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	<entry>
		<id>https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244294</id>
		<title>Dynamic Neural Retraining System</title>
		<link rel="alternate" type="text/html" href="https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244294"/>
		<updated>2025-09-05T23:32:14Z</updated>

		<summary type="html">&lt;p&gt;LL:/* Risks and safety */ new information re: risks and safety to advise consultation with health care provider&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;Annie Hopper created the &#039;&#039;&#039;Dynamic Neural Retraining System&#039;&#039;&#039; or &#039;&#039;&#039;DNRS&#039;&#039;&#039; in 2008, and states this is based on her recovery from &amp;quot;severe Multiple Chemical Sensitivity, Fibromyalgia and Electric Hypersensitivity Syndrome&amp;quot;.&amp;lt;ref name=&amp;quot;team&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/meet-the-dnrs-team/ | title = Meet the DNRS™ Team | last = Tozer | first = James|website=Dynamic Neural Retraining System|language=en-CA|access-date=2020-09-23}}&amp;lt;/ref&amp;gt; Prior to becoming ill, healing and developing DNRS, Annie Hopper was a core beliefs counsellor and weekly newspaper columnist.&lt;br /&gt;
&lt;br /&gt;
==Theory ==&lt;br /&gt;
[https://retrainingthebrain.com/ The DNRS website]  positions limbic system impairment as the cause of brain changes, and that this causes a &amp;quot;maladaptive stress response&amp;quot; which then causes certain physical symptoms, which the website lists.&amp;lt;ref name=&amp;quot;about&amp;quot;&amp;gt;{{Cite web|url=https://retrainingthebrain.com/program-information/|title=How The Program Works|last=Hopper|first=Annie|authorlink=|date=|website=Dynamic Neural Retraining System|language=en-CA|archive-url=|archive-date=|url-status=|access-date=2025-09-05}}&amp;lt;/ref&amp;gt; Limbic system impairment can have multiple causes; the common result is a  type of neurological dysregulation in the brain. This can lead to central sensitization, a condition where the brain and nervous system become hypersensitive, amplifying pain, stress, and normal sensory input. DNRS assists in recovery through mood elevation, desensitization and visualization to facilitate &amp;quot;new, healthy neural pathways&amp;quot;.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Components ==&lt;br /&gt;
The program is a psychologically based self-help approach that states it involves &lt;br /&gt;
*[[cognitive behavioral therapy]]&lt;br /&gt;
*[[mindfulness]] based cognitive restructuring&lt;br /&gt;
*emotional restructuring therapy&lt;br /&gt;
*[[Neurolinguistic programming]] (NLP)&lt;br /&gt;
*incremental training (a form of neural shaping)&lt;br /&gt;
*behaviour modification therapy&lt;br /&gt;
&lt;br /&gt;
The program includes a one-year subscription which includes 12 hours of video tutorials followed by a consistent, regular daily practice. Program registrants commit to 6 months of practice of one hour per day.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==ME/CFS ==&lt;br /&gt;
The DNRS website claims it can &amp;quot;rewire chronic illness disease patterns in the brain&amp;quot; and that &amp;quot;the program is an effective treatment for [[Multiple chemical sensitivity|chemical sensitivities]], [[chronic fatigue syndrome]], [[fibromyalgia]] and many other chronic illnesses&amp;quot;. This rewiring is considered to be reflected through changed symptoms rather than being reliant on objective evidence of changes in brain function or connectivity.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; Peripheral or [[autonomic nervous system]] changes are not discussed.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; &lt;br /&gt;
&lt;br /&gt;
Evidence for dynamic neural retraining in the peer-reviewed evidence is scant. A 2021 meta-analysis of mind-body intervention studies in ME/CFS could not source any peer-reviewed data on DNRS in ME/CFS despite authors explicitly including related terms in their search.&amp;lt;ref&amp;gt;{{Cite journal|title=Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|date=2021-06-24|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC8305555/|journal=Medicina|volume=57|issue=7|pages=652|last=Khanpour Ardestani|first=Samaneh|last2=Karkhaneh|first2=Mohammad|last3=Stein|first3=Eleanor|last4=Punja|first4=Salima|last5=Junqueira|first5=Daniela R.|last6=Kuzmyn|first6=Tatiana|last7=Pearson|first7=Michelle|last8=Smith|first8=Laurie|last9=Olson|first9=Karin|last10=Vohra|first10=Sunita|language=en|doi=10.3390/medicina57070652|issn=1648-9144}}&amp;lt;/ref&amp;gt; There appear to be no trials of DNRS in ME/CFS in the published literature as of 2025.  &lt;br /&gt;
==Risks and safety ==&lt;br /&gt;
A [https://clinicaltrials.gov/study/NCT06933173 clinical trial] is underway to study the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC). As of yet, there is no direct research to connect mind-body interventions (MBIs) and how it refocuses the brain, mind, body, and behaviour to interact and improve health and well-being. it is therefore unclear to state what risks it and similar treatment modalities present.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
While some individuals may experience feelings of guilt if they do not see the improvements they hope for through DNRS or similar programs, it is important to recognize that recovery is influenced by a wide range of personal variables. These approaches emphasize individual empowerment, and responses can differ greatly depending on each person’s unique circumstances. Everyone’s health journey is unique. Prior to beginning a new treatment, it is advisable to consult with your health care provider. &amp;lt;ref&amp;gt;{{Cite journal|title=Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID|date=2023-03-07|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC10048882/|journal=International Journal of Molecular Sciences|volume=24|issue=6|pages=5124|last=Tate|first=Warren P.|last2=Walker|first2=Max O. M.|last3=Peppercorn|first3=Katie|last4=Blair|first4=Anna L. H.|last5=Edgar|first5=Christina D.|language=en|doi=10.3390/ijms24065124|issn=1422-0067}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Evidence ==&lt;br /&gt;
The University of Alberta opened a [https://clinicaltrials.gov/study/NCT06933173 clinical trial on DNRS] in July of 2025 to measure the effectiveness or potential risks of DNRS, and to determine how the brain is &amp;quot;rewired&amp;quot; or &amp;quot;retrained&amp;quot; or that neural networks within the brain are altered by the treatment.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Evidence consists of an unpublished presentation, which has not been peer reviewed, part of which can be found on the DNRS website, and a number of claims by coaches or facilitators who stated they recovered from multiple illnesses using it.&amp;lt;ref name=&amp;quot;ResearchSep2020&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/research-3/ | title = Research | last = Tozer | first = James | authorlink = | date = n.d.|website=Dynamic Neural Retraining System|language=en-CA| archive-url = | archive-date = |url-status = | access-date=2020-09-23}}&amp;lt;/ref&amp;gt; According to the presentation, brain imaging or brain function tests were not used to assess neuroplasticity after the DNRS course, and all results were based on patient questionnaires.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot;&amp;gt;{{Citation|vauthors=Guenter et al | first = | title = Neuroplasticity-based treatment for fibromyalgia, chronic fatigue and multiple chemical sensitivity: feasibility and outcomes| publisher = | date = 2019 | url=|volume=|issue=| pages=|chapter=|edition= | last2 = | first2 = }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The presentation on the website does not provide results separately for patients with ME/CFS, although some patients reported having it. Many patients have provided testimonials on the DNRS website to share their [https://retrainingthebrain.com/?post_type=success-story&amp;amp;s=chronic+fatigue healing process from the effects of ME/ CFS.]&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Learn more ==&lt;br /&gt;
*[https://clinicaltrials.gov/study/NCT06933173 Clinical Trial,] Mind-Body in Long COVID and Myalgic Encephalomyelitis Study (MILES): A Patient-Centred RCT &lt;br /&gt;
*[https://paradigmchange.me/wp/retraining/ Some Comments on So-Called “Brain Retraining” Programs] - Psychologist Lisa Petrison comments on the unproven scientific claims and potential harm - Paradigmchange.me&lt;br /&gt;
*[https://retrainingthebrain.com/how-the-program-works/ How the program works - DNRS]&lt;br /&gt;
*[https://www.virology.ws/2020/09/02/trial-by-error-what-is-the-dynamic-neural-retraining-system/ Trial By Error: What Is the Dynamic Neural Retraining System?] - [[Virology blog]]&lt;br /&gt;
&lt;br /&gt;
==See also ==&lt;br /&gt;
*[[Brain training]]&lt;br /&gt;
&lt;br /&gt;
==References ==&lt;br /&gt;
{{Reflist}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Brain training]]&lt;br /&gt;
[[Category:Potential treatments]]&lt;br /&gt;
[[Category:Psychological and behavioral therapies]]&lt;/div&gt;</summary>
		<author><name>LL</name></author>
	</entry>
	<entry>
		<id>https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244293</id>
		<title>Dynamic Neural Retraining System</title>
		<link rel="alternate" type="text/html" href="https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244293"/>
		<updated>2025-09-05T22:19:02Z</updated>

		<summary type="html">&lt;p&gt;LL:/* Risks and safety */ grammar&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;Annie Hopper created the &#039;&#039;&#039;Dynamic Neural Retraining System&#039;&#039;&#039; or &#039;&#039;&#039;DNRS&#039;&#039;&#039; in 2008, and states this is based on her recovery from &amp;quot;severe Multiple Chemical Sensitivity, Fibromyalgia and Electric Hypersensitivity Syndrome&amp;quot;.&amp;lt;ref name=&amp;quot;team&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/meet-the-dnrs-team/ | title = Meet the DNRS™ Team | last = Tozer | first = James|website=Dynamic Neural Retraining System|language=en-CA|access-date=2020-09-23}}&amp;lt;/ref&amp;gt; Prior to becoming ill, healing and developing DNRS, Annie Hopper was a core beliefs counsellor and weekly newspaper columnist.&lt;br /&gt;
&lt;br /&gt;
==Theory ==&lt;br /&gt;
[https://retrainingthebrain.com/ The DNRS website]  positions limbic system impairment as the cause of brain changes, and that this causes a &amp;quot;maladaptive stress response&amp;quot; which then causes certain physical symptoms, which the website lists.&amp;lt;ref name=&amp;quot;about&amp;quot;&amp;gt;{{Cite web|url=https://retrainingthebrain.com/program-information/|title=How The Program Works|last=Hopper|first=Annie|authorlink=|date=|website=Dynamic Neural Retraining System|language=en-CA|archive-url=|archive-date=|url-status=|access-date=2025-09-05}}&amp;lt;/ref&amp;gt; Limbic system impairment can have multiple causes; the common result is a  type of neurological dysregulation in the brain. This can lead to central sensitization, a condition where the brain and nervous system become hypersensitive, amplifying pain, stress, and normal sensory input. DNRS assists in recovery through mood elevation, desensitization and visualization to facilitate &amp;quot;new, healthy neural pathways&amp;quot;.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Components ==&lt;br /&gt;
The program is a psychologically based self-help approach that states it involves &lt;br /&gt;
*[[cognitive behavioral therapy]]&lt;br /&gt;
*[[mindfulness]] based cognitive restructuring&lt;br /&gt;
*emotional restructuring therapy&lt;br /&gt;
*[[Neurolinguistic programming]] (NLP)&lt;br /&gt;
*incremental training (a form of neural shaping)&lt;br /&gt;
*behaviour modification therapy&lt;br /&gt;
&lt;br /&gt;
The program includes a one-year subscription which includes 12 hours of video tutorials followed by a consistent, regular daily practice. Program registrants commit to 6 months of practice of one hour per day.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==ME/CFS ==&lt;br /&gt;
The DNRS website claims it can &amp;quot;rewire chronic illness disease patterns in the brain&amp;quot; and that &amp;quot;the program is an effective treatment for [[Multiple chemical sensitivity|chemical sensitivities]], [[chronic fatigue syndrome]], [[fibromyalgia]] and many other chronic illnesses&amp;quot;. This rewiring is considered to be reflected through changed symptoms rather than being reliant on objective evidence of changes in brain function or connectivity.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; Peripheral or [[autonomic nervous system]] changes are not discussed.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; &lt;br /&gt;
&lt;br /&gt;
Evidence for dynamic neural retraining in the peer-reviewed evidence is scant. A 2021 meta-analysis of mind-body intervention studies in ME/CFS could not source any peer-reviewed data on DNRS in ME/CFS despite authors explicitly including related terms in their search.&amp;lt;ref&amp;gt;{{Cite journal|title=Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|date=2021-06-24|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC8305555/|journal=Medicina|volume=57|issue=7|pages=652|last=Khanpour Ardestani|first=Samaneh|last2=Karkhaneh|first2=Mohammad|last3=Stein|first3=Eleanor|last4=Punja|first4=Salima|last5=Junqueira|first5=Daniela R.|last6=Kuzmyn|first6=Tatiana|last7=Pearson|first7=Michelle|last8=Smith|first8=Laurie|last9=Olson|first9=Karin|last10=Vohra|first10=Sunita|language=en|doi=10.3390/medicina57070652|issn=1648-9144}}&amp;lt;/ref&amp;gt; There appear to be no trials of DNRS in ME/CFS in the published literature as of 2025.  &lt;br /&gt;
==Risks and safety ==&lt;br /&gt;
A [https://clinicaltrials.gov/study/NCT06933173 clinical trial] is underway to study the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC). As of yet, there is no direct research to connect mind-body interventions (MBIs) and how it refocuses the brain, mind, body, and behaviour to interact and improve health and well-being. it is therefore unclear to state what risks it and similar treatment modalities present.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt;  &lt;br /&gt;
&lt;br /&gt;
It is generally acknowledged that patients who fail to improve through DNRS and similar programs discuss feelings of guilt, as these and similar systems frame recovery as within the patient&#039;s control, even in literature that views these interventions in a positive light.&amp;lt;ref&amp;gt;{{Cite journal|title=Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID|date=2023-03-07|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC10048882/|journal=International Journal of Molecular Sciences|volume=24|issue=6|pages=5124|last=Tate|first=Warren P.|last2=Walker|first2=Max O. M.|last3=Peppercorn|first3=Katie|last4=Blair|first4=Anna L. H.|last5=Edgar|first5=Christina D.|language=en|doi=10.3390/ijms24065124|issn=1422-0067}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Evidence ==&lt;br /&gt;
The University of Alberta opened a [https://clinicaltrials.gov/study/NCT06933173 clinical trial on DNRS] in July of 2025 to measure the effectiveness or potential risks of DNRS, and to determine how the brain is &amp;quot;rewired&amp;quot; or &amp;quot;retrained&amp;quot; or that neural networks within the brain are altered by the treatment.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Evidence consists of an unpublished presentation, which has not been peer reviewed, part of which can be found on the DNRS website, and a number of claims by coaches or facilitators who stated they recovered from multiple illnesses using it.&amp;lt;ref name=&amp;quot;ResearchSep2020&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/research-3/ | title = Research | last = Tozer | first = James | authorlink = | date = n.d.|website=Dynamic Neural Retraining System|language=en-CA| archive-url = | archive-date = |url-status = | access-date=2020-09-23}}&amp;lt;/ref&amp;gt; According to the presentation, brain imaging or brain function tests were not used to assess neuroplasticity after the DNRS course, and all results were based on patient questionnaires.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot;&amp;gt;{{Citation|vauthors=Guenter et al | first = | title = Neuroplasticity-based treatment for fibromyalgia, chronic fatigue and multiple chemical sensitivity: feasibility and outcomes| publisher = | date = 2019 | url=|volume=|issue=| pages=|chapter=|edition= | last2 = | first2 = }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The presentation on the website does not provide results separately for patients with ME/CFS, although some patients reported having it. Many patients have provided testimonials on the DNRS website to share their [https://retrainingthebrain.com/?post_type=success-story&amp;amp;s=chronic+fatigue healing process from the effects of ME/ CFS.]&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Learn more ==&lt;br /&gt;
*[https://clinicaltrials.gov/study/NCT06933173 Clinical Trial,] Mind-Body in Long COVID and Myalgic Encephalomyelitis Study (MILES): A Patient-Centred RCT &lt;br /&gt;
*[https://paradigmchange.me/wp/retraining/ Some Comments on So-Called “Brain Retraining” Programs] - Psychologist Lisa Petrison comments on the unproven scientific claims and potential harm - Paradigmchange.me&lt;br /&gt;
*[https://retrainingthebrain.com/how-the-program-works/ How the program works - DNRS]&lt;br /&gt;
*[https://www.virology.ws/2020/09/02/trial-by-error-what-is-the-dynamic-neural-retraining-system/ Trial By Error: What Is the Dynamic Neural Retraining System?] - [[Virology blog]]&lt;br /&gt;
&lt;br /&gt;
==See also ==&lt;br /&gt;
*[[Brain training]]&lt;br /&gt;
&lt;br /&gt;
==References ==&lt;br /&gt;
{{Reflist}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Brain training]]&lt;br /&gt;
[[Category:Potential treatments]]&lt;br /&gt;
[[Category:Psychological and behavioral therapies]]&lt;/div&gt;</summary>
		<author><name>LL</name></author>
	</entry>
	<entry>
		<id>https://me-pedia.org/w/index.php?title=Talk:Brain_retraining&amp;diff=244292</id>
		<title>Talk:Brain retraining</title>
		<link rel="alternate" type="text/html" href="https://me-pedia.org/w/index.php?title=Talk:Brain_retraining&amp;diff=244292"/>
		<updated>2025-09-05T22:04:41Z</updated>

		<summary type="html">&lt;p&gt;LL:Created page with &amp;quot;==  -- ~~~~ ==  DNRS should be added to the list of brain retraining programs. Annie Hopper created the program in 2008 -- retrainingthebrain.com.  This predates ANS Rewire (2016) and Re-origin in 2020, both of which are listed.&amp;quot;&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==  -- [[User:LL|LL]] ([[User talk:LL|talk]]) 22:04, September 5, 2025 (UTC) ==&lt;br /&gt;
&lt;br /&gt;
DNRS should be added to the list of brain retraining programs. Annie Hopper created the program in 2008 -- retrainingthebrain.com.&lt;br /&gt;
&lt;br /&gt;
This predates ANS Rewire (2016) and Re-origin in 2020, both of which are listed.&lt;/div&gt;</summary>
		<author><name>LL</name></author>
	</entry>
	<entry>
		<id>https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244291</id>
		<title>Dynamic Neural Retraining System</title>
		<link rel="alternate" type="text/html" href="https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244291"/>
		<updated>2025-09-05T21:58:12Z</updated>

		<summary type="html">&lt;p&gt;LL:/* References */ added clinical trial information&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;Annie Hopper created the &#039;&#039;&#039;Dynamic Neural Retraining System&#039;&#039;&#039; or &#039;&#039;&#039;DNRS&#039;&#039;&#039; in 2008, and states this is based on her recovery from &amp;quot;severe Multiple Chemical Sensitivity, Fibromyalgia and Electric Hypersensitivity Syndrome&amp;quot;.&amp;lt;ref name=&amp;quot;team&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/meet-the-dnrs-team/ | title = Meet the DNRS™ Team | last = Tozer | first = James|website=Dynamic Neural Retraining System|language=en-CA|access-date=2020-09-23}}&amp;lt;/ref&amp;gt; Prior to becoming ill, healing and developing DNRS, Annie Hopper was a core beliefs counsellor and weekly newspaper columnist.&lt;br /&gt;
&lt;br /&gt;
==Theory ==&lt;br /&gt;
[https://retrainingthebrain.com/ The DNRS website]  positions limbic system impairment as the cause of brain changes, and that this causes a &amp;quot;maladaptive stress response&amp;quot; which then causes certain physical symptoms, which the website lists.&amp;lt;ref name=&amp;quot;about&amp;quot;&amp;gt;{{Cite web|url=https://retrainingthebrain.com/program-information/|title=How The Program Works|last=Hopper|first=Annie|authorlink=|date=|website=Dynamic Neural Retraining System|language=en-CA|archive-url=|archive-date=|url-status=|access-date=2025-09-05}}&amp;lt;/ref&amp;gt; Limbic system impairment can have multiple causes; the common result is a  type of neurological dysregulation in the brain. This can lead to central sensitization, a condition where the brain and nervous system become hypersensitive, amplifying pain, stress, and normal sensory input. DNRS assists in recovery through mood elevation, desensitization and visualization to facilitate &amp;quot;new, healthy neural pathways&amp;quot;.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Components ==&lt;br /&gt;
The program is a psychologically based self-help approach that states it involves &lt;br /&gt;
*[[cognitive behavioral therapy]]&lt;br /&gt;
*[[mindfulness]] based cognitive restructuring&lt;br /&gt;
*emotional restructuring therapy&lt;br /&gt;
*[[Neurolinguistic programming]] (NLP)&lt;br /&gt;
*incremental training (a form of neural shaping)&lt;br /&gt;
*behaviour modification therapy&lt;br /&gt;
&lt;br /&gt;
The program includes a one-year subscription which includes 12 hours of video tutorials followed by a consistent, regular daily practice. Program registrants commit to 6 months of practice of one hour per day.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==ME/CFS ==&lt;br /&gt;
The DNRS website claims it can &amp;quot;rewire chronic illness disease patterns in the brain&amp;quot; and that &amp;quot;the program is an effective treatment for [[Multiple chemical sensitivity|chemical sensitivities]], [[chronic fatigue syndrome]], [[fibromyalgia]] and many other chronic illnesses&amp;quot;. This rewiring is considered to be reflected through changed symptoms rather than being reliant on objective evidence of changes in brain function or connectivity.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; Peripheral or [[autonomic nervous system]] changes are not discussed.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; &lt;br /&gt;
&lt;br /&gt;
Evidence for dynamic neural retraining in the peer-reviewed evidence is scant. A 2021 meta-analysis of mind-body intervention studies in ME/CFS could not source any peer-reviewed data on DNRS in ME/CFS despite authors explicitly including related terms in their search.&amp;lt;ref&amp;gt;{{Cite journal|title=Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|date=2021-06-24|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC8305555/|journal=Medicina|volume=57|issue=7|pages=652|last=Khanpour Ardestani|first=Samaneh|last2=Karkhaneh|first2=Mohammad|last3=Stein|first3=Eleanor|last4=Punja|first4=Salima|last5=Junqueira|first5=Daniela R.|last6=Kuzmyn|first6=Tatiana|last7=Pearson|first7=Michelle|last8=Smith|first8=Laurie|last9=Olson|first9=Karin|last10=Vohra|first10=Sunita|language=en|doi=10.3390/medicina57070652|issn=1648-9144}}&amp;lt;/ref&amp;gt; There appear to be no trials of DNRS in ME/CFS in the published literature as of 2025.  &lt;br /&gt;
==Risks and safety ==&lt;br /&gt;
A [https://clinicaltrials.gov/study/NCT06933173 clinical trial] is underway to study the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC). As of yet, there is no direct research to connect Mind-body interventions (MBIs) and how it refocuses the brain, mind, body, and behaviour interact to improve health and well-being. it is therefore unclear to state what risks it and similar treatment modalities present.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt;  &lt;br /&gt;
&lt;br /&gt;
It is generally acknowledged that patients who fail to improve through DNRS and similar programs discuss feelings of guilt, as these and similar systems frame recovery as within the patient&#039;s control, even in literature that views these interventions in a positive light.&amp;lt;ref&amp;gt;{{Cite journal|title=Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID|date=2023-03-07|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC10048882/|journal=International Journal of Molecular Sciences|volume=24|issue=6|pages=5124|last=Tate|first=Warren P.|last2=Walker|first2=Max O. M.|last3=Peppercorn|first3=Katie|last4=Blair|first4=Anna L. H.|last5=Edgar|first5=Christina D.|language=en|doi=10.3390/ijms24065124|issn=1422-0067}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Evidence ==&lt;br /&gt;
The University of Alberta opened a [https://clinicaltrials.gov/study/NCT06933173 clinical trial on DNRS] in July of 2025 to measure the effectiveness or potential risks of DNRS, and to determine how the brain is &amp;quot;rewired&amp;quot; or &amp;quot;retrained&amp;quot; or that neural networks within the brain are altered by the treatment.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Evidence consists of an unpublished presentation, which has not been peer reviewed, part of which can be found on the DNRS website, and a number of claims by coaches or facilitators who stated they recovered from multiple illnesses using it.&amp;lt;ref name=&amp;quot;ResearchSep2020&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/research-3/ | title = Research | last = Tozer | first = James | authorlink = | date = n.d.|website=Dynamic Neural Retraining System|language=en-CA| archive-url = | archive-date = |url-status = | access-date=2020-09-23}}&amp;lt;/ref&amp;gt; According to the presentation, brain imaging or brain function tests were not used to assess neuroplasticity after the DNRS course, and all results were based on patient questionnaires.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot;&amp;gt;{{Citation|vauthors=Guenter et al | first = | title = Neuroplasticity-based treatment for fibromyalgia, chronic fatigue and multiple chemical sensitivity: feasibility and outcomes| publisher = | date = 2019 | url=|volume=|issue=| pages=|chapter=|edition= | last2 = | first2 = }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The presentation on the website does not provide results separately for patients with ME/CFS, although some patients reported having it. Many patients have provided testimonials on the DNRS website to share their [https://retrainingthebrain.com/?post_type=success-story&amp;amp;s=chronic+fatigue healing process from the effects of ME/ CFS.]&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Learn more ==&lt;br /&gt;
*[https://clinicaltrials.gov/study/NCT06933173 Clinical Trial,] Mind-Body in Long COVID and Myalgic Encephalomyelitis Study (MILES): A Patient-Centred RCT &lt;br /&gt;
*[https://paradigmchange.me/wp/retraining/ Some Comments on So-Called “Brain Retraining” Programs] - Psychologist Lisa Petrison comments on the unproven scientific claims and potential harm - Paradigmchange.me&lt;br /&gt;
*[https://retrainingthebrain.com/how-the-program-works/ How the program works - DNRS]&lt;br /&gt;
*[https://www.virology.ws/2020/09/02/trial-by-error-what-is-the-dynamic-neural-retraining-system/ Trial By Error: What Is the Dynamic Neural Retraining System?] - [[Virology blog]]&lt;br /&gt;
&lt;br /&gt;
==See also ==&lt;br /&gt;
*[[Brain training]]&lt;br /&gt;
&lt;br /&gt;
==References ==&lt;br /&gt;
{{Reflist}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Brain training]]&lt;br /&gt;
[[Category:Potential treatments]]&lt;br /&gt;
[[Category:Psychological and behavioral therapies]]&lt;/div&gt;</summary>
		<author><name>LL</name></author>
	</entry>
	<entry>
		<id>https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244280</id>
		<title>Dynamic Neural Retraining System</title>
		<link rel="alternate" type="text/html" href="https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244280"/>
		<updated>2025-08-21T23:05:22Z</updated>

		<summary type="html">&lt;p&gt;LL:typo&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;Annie Hopper created the &#039;&#039;&#039;Dynamic Neural Retraining System&#039;&#039;&#039; or &#039;&#039;&#039;DNRS&#039;&#039;&#039; in 2008, and states this is based on her recovery from &amp;quot;severe Multiple Chemical Sensitivity, Fibromyalgia and Electric Hypersensitivity Syndrome&amp;quot;.&amp;lt;ref name=&amp;quot;team&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/meet-the-dnrs-team/ | title = Meet the DNRS™ Team | last = Tozer | first = James|website=Dynamic Neural Retraining System|language=en-CA|access-date=2020-09-23}}&amp;lt;/ref&amp;gt; Prior to becoming ill, healing and developing DNRS, Annie Hopper was a core beliefs counsellor and weekly newspaper columnist.&lt;br /&gt;
&lt;br /&gt;
==Theory ==&lt;br /&gt;
[https://retrainingthebrain.com/ The DNRS website]  positions limbic system impairment as the cause of brain changes, and that this causes a &amp;quot;maladaptive stress response&amp;quot; which then causes certain physical symptoms, which the website lists.&amp;lt;ref name=&amp;quot;about&amp;quot;&amp;gt;{{Cite web|url=https://retrainingthebrain.com/how-the-program-works/|title=How The Program Works|last=Tozer|first=James|authorlink=|date=|website=Dynamic Neural Retraining System|language=en-CA|archive-url=|archive-date=|url-status=|access-date=2020-09-23}}&amp;lt;/ref&amp;gt; Limbic system impairment can have multiple causes; the common result is a  type of neurological dysregulation in the brain. This can lead to central sensitization, a condition where the brain and nervous system become hypersensitive, amplifying pain, stress, and normal sensory input. DNRS assists in recovery through mood elevation, desensitization and visualization to facilitate &amp;quot;new, healthy neural pathways&amp;quot;.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Components ==&lt;br /&gt;
The program is a psychologically based self-help approach that states it involves &lt;br /&gt;
*[[cognitive behavioral therapy]]&lt;br /&gt;
*[[mindfulness]] based cognitive restructuring&lt;br /&gt;
*emotional restructuring therapy&lt;br /&gt;
*[[Neurolinguistic programming]] (NLP)&lt;br /&gt;
*incremental training (a form of neural shaping)&lt;br /&gt;
*behaviour modification therapy&lt;br /&gt;
&lt;br /&gt;
The program includes a one-year subscription which includes 12 hours of video tutorials followed by a consistent, regular daily practice. Program registrants commit to 6 months of practice of one hour per day.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==ME/CFS ==&lt;br /&gt;
The DNRS website claims it can &amp;quot;rewire chronic illness disease patterns in the brain&amp;quot; and that &amp;quot;the program is an effective treatment for [[Multiple chemical sensitivity|chemical sensitivities]], [[chronic fatigue syndrome]], [[fibromyalgia]] and many other chronic illnesses&amp;quot;. No brain scans or brain imaging studies support this &amp;quot;rewiring the brain&amp;quot; claim, no other evidence is given to support this claim, and there is no evidence that brain-only dysfunction is the sole cause of any of these illnesses.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; DNRS does not suggest any benefits that could lead to improvement in [[Mitochondrion|mitochondria]] or [[immune system]] functioning, or any change in [[dorsal root ganglia]] inflammation,&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; all of which research has found to be involved in ME/CFS. Peripheral nerve changes, the [[autonomic nervous system]] changes, and POTS are not mentioned.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; The only scientific support is not published in full and not peer-reviewed, and appears as a graph and basic summary of some aspects of a preliminary report based on questionnaires from a group who tried DNRS. Only some results are reported, and it shows a high drop-out rate, and unsurprisingly shows that those who did not drop-out did improve to a degree.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt; There is no information about whether participants had been professionally diagnosed, the results of the patients self-reporting CFS are not given, and full results are not reported, which is an indicator of [[research bias in ME/CFS|bias]].&lt;br /&gt;
&lt;br /&gt;
ME/CFS is a neurological disease which is also multisystemic; symptoms include immune system dysfunction including altered [[cytokine]] expression, digestive / gastrointestinal symptoms that in some cases become severe enough to need tube feeding or even cause death from [[Sophia Mirza|kidney failure]], [[mitochondria dysfunction]], hormonal changes caused by the endocrine system, multiple types of pain, new intolerances to certain foods or sensory intolerances, alterations in the shape of [[erythrocyte|red blood cells]], changes in the circulatory system for example [[postural orthostatic tachycardia syndrome]] (POTS), and significant [[cognitive dysfunction]].&amp;lt;ref name=&amp;quot;ICC2011primer&amp;quot; /&amp;gt; &lt;br /&gt;
&lt;br /&gt;
The theory of ME/CFS as a long-term consequence of [[trauma]] lacks evidence and has significant evidence against it, with many patients having no trauma history and most reporting that the onset if the disease was linked to a [[viral onset hypothesis|virus]], other [[infection]], or physical injury.&amp;lt;ref name=&amp;quot;ICC2011primer&amp;quot; /&amp;gt; A study of military veterans by Murphy et al. (2003) could not find a link between [[Post-traumatic stress disorder]] and CFS-like symptoms.&amp;lt;ref name=&amp;quot;veterans2003&amp;quot;&amp;gt;{{Cite journal | last = Murphy | first = Frances M. | authorlink = Frances Murphy | last2 = Lee | first2 = Kyung Y. | authorlink2 = Kyung Lee | last3 = Mahan | first3 = Clare M. | author-link3 = Clare Mahan | last4 = Natelson | first4 = Benjamin H. | author-link4 = Benjamin Natelson | last5 = Kang | first5 = Han K. | author-link5 = Han Kang | date = 2003-01-15 | title = Post-Traumatic Stress Disorder and Chronic Fatigue Syndrome-like Illness among Gulf War Veterans: A Population-based Survey of 30,000 Veterans |url =https://academic.oup.com/aje/article/157/2/141/90101|journal=American Journal of Epidemiology|language=en|volume=157|issue=2 | pages = 141–148|doi=10.1093/aje/kwf187|issn=0002-9262|quote=|via=}}&amp;lt;/ref&amp;gt; Heins et al. (2011) found no relationship between childhood maltreatment and response to [[Cognitive behavioral therapy|CBT]] therapy for CFS.&amp;lt;ref name=&amp;quot;Heins2011&amp;quot;&amp;gt;{{Cite journal | last = Heins | first = Marianne J. | authorlink = Marianne Heins | last2 = Knoop | first2 = Hans | authorlink2 = Hans Knoop | last3 = Lobbestael | first3 = Jill | authorlink3 = Jill Lobbestael | last4 = Bleijenberg | first4 = Gijs | authorlink4 = Gijs Bleijenberg | authorlink5 = | date = Dec 2011 | title = Childhood maltreatment and the response to cognitive behavior therapy for chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/m/pubmed/22118383/|journal=Journal of Psychosomatic Research|volume=71|issue=6 | pages = 404–410|doi=10.1016/j.jpsychores.2011.05.005|issn=1879-1360|pmid=22118383|quote=|via=}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Clark, 2018&amp;quot;&amp;gt;{{Citation | last = Clark | first1 = James E. | author-link1 = James Clark | last2 =Davidson | first2 = Sean L. | authorlink2 = Sean Davidson | last3 = Maclachlan | first3 = Laura| authorlink3 = Laura Maclachlan | last4 = Newton | first4 = Julia| authorlink4 = Julia Newton | last5 = Watson | first5 = Stuart | authorlink5 = Stuart Watson | title = Rethinking childhood adversity in chronic fatigue syndrome | journal = Fatigue: Biomedicine, Health &amp;amp; Behavior | volume = | issue =  | page = | date = 2017 | pmid = | doi =  10.1080/21641846.2018.1384095 }}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Morris2019&amp;quot;&amp;gt;{{Cite journal | last = Morris | first = Gerwyn | authorlink = Gerwyn Morris | last2 = Berk | first2 = Michael | authorlink2 = Michael Berk | last3 = Maes | first3 = Michael | authorlink3 = Michael Maes | last4 = Carvalho | first4 = André F. | author-link4 = André Carvalho | last5 = Puri | first5 = Basant K. | author-link5 = Basant Puri | date = 2019-01-26 | title = Socioeconomic Deprivation, Adverse Childhood Experiences and Medical Disorders in Adulthood: Mechanisms and Associations |url =https://doi.org/10.1007/s12035-019-1498-1|journal=Molecular Neurobiology|language=en|volume=|issue= | pages = 1-25|doi=10.1007/s12035-019-1498-1|issn=1559-1182|quote=|via=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
==Risks and safety ==&lt;br /&gt;
There is no scientific evidence that DNRS has positive benefits or that it is a safe treatment, no clinical trials have been conducted, and DNRS was not developed by a medical professional or scientist.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt; &lt;br /&gt;
&lt;br /&gt;
The hallmark symptom of ME/CFS is [[post-exertional malaise]] which can be triggered by too much cognitive effort; in [[severe and very severe ME]] watching too much TV or listening to audio may cause post-exertional malaise or permanent deterioration, which may mean the commitment and work needed by DNRS is both impossible and very harmful.&amp;lt;ref name=&amp;quot;ICC2011primer&amp;quot;&amp;gt;{{citation | last1 = Carruthers | first1 = BM | author-link1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | author-link6 = Terry Mitchell | last7 = Staines | first7 = D | author-link8 = Donald Staines | last8 = Powles | first8 = ACP | author-link8 = A C Peter Powles | last9 = Speight | first9 = N | author-link9 = Nigel Speight | last10 = Vallings | first10 = R | author-link10 = Rosamund Vallings | last11 = Bateman | first11 =  L | author-link11 = Lucinda Bateman | last12 = Bell | first12 = DS | author-link12 = David Bell | last13 = Carlo-Stella | first13 =  N | author-link13 = Nicoletta Carlo-Stella | last14 = Chia | first14 =  J | author-link14 = John Chia | last15 = Darragh | first15 =  A | author-link15 = Austin Darragh | last16 = Gerken | first16 =  A | author-link16 = Anne Gerken | last17 = Jo | first17 =  D | author-link17 = Daehyun Jo | last18 = Lewis | first18 =  DP | author-link18 = Donald Lewis | last19 = Light | first19 = AR | author-link19 = Alan Light | last20 = Light | first20 =  KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 =  S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 =  J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 =  I | authorlink23 =  Ismael Mena | last24 = Miwa | first24 =  K | authorlink24 =  Kunihisa Miwa | last25 = Murovska | first25 =  M | authorlink25= Modra Murovska | last26 = Stevens | first26 =  SR | authorlink26 =  Staci Stevens | title = Myalgic encephalomyelitis: Adult &amp;amp; Paediatric: International Consensus Primer for Medical Practitioners | date = 2012&lt;br /&gt;
| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Some components of the program such as [[cognitive behavioral therapy]], mindfulness and stress management techniques have not been shown to be effective in the majority of ME/CFS, and some have resulted in substantial rates of harm. If used as a trauma recovery or stress management program, it is not known how this compares with well-established, proven treatments.&lt;br /&gt;
&lt;br /&gt;
==Evidence ==&lt;br /&gt;
No clinical trials have been conducted to show the effectiveness or potential risks of DNRS, and there is no evidence that the brain is &amp;quot;rewired&amp;quot; or &amp;quot;retrained&amp;quot; or that neural networks within the brain are altered by the treatment.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Evidence consists of an unpublished presentation, which has not been peer reviewed, part of which can be found on the DNRS website, and a number of claims by coaches or facilitators who stated they recovered from multiple illnesses using it.&amp;lt;ref name=&amp;quot;ResearchSep2020&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/research-3/ | title = Research | last = Tozer | first = James | authorlink = | date = n.d.|website=Dynamic Neural Retraining System|language=en-CA| archive-url = | archive-date = |url-status = | access-date=2020-09-23}}&amp;lt;/ref&amp;gt; According to the presentation, brain imaging or brain function tests were not used to assess neuroplasticity after the DNRS course, and all results were based on patient questionnaires.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot;&amp;gt;{{Citation|vauthors=Guenter et al | first = | title = Neuroplasticity-based treatment for fibromyalgia, chronic fatigue and multiple chemical sensitivity: feasibility and outcomes| publisher = | date = 2019 | url=|volume=|issue=| pages=|chapter=|edition= | last2 = | first2 = }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The presentation on the website does not provide results separately for patients with ME/CFS, although some patients reported having it.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Learn more ==&lt;br /&gt;
*[https://www.virology.ws/2020/09/02/trial-by-error-what-is-the-dynamic-neural-retraining-system/ Trial By Error: What Is the Dynamic Neural Retraining System?] - [[Virology blog]]&lt;br /&gt;
*[https://paradigmchange.me/wp/retraining/ Some Comments on So-Called “Brain Retraining” Programs] - Psychologist Lisa Petrison comments on the unproven scientific claims and potential harm - Paradigmchange.me&lt;br /&gt;
*[https://retrainingthebrain.com/how-the-program-works/ How the program works - DNRS]&lt;br /&gt;
&lt;br /&gt;
==See also ==&lt;br /&gt;
*[[Brain training]]&lt;br /&gt;
&lt;br /&gt;
==References ==&lt;br /&gt;
{{Reflist}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Brain training]]&lt;br /&gt;
[[Category:Potential treatments]]&lt;br /&gt;
[[Category:Psychological and behavioral therapies]]&lt;/div&gt;</summary>
		<author><name>LL</name></author>
	</entry>
	<entry>
		<id>https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244279</id>
		<title>Dynamic Neural Retraining System</title>
		<link rel="alternate" type="text/html" href="https://me-pedia.org/w/index.php?title=Dynamic_Neural_Retraining_System&amp;diff=244279"/>
		<updated>2025-08-21T23:01:43Z</updated>

		<summary type="html">&lt;p&gt;LL:/* Theory */ There are factual inaccuracies in this page. Corrections to reflect.&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;Annie Hopper created the &#039;&#039;&#039;Dynamic Neural Retraining System&#039;&#039;&#039; or &#039;&#039;&#039;DNRS&#039;&#039;&#039; in 2008, and states this is based on her recovery from &amp;quot;severe Multiple Chemical Sensitivity, Fibromyalgia and Electric Hypersensitivity Syndrome&amp;quot;.&amp;lt;ref name=&amp;quot;team&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/meet-the-dnrs-team/ | title = Meet the DNRS™ Team | last = Tozer | first = James|website=Dynamic Neural Retraining System|language=en-CA|access-date=2020-09-23}}&amp;lt;/ref&amp;gt; Prior to becoming ill, healing and developing DNRS, Annie Hopper was a core beliefs counsellor and weekly newspaper columnist.&lt;br /&gt;
&lt;br /&gt;
==Theory ==&lt;br /&gt;
[https://retrainingthebrain.com/ The DNRS website]  positions limbic system impairment as the cause of brain changes, and that this causes a &amp;quot;maladaptive stress response&amp;quot; which then causes certain physical symptoms, which the website lists.&amp;lt;ref name=&amp;quot;about&amp;quot;&amp;gt;{{Cite web|url=https://retrainingthebrain.com/how-the-program-works/|title=How The Program Works|last=Tozer|first=James|authorlink=|date=|website=Dynamic Neural Retraining System|language=en-CA|archive-url=|archive-date=|url-status=|access-date=2020-09-23}}&amp;lt;/ref&amp;gt; Limbic system impairment can have multiple causes; the common reslut is a  type of neurological dysregulation in the brain. This can lead to central sensitization, a condition where the brain and nervous system become hypersensitive, amplifying pain, stress, and normal sensory input. DNRS assists in recovery through mood elevation, desensitization and visualization to facilitate &amp;quot;new, healthy neural pathways&amp;quot;.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Components ==&lt;br /&gt;
The program is a psychologically based self-help approach that states it involves &lt;br /&gt;
*[[cognitive behavioral therapy]]&lt;br /&gt;
*[[mindfulness]] based cognitive restructuring&lt;br /&gt;
*emotional restructuring therapy&lt;br /&gt;
*[[Neurolinguistic programming]] (NLP)&lt;br /&gt;
*incremental training (a form of neural shaping)&lt;br /&gt;
*behaviour modification therapy&lt;br /&gt;
&lt;br /&gt;
The program includes a one-year subscription which includes 12 hours of video tutorials followed by a consistent, regular daily practice. Program registrants commit to 6 months of practice of one hour per day.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==ME/CFS ==&lt;br /&gt;
The DNRS website claims it can &amp;quot;rewire chronic illness disease patterns in the brain&amp;quot; and that &amp;quot;the program is an effective treatment for [[Multiple chemical sensitivity|chemical sensitivities]], [[chronic fatigue syndrome]], [[fibromyalgia]] and many other chronic illnesses&amp;quot;. No brain scans or brain imaging studies support this &amp;quot;rewiring the brain&amp;quot; claim, no other evidence is given to support this claim, and there is no evidence that brain-only dysfunction is the sole cause of any of these illnesses.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; DNRS does not suggest any benefits that could lead to improvement in [[Mitochondrion|mitochondria]] or [[immune system]] functioning, or any change in [[dorsal root ganglia]] inflammation,&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; all of which research has found to be involved in ME/CFS. Peripheral nerve changes, the [[autonomic nervous system]] changes, and POTS are not mentioned.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt; The only scientific support is not published in full and not peer-reviewed, and appears as a graph and basic summary of some aspects of a preliminary report based on questionnaires from a group who tried DNRS. Only some results are reported, and it shows a high drop-out rate, and unsurprisingly shows that those who did not drop-out did improve to a degree.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt; There is no information about whether participants had been professionally diagnosed, the results of the patients self-reporting CFS are not given, and full results are not reported, which is an indicator of [[research bias in ME/CFS|bias]].&lt;br /&gt;
&lt;br /&gt;
ME/CFS is a neurological disease which is also multisystemic; symptoms include immune system dysfunction including altered [[cytokine]] expression, digestive / gastrointestinal symptoms that in some cases become severe enough to need tube feeding or even cause death from [[Sophia Mirza|kidney failure]], [[mitochondria dysfunction]], hormonal changes caused by the endocrine system, multiple types of pain, new intolerances to certain foods or sensory intolerances, alterations in the shape of [[erythrocyte|red blood cells]], changes in the circulatory system for example [[postural orthostatic tachycardia syndrome]] (POTS), and significant [[cognitive dysfunction]].&amp;lt;ref name=&amp;quot;ICC2011primer&amp;quot; /&amp;gt; &lt;br /&gt;
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The theory of ME/CFS as a long-term consequence of [[trauma]] lacks evidence and has significant evidence against it, with many patients having no trauma history and most reporting that the onset if the disease was linked to a [[viral onset hypothesis|virus]], other [[infection]], or physical injury.&amp;lt;ref name=&amp;quot;ICC2011primer&amp;quot; /&amp;gt; A study of military veterans by Murphy et al. (2003) could not find a link between [[Post-traumatic stress disorder]] and CFS-like symptoms.&amp;lt;ref name=&amp;quot;veterans2003&amp;quot;&amp;gt;{{Cite journal | last = Murphy | first = Frances M. | authorlink = Frances Murphy | last2 = Lee | first2 = Kyung Y. | authorlink2 = Kyung Lee | last3 = Mahan | first3 = Clare M. | author-link3 = Clare Mahan | last4 = Natelson | first4 = Benjamin H. | author-link4 = Benjamin Natelson | last5 = Kang | first5 = Han K. | author-link5 = Han Kang | date = 2003-01-15 | title = Post-Traumatic Stress Disorder and Chronic Fatigue Syndrome-like Illness among Gulf War Veterans: A Population-based Survey of 30,000 Veterans |url =https://academic.oup.com/aje/article/157/2/141/90101|journal=American Journal of Epidemiology|language=en|volume=157|issue=2 | pages = 141–148|doi=10.1093/aje/kwf187|issn=0002-9262|quote=|via=}}&amp;lt;/ref&amp;gt; Heins et al. (2011) found no relationship between childhood maltreatment and response to [[Cognitive behavioral therapy|CBT]] therapy for CFS.&amp;lt;ref name=&amp;quot;Heins2011&amp;quot;&amp;gt;{{Cite journal | last = Heins | first = Marianne J. | authorlink = Marianne Heins | last2 = Knoop | first2 = Hans | authorlink2 = Hans Knoop | last3 = Lobbestael | first3 = Jill | authorlink3 = Jill Lobbestael | last4 = Bleijenberg | first4 = Gijs | authorlink4 = Gijs Bleijenberg | authorlink5 = | date = Dec 2011 | title = Childhood maltreatment and the response to cognitive behavior therapy for chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/m/pubmed/22118383/|journal=Journal of Psychosomatic Research|volume=71|issue=6 | pages = 404–410|doi=10.1016/j.jpsychores.2011.05.005|issn=1879-1360|pmid=22118383|quote=|via=}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Clark, 2018&amp;quot;&amp;gt;{{Citation | last = Clark | first1 = James E. | author-link1 = James Clark | last2 =Davidson | first2 = Sean L. | authorlink2 = Sean Davidson | last3 = Maclachlan | first3 = Laura| authorlink3 = Laura Maclachlan | last4 = Newton | first4 = Julia| authorlink4 = Julia Newton | last5 = Watson | first5 = Stuart | authorlink5 = Stuart Watson | title = Rethinking childhood adversity in chronic fatigue syndrome | journal = Fatigue: Biomedicine, Health &amp;amp; Behavior | volume = | issue =  | page = | date = 2017 | pmid = | doi =  10.1080/21641846.2018.1384095 }}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Morris2019&amp;quot;&amp;gt;{{Cite journal | last = Morris | first = Gerwyn | authorlink = Gerwyn Morris | last2 = Berk | first2 = Michael | authorlink2 = Michael Berk | last3 = Maes | first3 = Michael | authorlink3 = Michael Maes | last4 = Carvalho | first4 = André F. | author-link4 = André Carvalho | last5 = Puri | first5 = Basant K. | author-link5 = Basant Puri | date = 2019-01-26 | title = Socioeconomic Deprivation, Adverse Childhood Experiences and Medical Disorders in Adulthood: Mechanisms and Associations |url =https://doi.org/10.1007/s12035-019-1498-1|journal=Molecular Neurobiology|language=en|volume=|issue= | pages = 1-25|doi=10.1007/s12035-019-1498-1|issn=1559-1182|quote=|via=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
==Risks and safety ==&lt;br /&gt;
There is no scientific evidence that DNRS has positive benefits or that it is a safe treatment, no clinical trials have been conducted, and DNRS was not developed by a medical professional or scientist.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt; &lt;br /&gt;
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The hallmark symptom of ME/CFS is [[post-exertional malaise]] which can be triggered by too much cognitive effort; in [[severe and very severe ME]] watching too much TV or listening to audio may cause post-exertional malaise or permanent deterioration, which may mean the commitment and work needed by DNRS is both impossible and very harmful.&amp;lt;ref name=&amp;quot;ICC2011primer&amp;quot;&amp;gt;{{citation | last1 = Carruthers | first1 = BM | author-link1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | author-link6 = Terry Mitchell | last7 = Staines | first7 = D | author-link8 = Donald Staines | last8 = Powles | first8 = ACP | author-link8 = A C Peter Powles | last9 = Speight | first9 = N | author-link9 = Nigel Speight | last10 = Vallings | first10 = R | author-link10 = Rosamund Vallings | last11 = Bateman | first11 =  L | author-link11 = Lucinda Bateman | last12 = Bell | first12 = DS | author-link12 = David Bell | last13 = Carlo-Stella | first13 =  N | author-link13 = Nicoletta Carlo-Stella | last14 = Chia | first14 =  J | author-link14 = John Chia | last15 = Darragh | first15 =  A | author-link15 = Austin Darragh | last16 = Gerken | first16 =  A | author-link16 = Anne Gerken | last17 = Jo | first17 =  D | author-link17 = Daehyun Jo | last18 = Lewis | first18 =  DP | author-link18 = Donald Lewis | last19 = Light | first19 = AR | author-link19 = Alan Light | last20 = Light | first20 =  KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 =  S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 =  J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 =  I | authorlink23 =  Ismael Mena | last24 = Miwa | first24 =  K | authorlink24 =  Kunihisa Miwa | last25 = Murovska | first25 =  M | authorlink25= Modra Murovska | last26 = Stevens | first26 =  SR | authorlink26 =  Staci Stevens | title = Myalgic encephalomyelitis: Adult &amp;amp; Paediatric: International Consensus Primer for Medical Practitioners | date = 2012&lt;br /&gt;
| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Some components of the program such as [[cognitive behavioral therapy]], mindfulness and stress management techniques have not been shown to be effective in the majority of ME/CFS, and some have resulted in substantial rates of harm. If used as a trauma recovery or stress management program, it is not known how this compares with well-established, proven treatments.&lt;br /&gt;
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==Evidence ==&lt;br /&gt;
No clinical trials have been conducted to show the effectiveness or potential risks of DNRS, and there is no evidence that the brain is &amp;quot;rewired&amp;quot; or &amp;quot;retrained&amp;quot; or that neural networks within the brain are altered by the treatment.&amp;lt;ref name=&amp;quot;about&amp;quot; /&amp;gt;&lt;br /&gt;
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Evidence consists of an unpublished presentation, which has not been peer reviewed, part of which can be found on the DNRS website, and a number of claims by coaches or facilitators who stated they recovered from multiple illnesses using it.&amp;lt;ref name=&amp;quot;ResearchSep2020&amp;quot;&amp;gt;{{Cite web | url=https://retrainingthebrain.com/research-3/ | title = Research | last = Tozer | first = James | authorlink = | date = n.d.|website=Dynamic Neural Retraining System|language=en-CA| archive-url = | archive-date = |url-status = | access-date=2020-09-23}}&amp;lt;/ref&amp;gt; According to the presentation, brain imaging or brain function tests were not used to assess neuroplasticity after the DNRS course, and all results were based on patient questionnaires.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot;&amp;gt;{{Citation|vauthors=Guenter et al | first = | title = Neuroplasticity-based treatment for fibromyalgia, chronic fatigue and multiple chemical sensitivity: feasibility and outcomes| publisher = | date = 2019 | url=|volume=|issue=| pages=|chapter=|edition= | last2 = | first2 = }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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The presentation on the website does not provide results separately for patients with ME/CFS, although some patients reported having it.&amp;lt;ref name=&amp;quot;Guenter2019&amp;quot; /&amp;gt;&lt;br /&gt;
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==Learn more ==&lt;br /&gt;
*[https://www.virology.ws/2020/09/02/trial-by-error-what-is-the-dynamic-neural-retraining-system/ Trial By Error: What Is the Dynamic Neural Retraining System?] - [[Virology blog]]&lt;br /&gt;
*[https://paradigmchange.me/wp/retraining/ Some Comments on So-Called “Brain Retraining” Programs] - Psychologist Lisa Petrison comments on the unproven scientific claims and potential harm - Paradigmchange.me&lt;br /&gt;
*[https://retrainingthebrain.com/how-the-program-works/ How the program works - DNRS]&lt;br /&gt;
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==See also ==&lt;br /&gt;
*[[Brain training]]&lt;br /&gt;
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==References ==&lt;br /&gt;
{{Reflist}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Brain training]]&lt;br /&gt;
[[Category:Potential treatments]]&lt;br /&gt;
[[Category:Psychological and behavioral therapies]]&lt;/div&gt;</summary>
		<author><name>LL</name></author>
	</entry>
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