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A Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis

2018-07-16T14:18:52Z

Jannik:create

Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis
http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html
Katharina Voss, Copyright 2018 (Author of a German textbook on ME entitled
"ME - Myalgische Enzephalomyelitis vs. Chronic Fatigue Syndrom: Fakten Hintergründe Forschung", tredition 2017)
Saturday, June 9th, 2018

'''Doctor Inquiries - My Therapy Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis'''
==Introduction==
I receive numerous inquiries from doctors at home and abroad who have been made aware of my
blog post about the successful antiretroviral therapy (ART) of my ME afflicted daughter by their
patients suffering from Myalgic Encephalomyelitis (ME). These physicians are interested in my
therapy regime developed by me for my daughter and sometimes also want to clarify further
questions about [[ART]] for ME.
Until now I responded to these questions individually. In order to spare myself this
constantly growing (unpaid) work in the future, but above all to also involve patients in this
therapeutic concept and make my method comprehensible to them, I have now decided to publish
my so far very successful treatment strategy. Unfortunately, I also had to realize that not all doctors
who contacted me have been taking my notes on the urgency and frequency of blood and urine
testing seriously. My proposals on dosage and accompanying treatments do not seem to always be
taken seriously either. By publishing my concept, every patient can now get an idea and decide for
oneself whether to accept my suggestions.

'''As a matter of principle, however, I would like to state in advance that these are by no means
medical recommendations or advice, but merely suggestions based on the experience I and other
patients have gathered and on my intensive research of literature on the subject. In addition I refer
to my disclaimer.'''

==ART for ME==
Treatment with antiretroviral drugs ([[ARV]]) for ME is above all based on research by [[Judy Mikovits]]
et al., who - like several other researchers - found a human [[gamma-retrovirus]] (HGRV) in the blood
of ME patients (see my blog post). Eligible [[ARV]]s for treatment of HGRV infection are [[AZT]],
[[Tenofovir]] and Raltegravir. The profile of side effects of [[AZT]], however, is much more severe than
that of the reverse transcriptase inhibitor [[Tenofovir]]. Since the proliferation of infected cells must
first be stopped, it is advisable - at least according to Dr. [[Judy Mikovits]] and the experience of
patients treated with [[ART]] - to start treatment with [[Tenofovir]] and add the integrase inhibitor
Raltegravir later, if required at all.
Some patients treated by Dr [[John Chia]] also reported successful [[ART]] with nucleoside reverse
transcriptase inhibitor Lamivudine. In addition, I received reports of patients who have been
successfully treated with Truvada, a combination drug containing [[Tenofovir]] and used in Pre-
exposure Prophylaxis ([[PrEP]]).

Since [[retrovirus]] research in ME is undermined for various reasons (see my book [[ME - Myalgische Enzephalomyelitis vs. Chronic Fatigue Syndrom - Fakten Hintergründe Forschung]]), there are unfortunately no tests that could serve as a reliable indicator for [[ART]]. One could potentially look
for reduced NK cell activity, a defect in antiviral enzyme RNase L, increased HHV-6 titers and
proliferation of Anellovirus in plasma.
While such tests may facilitate the identification of responders, this is hardly a certain method, as
valid examinations are still absent.
Even SG-PERT, a testing procedure that quantifies reverse transcriptase activity and can, for
example, be performed at the Nationales Referenzzentrum für Retroviren, unfortunately does not
indicate whether one is a responder. This was demonstrated by our and other patients' experiences.
Perhaps this test does not detect the possibly ultra low-level activity of an HGRV reverse
transcriptase enzyme?

Even if one is not a supporter of the [[retrovirus]] causation hypothesis, [[Tenofovir]] could still be
contemplated as a treatment option for ME patients, as it has immunomodulatory properties and
acts as an anti-inflammatory agent - at least in patients with proven [[retrovirus]] infection.
However, since experience to date shows that an integrase inhibitor usually needs to be added after
a while in order for the patient to continue making progress, there is some evidence to suggest that
the efficacy of [[Tenofovir]] in ME patients is due less to its anti-inflammatory and immunomodulatory
properties than to inhibition of [[retrovirus]] replication.

==ART for ME: Preconditions==
According to the current state of knowledge, it can generally be assumed that only those patients
who meet the [[International Consensus Criteria]] will benefit from [[ART]] (Carruthers et al. 2011, here a
short version of the criteria in German). These are patients whose main symptom is not tiredness or
generalized fatigue, but a pathological muscle exhaustibility resulting in neuro-immunological
exacerbation ([[PENE]]) even after slight exertion. (More on ME in my book)

In any case, if the attending physician is inexperienced in treatment with [[ART]], cooperation with an
[[HIV]] specialist is essential in order to better assess potential risks and side effects.

==Laboratory controls==
Before starting any monotherapy with an [[ARV]], it is imperative that both an [[HIV]] test and a Hepatitis
B test are carried out. This is important not only to prevent the development of drug resistance in
the case of actual infection with [[HIV]] or Hepatitis B, but also to provide documentation to health
insurance if one intends to lay claim to payment of [[Viread]].
The following further examinations are necessary before therapy and for follow-up (since I do not
guarantee the comprehensiveness of my information and some patients require additional
examinations, any necessary examinations should again be discussed with an [[HIV]] specialist):
*Gamma-GT
*GOT
*GPT
*GFR
*creatinine
*Large blood count
*erythrocytes
*leukocytes
*thrombocytes
*lymphocytes
*CD3 cells
*CD4 cells
*NK cells
*potassium
*Blood sugar tests
*Blood fat levels (total cholesterol and triglycerides, HDL and LDL cholesterol)
*Bone metabolism (determination of calcium, phosphate, total protein, albumine in blood)
*In order to determine kidney function, a 24-hour urine collection test (+ blood serum) is
recommended.

All these values must be measured again after 4 weeks of treatment and thereafter be checked at
regular intervals, which - in case of known risk - must be carried out either closely or every one to
two or three months.
When evaluating lab parameters, it must furthermore be taken into account whether and if so
which dietary supplements patients are taking.

==My therapy plan==
Now, these are the details of my special treatment concept, which is based on [[Judy Mikovits]]',
Harvey Alter and Ila Singh's research as well as primarily on my own literature research and
considerations. The concept I developed is mainly based on two pillars, on the one hand the
unorthodox handling of dosage and on the other hand some very specific additional
phytotherapeutic treatments.

===Dosage===
First, on the unusual handling of dosage, one of the two pillars of my therapy concept. In other
retroviral infections, [[ART]] is usually started at the full dose that is maintained as long as the patient
tolerates the drug well and no resistancies develop. This approach does not seem to work well for
severely ill ME patients - according to our experience. The patient who is responding to the drug
then does make extremely rapid progress, but also experiences unbearable side effects at the
immunological and neurological levels, which eventually force him to discontinue therapy.
Subsequently, all progress disappears relatively quickly again, so that the patient is soon as bad as
before or - in the case of a progressive course of the disease - increasingly worse again.

In contrast to [[HIV]]-infected individuals, in which the illness has usually not yet fully broken out
when they start treatment, in a severely ill person with ME the full picture of the illness is already
apparent. This is probably why these patients are more likely to develop an immune reconstitution
syndrome ([[IRIS]]) when starting therapy, just like previously untreated [[HIV]]-infected patients who
have already developed AIDS. In the latter, very low CD4 cell counts, a high viral load prior to
commencement of therapy and rapid decrease thereof under treatment seem to be predictors of
[[IRIS]]. This could be similar in ME patients.

[[IRIS]] is marked by an aggravation of the infectious or inflammatory process, induced by the start of
treatment with [[ART]]. Regeneration of the immune system reveals latent infections, which often
could not be identified or objectivized beforehand, and may cause severe immunological and
neurological symptoms. This is especially applicable for the severely ill who begin treatment at full
dosage. Slow, low dose introduction of drugs and dietary supplements is recommended for ME
anyway, and it is apparent that the severely ill ME patient's organism will also need to gradually get
accustomed to [[ART]] in order to avoid severe side effects that could lead to discontinuation of
therapy.
The basis for the idea of an unorthodox approach to dosage was the certainty that [[gamma-
retroviruses]] found in the blood of ME patients by some researchers - unlike HI viruses - replicate
only very slowly (cf. my book).

That is why - these were my thoughts - resistancies cannot develop as quickly. It was
probably a hitherto unique experiment which we started, and it was associated with great risk,
because no doctor and no scientist could tell us for sure whether a resistance would not in fact
develop when starting at a low dose. To my knowledge, none of the few ME patients who undergo
ART had tried this before. But our experiment was worth it, because it shas been successful.
However, it is important to know that, according to Dr. Mikovits, one can only start with a low dose
if there is no acute co-infection, e.g. because of the risk of resistance emergence. If an acute co-
infection is present, it is probably advisable to fight it first and/or to enter [[ART]] at full dose, whereas
however side effects, as explained, can turn out violently in severely ill patients.

===Dosage details===
Our experience has shown that severely ill ME patients ([[Bell]] scale 0) can apparently start safely
with an eighth of a [[Tenofovir]] tablet - in our case it was [[Viread]], which contains 245mg [[Tenofovir]] disoproxil per pill. Of course, I cannot guarantee whether this will apply to all patients;
unfortunately, use of this drug is and for the time being remains an experiment that many do not
want to forego, because they have their backs to the wall and are heading for a certain end without
treatment.

According to our findings, one can take a lot of time with the increase in dose and wait in peace
until the organism has adapted to every further small increase. In our case, it took seven months to
reach full dose. Patience is therefore required, because significant improvements only occur in most
responders after reaching full dose. However, after three to four months of daily intake of 245mg,
progress should become apparent. (There is, however, also talk of a patient who only experienced
significant improvements after 6 months of Truvada application.) If it has not occurred by then, it
can be assumed that the drug is not effective in a patient. The improvement in condition is
incidentally often wave-like, with ups and downs, but the overall tendency should be an upwards
one.

Moderately and mildly ill patients can - according to the experiences of other patients
described - presumably enter therapy at a higher dose with rapid increase or immediately at the full
dose of 245mg. In that case, faster progress is to be expected if the drug is effective. But even in
these patients, significant improvements are usually only to be expected after three to four months
(cf. p. 3 here).

The first small improvements are sometimes noticeable after a shorter period of time - in some
patients also at low doses - but mostly concerning physiological processes, such as improved sleep
quality and a return to an intact day/night rhythm, improved blood circulation in the limbs, fewer
food intolerances, etc., but sometimes also concerning neurosensory symptoms, e.g. a reduction in
sensory hypersensitivity.

===Risks and side effects===
Patients and doctors must inform themselves about the risks and side effects of [[ART]]. Relatively
little can be said about side effects, since they differ individually in ME patients. The most
important side effects can be found listed in the medication's package inserts. All ME patients have
to expect side effects, those affected more severely even more so particularly. However, the mildly
and moderately ill should also be prepared for side effects. In particular, immunological reactions
occur in responders, such as chills, sore throat, neck and limb pains, elevated temperature,
headaches, gastrointestinal symptoms. These immune reactions are also an indicator that the patient
is a responder. But as soon as the body has adapted to the dose increase, those symptoms disappear
again.

===Alternative to [[Viread]]===
A good alternative to [[Viread]] is the proprietary drug [[Vemlidy]] (TAF = [[Tenofovir]] alafenamid), which has a much better side effect profile, although it is supposed to be equally as potent as [[Viread]].
[[Vemlidy]] can be taken at its full dose straightaway. It is possible to start out with a smaller dose, too,
but it is better to reach full dosage soon to prevent the development of resistance. This is because it
contains far less [[Tenofovir]] than [[Viread]].

Because of its better tolerability, especially with regard to kidney function and bone density,
[[Vemlidy]] is probably also better suited for older patients. The only catch on [[Vemlidy]] - besides the
fact that, unlike [[Viread]], it is not yet available as a generic drug - is that it is still relatively new on
the market, studies on which integrase inhibitors it can be combined with are still missing and only
very few ME patients have had experience with it so far. The interaction between [[Vemlidy]] and, for
example, the integrase inhibitor Raltegravir, which, as mentioned at the beginning, has to be added
at some point, has not yet been investigated, but none is expected.

===Additional phytotherapeutic treatments===
The other pillar of my treatment concept is the additional administration of antiretrovirally active
phytotherapeutics. This has enabled us to successfully prevent the use of a synthetic integrase
inhibitor such as Raltegravir and also avoid protease inhibitors required in regular anti-[[HIV]]
combination therapy. This not only saves a lot of money, but also a range of possible side effects
and long-term damage. Furthermore, the risk of resistance development with these phytotherapeutic
agents is relatively low.

First and foremost [[Cistus Incanus]]. Cistus shows broad antiviral activity in vitro with a low risk of
virus resistance. It is in a way effective as an entry inhibitor in [[HIV]] (Rebensburg et al. 2016) and
contains several anti-[[HIV]] components.

It works at the entry level already, which means that treatment with Cistus blocks the entrance of
the virus into the host cell at a very early stage and prevents the docking of virus particles onto
cells. This effect provides maximum protection of host cells against virus attack. Many other,
synthetic entry inhibitors - according to the study - only take effect at a later stage of the entrance
procedure. Cistus, however, already acts as a so-called attachment inhibitor, similar to Pelargonium
sidoides, a medicinal plant from South Africa. (Helfer et al. 2014) Cistus is also said to have an
advantage over synthetic integrase inhibitors, as it is effective against more [[HIV]] genotypes than, for
example, Raltegravir. (Cf. also e.g. Depatureaux et al. 2015)

On the side, Cistus also effectively fights upper respiratory tract infections, possesses antibacterial,
antiviral and antifungal properties and thus also attacks the so numerous but mostly occult
infections present in ME patients. It has also shown in vitro growth-inhibiting activity against
Borrelia, with which ME patients are often co-infected.

In our case, a total of 2100mg of Cistus in capsule form distributed throughout the day has proven
to be an effective dose. It is imperative that Cistus be taken with a time gap of at least two hours
between it and [[Viread]]/[[Vemlidy]]. According to our experience, it is probably a good idea to start with
Cistus before beginning [[ART]], so that co-infections can be treated in advance. Moreover, this way
the organism does not have to get used to two new drugs at the same time. [[Cistus Incanus]] is
available in capsules and lozenges, for example, the latter can also be used for immunological
reactions such as sore throat or fungal infections in the mouth and throat. With all the intolerances
that are so common in ME patients, it is probably better to start treatment with Cistus slowly, too
and then gradually increase the dose.

[[Reishi]] (Ganoderma lucidum), recommended to us by Dr. Mikovits, strengthens and activates the
immune system and has a number of other interesting properties, especially for ME patients,
because Reishi also inhibits EBV activation. In addition, according to my literature research, it is
effective against [[HIV]]-1 and inhibits [[HIV]]-1 protease. That is why we use it as a protease inhibitor;
one capsule (500mg) per day.

In addition, one can take [[green tea]] capsules. Some green tea plant extracts have, according to my
research, an inhibitory effect on the activity of the Rauscher mouse leukemia virus, which is related
to HGRV in some ways, and also on [[HIV]] reverse transcriptase. Green tea contains epigallocatechin-
3 gallate, a powerful antioxidant, which thereby also inhibits the replication of HI viruses and could
thus potentially be used as an additional therapy for [[HIV]]-1 infection. According to Dr. Mikovits, in
a way it draws retroviruses from the tissue. We take one 250mg green tea capsule daily.

Whether our successful, to my knowledge until now unique experiment with a synthetic reverse
transcriptase inhibitor in combination with phytotherapeutic entry, protease and reverse
transcriptase inhibitors (unique at least with regard to the - high-dose - use of [[Cistus Incanus]] as
entry inhibitor and which I consider the most important and effective additional treatment) is
applicable to other patients will only become apparent over the course of time. If this does not work
for others, chemical integrase inhibitor Raltegravir would most likely have to be added after some
time, usually at the latest after one year, namely when progress stagnates or even decline sets in
again.

Since the research team of the internationally renowned Helmholtz Association of German Research
Centres in Munich, which discovered the infection-blocking effect of Cistus against the HI
[[retrovirus]], assumes that the antiviral activity of [[Cistus Incanus]] will allow for a dose reduction in
anti-[[HIV]] combination therapies and thus to curb side effects and toxicity risk, it does not seem so
far-fetched if I postulate the same infection blocking effect of Cistus against HGRV, which may
cause the ME disease. The Helmholtz scientists have, by the way, already filed a world patent
application.

===Raltegravir===
[[Raltegravir]] is so far the chemical integrase inhibitor of choice for ME patients. As long as the
patient continues to make progress, however, experience to date suggests that it is not necessary to
take it. Only when no more progress is being achieved would Raltegravir have to be added.
With regard to the dosage of Raltegravir for ME, there are only testimonials from patients, which I
can solely reproduce here, as we ourselves - thanks to [[Cistus Incanus]] - have not yet gathered any
experience with the drug. Raltegravir is described by patients who take it as a very strong drug. It
might therefore be advisable to start out with a lower dosage, e.g. half the original dose as well.
That would be 200mg in the morning and 200mg in the evening. By the time a patient starts
treatment with Raltegravir, one should already be doing reasonably well overall, not least because
of possible side effects.

===Mitochondria===
Most often mitochondrial function is being doctored with all possible means in ME patients - not
seldom with the result that the patient is subsequently even worse off. But what if strengthening of
the [[mitochondria]] leads to cells infected with a possible [[retrovirus]] also being strengthened and thus
able to multiply even faster?

Therefore, it is in my opinion important to first of all gain control over the possible [[retrovirus]] and
all other, mostly occult viruses and bacterial infections. By the way, mitochondrial function, which
is reduced by disease, repairs all by itself through [[ART]] - at least this is our experience.

That is why strengthening the mitochondrial function while taking synthetic [[ARV]] is primarily about
buffering potentially harmful effects of the drugs. Time-displaced to [[Viread]]/[[Vemlidy]] intake, N-
acetylcysteine ([[NAC]], caution in case of [[histamine]] intolerance!), [[glutathione]] or [[Niacinamide]]
(vitamin B3 flush-free) is suitable for this purpose.

Actually, it has been proven in vitro that [[NAC]] and [[glutathione]] also suppress the replication of [[HIV]]-
1 and are therefore antiretrovirally active in addition to their mitochdria-strengthening properties.
Especially in [[HIV]] patients with advanced immunodeficiency, a short-term, high-dose combination
treatment with NAC and vitamin C seems to be of therapeutic value. Glutathione deficiency is also
common in [[HIV]]-infected individuals and therefore administration of NAC seems to be a useful
supplementary therapy, not only to increase protection against oxidative stress and improve immune
system functionality, but also to promote the detoxification of drugs.

Treatment with [[NAC]] could therefore also be useful for other diseases in which [[glutathione]]
deficiency or oxidative stress plays a role (such as ME!) - according to the results of a study on
[[HIV]].

[[Niacinamide]] (vitamin B3), especially nicotinamide riboside, has proven to be a promising treatment
strategy for mitochondrial myopathy in animal models. It has beneficial effects on energy
metabolism and neuroprotection.

But what could be even more crucial: Niacinamide seems to be effective against multi-resistant
germs, which even healthy people, but especially ME patients, are often abundantly populated with.
A population which a healthy person can usually cope with well could possibly have a devastating
effect on weakened ME patients combined with viral loads. With niacinamide flush-free 500mg
daily, a dose still below the tolerable upper intake level set by the European Food Safety Authority,
a low-cost option for controlling these hospital germs is available.

===General remarks===
Good vitamin and mineral supplementation during antiretroviral therapy is also important, the usual
things to take with ME. Before doing blood tests, various dietary supplements should be
discontinued in order not to falsify results. The intake of dietary supplements should always be
time-displaced with respect to [[ARV]]s. Attention must also be paid to any interactions and whether
contraindications are present. Milk thistle (silybum marianum) for liver detoxification is - if
tolerated - certainly not wrong either. Besides, patients undergoing treatment with [[ARV]] should
drink plenty, ideally water, and eat as healthy a diet as possible. Often this is not feasible at the
beginning of [[ART]] for many ME patients because of the numerous food intolerances present, but
those disappear - just like fragrance intolerances - under therapy by themselves - thus our
experience at least.

==Outlooks==
Based on the few experiences available so far worldwide, it must be assumed that [[ART]] will be a
permanent medication. This is also supported by our experiences to date. So there is no talk of a
cure, just as little as for [[HIV]] patients who are treated with [[ART]]. In the case of successful [[ART]],
however, even as an ME patient one can expect to be able to lead a reasonably, ideally even quite
normal life - at least as long as one tolerates the strong drugs well and does not suffer from too
pronounced persistent side effects.
Abortion of therapy can lead to a relatively rapid return of the full-blown clinical picture of the
disease. Attempts to establish a two-day break every week in order to keep the toxicity risk as low
as possible were not effective in our case because a significant deterioration of the condition would
occur at the latest on the second day and symptoms would flare up again.
Even with very successful [[ART]], a few but not always restrictive symptoms can persist for quite a
while. Whether a completely symptom-free life under [[ART]] is possible, we are not yet able to say at
this time.

During recovery, mood swings and a temporary increase in irritability, i.e. a certain overall mood
instability, may become apparent. The same has been reported from those recovering from previous
epidemics. (Cf. Lancet 1956) Interestingly, these symptoms do not occur at all or only very rarely in
many severely ill patients during the illness. Whether they are pathologically caused or only come
to light through the attainment of full consciousness about the extent of losses suffered due to
disease, which the severely ill cannot fully realize, has not yet been researched.
Another hurdle during gradual regeneration is the difficulty of regaining confidence in one's own
body. If one has for many years made the experience that any form of stress leads to a deterioration
in the condition, adapting is not always easy. But over time, confidence returns, namely when one
has often enough experienced that one no longer has to "pay" for physical, mental and emotional
efforts with Post-Exertional Neuroimmune Exhaustion ([[PENE]]).
But one thing you should know before deciding on [[ART]]: [[ARV]]s aren't candy! We therefore hope that
in the not too distant future there will be treatment options that will make the use of synthetic [[ARV]]s
obsolete. And I already have an idea...

This blog entry is dedicated to Dr. [[Judy Mikovits]].

Katharina Voss, Copyright 2018

translated with [https://deepl.com deepl.com] by ys

ME - Myalgische Enzephalomyelitis vs. Chronic Fatigue Syndrom - Fakten Hintergründe Forschung

2018-07-16T14:09:15Z

Jannik:update

{{Infobox book
| name = ME - Myalgische Enzephalomyelitis vs. Chronic Fatigue Syndrom - Fakten Hintergründe Forschung
| image = File:ME Katharina Voss.jpeg
| caption =
| author = Katharina Voss
| illustrator =
| cover_artist =
| country = [[Germany]]
| language = German
| subject =
| genre = Medical
| publisher = tredition
| pub_date = 2017
| media_type = print
| pages = 572
| isbn = 978-3743924949
| website =
}}
'''ME - Myalgische Enzephalomyelitis vs. Chronic Fatigue Syndrom - Fakten Hintergründe Forschung''' (ME - Myalgic Encephalomyelitis vs. Chronic Fatigue Syndrome – Facts, Background, Research) is a German book by Katharina Voss.

==Synopsis==
A book about myalgic encephalomyelitis, also erroneously referred to as "Chronic Fatigue Syndrome" or "ME/CFS", and more recently also as "Systemic Exertion Intolerance Disease" or "SEID".

A book about the most common and devastating disease your doctor has never heard of.

A book about a disease which in the opinion of a large part of the medical profession does not exist, and which, according to many physicians, psychiatrists and psychosomatics, exists only in the minds of patients - although it was already classified as a neurological disease by the WHO more than 40 years ago! Severe physical and mental constraints cause cruel suffering among those affected. For many years or decades patients have to endure a quality of life comparable to that of end-stage AIDS and cancer patients - without being adequately supplied with medication.

In the first part of the book comprehensive information about the historical and medical facts about myalgic encephalomyelitis and the sometimes serious grievances in the treatment of patients are given. In the second part, the background is explained on the basis of well-documented facts, which have led to this disease becoming the orphan of our health care system and today is trivialized, psychopathologized or even denied. In the third part, a selection of interesting results from recent biomedical ME/"CFS" research will be presented.

The book is not only for doctors and all those employed in medical care, but also for patients, their relatives and the many patients who have not been diagnosed so far. They are given the necessary tools in order to defend themselves against misdiagnosis and falsehoods. Likewise their attorneys and legal representatives, so that they can get a picture of the current state of research.

==Links==
*[https://www.amazon.de/ME-Myalgische-Enzephalomyelitis-Hintergr%C3%BCnde-Forschung/dp/3743924943 ME - Fakten Hintergründe Forschung - Amazon (DE)]

==Learn more==
*[http://www.cfs-aktuell.de/Dezember15_1.htm A Rezension '''Katharina Voss: ME - Myalgische Enzephalomyelitis vs. Chronic Fatigue Syndrom Fakten Hintergründe Forschung''' of Regina Clos]
*[http://meversuscfs.blogspot.co.uk/ Katharina Voss' blog]

==References==
<references>

</references>
[[Category:Books]]
[[Category:Deutsche books]]

Talk:Sarah Myhill

2018-07-15T16:31:02Z

Jannik:cleanup

Sarah Myhill

2018-07-15T16:30:51Z

Jannik:/* Clinical Practice */

[[File:Sarahmyhill.jpg|right|upright]]
Doctor '''Sarah Myhill''' is a British doctor running her own specialist M.E. clinic in Knighton, Powys LD7 1SL, Wales, United Kingdom. [http://www.doctormyhill.co.uk/ Her web site] is an extensive resource of articles and information based on her treatment of patients. The website runs to 920 webpages and has had over 6 million individual visits.

Dr Myhill's view is that [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] is characterized by a cellular metabolic [[mitochondria]]l dysfunction and has published several studies.<ref name="Myhill2013"/><ref name="Booth2012"/><ref name="Myhill2009"/><ref>[http://drmyhill.co.uk/wiki/CFS_-_The_Central_Cause:_Mitochondrial_Failure CFS - The Central Cause: Mitochondrial Failure]</ref> Dr Myhill has treated in excess of 10,000 CFS/ME sufferers over her 30 year career.

Dr Myhill explains her philosophy of medicine [http://www.doctormyhill.co.uk/wiki/About_my_practice here].

==Clinical Practice==
Dr Myhill has an experienced staff supporting her clinical practice. For individuals unable to visit in person staff will coordinate with the individual's primary care provider, will send lab kits for blood draw to be analyzed by Dr Myhill. She produces detailed analysis of blood work, provides recommendations and will discuss cases by telephone. Blood test analysis provides measures of ATP production and mitochondrial efficiency based upon her published research. While other physicians seem to understand her analytical methods, few, if any, are comfortable commenting on their significance. For decades, Dr Myhill has prioritized patient support and treatment results over independent corroboration.

Dr Myhill also supports Miss Voss's Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis<ref>[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]</ref><ref>[http://www.drmyhill.co.uk/wiki/A_Regime_for_Antiretroviral_Treatment_of_Myalgic_Encephalomyelitis A Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis]</ref>!

==Complaints==
Dr Myhill has been the subject of complaints to the General Medical Council.<ref name="Myhill201004BBC"/> A recent Freedom of Information Act request confirmed that Dr Myhill is the most investigated doctor in the history of the GMC. She has been subject to in excess of 30 investigations in the last 15 years. None of the complainants against Dr Myhill were patients. All complaints against her have been dropped and she practises with a full unrestricted medical licence.

==Notable studies==
*2009, [[Chronic fatigue syndrome]] and [[Mitochondria|mitochondrial]] dysfunction<ref name="Myhill2009"/> [http://www.ijcem.com/files/IJCEM812001.pdf (Full Text)]
*2012, [[Mitochondria|Mitochondrial]] dysfunction and the pathophysiology of [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] ([[ME/CFS]])<ref name="Booth2012"/> [http://www.ijcem.com/files/IJCEM1204005.pdf (Full Text)]
*2013, Targeting mitochondrial dysfunction in the treatment of [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] ([[ME/CFS]])<ref name="Myhill2013"/> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515971/ (Full Text)]

==Book==
*2014, updated 2018 - ''[[Diagnosis and Treatment of Chronic Fatigue Syndrome: It's Mitochondria, Not Hypochondria]]'' by Sarah Myhill. Edited by, and with a chapter by Craig Robinson.

==Talks and interviews==
(More talks and interviews can be found on [https://www.youtube.com/playlist?list=PLcy0gKHd07NUYlup5f9POdK9GDua8ecSm YouTube playlist for Dr Myhill])
*2007, Speaker at the 2nd Invest in ME International ME Conference on ''Treatments and Diagnosis – A GP’s Perspective''<ref>http://www.investinme.eu/IIMEC2.shtml#agenda</ref> [http://www.investinme.eu/IIMEC2.shtml#dvd DVD available]
*2015, [http://www.doctormyhill.co.uk/wiki/Biocare_Summer_2015_Conference Biocare Summer 2015 Conference]
*2016, [http://www.drmyhill.co.uk/wiki/OMEGA_AGM_Seminar_2016 OMEGA AGM Seminar 2016]
*2018, [https://www.youtube.com/watch?v=UYOLVruElJU Dr. Myhill Calls For The GMC To Investigate The PACE Trial Authors]

==Contact==
*[http://www.drmyhill.co.uk/ Dr Myhill's Wiki style Website]
*[https://www.facebook.com/groups/108048875899603/ Support Dr Sarah Myhill public Facebook group]
*[https://www.facebook.com/groups/435645003161721/ Support for followers of Dr Myhill's protocol closed Facebook group]
*[https://www.facebook.com/Supporters-of-Dr-Sarah-Myhill-230752230289407/ Supporters of Dr Sarah Myhill Facebook page]
*[https://twitter.com/MyhillNews Dr Myhill's official Twitter feed]
*[https://www.youtube.com/playlist?list=PLcy0gKHd07NUYlup5f9POdK9GDua8ecSm YouTube playlist for Dr Myhill]
*Address: Upper Weston, Knighton LD7 1SL, Wales, United Kingdom ({{Coord|52.326276|-3.155665|display=title}})

==Learn more==
*2012, [http://www.prohealth.com/library/showarticle.cfm?libid=17086 "Booth, Myhill, McLaren-Howard Comment on ME/CFS Mitochondrial Dysfunction Paper" by Norman E. Booth, Sarah Myhill, John McLaren-Howard for [[ProHealth]]]
*[http://www.doctormyhill.co.uk/wiki/CFS_Checklist_-_start_off_and_check_your_treatment_regime_here CFS Checklist - start off and check your treatment regime here]

==See also==
*[[John McLaren-Howard]]

==References==
<references>

<ref name="Booth2012">{{citation
| last1 = Booth | first1 = NE | authorlink1 = Norman Booth
| last2 = Myhill | first2 = S | authorlink2 = Sarah Myhill
| last3 = McLaren-Howard | first3 = J | authorlink3 = John McLaren-Howard
| title = Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
| journal = International Journal of Clinical Experimental Medicine | volume = 5| issue = 3| pages = 208–220
| date = 15 Jun 2012
| pmid = 22837795
| url = http://www.ncbi.nlm.nih.gov/pubmed/22837795
}}</ref>

<ref name="Myhill2009">{{citation
| last1 = Myhill | first1 = S | authorlink1 = Sarah Myhill
| last2 = Booth | first2 = NE | authorlink2 = Norman Booth
| last3 = McLaren-Howard | first3 = J | authorlink3 = John McLaren-Howard
| title = Chronic fatigue syndrome and mitochondrial dysfunction
| journal = International Journal of Clinical Experimental Medicine | volume = 2| issue = 1| pages = 1–16
| date = 15 Jan 2009
| pmid = 19436827
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/
}}</ref>
<ref name="Myhill2013">{{citation
| last1 = Myhill | first1 = S | authorlink1 = Sarah Myhill
| last2 = Booth | first2 = NE | authorlink2 = Norman Booth
| last3 = McLaren-Howard | first3 = J | authorlink3 = John McLaren-Howard
| title = Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit
| journal = International Journal of Clinical Experimental Medicine | volume = 6| issue = 1| pages = 1–15
| date = 2013
| pmid = 23236553
| url =
}}
</ref>
<ref name="Myhill201004BBC">{{citation
| title = Dr. Myhill on BBC News
| type = video
| date = 29 Apr 2010
| url = https://www.youtube.com/watch?v=gW_GMCcuUcU
}}</ref>

</references>

[[Category:Researchers]]
[[Category:UK researchers]]
[[Category:Clinicians]]
[[Category:British clinicians]]
[[Category:Authors]]

Talk:Sarah Myhill

2018-07-15T16:30:08Z

Jannik:myhill Antiretroviral Treatment

Dr. Myhill also supports Miss Voss's Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis<ref>[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]</ref><ref>[http://www.drmyhill.co.uk/wiki/A_Regime_for_Antiretroviral_Treatment_of_Myalgic_Encephalomyelitis A Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis]</ref>!

Green tea

2018-07-15T16:14:20Z

Jannik:/* Costs and availability */

Green tea is a type of tea that is made from Camellia sinensis leaves that have not undergone the same withering and oxidation process used to make oolong teas and black teas.

Some of the extracts of Green tea inhibit the activity of the Murine leukemia virus<ref>[https://journals.lww.com/aidsonline/fulltext/2002/04120/polyphenolic_antioxidant.20.aspx Polyphenolic antioxidant (–)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent]</ref>.
Green tea contains epigallocatechin-3-gallat which is a strong [[antioxidant]].

==Theory==

Regular green tea is 99.9% water, provides 1 Calorie per 100 mL serving, is devoid of significant nutrient content (table) and contains phytochemicals, such as polyphenols and caffeine. Polyphenols found in green tea include epigallocatechin gallate (EGCG), epicatechin gallate, epicatechins and flavanols,[1] which have antioxidant, anticarcinogen, anti-inflammatory, and anti-radiation biochemical effects in vitro.Other components include three kinds of flavonoids, known as kaempferol, quercetin, and myricetin.

==Evidence==

==Clinicians==

==Risks and side effects==

==Costs and availability==
It is nutritional supplement so its available without prescription.
In Germany a 250mg capsule costs only about 0,14€ (approx. 0,17 US-$).

==Learn more==
You can drink it as tea but it is also available as capsules.

It is used in the treatment regime against ME of Ms Voss to prevent the use of [[Raltegravir]]
*[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]

==See also==

==References==
<references/>

[[Category:Potential treatments]]

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Herbs]]

{{stub}}

Green tea

2018-07-15T16:07:52Z

Jannik:Add "inhibit the activity of the Murine leukemia virus"

Green tea is a type of tea that is made from Camellia sinensis leaves that have not undergone the same withering and oxidation process used to make oolong teas and black teas.

Some of the extracts of Green tea inhibit the activity of the Murine leukemia virus<ref>[https://journals.lww.com/aidsonline/fulltext/2002/04120/polyphenolic_antioxidant.20.aspx Polyphenolic antioxidant (–)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent]</ref>.
Green tea contains epigallocatechin-3-gallat which is a strong [[antioxidant]].

==Theory==

Regular green tea is 99.9% water, provides 1 Calorie per 100 mL serving, is devoid of significant nutrient content (table) and contains phytochemicals, such as polyphenols and caffeine. Polyphenols found in green tea include epigallocatechin gallate (EGCG), epicatechin gallate, epicatechins and flavanols,[1] which have antioxidant, anticarcinogen, anti-inflammatory, and anti-radiation biochemical effects in vitro.Other components include three kinds of flavonoids, known as kaempferol, quercetin, and myricetin.

==Evidence==

==Clinicians==

==Risks and side effects==

==Costs and availability==

==Learn more==
You can drink it as tea but it is also available as capsules.

It is used in the treatment regime against ME of Ms Voss to prevent the use of [[Raltegravir]]
*[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]

==See also==

==References==
<references/>

[[Category:Potential treatments]]

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Herbs]]

{{stub}}

Green tea

2018-07-15T16:06:35Z

Jannik:/* Learn more */

Green tea is a type of tea that is made from Camellia sinensis leaves that have not undergone the same withering and oxidation process used to make oolong teas and black teas.

==Theory==

Regular green tea is 99.9% water, provides 1 Calorie per 100 mL serving, is devoid of significant nutrient content (table) and contains phytochemicals, such as polyphenols and caffeine. Polyphenols found in green tea include epigallocatechin gallate (EGCG), epicatechin gallate, epicatechins and flavanols,[1] which have antioxidant, anticarcinogen, anti-inflammatory, and anti-radiation biochemical effects in vitro.Other components include three kinds of flavonoids, known as kaempferol, quercetin, and myricetin.

==Evidence==

==Clinicians==

==Risks and side effects==

==Costs and availability==

==Learn more==
You can drink it as tea but it is also available as capsules.

It is used in the treatment regime against ME of Ms Voss to prevent the use of [[Raltegravir]]
*[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]

==See also==

==References==
<references/>

[[Category:Potential treatments]]

[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Herbs]]

{{stub}}

Reishi mushroom

2018-07-15T16:04:24Z

Jannik:create

Reishi (Ganoderma lucidum) is a mushroom of the family Ganodermataceae and contains much [[triterpene]] which work against [[inflammation]]. They have similar effect as [[cortisone]] but help the body in a natural way.
Reishi activates and supports the [[immune system]] <ref>[https://doi.org/10.1002/chin.200650268 Ganoderma — A Therapeutic Fungal Biofactory]</ref>.
Reishi inhibits the activation of [[Epstein-Barr virus]] <ref>[https://www.ncbi.nlm.nih.gov/pubmed/14695801 Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.]</ref>

== Learn more ==
* [https://en.wikipedia.org/wiki/Reishi Lingzhi mushroom in wikipedia]

It is used in the treatment regime against ME of Ms Voss to prevent the use of [[Raltegravir]].
*[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]

== References ==
<references />

[[Category:Potential treatments]]

Raltegravir

2018-07-14T16:21:55Z

Jannik:fix

Raltegravir is an antiretroviral drug. It is normally used against HIV. It is a chemical integrase inhibitor<ref>[https://www.ncbi.nlm.nih.gov/pubmed/20335265 Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.]</ref>.
Raltegravir stops the HIV integrase enzyme from working and prevents the virus from multiplying in the cells in the body<ref>[https://www.medicines.org.uk/emc/files/pil.6171.pdf Package leaflet: Isentress (Raltegravir) - PDF]</ref>.

== References ==
<references />
[[Category:Antivirals]]
[[Category:Potential treatments]]
[[Category:Antiretrovirals]]

Raltegravir

2018-07-14T16:14:17Z

Jannik:add category

Raltegravir is an antiretroviral drug. It is normally used against HIV. It is a chemical integrase inhibitor<ref>[https://www.ncbi.nlm.nih.gov/pubmed/20335265 Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.]</ref>.
Raltegravir stops the HIV integrase enzyme from working and prevents the virus from multiplying in the cells in the body<ref>[https://www.medicines.org.uk/emc/files/pil.6171.pdf Package leaflet: Isentress (Raltegravir) - PDF.]</ref>.

== References ==
<references />
[[Category:Antivirals]]
[[Category:Potential treatments]]
[[Category:Antiretrovirals]]

Cistus Incanus

2018-07-14T15:45:28Z

Jannik:add other activities

Cistus Incanus is a natural product and sold as a nutritional supplement.
It works against the retrovirus HIV by targetting the proteins<ref>[https://www.nature.com/articles/srep20394 Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins]</ref>. It works as an entry inhibitor<ref>[https://www.nature.com/articles/srep20394 Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins]</ref> at the entry level which means it prevents the entry of the virus into the cell in a very early state and prevents virus particles from docking on cells.

It works also against bacteria<ref>[https://www.tandfonline.com/doi/abs/10.1080/10412905.1995.9698549 Composition and Antimicrobial Activity of the Essential oil of Cistus creticus L.]</ref> and viruses
<ref>[https://www.ncbi.nlm.nih.gov/pubmed/17572513?dopt=Abstract A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance.]</ref> and has antifungal activity<ref>[http://europepmc.org/abstract/med/10709448 Antibacterial and antifungal activities of Cistus incanus and C. monspeliensis leaf extracts.]</ref>.

It seems that it also has positive effect against the cause of ME<ref>[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]</ref>

== Learn more ==
It is used in the treatment regime against ME of Ms Voss to prevent the use of [[Raltegravir]].
*[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]

== References ==
<references />

[[Category:Potential treatments]]

Cistus Incanus

2018-07-14T15:40:46Z

Jannik:add category

Cistus Incanus is a natural product and sold as a nutritional supplement.
It works against the retrovirus HIV by targetting the proteins<ref>[https://www.nature.com/articles/srep20394 Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins]</ref>. It works as an entry inhibitor<ref>[https://www.nature.com/articles/srep20394 Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins]</ref> at the entry level which means it prevents the entry of the virus into the cell in a very early state and prevents virus particles from docking on cells.

It seems that it also has positive effect against the cause of ME<ref>[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]</ref>

== Learn more ==
It is used in the treatment regime against ME of Ms Voss to prevent the use of [[Raltegravir]].
*[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]

== References ==
<references />

[[Category:Potential treatments]]

Cistus Incanus

2018-07-14T15:39:55Z

Jannik:fix sentence

Cistus Incanus

2018-07-14T15:38:40Z

Jannik:add cistus incanus

Raltegravir

2018-07-14T15:28:32Z

Jannik:add categories

Raltegravir is an antiretroviral drug. It is normally used against HIV. It is a chemical integrase inhibitor<ref>[https://www.ncbi.nlm.nih.gov/pubmed/20335265 Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.]</ref>.
Raltegravir stops the HIV integrase enzyme from working and prevents the virus from multiplying in the cells in the body<ref>[https://www.medicines.org.uk/emc/files/pil.6171.pdf Package leaflet: Isentress (Raltegravir) - PDF.]</ref>.
<references />
[[Category:Antivirals]]
[[Category:Potential treatments]]

Raltegravir

2018-07-14T15:26:45Z

Jannik:add page Raltegravir

Viread

2018-07-13T16:41:02Z

Jannik:ref

Viread is an antiretroviral medicine.
It contains 245mg Tenofovir disoproxil per pill<ref>[https://www.medicines.org.uk/emc/files/pil.1615.pdf Viread instruction leaflet - PDF]</ref>.
It is normaly used for treatment of HIV or Hepatitis B. In combination with Emtricitabine (Emtricitabine/tenofovir) it is used for treatment and prevention (PREP) of HIV.

== Treatment of ME ==

Some people are taking Viread against ME, so it could help at least in some cases<ref>[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]</ref> <ref>[http://www.drmyhill.co.uk/wiki/A_Regime_for_Antiretroviral_Treatment_of_Myalgic_Encephalomyelitis A Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis]</ref> <ref>[https://www.healthrising.org/forums/threads/in-full-remission.5467/ In Full Remission]</ref>.

<references />
[[Category:Antivirals]]

Viread

2018-07-13T16:39:47Z

Jannik:heading

Viread

2018-07-13T16:39:09Z

Jannik:category

Viread is an antiretroviral medicine.
It contains 245mg Tenofovir disoproxil per pill<ref>[https://www.medicines.org.uk/emc/files/pil.1615.pdf Viread instruction leaflet - PDF]</ref>.
It is normaly used for treatment of HIV or Hepatitis B. In combination with Emtricitabine (Emtricitabine/tenofovir) it is used for treatment and prevention (PREP) of HIV.

Treatment of ME
Some people are taking Viread against ME, so it could help at least in some cases<ref>[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]</ref> <ref>[http://www.drmyhill.co.uk/wiki/A_Regime_for_Antiretroviral_Treatment_of_Myalgic_Encephalomyelitis A Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis]</ref>.
<references />
[[Category:Antivirals]]

Viread

2018-07-13T16:36:02Z

Jannik:fix invalid ref

Viread is an antiretroviral medicine.
It contains 245mg Tenofovir disoproxil per pill<ref>[https://www.medicines.org.uk/emc/files/pil.1615.pdf Viread instruction leaflet - PDF]</ref>.
It is normaly used for treatment of HIV or Hepatitis B. In combination with Emtricitabine (Emtricitabine/tenofovir) it is used for treatment and prevention (PREP) of HIV.

Treatment of ME
Some people are taking Viread against ME, so it could help at least in some cases<ref>[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]</ref> <ref>[http://www.drmyhill.co.uk/wiki/A_Regime_for_Antiretroviral_Treatment_of_Myalgic_Encephalomyelitis A Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis]</ref>.

Viread

2018-07-13T16:35:12Z

Jannik:add links to treatment of me

Viread is an antiretroviral medicine.
It contains 245mg Tenofovir disoproxil per pill<ref>[https://www.medicines.org.uk/emc/files/pil.1615.pdf Viread instruction leaflet - PDF]</ref>.
It is normaly used for treatment of HIV or Hepatitis B. In combination with Emtricitabine (Emtricitabine/tenofovir) it is used for treatment and prevention (PREP) of HIV.

Treatment of ME
Some people are taking Viread against ME, so it could help at least in some cases<ref>[http://meversuscfs.blogspot.com/2018/06/arztanfragen-mein-therapieregime-fur.html My antiretroviral Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis (Deutsch: #Arztanfragen - Mein Therapieregime für die antiretrovirale Behandlung bei Myalgischer Enzephalomyelitis)]</ref> <ref> http://www.drmyhill.co.uk/wiki/A_Regime_for_Antiretroviral_Treatment_of_Myalgic_Encephalomyelitis A Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis]</ref>.

Talk:List of myalgic encephalomyelitis and chronic fatigue syndrome outbreaks

2018-07-13T16:28:36Z

Jannik:only nurses/staff ill?!

The list of outbreaks by region needs to refer to the items in the dated list without copying-and-pasting the existing description. We may need to use in-page links to do that. [[User:Olliec|Olliec]] ([[User talk:Olliec|talk]]) 23:59, 8 December 2015 (PST)

----

please, what's the relevance of the numbering beside each outbreak ? --[[User:Suelala|Suelala]] ([[User talk:Suelala|talk]]) 18:13, 24 February 2016 (PST)

There is none. It should probably be deleted. We should also begin to add references to each outbreak since most of them where either written up in medical journals or government reports, or at the very least in periodicals of the time. Thank you so much for your help Suelala!! --[[User:JenB|JenB]] ([[User talk:JenB|talk]]) 20:19, 24 February 2016 (PST)

----

I'd like some feedback please, whether the current format, or a sortable table, is a better layout. Table can be re-sorted by date, region, location - but we lose the 'table of contents' summary. See http://me-pedia.org/wiki/User_talk:Suelala/workinprogress. --[[User:Suelala|Suelala]] ([[User talk:Suelala|talk]]) 21:47, 12 May 2016 (PDT)

----
Possibly useful reference: http://www.wikidoc.org/index.php/ME/CFS_outbreaks --[[User:JenB|JenB]] ([[User talk:JenB|talk]]) 11:53, 15 October 2016 (PDT)

----
Would it be possible to have a list of confirmed versus suspected outbreaks? Without extensive sources for each, I fear this doesn't look as credible as it might. -- [[User:JaimeS|JaimeS]]

----
I think its interesting that only nurses/staff got ill in some hospitals during the outbreak, e.g. 1955 - Durban and Durban City, South Africa
Shouldn't there be a lot of infected ill patients

Viread

2018-07-13T16:24:15Z

Jannik:create viread page

Viread is an antiretroviral medicine.
It contains 245mg Tenofovir disoproxil per pill.<ref>[https://www.medicines.org.uk/emc/files/pil.1615.pdf Viread instruction leaflet - PDF]</ref>
It is normaly used for treatment of HIV or Hepatitis B. In combination with Emtricitabine (Emtricitabine/tenofovir) it is used for treatment and prevention (PREP) of HIV.