MEpedia - User contributions [en]

Photo gallery of very severe patients

2026-04-28T01:18:17Z

Liface:Added another photo of Whitney

This is a photo gallery of very severe ME patients who have explicitly given permission for their photos to be used for advocacy. The idea behind this gallery is to give the community more resources to make the very severe the face of this condition.

<gallery mode="nolines" widths="250" heights="250">
File:Whitneytransport.jpg|Whitney Dafoe
File:Whitney Dafoe with eyes covered.jpg|Whitney Dafoe
File:Whitney Dafoe weight loss.png|Whitney Dafoe
</gallery>

File:Whitney Dafoe weight loss.png

2026-04-28T01:12:29Z

Liface:

Permission granted from Whitney Dafoe

Photo gallery of very severe patients

2026-04-27T22:05:24Z

Liface:added description

Photo gallery of very severe patients

2026-04-27T22:03:25Z

Liface:added another image

<gallery mode="nolines" widths="250" heights="250">
File:Whitneytransport.jpg|Whitney Dafoe
File:Whitney Dafoe with eyes covered.jpg|Whitney Dafoe
</gallery>

Photo gallery of very severe patients

2026-04-27T22:02:16Z

Liface:test

<gallery mode="packed">
File:Whitneytransport.jpg|Whitney Dafoe
</gallery>

File:Whitney Dafoe with eyes covered.jpg

2026-04-27T22:01:46Z

Liface:

Permission granted by Whitney Dafoe

Photo gallery of very severe patients

2026-04-27T22:00:14Z

Liface:Creating a photo gallery of very severe ME patients

<gallery>
File:Whitneytransport.jpg|Whitney Dafoe
</gallery>

File:Whitneytransport.jpg

2026-04-27T21:56:45Z

Liface:

Whitney Dafoe being transported outside his house. Permission granted by Whitney Dafoe

Aripiprazole

2026-04-08T14:49:52Z

Liface:added a lot of good stuff

{{NeedsImage}}
'''Aripiprazole''', which is also sold under the brand names '''Abilify''' and '''Aripiprazol''', is an atypical [[Antipsychotic|antipsychotic drug]] and [[:Category:Anti-inflammatories |anti-inflammatory drug]] that was first popularized for off-label use in ME by Hector Bonilla out of Stanford in 2019.
==Theory==
Dopamine D2 receptor agonists have been shown to mediate neuroinflammation, microglial activation, and cell death in animal models and humans.

One alternative theory of aripiprazole’s mode of action is that it may work as a biofilm disruptor<ref>{{Cite journal | last = Rajasekharan | first = Satish Kumar | last2 = Lee | first2 = Jin-Hyung | last3 = Lee | first3 = Jintae | date = Oct 2019 | title = Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans |url =https://pubmed.ncbi.nlm.nih.gov/31173863/ | journal = International Journal of Antimicrobial Agents | volume = 54 | issue = 4 | pages = 518–523|doi=10.1016/j.ijantimicag.2019.05.016|issn=1872-7913|pmid=31173863|pmc=|quote=|via=}}</ref> and affect the gut-brain axis that way.

==Evidence==
[https://pubmed.ncbi.nlm.nih.gov/33536023/ A retrospective Stanford study] of 101 ME/CFS patients found that 74% experienced improvements in symptoms such as fatigue, brain fog, unrefreshing sleep, and post-exertional malaise while taking low-dose aripiprazole.

The TREATME survey found that 32% of 133 individuals with ME/CFS (n=123) or Long COVID (n=13) who tried a </=2 mg dose of aripiprazole reported “moderate to much better” symptom improvement. 9% of 33 individuals with ME/CFS (n=31) or Long COVID (n=2) who tried a >2 mg dose of aripiprazole reported “moderate to much better” symptom improvement.

==== Tachycardaxis / loss of effect ====
About half of users report that Low dose Abilify's effect diminishes or stops working after some time. A break may restore them, or one can try switching to another D2 agonist.

Poll conducted on Reddit, Facebook, and Twitter:
If you saw a positive effect from LDA, did it regress?

* Stayed the same or increased: 28 (56%)
* Partially regressed: 14 (28%)
* Completely regressed: 8 (16%)
If benefits diminished, did a break restore them?

* Regained some benefit: 3 (37.5%)
* No benefit: 5 (62.5%)

==Clinicians==
Hector Bonilla out of Stanford popularized the use of low dose Abilify in ME in 2019.

==Risks and safety==

==Costs and availability==
Aripiprazole is not approved for use in [[ME/CFS]], and no clinical trials have been conducted with ME/CFS patients. Aripiprazole is approved by the FDA, by the European Medicines Agency (EMA) and UK's Medicines Agency for schizophrenia, manic episodes in bipolar I disorder, and for irritability associated with autistic disorders, and other uses.<ref name="Abilify">{{Cite web | url = https://www.medicines.org.uk/emc/product/7148/smpc | access-date = 2021-11-03 | title = Abilify 5mg tablets | website = Electronic Medicines Compendium}}</ref> Aripiprazole is sometimes used as an add-on treatment together with an [[antidepressant]].<ref name="FDAleaflet" />

Aripiprazole, including the brand name Abilify, is an inexpensive prescription-only drug, available as an oral solution, tablet, disolvable powder, and as a powder for injections.<ref name="FDAleaflet">{{Cite web | website = Food and Drug Administration | url =https://www.fda.gov/media/73102/download | title = Ability medication guide | date = | access-date = 2021-11-03}}</ref><ref name="medicinesUK">{{Cite web | url = https://www.medicines.org.uk/emc/search?q=Aripiprazole+ | title = Aripiprazole Search Results | last = | first = | author-link = | date = | website = Electronic Medicines Compendium| archive-url = | archive-date = |url-status = | access-date=2021-11-03}}</ref>

==Patient group statements==
*[https://meassociation.org.uk/2021/05/me-association-statement-aripiprazole-abilify-me-cfs/ ME Association statement on Aripiprazole (Abilify) for ME/CFS (2021)]
*[https://www.actionforme.org.uk/news/responding-to-questions-about-abilify/ Responding to questions about Ability] - Action for ME (2021)
*[https://anzmes.org.nz/what-is-me/frequently-asked-questions/ What is M.E.? | FAQ] - Australia and New Zealand ME Association (2021)

==Talks, presentations and videos ==
*[https://meassociation.org.uk/2021/10/iacfs-me-conference-dr-hector-bonilla-on-case-presentation-treating-me-cfs-with-aripiprazole/ Case Presentation: Treating ME/CFS with Aripiprazole. IACFS/ME Conference 2021] - Hector Bonilla
*2021, [https://med.stanford.edu/content/dam/sm/dbds/documents/data-studio/abstract.20201118.pdf The Impact of Aripiprazole on Chronic Fatigue Syndrome] - Hector Bonilla

==Notable studies ==
* 2012, The role of Antipsychotics in the Management of Fibromyalgia<ref name="Calandre2012">{{Cite journal | last = Calandre | first = Elena P. | last2 = Rico-Villademoros | first2 = Fernando | date = 2012-02-01 | title = The Role of Antipsychotics in the Management of Fibromyalgia | url = https://doi.org/10.2165/11597130-000000000-00000 | journal = CNS Drugs|language=en | volume = 26 | issue = 2 | pages = 135–153|doi=10.2165/11597130-000000000-00000|issn=1179-1934}}</ref> - [https://link.springer.com/article/10.2165/11597130-000000000-00000 (Abstract)]
* 2018, Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation<ref name="PMC5965391">{{Cite journal | last = Omori | first = Yuki | last2 = Kanbayashi | first2 = Takashi | last3 = Sagawa | first3 = Yohei | last4 = Imanishi | first4 = Aya | last5 = Tsutsui | first5 = Ko | last6 = Takahashi | first6 = Yuya | last7 = Takeshima | first7 = Masahiro | last8 = Takaki | first8 = Manabu | last9 = Nishino | first9 = Seiji | date = 2018-05-18 | title = Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/ | journal = Neuropsychiatric Disease and Treatment | volume = 14 | pages = 1281–1286|doi=10.2147/NDT.S158865|issn=1176-6328|pmc=5965391|pmid=29849459}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/ (Full text)]
* 2019, Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans<ref>{{Cite journal | last = Rajasekharan | first = Satish Kumar | last2 = Lee | first2 = Jin-Hyung | last3 = Lee | first3 = Jintae | date = Oct 2019 | title = Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans |url =https://pubmed.ncbi.nlm.nih.gov/31173863/ | journal = International Journal of Antimicrobial Agents | volume = 54 | issue = 4 | pages = 518–523|doi=10.1016/j.ijantimicag.2019.05.016|issn=1872-7913|pmid=31173863}}</ref>
* 2021, Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole<ref name="Crosby2021">{{Cite journal | last = Crosby | first = L.D. | author-link = Laurel Crosby | last2 = Kalanidhi | first2 = S. | author-link2 = | last3 = Bonilla | first3 = A. | author-link3 = | last4 = Subramanian | first4 = A. | author-link4 = | last5 = Ballon | first5 = J. S. | author-link5 = | last6 = Bonilla | first6 = H. | author-link6 = Hector Bonilla | date = 2021-02-03 | title = Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole | url =https://doi.org/10.1186/s12967-021-02721-9 | journal = Journal of Translational Medicine|language=en | volume = 19 | issue = 1 | pages = 50|doi=10.1186/s12967-021-02721-9|issn=1479-5876|pmc=PMC7860172|pmid=33536023|access-date=|quote=|via=}}</ref> [https://doi.org/10.1186/s12967-021-02721-9 (Full text)]
::[https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02875-6 correction]
*2021, Extremely Severe ME/CFS—A Personal Account <ref name="Dafoe2021">{{Cite journal | last = Dafoe | first = Whitney | author-link = | date = May 2021 | title = Extremely Severe ME/CFS—A Personal Account | url = https://www.mdpi.com/2227-9032/9/5/504 | journal = Healthcare|language=en | volume = 9 | issue = 5 | pages = 504|doi=10.3390/healthcare9050504|pmc=|pmid=|access-date=|quote=|via=}}</ref> [https://www.mdpi.com/1088982 (Full text)]

==Articles and blogs ==
*2021, [https://www.healthrising.org/blog/2021/03/09/abilify-chronic-fatigue-syndrome-promise/ Abilify shows promise in retrospective Chronic Fatigue Syndrome (ME/CFS) study] - Cort Johnson, Health Rising

== Blogs ==
* Oct 2020,[https://www.healthrising.org/blog/2020/10/03/celebrating-whitney-dafoe-and-his-awakening-on-his-37th-birthday/ Celebrating Whitney's Dafoe and his "Awakening" on his 37th birthday] - Health Rising

==See also==
*[[Fibromyalgia]]
*[[Fibromyalgia drugs]]
*[[Myalgic encephalomyelitis]]
*[[Whitney Dafoe]]

==Learn more==
*[https://www.drugs.com/international/aripiprazole.html Aripiprazole] - Drugs.com
==References ==
{{Reflist}}

[[Category:Antipsychotics]]
[[Category:Potential treatments]]
[[Category:Anti-inflammatories]]

Aripiprazole

2026-04-06T01:36:23Z

Liface:/* Clinicians */ Hector Bonilla

{{NeedsImage}}
'''Aripiprazole''', which is also sold under the brand names '''Abilify''' and '''Aripiprazol''', is an atypical [[Antipsychotic|antipsychotic drug]] and [[:Category:Anti-inflammatories |anti-inflammatory drug]] used for a number of different conditions including:
*Agitated state
*Autism
*Bipolar disorder (manic depression)
*[[Borderline Personality Disorder]]
*Obsessive Compulsive Disorder
*[[Post-traumatic stress disorder]] (PTSD)
*Schizophrenia and Schizoaffective Disorder
*Tourette's syndrome<ref name="drugscom">{{Cite web | url = https://www.drugs.com/international/aripiprazole.html | title = Aripiprazole | website = Drugs.com|language=en | access-date = 2020-10-04}}</ref>

==Theory==
One hypothesized theory of aripiprazole’s mode of action is that it may work as a biofilm disruptor<ref>{{Cite journal | last = Rajasekharan | first = Satish Kumar | last2 = Lee | first2 = Jin-Hyung | last3 = Lee | first3 = Jintae | date = Oct 2019 | title = Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans |url =https://pubmed.ncbi.nlm.nih.gov/31173863/ | journal = International Journal of Antimicrobial Agents | volume = 54 | issue = 4 | pages = 518–523|doi=10.1016/j.ijantimicag.2019.05.016|issn=1872-7913|pmid=31173863|pmc=|quote=|via=}}</ref> and affect the gut-brain axis that way.

==Evidence==
About half of users report that Low dose Abilify's effect diminishes or stops working after some time. A break may restore them, or one can try switching to another D2 agonist.

Poll conducted on Reddit, Facebook, and Twitter:
If you saw a positive effect from LDA, did it regress?

* Stayed the same or increased: 28 (56%)
* Partially regressed: 14 (28%)
* Completely regressed: 8 (16%)
If benefits diminished, did a break restore them?

* Regained some benefit: 3 (37.5%)
* No benefit: 5 (62.5%)

==Clinicians==
Hector Bonilla out of Stanford popularized the use of low dose Abilify in ME in 2019.

==Risks and safety==

==Costs and availability==
Aripiprazole is not approved for use in [[ME/CFS]], and no clinical trials have been conducted with ME/CFS patients. Aripiprazole is approved by the FDA, by the European Medicines Agency (EMA) and UK's Medicines Agency for schizophrenia, manic episodes in bipolar I disorder, and for irritability associated with autistic disorders, and other uses.<ref name="Abilify">{{Cite web | url = https://www.medicines.org.uk/emc/product/7148/smpc | access-date = 2021-11-03 | title = Abilify 5mg tablets | website = Electronic Medicines Compendium}}</ref> Aripiprazole is sometimes used as an add-on treatment together with an [[antidepressant]].<ref name="FDAleaflet" />

Aripiprazole, including the brand name Abilify, is an inexpensive prescription-only drug, available as an oral solution, tablet, disolvable powder, and as a powder for injections.<ref name="FDAleaflet">{{Cite web | website = Food and Drug Administration | url =https://www.fda.gov/media/73102/download | title = Ability medication guide | date = | access-date = 2021-11-03}}</ref><ref name="medicinesUK">{{Cite web | url = https://www.medicines.org.uk/emc/search?q=Aripiprazole+ | title = Aripiprazole Search Results | last = | first = | author-link = | date = | website = Electronic Medicines Compendium| archive-url = | archive-date = |url-status = | access-date=2021-11-03}}</ref>

==Patient group statements==
*[https://meassociation.org.uk/2021/05/me-association-statement-aripiprazole-abilify-me-cfs/ ME Association statement on Aripiprazole (Abilify) for ME/CFS (2021)]
*[https://www.actionforme.org.uk/news/responding-to-questions-about-abilify/ Responding to questions about Ability] - Action for ME (2021)
*[https://anzmes.org.nz/what-is-me/frequently-asked-questions/ What is M.E.? | FAQ] - Australia and New Zealand ME Association (2021)

==Talks, presentations and videos ==
*[https://meassociation.org.uk/2021/10/iacfs-me-conference-dr-hector-bonilla-on-case-presentation-treating-me-cfs-with-aripiprazole/ Case Presentation: Treating ME/CFS with Aripiprazole. IACFS/ME Conference 2021] - Hector Bonilla
*2021, [https://med.stanford.edu/content/dam/sm/dbds/documents/data-studio/abstract.20201118.pdf The Impact of Aripiprazole on Chronic Fatigue Syndrome] - Hector Bonilla

==Notable studies ==
* 2012, The role of Antipsychotics in the Management of Fibromyalgia<ref name="Calandre2012">{{Cite journal | last = Calandre | first = Elena P. | last2 = Rico-Villademoros | first2 = Fernando | date = 2012-02-01 | title = The Role of Antipsychotics in the Management of Fibromyalgia | url = https://doi.org/10.2165/11597130-000000000-00000 | journal = CNS Drugs|language=en | volume = 26 | issue = 2 | pages = 135–153|doi=10.2165/11597130-000000000-00000|issn=1179-1934}}</ref> - [https://link.springer.com/article/10.2165/11597130-000000000-00000 (Abstract)]
* 2018, Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation<ref name="PMC5965391">{{Cite journal | last = Omori | first = Yuki | last2 = Kanbayashi | first2 = Takashi | last3 = Sagawa | first3 = Yohei | last4 = Imanishi | first4 = Aya | last5 = Tsutsui | first5 = Ko | last6 = Takahashi | first6 = Yuya | last7 = Takeshima | first7 = Masahiro | last8 = Takaki | first8 = Manabu | last9 = Nishino | first9 = Seiji | date = 2018-05-18 | title = Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/ | journal = Neuropsychiatric Disease and Treatment | volume = 14 | pages = 1281–1286|doi=10.2147/NDT.S158865|issn=1176-6328|pmc=5965391|pmid=29849459}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/ (Full text)]
* 2019, Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans<ref>{{Cite journal | last = Rajasekharan | first = Satish Kumar | last2 = Lee | first2 = Jin-Hyung | last3 = Lee | first3 = Jintae | date = Oct 2019 | title = Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans |url =https://pubmed.ncbi.nlm.nih.gov/31173863/ | journal = International Journal of Antimicrobial Agents | volume = 54 | issue = 4 | pages = 518–523|doi=10.1016/j.ijantimicag.2019.05.016|issn=1872-7913|pmid=31173863}}</ref>
* 2021, Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole<ref name="Crosby2021">{{Cite journal | last = Crosby | first = L.D. | author-link = Laurel Crosby | last2 = Kalanidhi | first2 = S. | author-link2 = | last3 = Bonilla | first3 = A. | author-link3 = | last4 = Subramanian | first4 = A. | author-link4 = | last5 = Ballon | first5 = J. S. | author-link5 = | last6 = Bonilla | first6 = H. | author-link6 = Hector Bonilla | date = 2021-02-03 | title = Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole | url =https://doi.org/10.1186/s12967-021-02721-9 | journal = Journal of Translational Medicine|language=en | volume = 19 | issue = 1 | pages = 50|doi=10.1186/s12967-021-02721-9|issn=1479-5876|pmc=PMC7860172|pmid=33536023|access-date=|quote=|via=}}</ref> [https://doi.org/10.1186/s12967-021-02721-9 (Full text)]
::[https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02875-6 correction]
*2021, Extremely Severe ME/CFS—A Personal Account <ref name="Dafoe2021">{{Cite journal | last = Dafoe | first = Whitney | author-link = | date = May 2021 | title = Extremely Severe ME/CFS—A Personal Account | url = https://www.mdpi.com/2227-9032/9/5/504 | journal = Healthcare|language=en | volume = 9 | issue = 5 | pages = 504|doi=10.3390/healthcare9050504|pmc=|pmid=|access-date=|quote=|via=}}</ref> [https://www.mdpi.com/1088982 (Full text)]

==Articles and blogs ==
*2021, [https://www.healthrising.org/blog/2021/03/09/abilify-chronic-fatigue-syndrome-promise/ Abilify shows promise in retrospective Chronic Fatigue Syndrome (ME/CFS) study] - Cort Johnson, Health Rising

== Blogs ==
* Oct 2020,[https://www.healthrising.org/blog/2020/10/03/celebrating-whitney-dafoe-and-his-awakening-on-his-37th-birthday/ Celebrating Whitney's Dafoe and his "Awakening" on his 37th birthday] - Health Rising

==See also==
*[[Fibromyalgia]]
*[[Fibromyalgia drugs]]
*[[Myalgic encephalomyelitis]]
*[[Whitney Dafoe]]

==Learn more==
*[https://www.drugs.com/international/aripiprazole.html Aripiprazole] - Drugs.com
==References ==
{{Reflist}}

[[Category:Antipsychotics]]
[[Category:Potential treatments]]
[[Category:Anti-inflammatories]]

Aripiprazole

2026-04-06T01:31:22Z

Liface:/* Evidence */ added info about Abilify poll

{{NeedsImage}}
'''Aripiprazole''', which is also sold under the brand names '''Abilify''' and '''Aripiprazol''', is an atypical [[Antipsychotic|antipsychotic drug]] and [[:Category:Anti-inflammatories |anti-inflammatory drug]] used for a number of different conditions including:
*Agitated state
*Autism
*Bipolar disorder (manic depression)
*[[Borderline Personality Disorder]]
*Obsessive Compulsive Disorder
*[[Post-traumatic stress disorder]] (PTSD)
*Schizophrenia and Schizoaffective Disorder
*Tourette's syndrome<ref name="drugscom">{{Cite web | url = https://www.drugs.com/international/aripiprazole.html | title = Aripiprazole | website = Drugs.com|language=en | access-date = 2020-10-04}}</ref>

==Theory==
One hypothesized theory of aripiprazole’s mode of action is that it may work as a biofilm disruptor<ref>{{Cite journal | last = Rajasekharan | first = Satish Kumar | last2 = Lee | first2 = Jin-Hyung | last3 = Lee | first3 = Jintae | date = Oct 2019 | title = Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans |url =https://pubmed.ncbi.nlm.nih.gov/31173863/ | journal = International Journal of Antimicrobial Agents | volume = 54 | issue = 4 | pages = 518–523|doi=10.1016/j.ijantimicag.2019.05.016|issn=1872-7913|pmid=31173863|pmc=|quote=|via=}}</ref> and affect the gut-brain axis that way.

==Evidence==
About half of users report that Low dose Abilify's effect diminishes or stops working after some time. A break may restore them, or one can try switching to another D2 agonist.

Poll conducted on Reddit, Facebook, and Twitter:
If you saw a positive effect from LDA, did it regress?

* Stayed the same or increased: 28 (56%)
* Partially regressed: 14 (28%)
* Completely regressed: 8 (16%)
If benefits diminished, did a break restore them?

* Regained some benefit: 3 (37.5%)
* No benefit: 5 (62.5%)

==Clinicians==

==Risks and safety==

==Costs and availability==
Aripiprazole is not approved for use in [[ME/CFS]], and no clinical trials have been conducted with ME/CFS patients. Aripiprazole is approved by the FDA, by the European Medicines Agency (EMA) and UK's Medicines Agency for schizophrenia, manic episodes in bipolar I disorder, and for irritability associated with autistic disorders, and other uses.<ref name="Abilify">{{Cite web | url = https://www.medicines.org.uk/emc/product/7148/smpc | access-date = 2021-11-03 | title = Abilify 5mg tablets | website = Electronic Medicines Compendium}}</ref> Aripiprazole is sometimes used as an add-on treatment together with an [[antidepressant]].<ref name="FDAleaflet" />

Aripiprazole, including the brand name Abilify, is an inexpensive prescription-only drug, available as an oral solution, tablet, disolvable powder, and as a powder for injections.<ref name="FDAleaflet">{{Cite web | website = Food and Drug Administration | url =https://www.fda.gov/media/73102/download | title = Ability medication guide | date = | access-date = 2021-11-03}}</ref><ref name="medicinesUK">{{Cite web | url = https://www.medicines.org.uk/emc/search?q=Aripiprazole+ | title = Aripiprazole Search Results | last = | first = | author-link = | date = | website = Electronic Medicines Compendium| archive-url = | archive-date = |url-status = | access-date=2021-11-03}}</ref>

==Patient group statements==
*[https://meassociation.org.uk/2021/05/me-association-statement-aripiprazole-abilify-me-cfs/ ME Association statement on Aripiprazole (Abilify) for ME/CFS (2021)]
*[https://www.actionforme.org.uk/news/responding-to-questions-about-abilify/ Responding to questions about Ability] - Action for ME (2021)
*[https://anzmes.org.nz/what-is-me/frequently-asked-questions/ What is M.E.? | FAQ] - Australia and New Zealand ME Association (2021)

==Talks, presentations and videos ==
*[https://meassociation.org.uk/2021/10/iacfs-me-conference-dr-hector-bonilla-on-case-presentation-treating-me-cfs-with-aripiprazole/ Case Presentation: Treating ME/CFS with Aripiprazole. IACFS/ME Conference 2021] - Hector Bonilla
*2021, [https://med.stanford.edu/content/dam/sm/dbds/documents/data-studio/abstract.20201118.pdf The Impact of Aripiprazole on Chronic Fatigue Syndrome] - Hector Bonilla

==Notable studies ==
* 2012, The role of Antipsychotics in the Management of Fibromyalgia<ref name="Calandre2012">{{Cite journal | last = Calandre | first = Elena P. | last2 = Rico-Villademoros | first2 = Fernando | date = 2012-02-01 | title = The Role of Antipsychotics in the Management of Fibromyalgia | url = https://doi.org/10.2165/11597130-000000000-00000 | journal = CNS Drugs|language=en | volume = 26 | issue = 2 | pages = 135–153|doi=10.2165/11597130-000000000-00000|issn=1179-1934}}</ref> - [https://link.springer.com/article/10.2165/11597130-000000000-00000 (Abstract)]
* 2018, Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation<ref name="PMC5965391">{{Cite journal | last = Omori | first = Yuki | last2 = Kanbayashi | first2 = Takashi | last3 = Sagawa | first3 = Yohei | last4 = Imanishi | first4 = Aya | last5 = Tsutsui | first5 = Ko | last6 = Takahashi | first6 = Yuya | last7 = Takeshima | first7 = Masahiro | last8 = Takaki | first8 = Manabu | last9 = Nishino | first9 = Seiji | date = 2018-05-18 | title = Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/ | journal = Neuropsychiatric Disease and Treatment | volume = 14 | pages = 1281–1286|doi=10.2147/NDT.S158865|issn=1176-6328|pmc=5965391|pmid=29849459}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/ (Full text)]
* 2019, Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans<ref>{{Cite journal | last = Rajasekharan | first = Satish Kumar | last2 = Lee | first2 = Jin-Hyung | last3 = Lee | first3 = Jintae | date = Oct 2019 | title = Aripiprazole repurposed as an inhibitor of biofilm formation and sterol biosynthesis in multidrug-resistant Candida albicans |url =https://pubmed.ncbi.nlm.nih.gov/31173863/ | journal = International Journal of Antimicrobial Agents | volume = 54 | issue = 4 | pages = 518–523|doi=10.1016/j.ijantimicag.2019.05.016|issn=1872-7913|pmid=31173863}}</ref>
* 2021, Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole<ref name="Crosby2021">{{Cite journal | last = Crosby | first = L.D. | author-link = Laurel Crosby | last2 = Kalanidhi | first2 = S. | author-link2 = | last3 = Bonilla | first3 = A. | author-link3 = | last4 = Subramanian | first4 = A. | author-link4 = | last5 = Ballon | first5 = J. S. | author-link5 = | last6 = Bonilla | first6 = H. | author-link6 = Hector Bonilla | date = 2021-02-03 | title = Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole | url =https://doi.org/10.1186/s12967-021-02721-9 | journal = Journal of Translational Medicine|language=en | volume = 19 | issue = 1 | pages = 50|doi=10.1186/s12967-021-02721-9|issn=1479-5876|pmc=PMC7860172|pmid=33536023|access-date=|quote=|via=}}</ref> [https://doi.org/10.1186/s12967-021-02721-9 (Full text)]
::[https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02875-6 correction]
*2021, Extremely Severe ME/CFS—A Personal Account <ref name="Dafoe2021">{{Cite journal | last = Dafoe | first = Whitney | author-link = | date = May 2021 | title = Extremely Severe ME/CFS—A Personal Account | url = https://www.mdpi.com/2227-9032/9/5/504 | journal = Healthcare|language=en | volume = 9 | issue = 5 | pages = 504|doi=10.3390/healthcare9050504|pmc=|pmid=|access-date=|quote=|via=}}</ref> [https://www.mdpi.com/1088982 (Full text)]

==Articles and blogs ==
*2021, [https://www.healthrising.org/blog/2021/03/09/abilify-chronic-fatigue-syndrome-promise/ Abilify shows promise in retrospective Chronic Fatigue Syndrome (ME/CFS) study] - Cort Johnson, Health Rising

== Blogs ==
* Oct 2020,[https://www.healthrising.org/blog/2020/10/03/celebrating-whitney-dafoe-and-his-awakening-on-his-37th-birthday/ Celebrating Whitney's Dafoe and his "Awakening" on his 37th birthday] - Health Rising

==See also==
*[[Fibromyalgia]]
*[[Fibromyalgia drugs]]
*[[Myalgic encephalomyelitis]]
*[[Whitney Dafoe]]

==Learn more==
*[https://www.drugs.com/international/aripiprazole.html Aripiprazole] - Drugs.com
==References ==
{{Reflist}}

[[Category:Antipsychotics]]
[[Category:Potential treatments]]
[[Category:Anti-inflammatories]]