https://me-pedia.org/w/api.php?action=feedcontributions&feedformat=atom&user=NonameMEpedia - User contributions [en]2026-04-07T18:02:36ZUser contributionsMediaWiki 1.43.8https://me-pedia.org/w/index.php?title=Ribose&diff=97234Ribose2022-02-27T07:33:35Z<p>Noname:Wrote that neither study was placebo controlled</p>
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<div>'''Ribose''' is a carbohydrate with the formula C<sub>5</sub>H<sub>10</sub>O<sub>5</sub>, that exists in two forms: '''D-ribose''', which occurs in nature and L-ribose, which is the mirror image of D-ribose and does not occur in nature.<ref>[https://en.wikipedia.org/wiki/Ribose Wikipedia - Ribose]</ref> <br />
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D-ribose is a building block used by the cells in one of the chemical pathways that makes the energy molecule, [[ATP]].<ref name="dmdr" /><br />
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D-ribose comes in powder form, tastes sweet, and can used as a sugar substitute in drinks or on cereal.<br />
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==Use in ME/CFS and FM==<br />
It is used as a supplement for help boost muscle energy, such as for athletes and people with [[ME/CFS]], [[Fibromyalgia]], and coronary artery disease.<ref>[http://www.webmd.com/vitamins-supplements/ingredientmono-827-ribose.aspx?activeingredientid=827&activeingredientname=ribose WebMD - Vitamins and Supplements - Ribose]</ref> The theory is that if one supplies the body with the precursors to ATP, then it will be easier for the body to make ATP.<ref name="dmdr" /><br />
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==Sources==<br />
Supplemental d-ribose is manufactured from corn, so is to be avoided by those with corn allergies or insensitivities.<ref name="dmdr" /><br />
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==Evidence==<br />
A small study of 41 patients by [[Jacob Teitelbaum]] resulted in: "Approximately 66% of patients experienced significant improvement while on D-ribose [at a dose of 5 g, three times a day], with an average increase in energy on the VAS [visual analog scale categories: energy; sleep; mental clarity; and pain intensity] of 45% and an average improvement in overall well-being of 30% (p < 0.0001)." The study authors concluded that "D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome".<ref name="dr2006" /> A follow-up study by Teitelbaum and colleagues (2012) lead to similar results <ref>{{Cite journal|last=Teitelbaum|first=Jacob|date=2012-06-27|title=Treatment of Chronic Fatigue Syndrome and Fibromyalgia with D-Ribose– An Open-label, Multicenter Study|url=http://benthamopen.com/ABSTRACT/TOPAINJ-5-32|journal=The Open Pain Journal|language=en|volume=5|issue=1|pages=32–37|doi=10.2174/1876386301205010032}}</ref> Neither study was placebo controlled.<br />
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== Risks ==<br />
Oral D-Ribose intake is linked to memory loss, anxiety, and Aβ-like deposits associated with Alzheimer’s in mice.<ref>{{Cite web|url=https://forums.phoenixrising.me/threads/d-ribose-linked-to-memory-loss-anxiety-av-like-deposits-associated-with-alzheimers-in-mice.78772/|title=D-Ribose linked to Memory Loss, Anxiety, & Aβ-like deposits associated with Alzheimer’s in Mice|last=|first=|authorlink=|last2=|first2=|authorlink2=|date=|website=|archive-url=|archive-date=|url-status=|access-date=}}</ref><ref>{{Cite journal|last=Wu|first=Beibei|last2=Wei|first2=Yan|last3=Wang|first3=Yujing|last4=Su|first4=Tao|last5=Zhou|first5=Lei|last6=Liu|first6=Ying|last7=He|first7=Rongqiao|date=2015-10-07|title=Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741441/|journal=Oncotarget|volume=6|issue=33|pages=34128–34142|issn=1949-2553|pmc=4741441|pmid=26452037}}</ref><ref>{{Cite journal|last=Han|first=C.|last2=Lu|first2=Y.|last3=Wei|first3=Y.|last4=Wu|first4=B.|last5=Liu|first5=Y.|last6=He|first6=R.|date=Mar 2014|title=D -ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation|url=https://www.nature.com/articles/cddis201489|journal=Cell Death & Disease|language=en|volume=5|issue=3|pages=e1117–e1117|doi=10.1038/cddis.2014.89|issn=2041-4889|pmc=|pmid=|quote=|last7=|first7=|last8=|first8=|author-link=|author-link2=|access-date=|author-link3=|author-link4=|author-link5=|author-link6=|via=}}</ref><br />
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==Learn more==<br />
*[https://en.wikipedia.org/wiki/Ribose Wikipedia - Ribose]<br />
*[http://drmyhill.co.uk/wiki/d-ribose Dr Sarah Myhill - D-ribose]<br />
*2016, [https://cfsremission.wordpress.com/2016/02/25/d-ribose-revisited/ D-Ribose revisited]<br />
*2012, [https://cfsremission.wordpress.com/2012/11/19/d-ribose/ D-Ribose]<br />
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==See also==<br />
[[Muscle fatigability]]<br />
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==References==<br />
<references><br />
<ref name="dmdr">[http://drmyhill.co.uk/wiki/d-ribose Doctor Myhill - D-ribose]</ref><br />
<ref name="dr2006">{{Citation| doi = 10.1089/acm.2006.12.857| issn = 1075-5535| volume = 12| issue = 9| pages = 857–862| last1 = Teitelbaum| first1 = Jacob E.| last2 = Johnson| first2 = Clarence| last3 = St Cyr| first3 = John| title = The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study| journal = Journal of Alternative and Complementary Medicine (New York, N.Y.)| date = November 2006| pmid = 17109576}}</ref><br />
</references><br />
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[[Category:Potential treatments]]<br />
[[Category:Supplements]]<br />
[[Category:Sugars]]</div>Noname