113 | issue = 37 | page =
| date = 2016
| doi = 10.1073/pnas.1607571113
}}
</ref>
</references>
[[Category:Researchers]]
[[Category:USA researchers]]

Karl Morten

2016-11-24T20:09:28Z

Seanko:reference added

Dr '''Karl Morten''' is a senior researcher and laboratory manager at the Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford University, [[United Kingdom]].<ref>[https://www.obs-gyn.ox.ac.uk/team/karl-morten Oxford University: Karl Morten]</ref>. His work focuses on understanding the role of mitochondria in health and disease. Some of his work has been funded by the [[ME Association]].<ref>[http://www.meassociation.org.uk/2016/05/me-associations-contributions-towards-mitochondrial-muscle-research-in-mecfs-17-may-2016/ ME Association: contributions towards mitochondrial muscle research.]</ref>

==Notable studies==
'''Mitochondrial function in Neutrophils and Monocytes'''

In March 2016 the [[ME Association]] announced it would fund Dr Morten and Professor Joanna Poulton to to assess mitochondrial function in [[Neutrophil]] and [[Monocyte cells]] from ME/CFS patients.<ref>[http://www.meassociation.org.uk/2016/03/me-association-to-fund-fourth-study-into-the-role-of-the-mitochondria-in-mecfs-10-march-2016/ ME Association to fund fourth study into the role of the mitochondria in ME/CFS | 10 March 2016]</ref>

<blockquote>"The pilot study will set up the tests required to assess mitochondrial function in blood samples from ME/CFS patients. This will make the blood tests more globally accessible to a wide range of researchers allowing a more universal validation of the findings of Booth/Myhill."<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/ Booth & Myhill: Chronic fatigue syndrome and mitochondrial dysfunction]</ref></blockquote>

'''ME Association Christmas Appeal 2016'''

The ME Association Christmas Appeal for 2016 seeks to raise £50 000 to fund research by a team led by Dr Morten to study [[metabolomics]] in patients.<ref>[http://me-pedia.org/wiki/Karl_Morten MEA Xmas Appeal Announcment November 2016]</ref> Dr Morten will work alongside scientists from Oxford and Newcastle Universities including Prof [[Julia Newton]]. Part of the team is ME/CFS patient Jamie Strong. <ref>[http://www.meassociation.org.uk/2016/11/make-me-better-why-our-christmas-appeal-has-got-personal-for-jamie-23-november-2016/ Make ME Better! | Why our Christmas Appeal has got personal for Jamie | 23 November 2016]</ref>

The research will focus on the chemical clues left behind by mitochondrial cells and follow on from the work of Dr [[Robert Naviaux]] in this area.<ref>[http://www.pnas.org/content/113/37/E5472 Metabolic features of chronic fatigue syndrome: R Naviaux et al]</ref> 300 blood samples will analysed, many from the [[UK ME/CFS biobank]].

==Talks & interviews==

*[https://www.youtube.com/watch?v=L0vxtU0nDlA Talk on Research into Mitochondria & M.E. by Dr Karl Morten], [http://www.meassociation.org.uk/wp-content/uploads/MEA-OMEGA-talk-May-10th.pdf (Slides from the Lecture)]

==Online presence==
*[https://www.researchgate.net/profile/Karl_Morten/publications ResearchGate: Karl Morten]
*[https://www.obs-gyn.ox.ac.uk/team/karl-morten; Oxford University: Karl Morten]

==Learn more==
*[http://www.meassociation.org.uk/2016/11/make-me-better-0ur-biggest-ever-christmas-appeal-starts-today-9-november-2016/ ME Association Christmas Appeal 2016]

==See also==
*[[Julia Newton]]
*[[Metabolomics]]
*[[Mitochondria]]
*[[Neutrophil]]
*[[Robert Naviaux]]

==References==
<references/>

[[Category:Researchers]]
[[Category:UK researchers]]

Glutathione

2016-11-24T20:00:44Z

Seanko:formatting

Glutathione is an important [[antioxidant]] in the body. Low levels have been found in the brains of ME/CFS patients by Prof [[Dikoma Shungu]]. <ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>
==Learn more==
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
==See also==
*[[Dikoma Shungu]]
*[[N-acetylcysteine]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Biochemistry and cell biology]]
[[Category:Antioxidants|Antioxidants]]

Glutathione

2016-11-24T19:59:02Z

Seanko:introduction expanded

Glutathione is an important [[antioxidant]] in the body. Low levels have been found in the brains ME/CFS patients by Prof [[Dikoma Shungu]]. <ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

==Learn more==
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]

==See also==
*[[Dikoma Shungu]]
*[[N-acetylcysteine]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Biochemistry and cell biology]]
[[Category:Antioxidants|Antioxidants]]

Glutathione

2016-11-24T19:58:15Z

Seanko:introduction began

Glutathione is an important [[antioxidant]] in the body. Low levels have been found in ME/CFS patients by Prof [[Dikoma Shungu]]. <ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

==Learn more==
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]

==See also==
*[[Dikoma Shungu]]
*[[N-acetylcysteine]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Biochemistry and cell biology]]
[[Category:Antioxidants|Antioxidants]]

User:Seanko

2016-11-24T17:20:21Z

Seanko:contributor

Seanko is an MEpedia contributor

Dikoma Shungu

2016-11-24T17:13:43Z

Seanko:oxidative stress

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
'''Raised Lactic Acid & lowered Glutathone levels in the brain'''

In a series of 3 studies, Prof Shungu found high levels of lactic acid in ventricular cerebrospinal fluid and significant correlation between lactic acid levels and the severity of mental fatigue in ME/CFS patients. He later went on to discover levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref> and suggested oxidative stress was playing a role in the illness.

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]

'''Supplementation with N-Acetylcysteine'''

At the 2016 IACFS/ME confernce Dr Shungu presented evidence that supplementing patients with [[N-acetylcysteine]] raised levels of Glutathione in the brains of patients and their symptoms were improved.
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Shungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T17:01:15Z

Seanko:typo corrected

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
'''Raised Lactic Acid & lowered Glutathone levels in the brain'''

In a series of 3 studies, Prof Shungu found high levels of lactic acid in ventricular cerebrospinal fluid and significant correlation between lactic acid levels and the severity of mental fatigue in ME/CFS patients. He later went on to discover levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]

'''Supplementation with N-Acetylcysteine'''

At the 2016 IACFS/ME confernce Dr Shungu presented evidence that supplementing patients with [[N-acetylcysteine]] raised levels of Glutathione in the brains of patients and their symptoms were improved.
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Shungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T17:00:10Z

Seanko:formatting

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
'''Raised Lactic Acid & lowered Glutathone levels in the brain'''

In a series of 3 studies, Prof Shungu found high levels of lactic acid in ventricular cerebrospinal fluid and significant correlation between lactic acid levels and the severity of mental fatigue in ME/CFS patients. He later went on to discover levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]

'''Supplementation with N-Acetylcysteine'''

At the 2016 IACFS/ME confernce Dr Shungu presented evidence that supplementing patients with *[[N-acetylcysteine]] raised levels of Glutathione in the brains of patients and their symptoms were improved.
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Shungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T16:58:42Z

Seanko:formatting

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
'''Raised Lactic Acid & lowered Glutathone levels in the brain'''

In a series of 3 studies, Prof Shungu found high levels of lactic acid in ventricular cerebrospinal fluid and significant correlation between lactic acid levels and the severity of mental fatigue in ME/CFS patients. He later went on to discover levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]

'''Supplementation with N-Acetylcysteine'''

At the 2016 IACFS/ME confernce Dr Shungu presented evidence that supplementing patients with [[N-Acetylcysteine]] raised levels of Glutathione in the brains of patients and their symptoms were improved.
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Shungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T16:56:18Z

Seanko:formatting

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
'''Raised Lactic Acid & lowered Glutathone levels in the brain'''
In a series of 3 studies, Prof Shungu found high levels of lactic acid in ventricular cerebrospinal fluid and significant correlation between lactic acid levels and the severity of mental fatigue in ME/CFS patients. He later went on to discover levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]

'''Supplementation with N-Acetylcysteine'''
At the 2016 IACFS/ME confernce Dr Shungu presented evidence that supplementing patients with [[N-Acetylcysteine]] raised levels of Glutathione in the brains of patients and their symptoms were improved.
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Shungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T16:50:54Z

Seanko:intro to NAC study

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
In a series of 3 studies, Prof Shungu found high levels of lactic acid in ventricular cerebrospinal fluid and significant correlation between lactic acid levels and the severity of mental fatigue in ME/CFS patients.

He later went to discover levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]

At the 2016 IACFS/ME confernce Dr Shungu presented evidence that supllementting [[N-Acetylcysteine]] raised levels of Glutathione in the brains of patients and their symptoms were improved.
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Shungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T13:55:31Z

Seanko:rewording, typos

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
In a series of 3 studies, Prof Shungu found high levels of lactic acid in ventricular cerebrospinal fluid and significant correlation between lactic acid levels and the severity of mental fatigue in ME/CFS patients.

He later went to discover levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Shungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T13:51:56Z

Seanko:typo corrected

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
In a series of 3 studies, Prof Shungu founded high levels of lactic acid in ventricular ventricular cerebrospinal fluid compared to healthy individuals and those with generalized anxiety disorder. His team discovered significant correlation between ventricular CSF lactate and severity of mental fatigue in ME/CFS patients.

He later went to find levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Shungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Solve ME/CFS Initiative

2016-11-24T13:47:34Z

Seanko:dikoma shungu added

The '''Solve ME/CFS Initiative''' (SMCI) is a not-for-profit organization in the [[United States]] started in 1987, aimed at ending [[ME/CFS]]. Originally the organization was named the CFIDS Association of America, but changed its name in 2014.<ref>http://solvecfs.org/same-mission-new-name/</ref> Presently, [[Carol Head]] serves as President and CEO and Dr. [[Zaher Nahle]] serves as Research Director.

==History==
[[Kim McCleary]] served as the CEO of Chronic Fatigue and Immune Dysfunction Syndrome Association of America or CFIDS Association of America for 22 years, from 1991 until June 2013. During that time the Association was instrumental in developing a policy ruling for the Social Security Administration that recognized CFS as a disabling condition; fought to create [[CFSAC]], the ME/CFS advisory committee to the [[Health and Human Services]] Department; exposed the [[CDC]]'s misappropriation of millions of dollars designated by Congress for CFS research; and led fundraising and public awareness campaigns. At this time, the organization has decided to focus of advancing research, both in the private and governmental sectors.<ref>http://solvecfs.org/wp-content/uploads/2013/06/NAME_CHANGE_PressRelease.pdf</ref>

==Aims==
The organization's aim is: a world free of ME/CFS.<ref>http://solvecfs.org/about-us/</ref>

==Biobank==
The Solve ME/CFS Initiative operates the [[SolveCFS BioBank & Patient Registry]].<ref>[http://solvecfs.org/solvecfs-biobank/ Biobank]</ref> By doing so, an obstacle to researchers finding appropriate patient groups for research is ameliorated.

==Funding==
100% of their funding comes from individuals — patients and their loved ones.<ref>http://solvecfs.org/research/funding-mecfs-research/</ref> The Solve ME/CFS Initiative has a program called Team Resolve, which is a grassroots community fundraising program for those interested in fundraising on a smaller local level using innovative ideas such as sponsoring a pancake breakfast, hosting a party, or turning a hobby into a way to fundraise.<ref>http://solvecfs.org/fundraising/</ref>

Solve ME/CFS Initiative received four out of four stars and 90.23 out of 100 points from Charity Navigator, America's largest independent charity evaluator.<ref>https://www.charitynavigator.org/index.cfm?bay=search.summary&orgid=6512</ref>

In April 2016, Solve ME/CFS Initiative announced that it received a award from the Robert Wood Johnson Foundation to boost the [[SolveCFS BioBank & Patient Registry]].<ref>http://solvecfs.org/smci-receives-rwjf-award</ref>

==Public awareness campaign==
*[https://www.youtube.com/watch?v=cF2OuYFDriY Times Square Public Awareness Ad, Sept 1, 2016]

==Newsletters==
The Solve ME/CFS Chronicle newsletter is released several times at year. [http://solvecfs.org/get-involved/research1st-news-archive/ Archives for past issues are available online].

'''LATEST ISSUES'''
*[https://issuu.com/solvemecfsinitiative/docs/chronicle_081816_final_lores?e=17941417/38882642 '''Summer 2016'''] Headlines include: "The Solve ME/CFS Initiative Research Plan;" "Research Study Conclusions in Brief;" "The Federal Government and ME/CFS: The Year in Review;" "SMCI Volunteers and the Silver Screen: Making a Difference;" and "Patient Voices"
*[http://solvecfs.org/spring-chronicle/spring-chronicle-2016.pdf '''Spring 2016'''] Headlines include: "Solve ME/CFS Initiative Launches New In-House Research Program;" "NIH Provides Details on New Intramural Study;" "Solve ME/CFS Initiative Announces New Research Advisory Council;" "Solve ME/CFS Initiative Announces New Research Grants Program;" "Solve ME/CFS Initiative Meets with NIH, Congress;" "Solve ME/CFS Initiative Updates Its Report Card on Revised CFSAC Responses;" "Dr. [[Zaher Nahle]] Serves on CDC Workgroup;" and "Carol Head Joins CFSAC Subcommittee on Centers of Excellence"
*[http://solvecfs.org/wp-content/uploads/2015/12/Chronicle_Winter2015.pdf '''Winter 2015'''] Headlines include: "Significant Breakthrough for ME/CFS at the NIH;" "Overcoming the Challenges of a Complex Disease;" "Updates on Solve ME/CFS Initiative-Funded Research;" and "Humans of ME/CFS: We Want to Hear Your Story."

==Webinars online==
*[https://www.youtube.com/watch?v=ENrdrGj0p-c Nov 10, 2016 Webinar with Dr. [[Anthony Komaroff ]], "Hot Areas in ME/CFS Research"]
::[http://solvecfs.org/dr-anthony-komaroffs-responses-to-follow-up-webinar-questions/ Written questions and answers to Dr. Komaroff's webinar]
*[https://www.youtube.com/watch?v=mlhz7GRAqsg Oct 20, 2016 Webinar with [[Christopher Armstrong]], on recent metabolomics studies]
*[https://www.youtube.com/watch?v=hYgz1iV4e3Q Sept 8, 2016 Webinar with [[Elizabeth Unger]], PhD, MD, "Update on CDC's Public Health Approach To ME/CFS"]
*[https://www.youtube.com/watch?v=3fx_TradX4M Sept 1, 2016 Webinar with [[Maureen Hanson]], Ph.D., "Current and Previous Research on ME/CFS at Cornell University"]
*[https://www.youtube.com/watch?v=wJB95m4FLa0 May 19, 2016 Webinar with [[Jarred Younger]], Ph.D. "Chronic Fatigue Syndrome and Myalgic Encephalomyelitis: Can we find answers in the brain?"]
*[http://www.meaction.net/2016/04/24/transcript-solve-mecfs-interviews-dr-avi-nath/ April 21, 2016 Webinar with [[Avindra Nath]], MD, "Post Infectious Myalgic Encephalomyelopathy/Chronic Fatigue Syndrome"]
*[https://www.youtube.com/watch?v=Akc5upzbFxs March 17, 2016 [[Susan Levine]], MD, "The Future of ME CFS"]
::[http://solvecfs.org/dr-susan-levine-part1 Part 1 - Written questions and answers to Dr. Levine's webinar]
::[http://solvecfs.org/dr-susan-levine-part-2 Part 2 - Written questions and answers to Dr. Levine's webinar]
*[https://www.youtube.com/watch?v=vfmrPd4-rIE Nov 19, 2015 [[Dane Cook|Dane B. Cook]], PhD, "Deciphering Post-Exertion Malaise: The Intersection of Biology and Behavior"]
*[https://www.youtube.com/watch?v=a6NqOYdBRrg Oct 15, 2015 Dr. [[Alan Light]] "New Developments in ME/CFS Research"]
*[https://www.youtube.com/watch?v=ZWpIothVsAE Aug 3, 2015 Dr. [[Zaher Nahle]], Vice President of Research and Scientific Programs at the Solve ME/CFS Initiative]
*[https://www.youtube.com/watch?v=ux93w7yGQ5g Jul 16, 2015 [[Peter Rowe]], MD, "Inducing Post-Exertional Malaise in ME/CFS: A Look at the Research Evidence"]
::[http://solvecfs.org/dr.+peter-rowe-part-one Part 1 - Written questions and answers to Dr. Rowe's webinar]
::[http://solvecfs.org/dr-peter-rowe-part-two Part 2 - Written questions and answers to Dr. Rowe's webinar]
::[http://solvecfs.org/dr-peter-rowe-part-three Part 3 - Written questions and answers to Dr. Rowe's webinar]
::[http://solvecfs.org/dr-peter-rowe-part-four Part 4 - Written questions and answers to Dr. Rowe's webinar]
*[https://www.youtube.com/watch?v=hxJPrkWHcBo Jun 18, 2015 [[Lily Chu]], MD, MS, "Post-Exertional Malaise: History, Characteristics, Evidence"]
::[http://solvecfs.org/dr-lily-chu-q%26a-follow-up-to-june-18-webinar Written questions and answers to Dr. Chu's webinar]
*[https://www.youtube.com/watch?v=359XmpNBHM8 Apr 17, 2015 [[Lucinda Bateman]], MD, "Will SEID Diagnostic Criteria Improve Diagnosis and Treatment?"]
*[https://www.youtube.com/watch?v=40J4RaWiCH8&feature=youtu.be Dec 16, 2014 [[Carol Head]] and [[Suzanne Vernon]], PhD, "ME/CFS Research Year-End Summary"]
*[https://www.youtube.com/watch?v=w4OEGOCw3Dg&feature=youtu.be Nov 14, 2014 [[Lucinda Bateman]], MD, "Can ME CFS and Fibromyalgia Research Help You Sleep?"]
*[https://www.youtube.com/watch?v=YnCcEoFSgvc&feature=youtu.be Oct 23, 2014 [[Peter Rowe]], MD, "Neuromuscular Strain in ME/CFS"]
*[https://www.youtube.com/watch?v=c9ikUVCXnhU&feature=youtu.be Oct 1, 2014 Derya Unutmaz, MD, "Decoding the Human Immune Response"]
*[https://www.youtube.com/watch?v=k7OLt6J4ySk&feature=youtu.be Sept 18,2014 [[Dane Cook|Dane B. Cook]], PhD, "Deciphering Post-Exertional Malaise"]
*[https://www.youtube.com/watch?v=QjrBP7MFVPY&feature=youtu.be Aug 21, 2014 [[Patrick O. McGowan]], PhD, "Epigenetics of ME/CFS"]
*[https://www.youtube.com/watch?v=T0qdGJkY7iU&feature=youtu.be Jul 31, 2014 [[Suzanne Vernon]], PhD, "Research Institute Without Walls: Progress & Promise"]

==Webinars newsletters with links to download slides==
*[http://solvecfs.org/2016-webinar-series 2016 Webinar Series]
*[http://solvecfs.org/smci-2015-webinar-series/ 2015 Webinar Series]
*[http://solvecfs.org/mecfs-resources/patient-resources/solve-mecfs-initiative-2014-webinar-series/ 2014 Webinar Series]

==Contact information==
:Solve ME/CFS Initiative
:5455 Wilshire Blvd, Ste 806
:Los Angeles, CA 90036-0007
:Phone: 704-364-0016

==Online presence==
*[https://www.youtube.com/user/SolveCFS/videos YouTube]
*[http://solvecfs.org/ Web site]
*[https://www.facebook.com/CFIDSAssn/ Facebook]
*[https://twitter.com/plzsolvecfs Twitter]

==Learn more==
*[https://en.wikipedia.org/wiki/Solve_ME/CFS_Initiative Wikipedia - Solve ME/CFS Initiative]
*2016, [http://www.meaction.net/2016/07/25/introducing-the-seed-grant-ramsay-award-program/ Introducing the seed grant Ramsay award program]
*2016, [http://www.meaction.net/2016/08/02/smci-engaged-with-nih-officials-to-further-appropriate-mecfs-funding/ SMCI engaged with NIH officials to further appropriate MECFS funding]

==See also==
*[[Carol Head]]
*[[Zaher Nahle]]
*[[SolveCFS BioBank & Patient Registry]]
*[[Dikoma Shungu]]

==References==
<references>
</references>

[[Category:Research initiatives]]
[[Category:American research initiatives]]

Dikoma Shungu

2016-11-24T13:45:55Z

Seanko:notable studies updated

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
In a series of 3 studies, Prof Shungu founded high levels of lactic acid in ventricular ventricular cerebrospinal fluid compared to healthy individuals and those with generalized anxiety disorder. His team discovered significant correlation between ventricular CSF lactate and severity of mental fatigue in ME/CFS patients.

He later went to find levels of the antioxidant glutathion reduced by 36% in brain tisue<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Ahungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T13:28:24Z

Seanko:typos corrected, added link

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]].

==Notable studies==
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Ahungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]
*[[Solve ME/CFS Initiative]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T13:26:45Z

Seanko:funding info in introduction

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States. His research focuses on developing advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods to apply in clinical and biomedical research. He has used MRS to measure brain lactic acid, the antioxidant glutathione (GSH) and other metabolites in [[chronic fatigue syndrome]].<ref>[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College; Dikoma Shungu]</ref>. His work has been funded by the [[NIH]] and the [[Solve ME/CFS Initiative]]

==Notable studies==
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1315/abstract Ventricular cerebrospinal fluid lactate is increased in CFS compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR in Biomedicine. April 2009]
*[http://onlinelibrary.wiley.com/doi/10.1002/nbm.1512/abstract Increased ventricular lactate in CFS measured by H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR in Biomedicine. July 2010]
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Weill Cornell Medical College: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Ahungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-24T13:18:05Z

Seanko:links added

Dikoma Shungu

2016-11-24T13:10:29Z

Seanko:rewording

Dikoma Shungu

2016-11-24T13:06:21Z

Seanko:introduction expanded

Dikoma Shungu

2016-11-24T12:59:02Z

Seanko:photo added

[[File:Dikoma_shungu.png|right]]
Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States.

==Notable studies==
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Cornell University: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Ahungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

File:Dikoma shungu.png

2016-11-24T12:56:35Z

Seanko:Photo of Dikoma Shungu

Photo of Dikoma Shungu

Talk:Dikoma Shungu

2016-11-23T18:09:07Z

Seanko:to do list modified

To do

*marry up details & refernces to n-acetylcysteine
*add other notable studies & to be written up
*photo

[[seanko]]

Dikoma Shungu

2016-11-23T18:07:51Z

Seanko:links added

Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States.

==Notable studies==
*[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Cornell University: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Ahungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-23T18:05:34Z

Seanko:link added

Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States.

==Notable studies==

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Cornell University: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://solvecfs.org/new-2-million-cfs-grant-awarded-to-dr-dikoma-shungu-team/ Solve ME/CFS Initiative: New $2 million CFS grant awarded to Dr Dikoma Ahungu team]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

N-acetylcysteine

2016-11-23T17:59:41Z

Seanko:formatting

'''N-acetylcysteine''' also known as Acetylcysteine or N-acetyl-L-cysteine (NAC) increases levels of Glutathione (GSH), the most common antioxidant in the body. Taking GSH directly is costly and inefficient, NAC is a more efficient and economical means delivering GSH to cells.<ref>[https://examine.com/supplements/glutathione/ Examine:Glutathione]</ref> NAC is a pro-drug for l-cysteine which enables cells to synthesise Glutathione providing antioxidant benefits.<ref>[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]</ref>

==Evidence==

In a presentation to the 2016 IACFS/ME conference Dr [[Dikoma Shungu]] of Cornell University gave a presentation on a trial of NAC in ME/CFS patients. <ref>[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]</ref> Previously his team had found a 36% deficit of the tissue anti-oxidant occipital cortex glutathione (GSH) in the cortical areas of the brains ofME/CFS patients.<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

The trial supplemented patients with 1800g daily of GSH precursor n-acetylcysteine for 4 weeks and looked at levels of GSH. The study found that GSH had increased in patients and that symptoms were significantly reduced.

==Clinical use==

No official use for ME/CFS currently.

==Learn more==
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==See also==

*[[Center for Enervating NeuroImmune Disease]]
*[[Dikoma Shungu]]
*[[Martin Pall]]
*[[Nitric oxide hypothesis]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Antioxidants|Antioxidants]]

N-acetylcysteine

2016-11-23T17:59:01Z

Seanko:added Dikoma Shungu

'''N-acetylcysteine''' also known as Acetylcysteine or N-acetyl-L-cysteine (NAC) increases levels of Glutathione (GSH), the most common antioxidant in the body. Taking GSH directly is costly and inefficient, NAC is a more efficient and economical means delivering GSH to cells.<ref>[https://examine.com/supplements/glutathione/ Examine:Glutathione]</ref> NAC is a pro-drug for l-cysteine which enables cells to synthesise Glutathione providing antioxidant benefits.<ref>[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]</ref>

==Evidence==

In a presentation to the 2016 IACFS/ME conference Dr [[Dikoma Shungu]] of Cornell University gave a presentation on a trial of NAC in ME/CFS patients. <ref>[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]</ref> Previously his team had found a 36% deficit of the tissue anti-oxidant occipital cortex glutathione (GSH) in the cortical areas of the brains ofME/CFS patients.<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

The trial supplemented patients with 1800g daily of GSH precursor n-acetylcysteine for 4 weeks and looked at levels of GSH. The study found that GSH had increased in patients and that symptoms were significantly reduced.

==Clinical use==

No official use for ME/CFS currently.

==Learn more==
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==See also==

*[[Center for Enervating NeuroImmune Disease]]
[[Dikoma Shungu]]
*[[Martin Pall]]
*[[Nitric oxide hypothesis]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Antioxidants|Antioxidants]]

Talk:Martin Pall

2016-11-23T17:57:59Z

Seanko:to do list

To do

*add photo

N-acetylcysteine

2016-11-23T17:54:18Z

Seanko:links removed (redundant)

'''N-acetylcysteine''' also known as Acetylcysteine or N-acetyl-L-cysteine (NAC) increases levels of Glutathione (GSH), the most common antioxidant in the body. Taking GSH directly is costly and inefficient, NAC is a more efficient and economical means delivering GSH to cells.<ref>[https://examine.com/supplements/glutathione/ Examine:Glutathione]</ref> NAC is a pro-drug for l-cysteine which enables cells to synthesise Glutathione providing antioxidant benefits.<ref>[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]</ref>

==Evidence==

In a presentation to the 2016 IACFS/ME conference Dr [[Dikoma Shungu]] of Cornell University gave a presentation on a trial of NAC in ME/CFS patients. <ref>[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]</ref> Previously his team had found a 36% deficit of the tissue anti-oxidant occipital cortex glutathione (GSH) in the cortical areas of the brains ofME/CFS patients.<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

The trial supplemented patients with 1800g daily of GSH precursor n-acetylcysteine for 4 weeks and looked at levels of GSH. The study found that GSH had increased in patients and that symptoms were significantly reduced.

==Clinical use==

No official use for ME/CFS currently.

==Learn more==
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==See also==

*[[Center for Enervating NeuroImmune Disease]]
*[[Martin Pall]]
*[[Nitric oxide hypothesis]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Antioxidants|Antioxidants]]

Talk:Nitric oxide hypothesis

2016-11-23T17:51:11Z

Seanko:to do: article needs completion

http://www.nature.com/nature/journal/v456/n7221/abs/nature07414.html

*Article needs completion

N-acetylcysteine

2016-11-23T17:49:07Z

Seanko:link added

'''N-acetylcysteine''' also known as Acetylcysteine or N-acetyl-L-cysteine (NAC) increases levels of Glutathione (GSH), the most common antioxidant in the body. Taking GSH directly is costly and inefficient, NAC is a more efficient and economical means delivering GSH to cells.<ref>[https://examine.com/supplements/glutathione/ Examine:Glutathione]</ref> NAC is a pro-drug for l-cysteine which enables cells to synthesise Glutathione providing antioxidant benefits.<ref>[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]</ref>

==Evidence==

In a presentation to the 2016 IACFS/ME conference Dr [[Dikoma Shungu]] of Cornell University gave a presentation on a trial of NAC in ME/CFS patients. <ref>[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]</ref> Previously his team had found a 36% deficit of the tissue anti-oxidant occipital cortex glutathione (GSH) in the cortical areas of the brains ofME/CFS patients.<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

The trial supplemented patients with 1800g daily of GSH precursor n-acetylcysteine for 4 weeks and looked at levels of GSH. The study found that GSH had increased in patients and that symptoms were significantly reduced.

==Clinical use==

No official use for ME/CFS currently.

==Learn more==

*[https://en.wikipedia.org/wiki/Acetylcysteine Wikipedia - Acetylcysteine]
*[https://en.wikipedia.org/wiki/Glutathione Wikipedia - Glutathione]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==See also==

*[[Center for Enervating NeuroImmune Disease]]
*[[Martin Pall]]
*[[Nitric oxide hypothesis]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Antioxidants|Antioxidants]]

Nitric oxide hypothesis

2016-11-23T17:47:48Z

Seanko:links added

'''Nitric oxide hypothesis'''

==Theory==
Dr [[Martin Pall]] states: "I propose here a novel hypothesis of CFS in which either viral or bacterial infection induces one or more cytokines, IL-1beta IL-6, TNF-alpha and IFN-gamma. These induce nitric oxide synthase (iNOS), leading to increased nitric oxide levels. Nitric oxide, in turn, reacts with superoxide radical to generate the potent oxidant peroxynitrite. Multiple amplification and positive feedback mechanisms are proposed by which once peroxynitrite levels are elevated, they tend to be sustained at a high level."<ref>Pall, ML. (2000). Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. ''Medical Hypotheses, 54'' (1):115-25. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10790736</ref>

==Evidence==

==Learn more==
*[http://www.townsendletter.com/FebMarch2010/cureNO0210.html How Can We Cure NO/ONOO− Cycle Diseases?], Martin L. Pall, 2010
*[http://phoenixrising.me/archives/18836 Nitric oxide and its possible implication in ME/CFS (Part 1 of 2)], Phoenix Rising, August 25, 2014
*[http://phoenixrising.me/archives/25528 Nitric oxide and its possible implication in ME/CFS (Part 2 of 2)], Phoenix Rising, August 28, 2014
*[http://www.cortjohnson.org/forums/threads/fluge-mella-take-out-patent-on-nitric-oxide-treatment-for-me-cfs.2829/ Fluge/Mella Take out Patent on Nitric Oxide Treatment for ME/CFS], Health Rising, 31 Jul 2015

==See also==
*[[Martin Pall]]
*[[N-acetylcysteine]]

==References==
<references>

</references>

[[Category:Medical hypotheses]]

Martin Pall

2016-11-23T17:45:09Z

Seanko:links added

'''Martin Pall,''' PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.<ref>http://www.smb.wsu.edu/faculty-trainees-and-staff/faculty.</ref>

Dr. Pall developed the [[Nitric oxide hypothesis | Nitric Oxide Cycle Theory]], also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in [[chronic fatigue syndrome]]/[[myalgic encephalomyelitis]] (CFS/ME), [[Multiple Chemical Sensitivity]] (MCS), [[fibromyalgia]] (FM) and possibly a large number of other chronic inflammatory diseases. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.<ref>http://www.prohealth.com//library/showArticle.cfm?libid=12896</ref>

He believes that certain over-the-counter supplements, such as [[fish oil]], [[CoQ10]], [[vitamin E]], NAC ([[N-acetylcysteine]]), and other [[antioxidants]], can help downregulate the oxidation caused by the nitric oxide cycle.<ref>http://www.prohealth.com/library/showarticle.cfm?libid=16224</ref> He believes [[Vitamin B12]] injections can also be a potent nitric oxide scavenger.<ref>http://www.investinme.eu/IIMEC2.shtml</ref>

Dr. Pall was one of the authors of the [[International Consensus Criteria]].<ref name="Carruthers, 2011"/>

==Articles==
*2009 [http://www.prohealth.com/library/showarticle.cfm?libid=14467 ''Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS'']
*2007 [http://www.prohealth.com//library/showArticle.cfm?libid=12896''Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD'']

==Talks and Interviews==
*2007 Speaker at the 2nd Invest in ME International ME Conference - ''Biochemical Underpinnings of ME/CFS''<ref>http://www.investinme.eu/IIMEC2.shtml</ref> - [http://www.investinme.eu/IIMEC2.shtml#dvd DVD available]

==Publications on ME/CFS==
*2011, Myalgic encephalomyelitis: International Consensus Criteria.<ref>Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles AC, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell DS, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis D, Light AR, Marshall-Gradisbik S, Mena I, Mikovits JA, Miwa K, Murovska M, Pall ML, Stevens S. (2011). Myalgic encephalomyelitis: International Consensus Criteria. ''Journal of Internal Medicine, 270'' (4):327-38. doi: 10.1111/j.1365-2796.2011.02428.x. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21777306</ref>
* 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease.<ref> Pall, ML. (2008). Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease. ''Medical Hypotheses, 71'' (4):537-41. doi:10.1016/j.mehy.2008.05.023. Epub 2008 Jul 29. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18667279</ref>
*2005, Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due.<ref>Pall ML. (2005). Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due. ''Medical Hypotheses, 65'' (3):631-3. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15936892.</ref>
*2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.<ref>Smirnova IV, Pall ML. (2003). Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients. ''Molecular and Cellular Biochemistry, 248'' (1-2):93-5. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12870659</ref>
*2002, Chronic fatigue syndrome/myalgic encephalitis.<ref>Pall, ML. (2002). Chronic fatigue syndrome/myalgic encephalitis. ''British Journal of General Practice, 52'' (482):762. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12236283.</ref>
*2001, Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.<ref> Pall, ML. (2001). Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. ''Medical Hypotheses, 57'' (2):139-45. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11461161 </ref>
*2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.<ref>Pall ML, Satterlee JD. (2001). Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. ''Annals of the New York Academy of Science, 933.''323-9. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12000033</ref>
*2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome.<ref>Pall, ML. (2000). Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. ''Medical Hypotheses, 54'' (1):115-25. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10790736</ref>

==See Also==
*[[N-acetylcysteine]]
*[[Nitric oxide hypothesis]]

==References==
<references>
<ref name="Carruthers, 2011">
{{Citation
| last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers
| last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande
| last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir
| last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas
| last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick
| last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell
| last7 = Staines | first7 = D | authorlink7 = Donald Staines
| last8 = Powles | first8 = A C P | authorlink8 = A C Peter Powles
| last9 = Speight | first9 = N | authorlink9 = Nigel Speight
| last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings
| last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman
| last12 = Baumgarten-Austrheim| first12 = B | authorlink12 = Barbara Baumgarten-Austrheim
| last13 = Bell | first13 = DS | authorlink13 = David Bell
| last14 = Carlo-Stella | first14 = N | authorlink14 = Nicoletta Carlo-Stella
| last15 = Chia | first15 = J | authorlink15 = John Chia
| last16 = Darragh | first16 = A | authorlink16 = Austin Darragh
| last17 = Jo | first17 = D | authorlink17 = Daehyun Jo
| last18 = Lewis | first18 = D | authorlink18 = Donald Lewis
| last19 = Light | first19 = A | authorlink19 = Alan Light
| last20 = Marshall-Gradisnik | first20 = S | authorlink20 = Sonya Marshall-Gradisnik
| last21 = Mena | first21 = I | authorlink21 = Ismael Mena
| last22 = Mikovits | first22 = JA | authorlink22 = Judy Mikovits
| last23 = Miwa | first23 = K | authorlink23 = Kunihisa Miwa
| last24 = Murovska | first24 = M | authorlink24 = Modra Murovska
| last25 = Pall | first25 = ML | authorlink25 = Martin Pall
| last26 = Stevens | first26 = S | authorlink26 = Staci Stevens
| title = Myalgic encephalomyelitis: International Consensus Criteria.
| journal = Journal of Internal Medicine | volume = 270 | issue = 4 | page = 327-38
| date = 2011
| pmid = 21777306
| doi = 10.1111/j.1365-2796.2011.02428.x
}}
</ref>

[[Category:Researchers]]
[[Category:USA researchers]]

Martin Pall

2016-11-23T17:43:40Z

Seanko:link added

'''Martin Pall,''' PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.<ref>http://www.smb.wsu.edu/faculty-trainees-and-staff/faculty.</ref>

Dr. Pall developed the [[Nitric oxide hypothesis | Nitric Oxide Cycle Theory]], also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in [[chronic fatigue syndrome]]/[[myalgic encephalomyelitis]] (CFS/ME), [[Multiple Chemical Sensitivity]] (MCS), [[fibromyalgia]] (FM) and possibly a large number of other chronic inflammatory diseases. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.<ref>http://www.prohealth.com//library/showArticle.cfm?libid=12896</ref>

He believes that certain over-the-counter supplements, such as [[fish oil]], [[CoQ10]], [[vitamin E]], NAC (N-acetylcysteine), and other anti-oxidants, can help downregulate the oxidation caused by the nitric oxide cycle.<ref>http://www.prohealth.com/library/showarticle.cfm?libid=16224</ref> He believes [[Vitamin B12]] injections can also be a potent nitric oxide scavenger.<ref>http://www.investinme.eu/IIMEC2.shtml</ref>

Dr. Pall was one of the authors of the [[International Consensus Criteria]].<ref name="Carruthers, 2011"/>

==Articles==
*2009 [http://www.prohealth.com/library/showarticle.cfm?libid=14467 ''Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS'']
*2007 [http://www.prohealth.com//library/showArticle.cfm?libid=12896''Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD'']

==Talks and Interviews==
*2007 Speaker at the 2nd Invest in ME International ME Conference - ''Biochemical Underpinnings of ME/CFS''<ref>http://www.investinme.eu/IIMEC2.shtml</ref> - [http://www.investinme.eu/IIMEC2.shtml#dvd DVD available]

==Publications on ME/CFS==
*2011, Myalgic encephalomyelitis: International Consensus Criteria.<ref>Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles AC, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell DS, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis D, Light AR, Marshall-Gradisbik S, Mena I, Mikovits JA, Miwa K, Murovska M, Pall ML, Stevens S. (2011). Myalgic encephalomyelitis: International Consensus Criteria. ''Journal of Internal Medicine, 270'' (4):327-38. doi: 10.1111/j.1365-2796.2011.02428.x. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21777306</ref>
* 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease.<ref> Pall, ML. (2008). Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease. ''Medical Hypotheses, 71'' (4):537-41. doi:10.1016/j.mehy.2008.05.023. Epub 2008 Jul 29. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18667279</ref>
*2005, Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due.<ref>Pall ML. (2005). Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due. ''Medical Hypotheses, 65'' (3):631-3. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15936892.</ref>
*2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.<ref>Smirnova IV, Pall ML. (2003). Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients. ''Molecular and Cellular Biochemistry, 248'' (1-2):93-5. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12870659</ref>
*2002, Chronic fatigue syndrome/myalgic encephalitis.<ref>Pall, ML. (2002). Chronic fatigue syndrome/myalgic encephalitis. ''British Journal of General Practice, 52'' (482):762. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12236283.</ref>
*2001, Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.<ref> Pall, ML. (2001). Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. ''Medical Hypotheses, 57'' (2):139-45. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11461161 </ref>
*2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.<ref>Pall ML, Satterlee JD. (2001). Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. ''Annals of the New York Academy of Science, 933.''323-9. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12000033</ref>
*2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome.<ref>Pall, ML. (2000). Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. ''Medical Hypotheses, 54'' (1):115-25. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10790736</ref>

==See Also==
*[[N-acetylcysteine]]
*[[Nitric oxide hypothesis]]

==References==
<references>
<ref name="Carruthers, 2011">
{{Citation
| last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers
| last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande
| last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir
| last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas
| last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick
| last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell
| last7 = Staines | first7 = D | authorlink7 = Donald Staines
| last8 = Powles | first8 = A C P | authorlink8 = A C Peter Powles
| last9 = Speight | first9 = N | authorlink9 = Nigel Speight
| last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings
| last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman
| last12 = Baumgarten-Austrheim| first12 = B | authorlink12 = Barbara Baumgarten-Austrheim
| last13 = Bell | first13 = DS | authorlink13 = David Bell
| last14 = Carlo-Stella | first14 = N | authorlink14 = Nicoletta Carlo-Stella
| last15 = Chia | first15 = J | authorlink15 = John Chia
| last16 = Darragh | first16 = A | authorlink16 = Austin Darragh
| last17 = Jo | first17 = D | authorlink17 = Daehyun Jo
| last18 = Lewis | first18 = D | authorlink18 = Donald Lewis
| last19 = Light | first19 = A | authorlink19 = Alan Light
| last20 = Marshall-Gradisnik | first20 = S | authorlink20 = Sonya Marshall-Gradisnik
| last21 = Mena | first21 = I | authorlink21 = Ismael Mena
| last22 = Mikovits | first22 = JA | authorlink22 = Judy Mikovits
| last23 = Miwa | first23 = K | authorlink23 = Kunihisa Miwa
| last24 = Murovska | first24 = M | authorlink24 = Modra Murovska
| last25 = Pall | first25 = ML | authorlink25 = Martin Pall
| last26 = Stevens | first26 = S | authorlink26 = Staci Stevens
| title = Myalgic encephalomyelitis: International Consensus Criteria.
| journal = Journal of Internal Medicine | volume = 270 | issue = 4 | page = 327-38
| date = 2011
| pmid = 21777306
| doi = 10.1111/j.1365-2796.2011.02428.x
}}
</ref>

[[Category:Researchers]]
[[Category:USA researchers]]

N-acetylcysteine

2016-11-23T17:41:13Z

Seanko:link added

'''N-acetylcysteine''' also known as Acetylcysteine or N-acetyl-L-cysteine (NAC) increases levels of Glutathione (GSH), the most common antioxidant in the body. Taking GSH directly is costly and inefficient, NAC is a more efficient and economical means delivering GSH to cells.<ref>[https://examine.com/supplements/glutathione/ Examine:Glutathione]</ref> NAC is a pro-drug for l-cysteine which enables cells to synthesise Glutathione providing antioxidant benefits.<ref>[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]</ref>

==Evidence==

In a presentation to the 2016 IACFS/ME conference Dr [[Dikoma Shungu]] of Cornell University gave a presentation on a trial of NAC in ME/CFS patients. <ref>[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]</ref> Previously his team had found a 36% deficit of the tissue anti-oxidant occipital cortex glutathione (GSH) in the cortical areas of the brains ofME/CFS patients.<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

The trial supplemented patients with 1800g daily of GSH precursor n-acetylcysteine for 4 weeks and looked at levels of GSH. The study found that GSH had increased in patients and that symptoms were significantly reduced.

==Clinical use==

No official use for ME/CFS currently.

==Learn more==

*[https://en.wikipedia.org/wiki/Acetylcysteine Wikipedia - Acetylcysteine]
*[https://en.wikipedia.org/wiki/Glutathione Wikipedia - Glutathione]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==See also==

*[[Center for Enervating NeuroImmune Disease]]
*[[Martin Pall]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Antioxidants|Antioxidants]]

Center for Enervating NeuroImmune Disease

2016-11-22T18:56:54Z

Seanko:typos corrected

'''Center for Enervating NeuroImmune Disease''' (CEND) is a new center at Cornell University in Ithaca, NY and Weill Cornell Medical College in Manhattan, NYC, NY for the study of [[ME/CFS]]. The name was suggested by a patient. Enervating means causing you to feel weak and lacking in energy.It includes three laboratories at Weill Cornell, eight labs from the Cornell campus in Ithaca, and one at Ithaca College. They are hoping the center will attract additional researchers to study the illness.<ref>https://www.youtube.com/watch?time_continue=2759&v=3fx_TradX4M</ref>

==Mission==
To promote research to identify the cause(s), biomarkers, and pathophysiology of [[myalgic encephalomyelitis]], [[chronic fatigue syndrome]], or [[Systemic Exertion Intolerance Disease]] in order to lead to prevention and effective treatments.

==Learn More==
*[http://neuroimmune.cornell.edu/ Website]

==See Also==
*[[Maureen Hanson]] - Center Director
*[[Dikoma Shungu]] - Brain imaging, MRS & MRI
*[[Mark VanNess]]- ME/CFS Exercise Physiology, Scientific Advisory Committee Member ([[Workwell Foundation]])
*[[Staci Stevens]] - ME/CFS Exercise Physiology ([[Workwell Foundation]])
*[[Susan Levine]] - Immunology & Adult ME/CFS (in Private Practice)
*[[John Chia]] - Enteroviruses in ME/CFS (UCLA)

==References==

[[Category:Research initiatives]]
[[Category:American research initiatives]]

Center for Enervating NeuroImmune Disease

2016-11-22T18:54:46Z

Seanko:Staci Stevens & John Chia added

'''Center for Enervating NeuroImmune Disease''' (CEND) is a new center at Cornell University in Ithaca, NY and Weill Cornell Medical College in Manhattan, NYC, NY for the study of [[ME/CFS]]. The name was suggested by a patient. Enervating means causing you to feel weak and lacking in energy.It includes three laboratories at Weill Cornell, eight labs from the Cornell campus in Ithaca, and one at Ithaca College. They are hoping the center will attract additional researchers to study the illness.<ref>https://www.youtube.com/watch?time_continue=2759&v=3fx_TradX4M</ref>

==Mission==
To promote research to identify the cause(s), biomarkers, and pathophysiology of [[myalgic encephalomyelitis]], [[chronic fatigue syndrome]], or [[Systemic Exertion Intolerance Disease]] in order to lead to prevention and effective treatments.

==Learn More==
*[http://neuroimmune.cornell.edu/ Website]

==See Also==
*[[Maureen Hanson]] - Center Director
*[[Dikoma Shungu]] - Brain imaging, MRS & MRI
*[[Mark VanNess]]- ME/CFS Exercise Physiology, Scientific Advisory Committee Member [(Workwell Foundation)]
*[[Staci Stevens]] - ME/CFS Exercise Physiology [(Workwell Foundation)]
*[[Susan Levine]] - Immunology & Adult ME/CFS (in Private Preactice)
*[[John Chia]] - Enteroviruses in ME/CFS (UCLA)

==References==

[[Category:Research initiatives]]
[[Category:American research initiatives]]

N-acetylcysteine

2016-11-22T18:46:55Z

Seanko:introduction expanded

'''N-acetylcysteine''' also known as Acetylcysteine or N-acetyl-L-cysteine (NAC) increases levels of Glutathione (GSH), the most common antioxidant in the body. Taking GSH directly is costly and inefficient, NAC is a more efficient and economical means delivering GSH to cells.<ref>[https://examine.com/supplements/glutathione/ Examine:Glutathione]</ref> NAC is a pro-drug for l-cysteine which enables cells to synthesise Glutathione providing antioxidant benefits.<ref>[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]</ref>

==Evidence==

In a presentation to the 2016 IACFS/ME conference Dr [[Dikoma Shungu]] of Cornell University gave a presentation on a trial of NAC in ME/CFS patients. <ref>[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]</ref> Previously his team had found a 36% deficit of the tissue anti-oxidant occipital cortex glutathione (GSH) in the cortical areas of the brains ofME/CFS patients.<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref>

The trial supplemented patients with 1800g daily of GSH precursor n-acetylcysteine for 4 weeks and looked at levels of GSH. The study found that GSH had increased in patients and that symptoms were significantly reduced.

==Clinical use==

No official use for ME/CFS currently.

==Learn more==

*[https://en.wikipedia.org/wiki/Acetylcysteine Wikipedia - Acetylcysteine]
*[https://en.wikipedia.org/wiki/Glutathione Wikipedia - Glutathione]
*[https://en.wikipedia.org/wiki/Oxidative_stress Wikipedia - Oxidative Stress]
*[https://examine.com/supplements/glutathione/ Examine: Glutathione]
*[https://examine.com/supplements/n-acetylcysteine/ Examine: N-acetylcysteine]
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]
*[http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy: Dikoma Shungu et al (page 35 IACFS/ME Syllabus 2016)]

==See also==

[[Center for Enervating NeuroImmune Disease]]

==References==
<references/>

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Antioxidants|Antioxidants]]

Dikoma Shungu

2016-11-22T17:28:01Z

Seanko:formatting

Dr '''Dikoma Shunga''' is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States.

==Notable studies==

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Cornell University: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Dikoma Shungu

2016-11-22T17:26:06Z

Seanko:link added

Dr Dikoma Shunga is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States.

==Notable studies==

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Cornell University: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==
*[http://www.healthrising.org/blog/2013/03/10/your-brain-on-view-big-nih-chronic-fatigue-syndrome-grant/ Health Rising: Brain on Fire (October 2013)]

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]

Talk:Dikoma Shungu

2016-11-22T17:24:22Z

Seanko:to do list

To do

*marry up details & refernces to n-acetylcysteine
*add other notable studies
*photo

Talk:Center for Enervating NeuroImmune Disease

2016-11-22T17:22:23Z

Seanko:to do list

To do

Populate members section with individuals from
http://neuroimmune.cornell.edu/members/

Center for Enervating NeuroImmune Disease

2016-11-22T17:20:49Z

Seanko:Susan levine added

'''Center for Enervating NeuroImmune Disease''' (CEND) is a new center at Cornell University in Ithaca, NY and Weill Cornell Medical College in Manhattan, NYC, NY for the study of [[ME/CFS]]. The name was suggested by a patient. Enervating means causing you to feel weak and lacking in energy.It includes three laboratories at Weill Cornell, eight labs from the Cornell campus in Ithaca, and one at Ithaca College. They are hoping the center will attract additional researchers to study the illness.<ref>https://www.youtube.com/watch?time_continue=2759&v=3fx_TradX4M</ref>

==Mission==
To promote research to identify the cause(s), biomarkers, and pathophysiology of [[myalgic encephalomyelitis]], [[chronic fatigue syndrome]], or [[Systemic Exertion Intolerance Disease]] in order to lead to prevention and effective treatments.

==Learn More==
*[http://neuroimmune.cornell.edu/ Website]

==See Also==
*[[Maureen Hanson]] - Center Director
*[[Dikoma Shungu]] - Brain imaging, MRS & MRI
*[[Mark VanNess]]- ME/CFS Exercise Physiology, Scientific Advisory Committee Member
*[[Susan Levine]] - Immunology & Adult ME/CFS

==References==

[[Category:Research initiatives]]
[[Category:American research initiatives]]

Center for Enervating NeuroImmune Disease

2016-11-22T17:18:45Z

Seanko:dikoma shungu & mark VanNess added

'''Center for Enervating NeuroImmune Disease''' (CEND) is a new center at Cornell University in Ithaca, NY and Weill Cornell Medical College in Manhattan, NYC, NY for the study of [[ME/CFS]]. The name was suggested by a patient. Enervating means causing you to feel weak and lacking in energy.It includes three laboratories at Weill Cornell, eight labs from the Cornell campus in Ithaca, and one at Ithaca College. They are hoping the center will attract additional researchers to study the illness.<ref>https://www.youtube.com/watch?time_continue=2759&v=3fx_TradX4M</ref>

==Mission==
To promote research to identify the cause(s), biomarkers, and pathophysiology of [[myalgic encephalomyelitis]], [[chronic fatigue syndrome]], or [[Systemic Exertion Intolerance Disease]] in order to lead to prevention and effective treatments.

==Learn More==
*[http://neuroimmune.cornell.edu/ Website]

==See Also==
*[[Maureen Hanson]] - Center Director
*[[Dikoma Shungu]] - Brain imaging, MRS & MRI
*[[Mark VanNess]]- ME/CFS Exercise Physiology, Scientific Advisory Committee Member

==References==

[[Category:Research initiatives]]
[[Category:American research initiatives]]

Dikoma Shungu

2016-11-22T17:14:22Z

Seanko:links added

Dr Dikoma Shunga is a Professor of Professor of Physics in Radiology and member of the [[Center for Enervating NeuroImmune Disease]] at Cornell University in New York, the United States.

==Notable studies==

==Online presence==
*[http://vivo.med.cornell.edu/display/cwid-dcs7001 Cornell University: Dikoma Shungu]
*[https://www.ncbi.nlm.nih.gov/pubmed/?term=Shungu%20DC%5BAuthor%5D&cauthor=true&cauthor_uid=24749063 PubMed: Dikoma Shungu]

==Learn more==

==See also==
*[[Center for Enervating NeuroImmune Disease]]
*[[N-acetylcysteine]]

==References==

[[Category:Researchers]]
[[Category:USA researchers]]