MEpedia - User contributions [en]

Colin Tait

2025-12-22T16:17:29Z

DarthNZ:/* Online Presence */ Email Address Updated.

Colin Tait (Darth Vader), Nelson, New Zealand. BE Mech(1982), 1st Class Honours, Cant, NZ.

Discovered 2007 that CFS/Long Covid is Chronic Human Hibernation. Has developed 2 Effective Treatments for CFS/LC late 2005 to June 2025, mainly High Dose, 6 Month, Vitamin D Pulse Therapy.

=Online Presence=

*Website     : [https://WikiSite.info/Cfs/Main_Page WikiSite.info/Cfs/Main_Page]
* LinkedIn   : [https://www.linkedin.com/in/colin-tait-239a5528a linkedin.com/in/colin-tait-239a5528a]
*Facebook : [https://www.facebook.com/darth.vader.822072 facebook.com/darth.vader.822072] (Auckland, NZ).

*Email        : DarthNZ02@gmail.com

=Keywords=

DarthNZ

=See Also=
*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*[[Vitamin D Pulse Therapy]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

User:DarthNZ

2025-10-07T22:56:14Z

DarthNZ:"Charles Lapp" added.

=Time=

All times on my Posts + Edits are UTC, unless stated otherwise.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page].
* 10 or More Protected Pages with Content. 2 or More Open Pages with No Content.

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]
*  
*[[MEpedia]]
*[[Rosamund Vallings]]
*[[Open Main Page]]
*  
*[[Charles Lapp]]

User:DarthNZ

2025-10-07T22:46:00Z

DarthNZ:Tidy Up.

User:DarthNZ

2025-10-07T22:43:00Z

DarthNZ:/* Personal Details */ Tidy Up.

=Time=

All times on my Posts + Edits are UTC, unless stated otherwise.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page].
* 10 or More Protected Pages with Content. 2 or More Open Pages with No Content.

 

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]
*  
*[[MEpedia]]
*[[Rosamund Vallings]]
*[[Open Main Page]]

(DV 22:00 B29 Jul 2025).

User:DarthNZ

2025-07-29T08:10:54Z

DarthNZ:Tidy Up.

User:DarthNZ

2025-07-29T06:29:02Z

DarthNZ:/* Personal Details */ Tidy Up.

=Time=

All times on my Posts + Edits are UTC, unless stated otherwise.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 8:00 B29 Jul 2025).
* 10 or More Protected Pages with Content. 2 or More Open Pages with No Content.

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]
*  
*[[MEpedia]]
*[[Rosamund Vallings]]
*[[Open Main Page]]

User:DarthNZ

2025-07-29T06:26:21Z

DarthNZ:/* Personal Details */ Content Added.

=Time=

All times on my Posts + Edits are UTC, unless stated otherwise.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 8:00 B29 Jul 2025).
* 10 or More Protected Pages with Content. 2 or More Open Pages with No Content.

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]
*  
*[[MEpedia]]
*[[Rosamund Vallings]]
*[[Open Main Page]]

User:DarthNZ

2025-07-29T06:20:22Z

DarthNZ:/* Personal Details */ Date Changed.

=Time=

All times on my Posts + Edits are UTC, unless stated otherwise.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 8:00 B29 Jul 2025).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]
*  
*[[MEpedia]]
*[[Rosamund Vallings]]
*[[Open Main Page]]

User:DarthNZ

2025-07-29T06:17:48Z

DarthNZ:/* Personal Details */ Tidy Up.

=Time=

All times on my Posts + Edits are UTC, unless stated otherwise.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 20:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]
*  
*[[MEpedia]]
*[[Rosamund Vallings]]
*[[Open Main Page]]

User:DarthNZ

2025-07-29T06:15:15Z

DarthNZ:=Time= Added.

=Time=

All times on my Posts + Edits are UTC, unless stated otherwise.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 20:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]
*  
*[[MEpedia]]
*[[Rosamund Vallings]]
*[[Open Main Page]]

Talk:New Zealand

2025-07-27T06:27:30Z

DarthNZ:Created page with "== -- ~~~~ == =New Zealand Population= 65,000/5,364,880 = 1.2%. NZ Population Estimate Jul 2025. Wikipedia. (DV 7:00 H27 Jul 2025)."

== -- [[User:DarthNZ|DarthNZ]] ([[User talk:DarthNZ|talk]]) 06:27, July 27, 2025 (UTC) ==

=New Zealand Population=

65,000/5,364,880 = 1.2%. NZ Population Estimate Jul 2025. Wikipedia.

(DV 7:00 H27 Jul 2025).

New Zealand

2025-07-27T06:23:44Z

DarthNZ:/* Demographics */ Maths Error Recorrected. See Page Discussion.

[[File:New_Zealand_flag.svg.png|320px|right|thumb|'''New Zealand''']]
{{stub}}

==Demographics==
It is estimated that there are around 65,000 people with ME/CFS in New Zealand,<ref name=":0">{{Cite news | url=http://thewireless.co.nz/articles/the-children-left-bed-bound-by-fatigue | title = The children left bed-bound by fatigue | last = Monk | first = Felicity | date = July 31, 2018|work=The Wireless|access-date=2018-08-11|archive-url=|archive-date=|url-status=|publication-place=New Zealand}}</ref> with a significant estimated economic cost of $30,000 – $40,000/year/affected family.<ref>{{Cite news | url=http://anzmes.org.nz/747/ | title = Massey University is looking to recruit volunteers | last = anzmes01 | first = | date = 2014-12-16|work=ANZMES|access-date=2018-08-11|archive-url=|archive-date=|url-status=|language=en-NZ}}</ref> This represents a prevalence of 1.2% of the population.

Auckland, the largest and most populous area in New Zealand, has an estimated 6000 people living with ME/CFS.<ref>{{Cite web|url=https://givealittle.co.nz/cause/support4ME | title = 6,000+ Aucklanders suffer from this debilitating and misunderstood illness - Givealittle|website=givealittle.co.nz|language=en|access-date=2018-08-11}}</ref>

==Medical guidelines==

==National health department==

* [https://www.health.govt.nz Ministry of Health Manatū Hauora]

==Government health insurance==

==Private health insurance==

==Access to care==

==Social security and disability benefits==

==Patient groups==
===National===

*[[Associated New Zealand ME Society]]

===Regional===

*[http://anzmes.org.nz/what-is-me/support/ List of local support groups] (ANZMES)
*[[ME Auckland]]

==Research==

*2015, [http://anzmes.org.nz/dr-lynette-hodges-from-school-of-sport-and-exercise-at-massey-university-is-looking-to-recruit-volunteers-with-mecfs/ Repeated Exercise Study by Dr Lynette Hodges from The School of Sport and Exercise at Massey University]

===Research groups===

===Researchers===
*[[Lynette Hodges]]
*[[Warren Tate]]
*[[Carolyn Wilshire]]
*[[Rosamund Vallings]]
*[[Colin Tait]]

==Clinicians==

*[[Rosamund Vallings]]

==Clinics==

==Notable patients==

*[[Richie Barnett]] (Former Rugby League footballer)

==Learn more==
* July 31, 2018, [http://thewireless.co.nz/articles/the-children-left-bed-bound-by-fatigue The children left bed-bound by fatigue]<ref name=":0" />

==See also==

*[[Tapanui Flu]]

==References==
{{reflist}}
[[Category:Countries]]
[[Category:Oceania]]
[[Category:New Zealand]]

New Zealand

2025-07-27T06:17:19Z

DarthNZ:/* Demographics */ Maths Error Corrected.

[[File:New_Zealand_flag.svg.png|320px|right|thumb|'''New Zealand''']]
{{stub}}

==Demographics==
It is estimated that there are around 65,000 people with ME/CFS in New Zealand,<ref name=":0">{{Cite news | url=http://thewireless.co.nz/articles/the-children-left-bed-bound-by-fatigue | title = The children left bed-bound by fatigue | last = Monk | first = Felicity | date = July 31, 2018|work=The Wireless|access-date=2018-08-11|archive-url=|archive-date=|url-status=|publication-place=New Zealand}}</ref> with a significant estimated economic cost of $30,000 – $40,000/year/affected family.<ref>{{Cite news | url=http://anzmes.org.nz/747/ | title = Massey University is looking to recruit volunteers | last = anzmes01 | first = | date = 2014-12-16|work=ANZMES|access-date=2018-08-11|archive-url=|archive-date=|url-status=|language=en-NZ}}</ref> This represents a prevalence of 1.3% of the population.

Auckland, the largest and most populous area in New Zealand, has an estimated 6000 people living with ME/CFS.<ref>{{Cite web|url=https://givealittle.co.nz/cause/support4ME | title = 6,000+ Aucklanders suffer from this debilitating and misunderstood illness - Givealittle|website=givealittle.co.nz|language=en|access-date=2018-08-11}}</ref>

==Medical guidelines==

==National health department==

* [https://www.health.govt.nz Ministry of Health Manatū Hauora]

==Government health insurance==

==Private health insurance==

==Access to care==

==Social security and disability benefits==

==Patient groups==
===National===

*[[Associated New Zealand ME Society]]

===Regional===

*[http://anzmes.org.nz/what-is-me/support/ List of local support groups] (ANZMES)
*[[ME Auckland]]

==Research==

*2015, [http://anzmes.org.nz/dr-lynette-hodges-from-school-of-sport-and-exercise-at-massey-university-is-looking-to-recruit-volunteers-with-mecfs/ Repeated Exercise Study by Dr Lynette Hodges from The School of Sport and Exercise at Massey University]

===Research groups===

===Researchers===
*[[Lynette Hodges]]
*[[Warren Tate]]
*[[Carolyn Wilshire]]
*[[Rosamund Vallings]]
*[[Colin Tait]]

==Clinicians==

*[[Rosamund Vallings]]

==Clinics==

==Notable patients==

*[[Richie Barnett]] (Former Rugby League footballer)

==Learn more==
* July 31, 2018, [http://thewireless.co.nz/articles/the-children-left-bed-bound-by-fatigue The children left bed-bound by fatigue]<ref name=":0" />

==See also==

*[[Tapanui Flu]]

==References==
{{reflist}}
[[Category:Countries]]
[[Category:Oceania]]
[[Category:New Zealand]]

User:DarthNZ

2025-07-27T06:00:42Z

DarthNZ:/* See Also */ *Open Main Page Added.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 20:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]
*  
*[[MEpedia]]
*[[Rosamund Vallings]]
*[[Open Main Page]]

New Zealand

2025-07-26T17:41:31Z

DarthNZ:/* Researchers */ *Colin Tait Added.

[[File:New_Zealand_flag.svg.png|320px|right|thumb|'''New Zealand''']]
{{stub}}

==Demographics==
It is estimated that there are around 65,000 people with ME/CFS in New Zealand,<ref name=":0">{{Cite news | url=http://thewireless.co.nz/articles/the-children-left-bed-bound-by-fatigue | title = The children left bed-bound by fatigue | last = Monk | first = Felicity | date = July 31, 2018|work=The Wireless|access-date=2018-08-11|archive-url=|archive-date=|url-status=|publication-place=New Zealand}}</ref> with a significant estimated economic cost of $30,000 – $40,000/year/affected family.<ref>{{Cite news | url=http://anzmes.org.nz/747/ | title = Massey University is looking to recruit volunteers | last = anzmes01 | first = | date = 2014-12-16|work=ANZMES|access-date=2018-08-11|archive-url=|archive-date=|url-status=|language=en-NZ}}</ref> This represents a prevalence of 11% of the population.

Auckland, the largest and most populous area in New Zealand, has an estimated 6000 people living with ME/CFS.<ref>{{Cite web|url=https://givealittle.co.nz/cause/support4ME | title = 6,000+ Aucklanders suffer from this debilitating and misunderstood illness - Givealittle|website=givealittle.co.nz|language=en|access-date=2018-08-11}}</ref>

==Medical guidelines==

==National health department==

* [https://www.health.govt.nz Ministry of Health Manatū Hauora]

==Government health insurance==

==Private health insurance==

==Access to care==

==Social security and disability benefits==

==Patient groups==
===National===

*[[Associated New Zealand ME Society]]

===Regional===

*[http://anzmes.org.nz/what-is-me/support/ List of local support groups] (ANZMES)
*[[ME Auckland]]

==Research==

*2015, [http://anzmes.org.nz/dr-lynette-hodges-from-school-of-sport-and-exercise-at-massey-university-is-looking-to-recruit-volunteers-with-mecfs/ Repeated Exercise Study by Dr Lynette Hodges from The School of Sport and Exercise at Massey University]

===Research groups===

===Researchers===
*[[Lynette Hodges]]
*[[Warren Tate]]
*[[Carolyn Wilshire]]
*[[Rosamund Vallings]]
*[[Colin Tait]]

==Clinicians==

*[[Rosamund Vallings]]

==Clinics==

==Notable patients==

*[[Richie Barnett]] (Former Rugby League footballer)

==Learn more==
* July 31, 2018, [http://thewireless.co.nz/articles/the-children-left-bed-bound-by-fatigue The children left bed-bound by fatigue]<ref name=":0" />

==See also==

*[[Tapanui Flu]]

==References==
{{reflist}}
[[Category:Countries]]
[[Category:Oceania]]
[[Category:New Zealand]]

User:DarthNZ

2025-07-26T17:39:46Z

DarthNZ:/* See Also */ All Categories Removed.

User:DarthNZ

2025-07-26T17:36:38Z

DarthNZ:/* See Also */ Category:Clinicians by Country Deleted.

User:DarthNZ

2025-07-26T17:31:40Z

DarthNZ:/* See Also */ *Rosamund Vallings Added.

User:DarthNZ

2025-07-25T04:23:09Z

DarthNZ:/* See Also */ Link Added, Category Deleted.

User:DarthNZ

2025-07-25T04:14:16Z

DarthNZ:Categories Added.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 20:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]
[[Category:Clinicians by country]]

[[Category:New Zealand]]
[[Category:Websites]]

User:DarthNZ

2025-07-24T22:55:39Z

DarthNZ:/* See Also */   Added.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 20:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*  
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

[[Category:Clinicians by country]]

User:DarthNZ

2025-07-24T22:53:38Z

DarthNZ:/* See Also */ Content Added.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 20:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]
*[[Dauer]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

[[Category:Clinicians by country]]

User:DarthNZ

2025-07-24T19:00:09Z

DarthNZ:Category:Clinicians by country Added.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 20:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

[[Category:Clinicians by country]]

User:DarthNZ

2025-07-24T18:53:07Z

DarthNZ:/* Personal Details */ Tidy Up.

=Personal Details=

* DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
* Facebook : Search Darth Vader, Auck, NZ.
* LinkedIn, Nelson, NZ.
*  
* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 20:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

User:DarthNZ

2025-07-24T14:28:17Z

DarthNZ:Categories Added.

=Personal Details=

<pre>1. DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
Facebook : Search Darth Vader, Auck, NZ.
LinkedIn, Nelson, NZ. </pre>

* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 13:00 E24 Jul 2025 (UTC)).

=See Also=

*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*[[Vitamin D Pulse Therapy]]
*[[Colin Tait]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

User:DarthNZ

2025-07-24T14:22:33Z

DarthNZ:/* See Also */ Link .

User:DarthNZ

2025-07-24T13:32:06Z

DarthNZ:/* See Also */ *New Zealand Added.

Colin Tait

2025-07-24T13:27:25Z

DarthNZ:/* See also */ Content Added.

Colin Tait (Darth Vader), Nelson, New Zealand. BE Mech(1982), 1st Class Honours, Cant, NZ.

Discovered 2007 that CFS/Long Covid is Chronic Human Hibernation. Has developed 2 Effective Treatments for CFS/LC late 2005 to June 2025, mainly High Dose, 6 Month, Vitamin D Pulse Therapy.

=Online Presence=

*Website     : [https://WikiSite.info/Cfs/Main_Page WikiSite.info/Cfs/Main_Page]
* LinkedIn   : [https://www.linkedin.com/in/colin-tait-239a5528a linkedin.com/in/colin-tait-239a5528a]
*Facebook : [https://www.facebook.com/darth.vader.822072 facebook.com/darth.vader.822072] (Auckland, NZ).

*Email        : DarthVaderNZ02@gmail.com

=Keywords=

DarthNZ

=See Also=
*[[New Zealand]]
*[[Hibernation]]
*[[Strength Training]]
*[[Vitamin D Pulse Therapy]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

User:DarthNZ

2025-07-24T13:25:27Z

DarthNZ:Content Added.

=Personal Details=

<pre>1. DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
Facebook : Search Darth Vader, Auck, NZ.
LinkedIn, Nelson, NZ. </pre>

* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 13:00 E24 Jul 2025 (UTC)).

=See Also=

*[[Hibernation]]
*[[Strength Training]]
*[[Vitamin D Pulse Therapy]]

Talk:Kannaiyan Rabindranath

2025-07-24T13:07:24Z

DarthNZ:Content Deleted.

Page Created.

Colin Tait

2025-07-24T12:56:51Z

DarthNZ:Tidy. Keyword Added.

Colin Tait (Darth Vader), Nelson, New Zealand. BE Mech(1982), 1st Class Honours, Cant, NZ.

Discovered 2007 that CFS/Long Covid is Chronic Human Hibernation. Has developed 2 Effective Treatments for CFS/LC late 2005 to June 2025, mainly High Dose, 6 Month, Vitamin D Pulse Therapy.

=Online Presence=

*Website     : [https://WikiSite.info/Cfs/Main_Page WikiSite.info/Cfs/Main_Page]
* LinkedIn   : [https://www.linkedin.com/in/colin-tait-239a5528a linkedin.com/in/colin-tait-239a5528a]
*Facebook : [https://www.facebook.com/darth.vader.822072 facebook.com/darth.vader.822072] (Auckland, NZ).

*Email        : DarthVaderNZ02@gmail.com

=Keywords=

DarthNZ

=See also=
*[[New Zealand]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

User talk:DarthNZ

2025-07-24T12:51:38Z

DarthNZ:Content Shifted to my User Page.

{{Template:Welcome|realName=DarthNZ|name=DarthNZ}}

-- [[User:New user message|New user message]] ([[User talk:New user message|talk]]) 15:15, July 11, 2025 (UTC)

User:DarthNZ

2025-07-24T12:49:46Z

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User talk:DarthNZ

2025-07-24T12:48:06Z

DarthNZ:Personal Deatils Added.

{{Template:Welcome|realName=DarthNZ|name=DarthNZ}}

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=Personal Details=

<pre>1. DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
Facebook : Search Darth Vader, Auck, NZ.
LinkedIn, Nelson, NZ. </pre>

* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 13:00 E24 Jul 2025 (UTC)).

Talk:Kannaiyan Rabindranath

2025-07-24T12:44:03Z

DarthNZ:/* Page Contributors. */ new section

== Page Contributors. -- [[User:DarthNZ|DarthNZ]] ([[User talk:DarthNZ|talk]]) 12:44, July 24, 2025 (UTC) ==

=Page Contributors=

<pre>1. DarthNZ_ DV_ : Darth Vader/Colin Tait, Auckland, New Zealand.
Facebook : Search Darth Vader, Auck, NZ.
LinkedIn, Nelson, NZ. </pre>

* e : DarthVaderNZ02@gmail.com
* w : [https://wikisite.info/index.php/Cfs/Main_Page WikiSite.info/Cfs/Main_Page] (DV 13:00 E24 Jul 2025 (UTC)).

Dauer

2025-07-22T18:11:04Z

DarthNZ:/* See also */ *Hibernation Added.

'''Dauer''' is the German word for persistence or long-lived.<ref name=":0" /><ref>{{Cite web | url = https://dictionary.reverso.net/german-english/Dauer | title = Dauer translation English {{!}} German dictionary {{!}} Reverso | website = dictionary.reverso.net|access-date=2020-02-25}}</ref>

== Dauer larva ==
An alternative developmental stage known as '''dauer''' or '''dauer state''' has been found to in nematode worms, particularly ''Caenorhabditis elegans'', whereby the larva goes into a type of stasis as a result of harsh environmental conditions.<ref name=":1">{{Cite journal | last = Cassada | first = Randall C. | last2 = Russell | first2 = Richard L. | date = 1975-10-01 | title = The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans |url =http://www.sciencedirect.com/science/article/pii/0012160675901098|journal=Developmental Biology|language=en|volume=46|issue=2 | pages = 326–342|doi=10.1016/0012-1606(75)90109-8|issn=0012-1606}}</ref> The dauer worms stop feeding, and significantly reduce their movement, and have been reported to reversibly alter some of their sensory neurons.<ref name=":1" /><ref>{{Cite journal | last = Klassen | first = Matthew P. | last2 = Yuan | first2 = Quan | date = 2013-08-19 | title = Dendrite Plasticity: Branching Out for Greener Pastures |url =http://www.sciencedirect.com/science/article/pii/S0960982213008592|journal=Current Biology|language=en|volume=23|issue=16| pages=R687–R688|doi=10.1016/j.cub.2013.07.036|issn=0960-9822}}</ref>

== Used in relation to Chronic Fatigue Syndrome ==
Dauer, or hibernation, was used to explain [[Chronic Fatigue Syndrome]] in the paper [[Metabolic features of chronic fatigue syndrome|Metabolic features of chronic fatigue syndrome]]; CFS was described as a "hypometabolic response to environmental stress similar to dauer".<ref name=":0">{{Cite journal | last = Naviaux | first = Robert K. | authorlink = Robert Phair | last2 = Naviaux | first2 = Jane C. | authorlink2 = Jane Naviaux | last3 = Li | first3 = Kefeng | author-link3 = Kefeng Li | last4 = Bright | first4 = A. Taylor | author-link4 = | last5 = Alaynick | first5 = William A. | author-link5 = William Alaynick | last6 = Wang | first6 = Lin | author-link6 = Lin Wang | last7 = Baxter | first7 = Asha | author-link7 = | last8 = Nathan | first8 = Neil | author-link8 = | last9 = Anderson | first9 = Wayne | author-link9 = | date = 2016-08-29 | title = Metabolic features of chronic fatigue syndrome | url =http://www.pnas.org/content/early/2016/08/24/1607571113.full|journal=Proceedings of the National Academy of Sciences|language=en|volume=113|issue=37| pages = E5472–E5480|doi=10.1073/pnas.1607571113|issn=0027-8424|pmc = 5027464|pmid=27573827|access-date=Feb 25, 2020|quote=|via=}}</ref>

=== Letter: Reply to Vogt et at.===
A letter by Vogt et at. (2016) challenged the conclusions drawn, stating that psychosocial or psychological causes could not be ruled and challenging the validity of the diagnosis of [[chronic fatigue syndrome]].<ref name="VogtLetter2016">{{Cite journal | last = Vogt | first = Henrik | last2 = Ulvestad | first2 = Elling | last3 = Wyller | first3 = Vegard Bruun | date = 2016-11-15 | title = Metabolic features of chronic fatigue syndrome revisited | url =https://www.pnas.org/content/113/46/E7140|journal=Proceedings of the National Academy of Sciences|language=en|volume=113|issue=46| pages = E7140–E7141|doi=10.1073/pnas.1615143113|issn=0027-8424|pmid=27810961}}</ref> Naviaux et al. replied that "... chemical details of the metabolic findings in ME/CFS led directly to a survey of other hypometabolic syndromes like dauer, diapause, torpor, hibernation, and caloric restriction. It was the detailed nature and specific pattern of abnormalities affecting six pathways (sphingolipids, phospholipids, purines, cholesterol, polyamines, and redox metabolism), and not the over 50 other biochemical pathways interrogated, that focused our attention on dauer. In dauer, there is a reprioritization of sensory processing that is metabolically controlled (9). This situation bears similarities to ME/CFS."<ref name="ReplyToVogt15112016">{{Cite journal | last = Naviaux | first = Robert K. | last2 = Naviaux | first2 = Jane C. | last3 = Li | first3 = Kefeng | last4 = Bright | first4 = A. Taylor | last5 = Alaynick | first5 = William A. | last6 = Wang | first6 = Lin | last7 = Baxter | first7 = Asha | last8 = Nathan | first8 = Neil | last9 = Anderson | first9 = Wayne | date = 2016-11-03 | title = Reply to Vogt et al.: Metabolomics and chronic fatigue syndrome | url =https://www.pnas.org/content/113/46/E7142|journal=Proceedings of the National Academy of Sciences|language=en|volume=113|issue=46| pages = E7142–E7143|doi=10.1073/pnas.1616261113|issn=0027-8424}}</ref>

== Letter: Reply to Roerink et al. ==
A letter from Roerink et al. raised questions and concerns about the lack of controls for exercise, diet and drug use, which they stated may have affected the results.<ref>{{Cite journal | last = Roerink|first = Megan E. | authorlink = | last2 = Bronkhorst | first2 = Ewald M. | authorlink2 = | last3 = Meer | first3 = Jos W.M. | author-link3 = Jos van der Meer | last4 = van deer Meer | first4 = | author-link4 = | date = 2017-02-07 | title = Metabolome of chronic fatigue syndrome | url =https://www.pnas.org/content/114/6/E910|journal=Proceedings of the National Academy of Sciences|language=en|volume=114|issue=6| pages = E910–E910|doi=10.1073/pnas.1618447114|issn=0027-8424|pmc=|pmid=28126718|access-date=|quote=|via=}}</ref> Naviaux and Gordon replied that the initial phase was done only with ambulatory CFS patients (i.e., able to walk/mobile), and clarified and corrected points raised about statistical methods used.<ref>{{Cite journal | last = Naviaux | first = Robert K. | authorlink = Robert Naviaux | last2 = Gordon | first2 = Eric | authorlink2 = Eric Gordon | date = 2017-01-26 | title = Reply to Roerink et al.: Metabolomics of chronic fatigue syndrome | url =https://www.pnas.org/content/114/6/E911|journal=Proceedings of the National Academy of Sciences|language=en|volume=114|issue=6| pages = E911–E912|doi=10.1073/pnas.1618984114|issn=0027-8424|pmc=|pmid=|access-date=|quote=|via=}}</ref>

== Open Medicine Foundation ==
[[Category:Medical hypotheses]]
After the publication of the article, Dr [[Ronald Davis|Ron Davis]] invited [[Robert Naviaux]] to join the OMF Scientific Advisory Board.<ref>{{Cite journal | last = National Academy of Sciences | first = | authorlink = | date = 2017-05-02 | title = Correction for Naviaux et al., Metabolic features of chronic fatigue syndrome | url =https://www.pnas.org/content/114/18/E3749|journal=Proceedings of the National Academy of Sciences|language=en|volume=114|issue=18| pages = E3749–E3749|doi=10.1073/pnas.1703858114|issn=0027-8424|pmc=|pmid=28439011|access-date=|quote=|via=}}</ref>

==See also==
*[[Robert Naviaux]]
*[[Severe and very severe ME]]
*[[Metabolism]]
*[[Paralysis]]
*[[Hibernation]]

== References ==
{{reflist}}

Vitamin D

2025-07-22T17:33:19Z

DarthNZ:/* See also */ *Vitamin D Pulse Therapy Added.

'''Vitamin D''' is a fat-soluble steroid [[hormone]] responsible for the intestinal absorption of [[calcium]], [[iron]], [[magnesium]], [[Phosphorus|phosphate]] and [[zinc]]. In humans, dietary Vitamin D is negligible; most comes from exposure of skin to sunlight or from supplementation.

==Function ==
Vitamin D is fat-soluble, regulates calcium levels, helps modulate the immune system, and is vital to good bone health.<ref name="vdr" /><ref name="Paul2011" />

=== Vitamin D2 ===
Vitamin D2, known as ergocalciferol, is a vitamin D found in plants, mushrooms, and yeasts, and sometimes in foods fortified with vitamin D.<ref name="lpi">{{Cite web|url=https://lpi.oregonstate.edu/mic/vitamins/vitamin-D | title = Vitamin D | date = 2014-04-22 | website = Linus Pauling Institute|language=en|access-date=2018-12-23}}</ref>

=== Vitamin D3 ===
Vitamin D3, known as cholecalciferol, is synthesized in the human skin from the UVB radiation in sunlight. D3 can also be obtained from [[:Category:Supplements|supplements]].<ref name="lpi" />

==VDR gene ==
The VDR gene, also known as nuclear receptor subfamily 1 group I member 1, provides instructions for making vitamin D receptor, which controls the body's response to vitamin D.<ref name="vdr">https://medlineplus.gov/genetics/gene/vdr/</ref> Vitamin D-dependent rickets, alopecia areata (an autoimmune disease), intervertebral disc disease, kidney stones and leprosy have all been linked to the VDR gene.<ref name="vdr" />

== Immune function ==

Vitamin D improves [[regulatory T cell]] function in healthy adults<ref name="bock2011">{{Cite journal | doi = 10.1002/dmrr.1276| issn = 1520-7560| volume = 27 | issue = 8| pages = 942–945| last1 = Bock | first1 = Gerlies | last2 = Prietl | first2 = Barbara | last3 = Mader | first3 = Julia K. | last4 = Höller | first4 = Evelyne | last5 = Wolf | first5 = Michael | last6 = Pilz | first6 = Stefan | last7 = Graninger | first7 = Winfried B. | last8 = Obermayer-Pietsch | first8 = Barbara M. | last9 = Pieber | first9 = Thomas R.| title = The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial| journal = Diabetes/Metabolism Research and Reviews| date = Nov 2011 | pmid = 22069289 | url = https://pubmed.ncbi.nlm.nih.gov/22069289 }}</ref>
<ref name="smolders2009">{{Cite journal | doi = 10.1371/journal.pone.0006635| issn = 1932-6203| volume = 4 | issue = 8| pages = 6635| last1 = Smolders | first1 = Joost | last2 = Thewissen | first2 = Mariëlle | last3 = Peelen | first3 = Evelyn | last4 = Menheere | first4 = Paul | last5 = Tervaert | first5 = Jan Willem Cohen | last6 = Damoiseaux | first6 = Jan | last7 = Hupperts | first7 = Raymond| title = Vitamin D Status Is Positively Correlated with Regulatory T Cell Function in Patients with Multiple Sclerosis| journal = PLOS ONE| access-date = 2016-11-10| date = 2009-08-13| url = http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006635}}</ref> and in patients with relapsing remitting [[multiple sclerosis]],<ref name="smolders2009" /> suggesting that it may play a role in both preventing and ameliorating [[autoimmune disease]]. Experimental studies have shown that vitamin D helps protect against a proliferation of [[CD4+ T cell]]s, and reduces the number of [[Th1]] and [[interleukin 17|IL-17]] cytokines.<ref name="Paul2011">https://www.atsjournals.org/doi/full/10.1164/rccm.201108-1502CI</ref>

== Infectious disease ==

Vitamin D deficiency increases the risk of viral infections.{{Citation needed}}

===Epstein-Barr virus===

An [[Epstein-Barr virus]] protein [[EBNA]]-3 has an affinity for the [[Vitamin D receptor]] and may actually block the activation of VDR-dependent genes by Vitamin D.<ref name="hellman2010">{{Cite journal| doi = 10.1007/s00018-010-0441-4| issn = 1420-9071| volume = 67 | issue = 24| pages = 4249–4256| last1 = Yenamandra | first1 = Surya Pavan | last2 = Hellman | first2 = Ulf | last3 = Kempkes | first3 = Bettina | last4 = Darekar | first4 = Suhas Deoram | last5 = Petermann | first5 = Sabine | last6 = Sculley | first6 = Tom | last7 = Klein | first7 = George | last8 = Kashuba | first8 = Elena | title = Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes| journal = Cellular and molecular life sciences: CMLS| date = Dec 2010 | pmid = 20593215 | url = https://doi.org/10.1007%2Fs00018-010-0441-4 }}</ref>

==Deficiency ==
Vitamin D deficiency can cause complex medical problems, and because vitamin D cannot be absorbed from sunlight shining through windows, people who are [[severe and very severe ME|mostly or totally housebound]] are particularly at risk of Vitamin D deficiency.{{citation needed | date = 2022}}

{{See also|Vitamin D deficiency}}

==Supplementation==

===Recommended level===

The recommended blood level of Vitamin D varies considerably by government body and health society.

The US [[Institute of Medicine]] suggests levels between 20 ng/ml and 50ng/ml.<ref name="mayovitd">{{cite web | last = Theimer | first= Sharon | date = 2015-03-15 | title = Vitamin D Toxicity Rare in People Who Take Supplements, Mayo Clinic Study Finds|url= http://newsnetwork.mayoclinic.org/discussion/vitamin-d-toxicity-rare-in-people-who-take-supplements-mayo-clinic-study-finds/| publisher= Mayo Clinic News Network|access-date= 2016-11-10}}</ref>

The Vitamin D Council suggests a level of 50 ng/ml or 125 nmol/l as ideal.<ref name="VitDcouncil">[https://www.vitamindcouncil.org/about-vitamin-d/testing-for-vitamin-d/ Vitamin D Council - Testing for vitamin D]</ref><ref name="Why50nmgl">[https://www.vitamindcouncil.org/blog/why-should-you-keep-your-vitamin-d-level-around-50-ngml/ Vitamin D Council - Why should you keep your vitamin D level around 50 ng/ml?]</ref>

In the [[United States]], 41.6% have serum levels below 20 ng/ml, the threshold for deficiency or 82.1% of African-Americans and 69.2% of Hispanics.<ref name="forrest2011">{{Cite journal| doi = 10.1016/j.nutres.2010.12.001| issn = 1879-0739| volume = 31 | issue = 1| pages = 48–54| last1 = Forrest | first1 = Kimberly Y. Z. | last2 = Stuhldreher | first2 = Wendy L.| title = Prevalence and correlates of vitamin D deficiency in US adults| journal = Nutrition Research (New York, N.Y.)| date = Jan 2011 | pmid = 21310306 | url = https://tahomaclinic.com/Private/Articles4/WellMan/Forrest%202011%20-%20Prevalence%20and%20correlates%20of%20vitamin%20D%20deficiency%20in%20US%20adults.pdf }}</ref>

===Toxicity===

Taking very high Vitamin D levels long term can cause [[hypercalcemia]], which causes serious health problems, although more serious effects like kidney stones are relatively rare. Taking very high amounts of [[calcium]] (1,000mg daily) combined with moderate levels of vitamin D can also be harmful. The NHS and the US Office of Dietary Supplements both recommend a maximum daily limit of 100mcg (4,000IU).<ref name="mayovitd" />

== ME/CFS ==

A retrospective study found patients with CFS have lower levels of Vitamin D than the general population. However, it was uncertain whether this is correlated with the amount of time CFS patients spend indoors or with some other factor.<ref name="berkovitz2013">{{Cite journal | doi = 10.1024/0300-9831.79.4.250| issn = 0300-9831| volume = 79 | issue = 4| pages = 250–254| last1 = Berkovitz | first1 = Saul | authorlink = Saul Berkovitz | last2 = Ambler | first2 = Gareth | last3 = Jenkins | first3 = Michael | last4 = Thurgood | first4 = Sue| title = Serum 25-hydroxy Vitamin D Levels in Chronic Fatigue Syndrome: a Retrospective Survey| journal = International Journal for Vitamin and Nutrition Research| date = 2009-07-01| url = http://econtent.hogrefe.com/doi/abs/10.1024/0300-9831.79.4.250}}</ref><ref name="abokrysha2012">{{Cite journal | doi = 10.1111/j.1526-4637.2011.01304.x| issn = 1526-4637| volume = 13 | issue = 3| pages = 452–458| last = Abokrysha | first = Noha T.| title = Vitamin D deficiency in women with fibromyalgia in Saudi Arabia| journal = Pain Medicine (Malden, Mass.)| date = March 2012 | pmid = 22221390 | url = https://academic.oup.com/painmedicine/article/13/3/452/1852088}}</ref>

Raising Vitamin D levels has reportedly resulted in remission for some CFS patients.<ref name="IACFSME">[https://iacfsme.org/PDFS/Attachment-E-Annedore-Hoeck,-Vitamin-D.aspx IACFS/ME - Vitamin D deficiency results in chronic fatigue and multi-system symptoms]</ref>

Recent research has found no toxicity at 10,000 IU per day and levels as high as 15,000 IU/day are probably tolerated.{{citation needed | date = 2022}} At this dosage it will take 75-90 before symptom improvement is expected to be seen. Some people have seen some symptoms improved within days, but those are likely a small minority.{{Citation needed}}

In 2015, Witham et al. found that high-dose oral vitamin D3 did not improve markers of vascular health or fatigue in patients with [[chronic fatigue syndrome]]. The study consisted of patients meeting the the [[Fukuda criteria]] (1994) for CFS and the [[Canadian Consensus Criteria|Canadian (2003) ME/CFS criteria]] who were either given 100,000 units oral vitamin D3 or a matching placebo every 2 months for 6 months.<ref name="Witham2015" />

In 2017, a study by Earl et al. concluded that low serum concentrations of total 25(OH)D do not appear to be a contributing factor to the level of fatigue of CFS/ME.<ref name="Earl2017">[https://doi.org/10.11136/bmjopen-2016-015296 Earl KE, Sakellariou GK, Sinclair M, et al. Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England. BMJ Open. 2017;7(11):e015296. doi:10.1136/bmjopen-2016-015296]</ref>

== Fibromyalgia ==

A cohort of Saudi women with [[fibromyalgia]] was found to be Vitamin D deficient. Vitamin D status was inversely correlated with [[pain]]. High dose Vitamin D supplementation resulted in improvement or resolution of symptoms.<ref name="abokrysha2012" /> A second study also found improvement of symptoms with Vitamin D supplementation.<ref name="matthana2011">{{Cite journal | issn = 0379-5284| volume = 32 | issue = 9| pages = 925–929| last = Matthana | first = Mona H.| title = The relation between vitamin D deficiency and fibromyalgia syndrome in women| journal = Saudi Medical Journal| date = Sep 2011 | pmid = 21894355 | url = https://pubmed.ncbi.nlm.nih.gov/21894355/ }}</ref>

== Autoimmune disease ==

Low vitamin D is a possible or known risk factor for [[systemic lupus erythematosus]],<ref name="kamen2006">{{Cite journal | doi = 10.1016/j.autrev.2005.05.009| issn = 1568-9972| volume = 5 | issue = 2| pages = 114–117| last1 = Kamen | first1 = Diane L. | last2 = Cooper | first2 = Glinda S. | last3 = Bouali | first3 = Henda | last4 = Shaftman | first4 = Stephanie R. | last5 = Hollis | first5 = Bruce W. | last6 = Gilkeson | first6 = Gary S.| title = Vitamin D deficiency in systemic lupus erythematosus| journal = Autoimmunity Reviews| series = Special Issue on CIS Spring School of Autoimmune Diseases| access-date = 2016-11-10| date = February 2006| url = http://www.sciencedirect.com/science/article/pii/S1568997205000935}}</ref> [[multiple sclerosis]], [[rheumatoid arthritis]], type 1 diabetes,<ref name="Paul2011" /> [[inflammatory bowel disease]],<ref name="cantorna2004">{{Cite journal | issn = 1535-3702| volume = 229 | issue = 11| pages = 1136–1142| last1 = Cantorna | first1 = Margherita T. | last2 = Mahon | first2 = Brett D. | title = Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence| journal = Experimental Biology and Medicine | date = 2004-12-01| url = http://ebm.sagepub.com/content/229/11/1136 | pmid = 15564440}}</ref> alopecia areata (an autoimmune disease causing hair to fall out),<ref name="vdr" /> and the autoimmune thyroid disease [[Hashimoto's thyroiditis (hypothyroidism)]].<ref name="bizzaro2015">{{Cite journal | doi = 10.1007/s12026-014-8579-z| issn = 1559-0755| volume = 61 | issue = 1-2| pages = 46–52| last1 = Bizzaro | first1 = Giorgia | last2 = Shoenfeld | first2 = Yehuda | title = Vitamin D and autoimmune thyroid diseases: facts and unresolved questions| journal = Immunologic Research| date = February 2015 | pmid = 25407646 | url = https://pubmed.ncbi.nlm.nih.gov/25407646/}}</ref> Active [[Crohn's disease]] has also been found to be associated with lower Vitamin D levels.<ref name="hvas2013">{{Cite journal| doi = 10.1016/j.crohns.2013.01.012| issn = 1876-4479| volume = 7 | issue = 10| pages = 407-413| last1 = Jørgensen | first1 = Søren Peter | last2 = Hvas | first2 = Christian Lodberg | last3 = Agnholt | first3 = Jørgen | last4 = Christensen | first4 = Lisbet Ambrosius | last5 = Heickendorff | first5 = Lene | last6 = Dahlerup | first6 = Jens Frederik| title = Active Crohn's disease is associated with low vitamin D levels| journal = Journal of Crohn's & Colitis| date = November 2013 | pmid = 23403039 | url = https://academic.oup.com/ecco-jcc/article/7/10/e407/379813}}</ref>

===Multiple sclerosis===

Among people with early stage [[multiple sclerosis]] (MS), those with higher vitamin D levels had better outcomes five years after follow up.<ref name="NIHvitd">{{Citation | last = Torgan | first = Carol | date = 2014-02-03 | title = Vitamin D Levels Predict Multiple Sclerosis Progression|url= http://www.nih.gov/news-events/nih-research-matters/vitamin-d-levels-predict-multiple-sclerosis-progression|newspaper= NIH Research Matters|access-date= 2016-11-10}}</ref><ref name="ms-trust-vitaminD" />

It is theorized that there may be a link between low Vitamin D, [[Epstein-Barr virus]] and MS.<ref name="holmoy2008">{{Cite journal| doi = 10.1016/j.mehy.2007.04.030| issn = 0306-9877| volume = 70 | issue = 1| pages = 66–69| last = Holmøy | first = Trygve| title = Vitamin D status modulates the immune response to Epstein Barr virus: Synergistic effect of risk factors in multiple sclerosis| journal = Medical Hypotheses| access-date = 2016-11-10| date = 2008| url = http://www.sciencedirect.com/science/article/pii/S0306987707003167}}</ref>
<ref name="ms-trust-vitaminD">{{Cite web|url=https://mstrust.org.uk/life-ms/diet/vitamin-d | title = Vitamin D|website=MS Trust|language=en|access-date=2021-03-11}}</ref><ref name="ms-trust-ebv">{{Cite web|url=https://mstrust.org.uk/a-z/epstein-barr-virus | title = Epstein Barr virus|website=MS Trust|language=en|access-date=2021-03-11}}</ref>

There are high levels of both vitamin D deficiency among Scotland's 15,000 MS sufferers;<ref name="ms-scotland">{{Cite web|url=https://www.mssociety.org.uk/contact-us/scotland | title = Scotland | last = | first = | author-link =| date = |website=Multiple Sclerosis Society UK|language=en|archive-url=|archive-date=|url-status=|access-date=2021-03-11}}</ref> Scotland has the highest prevalence of MS anywhere in the world at over 200 per 100,000 of the population, with over 400 per 100,000 in Orkney, and Scottish ancestry is a recognized risk factor.<ref name="Tarlington2019">{{Cite journal | last = Tarlinton | first = Rachael Eugenie|author-link = | last2 = Khaibullin | first2=Timur | author-link2 = | last3 = Granatov | first3 = Evgenii | author-link3 = | last4 = Martynova | first4 = Ekaterina | authorlink4 = | last5 = Rizvanov | first5 = Albert | authorlink5 = |last6 = Khaiboullina | first6 = Svetlana | authorlink6 = | date = Jan 2019 | title = The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis|url=https://www.mdpi.com/1422-0067/20/2/303|journal=International Journal of Molecular Sciences|language=en|volume=20|issue=2|pages=303|doi=10.3390/ijms20020303|pmc=|pmid=|access-date=|quote=|via=}}</ref><ref name="ms-trust">{{Cite web|url=https://mstrust.org.uk/a-z/prevalence-and-incidence-multiple-sclerosis | title = Prevalence and incidence of multiple sclerosis|website=MS Trust|language=en|access-date=2021-03-11}}</ref>

==Notable studies==
*2014, Association between vitamin D status and markers of vascular health in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)<ref name="Witham2014">{{Cite journal | last1 = Witham | first1 = Miles | authorlink1 = | last2 = Kennedy | first2 = Gwen | authorlink2 = | last3 = Belch | first3 = Jill | authorlink3 = | last4 = Hill | first4 = Alexander | authorlink4 = | last5 = Khan | first5 = Faisel | authorlink5 = Faisel Khan | title = Association between vitamin D status and markers of vascular health in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) | journal = International Journal of Cardiology | volume = 174 | issue = 1 | page = 139 - 140 | date = 2014 | pmid = 25455721 | url = https://www.researchgate.net/profile/Jill-Belch/publication/261292125_Association_between_vitamin_D_status_and_markers_of_vascular_health_in_patients_with_chronic_fatigue_syndromemyalgic_encephalomyelitis_CFSME/links/5e1ddc32a6fdcc28e9c70319/Association-between-vitamin-D-status-and-markers-of-vascular-health-in-patients-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis-CFS-ME.pdf
| doi = 10.1016/j.ijcard.2014.03.145}}</ref>
*2015, Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome – A randomised controlled trial<ref name="Witham2015">{{Cite journal | last1 = Witham | first1 = MD | authorlink1 = | last2 = Adams | first2 = F | authorlink2 = | last3 = McSwiggan | first3 = S | authorlink3 = | last4 = Kennedy | first4 = G | authorlink4 = | last5 = Kabir | first5 = G | authorlink5 = | last6 = Belch | first6 = JJ | authorlink6 = | last7 = Khan | first7 = F | authorlink7 = Faisel Khan | title = Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome – A randomised controlled trial | journal = Nutrition, Metabolism and Cardiovascular Diseases | volume = 25 | issue = 3 | page = 287-294 | date = 2015 | url = https://www.nmcd-journal.com/article/S0939-4753(14)00315-9/fulltext | pmid = 25455721 | doi =10.1016/j.numecd.2014.10.007}}</ref>
*2017, Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England <ref name="Earl2017" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695299/ (Full Text)]
*2018, Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle<ref name="Wu2018">{{Cite journal | last =Wu | first = Fangnan | last2 = Huder | first2=Chaolu | last3 = Tian | first3=Zhenjun | date = 2018-10-04 | title = PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle|url=https://ojs.uclouvain.be/index.php/EBR/article/view/10353|journal=Exercise Biochemistry Review|language=en|volume=1|issue=4|doi=10.14428/ebr.v1i4.10353|issn=2593-7588}}</ref> [https://ojs.uclouvain.be/index.php/EBR/article/view/10353 (Abstract)]

==See also==
*[[Vitamin D deficiency]]
*[[Photophobia]] (light sensitivity)
*[[Severe and very severe ME]]
*[[Dr Lapp's supplement recommendations]]
*[[Malnutrition]]
*[[Vitamin D Pulse Therapy]]

==Learn more==
*[http://lpi.oregonstate.edu/mic/vitamins/vitamin-D Linus Pauling Institute Micronutrient Information Center - Vitamin D]
*[https://www.drugs.com/vitamin-d.html Vitamin D] - drugs.com
*[https://medlineplus.gov/ency/article/002405.htm Vitamin D] - MedlinePlus Encyclopedia

==References ==
{{reflist}}
[[Category:Potential treatments]]
[[Category:Supplements]]
[[Category:Vitamins]]
[[Category:Nutrients]]

Exercise

2025-07-22T17:01:21Z

DarthNZ:/* See also */ * Strength Training Added.

'''Exercise''' is any movement or '''physical activity''' considered to contribute to general health and well-being. Exercise may be recommended as part of a wellness regimen in ''any'' chronic illness.<ref name="Pederson2006">{{Cite journal | last = Pederson | first = B.K. | last2 = Saltin | first2 = B. | date = 2006 | title=Evidence for prescribing exercise as therapy in chronic disease | url=https://www.essa.org.au/wp-content/uploads/2015/06/Chronic-disease_Review-2006.pdf | journal=Scand J Med Sci Sports|volume=16|issue =Suppl 1 | pages = 3-63|via=}}</ref><ref name="Hovanec2015">{{Cite journal | last = Hovanec | first = Nina | last2 = Bellemore | first2 = Derek | last3 = Kuhnow | first3 = Jason | last4 = Miller | first4 = Felicia | last5 = van Vloten | first5 = Alexi | last6 = Vandervoort | first6 = Anthony A. | date = March 3, 2015 | title = Exercise Prescription Considerations for Individuals with Multiple Chronic Diseases: Systematic Review | url =https://www.omicsonline.org/open-access/exercise-prescription-considerations-for-individuals-with-multiple-chronic-diseases-systematic-review-2167-7182-1000201.php?aid=41826|journal=J Gerontol Geriatr Res|volume = 4 | issue = 201 | pages =|via=}}</ref> However, [[Post-exertional malaise|exercise intolerance]] is a central feature of [[ME/CFS]],<ref name=":0">{{Cite web | url = https://www.cdc.gov/me-cfs/symptoms-diagnosis/symptoms.html | title = Symptoms of ME/CFS {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | last = | first = | authorlink = | date = 2021-02-09 | website = cdc.gov|language=en-us|archive-url=|archive-date=|url-status=|access-date=2021-12-23}}</ref> and patients show multiple documented abnormal responses to exercise, including significant worsening of all symptoms; this is the opposite response to how healthy people respond to exercise.<ref name="PEM2017" /> Rather than increase health and well-being, evidence from ME/CFS patients shows that exercise or even increased activity significantly reduces their physical ''and'' [[Cognitive dysfunction|mental capacity]] over time, sometimes permanently.<ref name="nodecisions">{{Cite web | url = http://www.meassociation.org.uk/wp-content/uploads/2015-ME-Association-Illness-Management-Report-No-decisions-about-me-without-me-30.05.15.pdf | title=ME Association illness management report: no decisions about me without me | last = ME Association | first = | date = May 2015 | website = ME Association|archive-url=|archive-date=|url-status=|access-date=25 April 2018}}</ref>

Worsening of symptoms due to exercise in ME/CFS patients cannot be explained by [[deconditioning]] (lack of fitness), or by [[Cognitive behavioral model|psychological theories]] like [[illness beliefs|"symptom focusing"]] or catastrophizing; the effects of exercise or over-exertion in patients include increased immune system symptoms, an increase in inflammatory markers in the blood, increased lactate in blood plasma, an increase in [[lactic acid]] in the muscles, and oxidative damage to DNA.<ref name="Fulle2000">{{citation | last1 = Fulle | first1 = S | author-link1 = Stefania Fulle | last2 =Mecocci | first2 = P | authorlink2 = Patrizia Mecocci | last3 = Fanó | first3 = G | authorlink3 = Giorgio Fanó | last4 =Vecchiet | first4 = I | authorlink4 = Iacopo Vecchiet | last5 = Vecchini | first5 = A | authorlink5 = Alba Vecchini | last6 = Racciotti | first6 = D | authorlink6 = Delia Racciotti | last7 = Cherubini | first7 = A | author-link8 = Antonio Cherubini | last8 = Pizzigallo | first8 = E | author-link8 = Eligio Pizzigallo | last9 = Vecchiet | first9 = L | author-link9 = Leonardo Vecchiet | last10 = Senin | first10 = U | author-link10 = Umberto Senin | last11 = Beal | first11 = MF | author-link11 = M Flint Beal | title = Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome | journal = Free Radical Biology & Medicine | issn = 0891-5849| volume = 29 | issue = 12| pages = 1252–1259 | date = 2000-12-15 | pmid = 11118815 | doi = 10.1016/S0891-5849(00)00419-6 | url = https://www.researchgate.net/profile/Stefania_Fulle/publication/223664992_Specific_oxidative_alterations_in_vastus_lateralis_muscle_of_patients_with_the_diagnosis_of_chronic_fatigue_syndrome/links/54db93eb0cf23fe133ad601d.pdf/download?version=vrp }}</ref>

==Physiological effects of exercise==

Exercise causes a variety of temporary physiological changes in healthy people. This includes an increase in respiratory rate, heart rate, and blood pressure in order to keep up with higher energy demands.<ref name="Burton2004">{{Cite journal | last = Burton | first = Deborah Anne | last2 = Stokes | first2 = Keith | last3 = Hall | first3 = George M | date = December 1, 2004 | title = Physiological effects of exercise | url =https://academic.oup.com/bjaed/article/4/6/185/314696|journal=Continuing Education in Anaesthesia Critical Care & Pain| publisher = |volume=4|issue=6 | pages = 185-8|via=BJA Education}}</ref> The chemical reactions that break down nutrients -- [[glycolysis]], the [[citric acid cycle]], and the [[ion transportation|electron transport]] chain -- move more rapidly to liberate energy, and blood flow to muscles should increase. In healthy individuals, the amount of [[oxygen]] and carbon dioxide present in the blood should not alter significantly.<ref name="Burton2004" />

===Immune system===

In healthy people, exercise induces a variety of temporary changes to immune markers. Immediately after exercise, [[natural killer cell]] activity is decreased and [[Leukotriene]] B4 (LTB4) increase, along with the LTB4/PGE2 ratio. Exercise elevates levels of [[prostaglandin]] E2 (PGE2) for up to five days.<ref name="GrayJB1994">{{citation | last1 = Gray | first1 = J B | author-link1 = J B Gray | last2 =Martinovic | first2 = A M | authorlink2 = Andriya Martinovic | title = Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome| journal = Medical Hypotheses | volume = 43 | issue = 1 | page = 31–42 | date = Jul 1994 | pmid = 7968718 | doi = 10.1016/0306-9877(94)90046-9 | url = http://www.sciencedirect.com/science/article/pii/0306987794900469 }}</ref>

=== Infection ===
Several studies of a mouse model of [[Coxsackie B3]] [[myocarditis]] have found that exercise increases the virulence of the infection and results in poorer outcomes.<ref name="Cabinian1990">Cabinian AE, Kiel RJ, Smith F, Ho KL, Khatib R, Reyes MR. Modification of exercise-aggravated coxsackie virus B3 murine myocarditis by T-lymphocyte suppression in an inbred model. J. Lab. Clin. Med. 1990; 115: 454– 62.</ref><ref name="Kiel1989">Kiel RJ, Smith FE, Chason J, Khatib R, Reyes MD. Coxsackie B3 myocarditis in C3H/HeJ mice: Description of an inbred model and the effect of exercise on the virulence. Eur. J. Epidemiol. 1989; 5: 248– 67.</ref><ref name="Itback">{{Cite journal | last = Ilbäck | first = NG | date = June 1989 | title = Exercise in coxsackie B3 myocarditis: Effects on heart lymphocyte subpopulations and the inflammatory reaction | url =https://www.ncbi.nlm.nih.gov/pubmed/2543197|journal=American Heart Journal|volume=117 | pages = 1298-302|via=}}</ref><ref name="Gatmaitan1970">{{Cite journal | last = Gatmaitan | first = Bienvenido | date = June 1, 1970 | title = Augmentation of the Virulence of Murine Coxsackie Virus B-3 Myocardiopathy by Exercise | url =http://jem.rupress.org/content/131/6/1121|journal=Journal of Experimental Medicine|volume=131 | pages = 1121|via=}}</ref><ref name="Reyes2976">{{Cite journal | last = Reyes | first = MP | date = February 1976 | title = Interferon and neutralizing antibody in sera of exercised mice with coxsackievirus B-3 myocarditis |url =https://www.ncbi.nlm.nih.gov/pubmed/1250870|journal=Proceedings of the Society for Experimental Biology and Medicine|volume=151 | pages = 333-8|via=}}</ref>

===Neurotransmitters===

[[Acetylcholine]], an important [[neurotransmitter]] that regulates immune response and muscle strength, decreases during exercise.

== Effects of exercise in Chronic Fatigue Syndrome ==

===Post Exertional Malaise===

[[File:2010 VanNess Post exertional worsening of symptoms chart.png|right|frame|Post-exertional worsening of symptoms, VanNess et al. (2010)|377x377px]]
{{Main article| page_name=Post-exertional malaise}}[[File:2015 IOM report PEM chart.png|right|frame|PEM chart from the 2015 Institute of Medicine report|378x378px]]

[[myalgic encephalomyelitis|ME]] patients who exercise are likely to experience [[Post-exertional malaise]], a worsening of symptoms following physical, cognitive, or sensory [[exertion]].

===Pain threshold===
Pain thresholds, or the point at which a stimulus becomes painful, drop in people with [[chronic fatigue syndrome|CFS]] (as per the [[Fukuda criteria]]) after graded exercise. In healthy controls, pain thresholds rise. This phenomenon has been attributed to a dysfunction of the central anti-nociceptive mechanism in [[chronic fatigue syndrome|CFS]] patients.<ref name="Whiteside, 2004">{{Citation | last1 = Whiteside | first1 = Alan | author-link1 = | last2 =Hansen | first2 = Stig | authorlink2 = | last3 = Chaudhuri | first3 = Abhijit | authorlink3 = Abhijit Chaudhuri | title = Exercise lowers pain threshold in chronic fatigue syndrome| journal = Pain | volume = 109 | issue = 3 | page = 497-9| date = 2004 | pmid = 15157711| doi = 10.1016/j.pain.2004.02.029}}</ref>

===Immune System===
[[Histamine]], a chemical that is released in response to cellular damage and inflammation, is released during exercise in healthy individuals. The histamine dilates blood vessels in order to deliver nutrients to working muscles.<ref name="Romero2016">{{Cite journal | last = Romero | first = S.A. | last2 = Hocker | first2 = A.D. | last3 = Mangum | first3 = J.E. | last4 = Luttrell | first4 = M.J. | last5 = Turnbull | first5 =D.W. | last6 = Halliwill | first6 = J.R. | last7 = Struck | first7 = A.J. | last8 = Ely | first8 = M.R. | last9 = Sieck | first9 = D.C. | last10 =Dreyer | first10 = H.C. | last11 = Halliwill | first11 = J.R | date = 2016 | title=Evidence of a broad histamine footprint on the human exercise transcriptome | url =http://doi.org/10.1113/JP272177|journal=The Journal of Physiology|volume=594|issue=17 | pages = 5009-5023|via=}}</ref> However, patients with ME may experience increased histamine release due to increased mast cell populations at baseline.<ref name="Ronnberg2017">{{Cite journal | last = Rönnberg | first = E | last2 = Calounova | first2 = G | last3 = Pejler | first3 = G | date = June 2017 | title = Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients |url =https://www.ncbi.nlm.nih.gov/pubmed/27362406|journal=Asian Pac J Allergy Immunol|volume=35|issue=2 | pages = 75-81|via=}}</ref>

===Microbiome===

A small study of ten CFS patients found significant changes in the composition of the [[microbiome]] and increased bacterial translocation (movement from the intestine into the [[blood|bloodstream]]) following exercise. The study found increased Clostridium in the blood fifteen minutes after exercise and increased Bacilli 48 hours later.<ref name="ShuklaS2015">{{citation | last1 = Shukla | first1 = Sanjay K | author-link1 = Sanjay Shukla | last2 =Cook | first2 = Dane | authorlink2 = Dane Cook | last3 = Meyer | first3 = Jacob | authorlink3 = Jacob Meyer | last4 =Vernon | first4 = Suzanne D | authorlink4 = Suzanne Vernon | last5 = Le | first5 = Thao | authorlink5 = Thao Le | last6 = Clevidence | first6 = Derek | authorlink6 = Derek Clevidence | last7 =Robertson | first7 = Charles E | author-link8 = Charles Robertson | last8 = Schrodi | first8 = Steven J | author-link8 = Steven Schrodi | last9 =Yale | first9 = Steven | author-link9 = Steven Yale | last10 = Frank | first10 = Daniel N | author-link10 = Daniel Frank | title = Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)| journal = PLoS ONE | date = Dec 18, 2015 | pmid = 26683192 | doi = 10.1371/journal.pone.0145453 | url = http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145453 }}</ref>

=== Musculature ===
Exercise has also been found to induce both early and excessive lactic acid formation in the [[muscle fatigability|muscles]]<ref name="Plioplys1995">{{citation | last1 = Plioplys | first1 = AV | author-link1 = | last2 =Plioplys | first2 = S | authorlink2 = | title = Serum levels of carnitine in chronic fatigue syndrome: clinical correlates| journal = Neuropsychobiology | date = 1995 | volume = 32 | issue = 3 | page = 132-138 | pmid = 8544970| url = http://www.ncbi.nlm.nih.gov/pubmed/8544970 }}</ref> with reduced intracellular concentrations of [[ATP]] and acceleration of [[glycolysis]].<ref name="McCully1996">{{citation | last1 = McCully | first1 = KK | author-link1 = | last2 =Natelson | first2 = BH | authorlink2 = Benjamin Natelson | last3 = Iotti | first3 = S | authorlink3 = | last4 = Sisto | first4 = S | authorlink4 = | last5 = Leigh | first5 = JS Jr. | authorlink5 = | title = Reduced oxidative muscle metabolism in chronic fatigue syndrome | journal = Muscle Nerve | volume = 19 | issue = 5 | page = 621-625 | date = May 1996 | pmid = 8618560 | doi =| url = http://www.ncbi.nlm.nih.gov/pubmed/8618560 }}</ref> Several studies have found abnormal increases in plasma [[lactate]] following short period of moderate exercise that cannot be explained by [[deconditioning]].<ref name="LaneRJ1998">{{citation | last1 = Lane | first1 = R J | author-link1 = Russell Lane | last2 =Barrett | first2 = M C | authorlink2 = Michael Barrett | last3 = Taylor | first3 = D J | authorlink3 = Doris Taylor | last4 = Kemp | first4 = G J | authorlink4 = Graham Kemp | last5 = Lodi | first5 = R | authorlink5 = Raffaele Lodi | title = Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle| journal = Neuromuscul Disord | volume = 8 | issue = 3-4 | page = 204-9 | date = May 1998 | pmid = 9631403 | url = http://www.ncbi.nlm.nih.gov/pubmed/9631403 }}</ref> There are abnormalities in pH handling by peripheral muscle, and possible evidence of an increased acidosis and lactate accumulation.<ref name="JonesDE2010">{{citation | last1 = Jones | first1 = David EJ | author-link1 = David Jones | last2 =Hollingsworth | first2 = Kieren G | authorlink2 = Kieren Hollingsworth | last3 = Taylor | first3 = Renee R | authorlink3 = Renee Taylor | last4 = Blamire | first4 = Andrew M | authorlink4 = Andrew Blamire | last5 = Newton | first5 = Julia L | authorlink5 = Julia Newton | title = Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome| journal = J Intern Med | volume = 267 | issue = 4 | page = 394-401 | date = Apr 2010 | pmid = 20433583 | doi = 10.1111/j.1365-2796.2009.02160.x | url = http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2009.02160.x/abstract }}</ref>
<ref name="JonesDE2012">{{citation | last1 = Jones | first1 = David EJ | author-link1 = David Jones | last2 =Hollingsworth | first2 = Kieren G | authorlink2 = Kieren Hollingsworth | last3 = Jakovljevic | first3 = Djordje G | authorlink3 = Djordje Jakovljevic | last4 =Fattakhova | first4 = Gulnar | authorlink4 = Gulnar Fattakhova | last5 = Pairman | first5 = Jessie | authorlink5 = Jessie Pairman | last6 = Blamire | first6 = Andrew M | authorlink6 = Andrew Blamire | last7 =Trenell | first7 = Michael I | author-link8 = Michael Trenell | last8 = Newton | first8 = Julia L | author-link8 = Julia Newton| display-authors = | title = Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome | journal = Eur J Clin Invest | volume = 42 | issue = 2 | page = 186-94 | date = Jul 12, 2011 | pmid = 21749371 | doi = 10.1111/j.1365-2362.2011.02567.x | url = http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2362.2011.02567.x/abstract }}</ref><ref name="LengertN2015">{{citation | last1 = Lengert | first1 = Nicor | author-link1 = Nicor Lengert | last2 =Drossel | first2 = Barbara| authorlink2 = Barbara Drossel | title = In silico analysis of exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome| journal = Biophysical Chemistry | volume = 202 | page = 21–31 | date = Jul 2015 | pmid = 25899994 | doi = 10.1016/j.bpc.2015.03.009| url = http://www.sciencedirect.com/science/article/pii/S0301462215000630 }}</ref>

There is also evidence of loss of capacity to recover from acidosis on repeat exercise, as demonstrated by the [[two-day cardiopulmonary exercise test|Two-Day Cardiopulmonary Exercise Test]].<ref name="JonesDE2012" />

Finally, there is evidence of abnormalities of [[AMPK]] activation and glucose uptake in cultured skeletal muscle cells in ME/CFS patients.<ref name="BrownAE2015">{{Citation | last1 = Brown | first1 = Audrey E | author-link1 = Audrey Brown | last2 =Jones | first2 = David E | authorlink2 = David Jones | last3 = Walker | first3 = Mark | authorlink3 = Mark Walker | last4 = Newton | first4 = Julia L | authorlink4 = Julia Newton | title = Abnormalities of AMPK activation and glucose uptake in cultured skeletal muscle cells | journal = PLoS One | volume = 10 | issue = 4 | date = Apr 2, 2015 | pmid = 25836975 | doi = 10.1371/journal.pone.0122982 | url = http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122982 }}</ref>
[[File:Light2011-geneexpression-figure3.jpg|right|frame|Gene expression changes following moderate exercise (Light et al, 2011)|516x516px]]

=== Gene expression ===
There is evidence of increased expression of certain [[gene]]s following muscular exertion.<ref name="LightAR2009">{{citation | last1 = Light | first1 = Alan R | author-link1 = Alan Light | last2 =White | first2 = Andrea T | authorlink2 = Andrea White | last3 = Hughen | first3 = Ronald W | authorlink3 = Ronald Hughen | last4 =Light | first4 = Kathleen C | authorlink4 = Kathleen Light | title = Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects| journal = J Pain | volume = 10 | issue = 10 | page = 1099-112 | date = Jul 31, 2009 | pmid = 19647494 | doi = 10.1016/j.jpain.2009.06.003 | url = http://www.jpain.org/article/S1526-5900(09)00574-4/abstract}}</ref>
<ref name="LightAR2011">{{citation | last1 = Light | first1 = Alan R | author-link1 = Alan Light | last2 =Bateman | first2 = Lucinda | authorlink2 = Lucinda Bateman | last3 = Jo | first3 = Daehyun | authorlink3 = Daehyun Jo | last4 =Hughen | first4 = Ronald W | authorlink4 = Ronald Hughen | last5 = Vanhaitsma | first5 = TA | authorlink5 = Timothy VanHaitsma | last6 = White | first6 = Andrea T | authorlink6 = Andrea White | last7 =Light | first7 = Kathleen C | author-link8 = Kathleen Light | title = Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome | journal = J Intern Med | volume = 271 | issue = 1 | page = 64-81 | date = Jul 13, 2011 | pmid = 21615807 | doi = 10.1111/j.1365-2796.2011.02405.x | url = http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2011.02405.x/abstract }}</ref><ref name="WhiteAT2012">{{citation | last1 = White | first1 = Andrea T | author-link1 = Andrea White | last2 =Light | first2 = Alan R | authorlink2 = Alan Light | last3 = Hughen | first3 = Ronald W | authorlink3 = Ronald Hughen | last4 = VanHaitsma | first4 =Timothy A | authorlink4 = Timothy VanHaitsma | last5 = Light | first5 = Kathleen C | authorlink5 = Kathleen Light | title = Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls | journal = Psychosom Med | volume = 74 | issue = 1 | page = 46-54 | date = Dec 30, 2011 | pmid = 22210239 | doi = 10.1097/PSY.0b013e31824152ed | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256093/}}</ref> A 2011 study found that moderate exercise in CFS increased the expression of 13 genes (sensory, adrenergic and 1 [[cytokine]]) for 48 hours, and the increases correlated with fatigue and pain levels (see graph).<ref name="LightAR2011" />

=== Second day exercise test ===
{{Main article| page_name=Two-day cardiopulmonary exercise test}}

The seminal study on the response of chronic fatigue syndrome patients to a two-day cardiopulmonary exercise test was published by [[Mark VanNess]], [[Christopher Snell]] and [[Staci Stevens]] in 2007: "Diminished Cardiopulmonary Capacity During Post-Exertional Malaise".<ref name="VanNess2007">{{citation | last1 = VanNess | first1 = J Mark| author-link1 = Mark VanNess | last2 =Snell | first2 = Christopher R | authorlink2 = Christopher Snell | last3 = Stevens | first3 = Staci R | authorlink3 = Staci Stevens| title = Diminished Cardiopulmonary Capacity During Post-Exertional Malaise| journal = Journal of Chronic Fatigue Syndrome | volume = 14 | issue = 2 | page = 77-85 | date = 2007| doi = 10.1300/J092v14n02_07 | url = http://www.tandfonline.com/doi/abs/10.1300/J092v14n02_07 }}</ref> While people with CFS responded similarly to healthy controls on a first test, on a follow-up 24 hours later, they were unable to replicate their original normal results. Instead, they had significantly lower values for VO2 peak and AT; these differences could be used to identify the CFS patient over 90% of the time. A repeat study in 2013 confirmed these results.<ref name="SnellCR2013">{{citation | last1 = Snell | first1 = Christopher R | author-link1 = Christopher Snell | last2 =Stevens | first2 = Staci R | authorlink2 = Staci Stevens | last3 = Davenport | first3 = Todd E | authorlink3 = Todd Davenport | last4 =VanNess | first4 = J Mark | author-link4 = Mark VanNess| title = Discriminative Validity of Metabolic and Workload Measurements for Identifying People With Chronic Fatigue Syndrome | journal = Physical Therapy (APTA) | volume = 93 | issue = 11 | page = 1484-1492 | date = Oct 31, 2013 | pmid = 23813081 | doi = 10.2522/ptj.20110368 | url = https://academic.oup.com/ptj/article-lookup/doi/10.2522/ptj.20110368}}</ref>

In a confirmation study, Doctor [[Betsy Keller]] also found that patients could not repeat their performance on a second cardiopulmonary exercise test performed a day after the first.<ref name="KellerBA2014">{{citation | last1 = Keller | first1 = Betsy A | author-link1 = Betsy Keller | last2 =Pryor | first2 = John Luke | authorlink2 = John Pryor | last3 = Giloteaux | first3 = Ludovic| authorlink3 = Ludovic Giloteaux | title = Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment | journal = J Transl Med | volume = | issue = 12 | page = 104 | date = Apr 23, 2014 | pmid = 24755065 | doi = 10.1186/1479-5876-12-104 | url = http://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-12-104 }}</ref>

A review by [[Jo Nijs|Nijs]] et al. found that multiple studies showed reduced peak heart rate, reduced endurance, reduced peak work rate, reduced peak oxygen uptake, lower blood lactate values, and an increased respiratory exchange ratio in people with ME, ME/CFS, or CFS; see [[#Oxidative_impairement|Oxidative impairment]].<ref name="Nijs2014">{{Citation | last1 = Nijs | first1 = J | author-link1 = Jo Nijs | last2 =Nees | first2 = A | authorlink2 = | last3 = Paul | first3 = L | authorlink3 = | last4 = De Kooning | first4 = M | authorlink4 = | last5 = Ickmans | first5 = K | authorlink5 = | last6 = Meeus | first6 = M | authorlink6 = Mira Meeus | last7 =Van Oosterwijck | first7 = J | author-link8 = Jessica Van Oosterwijck | title = Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review | url = https://repository.uantwerpen.be/docman/irua/338b0c/9322.pdf | journal = Exercise Immunology Review | volume = | issue = 20 | page = 94-116 | date = 2014 | pmid = 24974723}}</ref>

It is important to note that CPET testing oxygen uptake (VO2), carbon dioxide output (VCO2), tidal volume (VT), blood pressure, and oxygen saturation are objective measures, and cannot be invalidated with inadequate effort.
{{Main article|Two-day cardiopulmonary exercise test}}

===Oxidative impairment===

DeBecker et al (2000) and VanNess et al (2003) found low VO2 during exercise testing;<ref name="DeBecker2000">{{Citation | last1 = De Becker | first1 = P | author-link1 = Pascale De Becker | last2 =Roeykens | first2 = J | authorlink2 = Johan Roeykens | last3 = Reynders | first3 = M | authorlink3 = Masha Reynders | last4 =McGregor | first4 = N | authorlink4 = Neil McGregor | last5 = De Meirleir | first5 = K | authorlink5 = Kenny de Meirleir| display-authors = | title = Exercise capacity in chronic fatigue syndrome | journal = Archives of Internal Medicine | issn = 0003-9926| volume = 160 | issue = 21| pages = 3270–3277 | date = 2000-11-27 | pmid = 11088089 | doi = 10.1001/archinte.160.21.3270 | url = http://archinte.jamanetwork.com/article.aspx?articleid=485564 }}</ref><ref name="Vanness2003">{{citation | last1 = VanNess | first1 = JM | author-link1 = Mark VanNess | last2 =Snell | first2 = CR | authorlink2 = Christopher Snell | last3 = Strayer | first3 = DR | authorlink3 = David Strayer | last4 = Dempsey | first4 = L | authorlink4 = Line Dempsey | last5 = Stevens | first5 = SR | authorlink5 = Staci Stevens | title = Subclassifying chronic fatigue syndrome through exercise testing | journal = Medicine and Science in Sports and Exercise | issn = 0195-9131| volume = 35 | issue = 6| pages = 908–913 | date = June 2003 | pmid = 12783037 | doi = 10.1249/01.MSS.0000069510.58763.E8 | url = https://www.researchgate.net/profile/Mark_Van_Ness/publication/10728803_Subclassifying_chronic_fatigue_syndrome_through_exercise_testing/links/0c96051793fc9a83e4000000.pdf }}</ref> Fulle et al. (2000) demonstrated oxidative damage to DNA<ref name="Fulle2000" />; and Wong et al. (1992) showed defects in oxidative metabolism and poor recovery of ATP after exercise.<ref name="Wong1992">{{citation | last1 = Wong | first1 = R | author-link1 = Roger Wong | last2 = Lopaschuk | first2 = G | authorlink2 = Gary Lopaschuk | last3 = Zhu | first3 = G | authorlink3 = Gang Zhu | last4 =Walker | first4 = D | authorlink4 = Dorothy Walker | last5 = Catellier | first5 = D | authorlink5 = Dianne Catellier | last6 = Burton | first6 = D | authorlink6 = David Burton | last7 =Teo | first7 = K | author-link8 = Koon Teo | last8 = Collins-Nakai | first8 = R | author-link8 = Ruth Collins-Nakai | last9 =Montague | first9 = T | author-link9 = Terrence Montague | title = Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy| journal = Chest | issn = 0012-3692| volume = 102 | issue = 6| pages = 1716–1722 | date = Dec 1992 | pmid = 1446478 | doi = 10.1378/chest.102.6.1716 | url = http://www.sciencedirect.com/science/article/pii/S0012369216408469}}</ref>

== Graded exercise therapy==
{{main article| page_name=Graded exercise therapy|title1=Graded exercise therapy (GET)}}
Graded exercise therapy involves incremental increases in physical activity or exercise over time, is a controversial treatment for ME/CFS, due to [[exercise intolerance]] being a central feature of the disease.

== Excessive exercise ==
Excessive exercise in healthy people, particularly athletes, is known to cause [[overtraining syndrome]], which is typically recognized by unexplained decreased exercise capacity in combination with other symptoms.<ref name="jointstatement2012">{{Cite journal | last = Meeusen | first = Romain | last2 = Duclos | first2 = Martine | last3 = Foster | first3 = Carl | last4 = Fry | first4 = Andrew | last5 = Gleeson | first5 = Michael | last6 = Nieman | first6 = David | last7 = Raglin | first7 = John | last8 = Rietjens | first8 = Gerard | last9 = Steinacker | first9 = Jürgen | date = 2013-01-01 | title = Prevention, diagnosis and treatment of the overtraining syndrome: Joint consensus statement of the European College of Sport Science (ECSS) and the American College of Sports Medicine (ACSM)| url = https://doi.org/10.1080/17461391.2012.730061|journal=European Journal of Sport Science|volume=13|issue=1 | pages = 1–24|doi=10.1080/17461391.2012.730061|issn=1746-1391}}</ref><ref name="Kreher2019">{{Cite journal| url = https://doi.org/10.1177%2F1941738111434406 | title = Overtraining Syndrome: A practical guide|website=SAGE Journals|language=en|doi=10.1177/1941738111434406|pmc=3435910|pmid=23016079|access-date=2019-02-28 | date = 2012 | last = Kreher | first = Jeffrey | authorlink = | last2 = Schwartz | first2 = Jennifer B. | authorlink2 = |archive-url=|archive-date=|url-status=|volume=4|issue=2 | pages = 128-138}}</ref> Overtraining syndrome, while commonly fatiguing, has different signs and symptoms than CFS,<ref name=":0" /><ref name="jointstatement2012" /><ref name="Derman2000" /> and effects of overtraining should not be confused with ME/CFS,<ref name="Mommersteeg2006">{{Cite journal | title = Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test | date = 2006-02-01| url = https://www.sciencedirect.com/science/article/pii/S0306453005001757|journal=Psychoneuroendocrinology|volume=31|issue=2 | pages = 216–225 | last = Mommersteeg | first = Paula M.C. | last2 = Heijnen | first2 = Cobi J. | last3 = Verbraak | first3 = Marc J.P.M. | last4 = van Doornen | first4 = Lorenz J.P. |language=en|doi=10.1016/j.psyneuen.2005.07.003|issn=0306-4530}}</ref> which is a multi-systemic neurological disease with a different symptom profile, involves multiple processes including [[mitochondria dysfunction]], [[neuroinflammation]], and [[#immune_system|abnormal immune system responses to exercise]], and has no known cure or established treatment.<ref name="ICC2011primer">{{citation | last1 = Carruthers | first1 = BM | author-link1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | author-link8 = Donald Staines | last8 = Powles | first8 = ACP | author-link8 = A C Peter Powles | last9 = Speight | first9 = N | author-link9 = Nigel Speight | last10 = Vallings | first10 = R | author-link10 = Rosamund Vallings | last11 = Bateman | first11 = L | author-link11 = Lucinda Bateman | last12 = Bell | first12 = DS | author-link12 = David Bell | last13 = Carlo-Stella | first13 = N | author-link13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | author-link14 = John Chia | last15 = Darragh | first15 = A | author-link15 = Austin Darragh | last16 = Gerken | first16 = A | author-link16 = Anne Gerken | last17 = Jo | first17 = D | author-link17 = Daehyun Jo | last18 = Lewis | first18 = DP | author-link18 = Donald Lewis | last19 = Light | first19 = AR | author-link19 = Alan Light | last20 = Light | first20 = KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens| title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf}}</ref><ref name=":0" /> ME/CFS cannot be diagnosed when symptoms may be the result of excessive exertion, for example prolonged or intense exercise, or when there is inadequate nutrition, and the [[Definitions of myalgic encephalomyelitis and chronic fatigue syndrome|most widely used diagnostic criteria]] also requires 6 months of symptoms before diagnosis.<ref name=":0" /><ref name="spence">{{Cite web | last = Spence | first = Vance | authorlink = Vance Spence|website=Irish M.E. Association| title = Snippets {{!}} A presentation by MERGE Chairman Dr Vance Spence on 12 November 2005 at the Oak Tree Court Conference Centre, Coventry, at the invitation of the Warwickshire Network for ME | url = https://www.imet.ie/imet_website/snippets/7th_december_2005_snippets.html}}</ref><ref name="Derman2000" />
{{Main article|Overtraining syndrome}}

==Exercise in other chronic illnesses ==
Exercise and increased physical activity is increasingly being promoted and encouraged for patients with chronic diseases<ref name="MiraleCure2015">{{Citation | title = Exercise: The miracle cure and the role of the doctor in promoting it | date = 2015 | url=https://www.aomrc.org.uk/wp-content/uploads/2016/05/Exercise_the_Miracle_Cure_0215.pdf | last = McNally | first = S. | author-link = |work=Academy of Medical Royal Colleges|location=London}}</ref> due to the positive effects found in a considerable number of different chronic illnesses and diseases, including:
*psychiatric diseases:
** [[depression]]
** [[schizophrenia]]
** [[stress]] and [[anxiety]]
* neurological diseases:
** [[dementia]]
** [[multiple sclerosis]] - although a temporary worsening of symptoms is common
** [[Parkinson's disease]]
* metabolic diseases:
** [[diabetes]] (both types 1 and 2) - although it should be avoided or modified in some circumstances
** [[hyperlipidemia]]
** [[metabolic syndrome]]
** [[obesity]]
** [[polycystic ovarian syndrome]] (PCOS)
* cardiovascular diseases:
** [[cerebral apoplexy]] (stroke, cerebrovascular accident, apoplexy)
** [[claudication intermittent]]
** [[coronary heart disease]] - only if unstable angina are certain other conditions are not present, high-intensity workouts should be avoided
** [[heart failure]] - only if certain conditions are met
** [[hypertension|high blood pressure]] - high-intensity workouts should be avoided and medication may be needed to reduce blood pressure first
* pulmonary (respiratory) diseases:
** [[asthma]] - if no infection is present and it does not cause severe exacerbation of asthma
** [[chronic obstructive pulmonary disease]] (COPD) - oxygen may be needed during exercise
** [[cystic fibrosis]] - if no infection is present
* musculoskeletal disorders:
** [[lower back pain|back pain]] - only if no event fracture is suspected, and with certain conditions
** [[cancer]] - under certain conditions and with supervision
** [[osteoarthritis]] - under certain conditions
** [[osteoporosis]] - exercise should not involve risk of a fall
** [[rheumatoid arthritis]]<ref name="Pederson2015">{{Cite journal | title = Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases | date = Dec 2015 | url = https://onlinelibrary.wiley.com/doi/10.1111/sms.12581|journal=Scandinavian Journal of Medicine & Science in Sports|volume=25|issue= | pages = 1–72 | last = Pedersen | first = B.K. | author-link = | last2 = Saltin | first2 = B. | authorlink2 = |language=en|doi=10.1111/sms.12581|pmc=|pmid=|access-date=|quote=|via=}}</ref> - under certain conditions and with supervision

Regular exercise has general benefits in chronically ill people '''without ME/CFS''' depend on doing the correct type and intensity of physical activity for the illness in order to avoid aggravating symptoms; if done correctly these include
* reduced risk of falls and fractures
* reduced risk of additional chronic diseases
* reduced [[depression]], especially for people medically ill with mild or moderate depression
*reduced [[Chronic pain|pain]] in certain conditions, particularly musculoskeletal or pain conditions, if the most appropriate type and intensity of physical activity is used.<ref name="Gloth2001">{{Cite journal | title = Physical therapy and exercise in pain management | date = 2001-09-01| url = https://www.sciencedirect.com/science/article/pii/S0749069005700847|journal=Clinics in Geriatric Medicine|volume=17|issue=3 | pages = 525–535 | last = Gloth | first = Mark J. | last2 = Matesi | first2 = Ann M.|language=en|doi=10.1016/S0749-0690(05)70084-7|issn=0749-0690}}</ref><ref name="Kujala2006">{{Cite journal | title = Benefits of exercise therapy for chronic diseases | date = 2006-01-01| url = https://bjsm.bmj.com/content/40/1/3|journal=British Journal of Sports Medicine|volume=40|issue=1 | pages = 3–4 | last = Kujala | first = U.M. | language=en|doi=10.1136/bjsm.2005.021717|pmc=PMC2491939|pmid=16371482|issn=0306-3674}}</ref>

==Talks and interviews==
*2009, [https://www.youtube.com/watch?v=vqy4gVNh0rI][[Staci Stevens]] speaking to CFSAC meeting
*2010, [http://www.hhs.gov/advcomcfs/meetings/presentations/presentation_10132010_snell-stevens.pdf Slide presentation to CFSAC] by [[Staci Stevens]], [[CFSAC]]
*2012, [https://www.youtube.com/watch?v=nL49DwGRs30 Clinical exercise testing in CFS/ME research and treatment] - [[Christopher Snell]]
*2012, [https://www.youtube.com/watch?v=kCO3pAbSq3I MECFS Alert Episode 32] - [[Staci Stevens]], Director of the Pacific Fatigue Lab, [[ME/CFS Alert]]
*2012, [https://www.youtube.com/watch?v=B20H1u1LjCE&feature=youtu.be Top 10 Things You Should Know About Post-Exertional Relapse] - [[Staci Stevens]]
*2013, [https://www.youtube.com/watch?v=zZ8aPYihkpQ CFS gene expression after exercise (part 1)] - [[Lucinda Bateman]]
*2014, [https://www.youtube.com/watch?v=q_cnva7zyKM Exercise and ME/CFS, Part 1] - [[Mark VanNess]] at Bristol Watershed
*2015, [https://www.youtube.com/watch?v=F1PP21TmUPs 72. Gene-expression and exercise / Gen-expressie en inspanning]<ref name="Bateman20151103interview">{{Citation | last1 = Bateman | first1 = Lucinda| author-link1 = Lucinda Bateman| title = Video interview: Gene-expression and exercise | journal = Wetenschap voor Patienten - ME/cvs Vereniging | date = Nov 3, 2015 | url = https://www.youtube.com/watch?v=F1PP21TmUPs}}</ref> – Dr. [[Lucinda Bateman]], [[Science for Patients]])
*2016, [https://www.youtube.com/watch?v=FXN6f53ba6k Expanding Physical Capability in ME/CFS. Part 1 of 2.] Dr. [[Mark VanNess]]
*2016, [https://www.youtube.com/watch?v=7BceGgEdMpA Expanding Physical Capability in ME/CFS. Part 2 of 2.] - [[Mark VanNess]]

==Notable studies==
*2000, The Differential Diagnosis and Clinical Approach to the Athlete With Chronic Fatigue<ref name="Derman2000">{{Cite journal | last = Lambert | first = M.I. | last2 = Derman | first2 = W.E. | date = 2000-01-01 | title = The differential diagnosis and clinical approach to the athlete with chronic fatigue | url =https://www.researchgate.net/profile/Wayne_Derman/publication/304013746_The_Differential_Diagnosis_and_Clinical_Approach_to_the_Athlete_With_Chronic_Fatigue/links/5762fb7e08aecb4f6fee0463/The-Differential-Diagnosis-and-Clinical-Approach-to-the-Athlete-With-Chronic-Fatigue.pdf |journal=International SportMed Journal|language=en|volume=1|issue=3|issn=1528-3356}}</ref>
*2011, [[PACE trial]]
*2011, Tired of being inactive: a systematic literature review of physical activity, physiological exercise capacity and muscle strength in patients with chronic fatigue syndrome<ref name="Nijs2011">{{Cite journal | last = Nijs | first = Jo | author-link = Jo Nijs | last2 = Aelbrecht | first2 = Senne | authorlink2 = Senne Aelbrecht | last3 = Meeus | first3 = Mira | authorlink3 = Mira Meeus | last4 = Van Oosterwijck | first4 = Jessica | authorlink4 = Jessica Van Oosterwijck | last5 = Zinzen | first5 = Evert | authorlink5 = Evert Zinzen | last6 = Clarys | first6 = Peter | authorlink6 = Peter Clarys | date = 2011 | title = Tired of being inactive: a systematic literature review of physical activity, physiological exercise capacity and muscle strength in patients with chronic fatigue syndrome | url =http://emerge.org.au/wp-content/uploads/2014/11/Nijs-J.-et-al.-Tired-of-being-inactive.-Disabil-Rehabil-2011-3317-18.1493-1500.pdf | journal=Disability and Rehabilitation|volume=33|issue=17-18 | pages = 1493–1500|doi=10.3109/09638288.2010.541543|issn=1464-5165|pmid=21166613|quote=|via=}}</ref> [http://emerge.org.au/wp-content/uploads/2014/11/Nijs-J.-et-al.-Tired-of-being-inactive.-Disabil-Rehabil-2011-3317-18.1493-1500.pdf (Abstract)]
*2016, [https://www.ncbi.nlm.nih.gov/pubmed/27187093 Effect of Acute Exercise on Fatigue in People with ME/CFS/SEID: A Meta-analysis]
*2016, [[Cochrane|Cochrane meta-analysis]]
*2017, [https://www.sciencedirect.com/science/article/pii/S088915911730051X Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]<ref name="PEM2017">{{Cite journal | last = Cook | first = Dane B. | author-link = Dane Cook | last2 = Light | first2 = Alan R. | authorlink2 = Alan Light | last3 = Light | first3 = Kathleen C. | authorlink3 = Kathleen Broderick | last4 = Broderick | first4 = Gordon | authorlink4 = Gordon Broderick | last5 = Shields | first5 = Morgan R. | authorlink5 = Morgan Shields | last6 = Dougherty | first6 = Ryan J. | authorlink6 = Ryan Dougherty | last7 = Meyer | first7 = JacobD. | author-link8 = Jacob Meyer | last8 = VanRiper | first8 = Stephanie | author-link8 = Stephanie Land | last9 = Stegner | first9 = Aaron J. | author-link9 = Aaron Stegner | date = May 1, 2017 | title = Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | url =http://www.sciencedirect.com/science/article/pii/S088915911730051X|journal=Brain, Behavior, and Immunity|volume=62|issue= | pages = 87–99|doi=10.1016/j.bbi.2017.02.009|issn=0889-1591|quote=|via=}}</ref>
* 2020, Prediction of Discontinuation of Structured Exercise Programme in Chronic Fatigue Syndrome Patient<ref name="Kujawski2020">{{Cite journal | last = Kujawski | first = Sławomir | author-link = | last2 = Cossington | first2 = Jo | authorlink2 = | last3 = Słomko | first3 = Joanna | authorlink3 = | last4 = Dawes | first4 = Helen | authorlink4 = | last5 = Strong | first5 = James W.L. | authorlink5 = | last6 = Estevez-Lopez | first6 = Fernando | authorlink6 = | last7 = Murovska | first7 = Modra | author-link8 = Modra Murovska | last8 = Newton | first8 = Julia L. | author-link8 = Julia Newton | last9 = Hodges | first9 = Lynette | author-link9 = Lynette Hodges | date = 2020-10-26 | title = Prediction of Discontinuation of Structured Exercise Programme in Chronic Fatigue Syndrome Patients |url =https://www.mdpi.com/2077-0383/9/11/3436|journal=Journal of Clinical Medicine|language=en|volume=9|issue=11 | pages = 3436|doi=10.3390/jcm9113436|issn=2077-0383|pmc = 7693605|pmid=33114704|access-date=|quote=|via=}}</ref> - [https://www.mdpi.com/2077-0383/9/11/3436/htm (Full text)]

==Learn more==
*2011 - [https://www.youtube.com/watch?v=Suq0dPMUbOk ME/CFS and Exercise: The VO2 Max Based Exercise Program, A Personal View] by Dan Moricoli
*2011 - [http://www.meresearch.org.uk/our-research/completed-studies/acidosis/ Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case–control study], an essay for [[ME Research UK]]
*2014 - [https://www.youtube.com/watch?v=kbaW4JKkin4 ME/CFS and Exercise: VO2 Max Testing with Nancy Klimas M.D. - PREVIEW] (this is a preview of a pay-per-view video)
*2014 - [http://www.deseretnews.com/article/865603384/Sufferers-of-chronic-fatigue-fibromyalgia-have-hope-in-new-diagnostic-tool.html Sufferers of chronic fatigue, fibromyalgia have hope in new diagnostic tool] by Wendy Leonard for ''Deseret News''
*2015 - [http://sallyjustme.blogspot.co.uk/2015/01/dr-vanness-on-recent-press-reports.html Dr. VanNess on recent press reports] by Sally Burch in [[Just ME]] blog
*2015 - [http://www.jacobspublishers.com/images/Physiology/J_J_Physiology_1_2_007.pdf Deviant Cellular and Physiological Responses to Exercise in Myalgic Encephalomyelitis and Chronic Fatigue Syndrome] by [[Frank Twisk|Frank N.M. Twisk]], and [[Keith Geraghty|Keith J. Geraghty]]<ref name="TwiskF2015">{{citation | last1 = Twisk | first1 = Frank NM | author-link1 = Frank Twisk | last2 = Geraghty | first2 = Keith J | authorlink2 = Keith Geraghty| title = Deviant Cellular and Physiological Responses to Exercise in Myalgic Encephalomyelitis and Chronic Fatigue Syndrome| journal = Jacobs Journal of Physiology | volume = 1 | issue =2 | pages = 007 | date = Jul 11, 2015 | url = http://www.jacobspublishers.com/images/Physiology/J_J_Physiology_1_2_007.pdf}}</ref>
*2015 - [https://www.omicsonline.org/open-access/objective-evidence-of-postexertional-malaise-in-myalgic-encephalomyelitis-and-chronic-fatigue-syndrome-2161-0673-1000159.pdf Objective Evidence of Post-exertional “Malaise” in Myalgic Encephalomyelitis and Chronic Fatigue Syndrome] by Frank N.M. Twisk
*2015 - [https://cfsremission.wordpress.com/2015/12/19/exercise-alteration-of-the-cfs-microbiome/ Exercise alteration of the CFS Microbiome] from [[CFS Remission]] blog
*Jan 2016 - [http://www.hindawi.com/journals/jar/2016/2497348/ Review Article: Understanding Muscle Dysfunction in Chronic Fatigue Syndrome] by Gina Rutherford, Philip Manning, and [[Julia Newton|Julia L. Newton]]<ref name="RutherfordG2016">{{citation | last1 = Rutherford | first1 = Gina | author-link1 = Gina Rutherford | last2 =Manning | first2 = Philip| authorlink2 = Philip Manning | last3 = Newton | first3 = Julia L | authorlink3 = Julia Newton | title = Review Article: Understanding Muscle Dysfunction in Chronic Fatigue Syndrome | journal = Journal of Aging Research | volume = 2016 | issue = 4| pages = 1-13 | date = Jan 13, 2016 | pmid = 26998359 | doi = 10.1155/2016/2497348 | url = http://www.hindawi.com/journals/jar/2016/2497348/}}</ref>
*Feb 10, 2016 - [http://www.prohealth.com/library/showarticle.cfm?libid=25096 Lost in Translation - The ME-Polio Connection and the Dangers of Exercise] by [[Nancy Blake]] for [[ProHealth]]
*Jul 2016 - [https://meaustralia.net/2016/07/06/australian-metabolomics-study-of-young-women/ Australian metabolomics study of young women with ME/CFS (CCC)] by Sasha Nimmo for ''ME Australia''
*Aug 2016 - [http://solvecfs.org/neuromuscular-strain-in-mecfs-research-study-conclusion/ Neuromuscular Strain in ME/CFS – Research Study Conclusion] in [[Solve ME/CFS Initiative]] Newsletter
*Oct 2017 - [https://www.npr.org/sections/health-shots/2017/10/02/554369327/for-people-with-chronic-fatigue-syndrome-more-exercise-isnt-better For People With Chronic Fatigue Syndrome, More Exercise Isn't Better - Michaeleen Doucleff, Shots: Health News From NPR]

== See also ==
*[[Two-day cardiopulmonary exercise test]]
*[[Graded exercise therapy]]
*[[Burnout]]
*[[Delayed onset muscle soreness]] (DOMS)
*[[Muscle fatigability]]
*[[Mitochondrion]]
*[[Deconditioning]]
*[[Post-exertional malaise]]
*[[Glass ceiling effect]]
*[[Strength Training]]

==References==
{{Reflist}}

[[Category:Potential treatments]]
[[Category:Psychological and behavioral therapies]]
[[Category:Energy system]]
[[Category:Depression alternative treatments]]
[[Category:Drug-free pain management]]
[[Category:Exercise treatments]]

Graded exercise therapy

2025-07-22T16:58:36Z

DarthNZ:/* See also */ * Strength Training Added.

[[File:Increasingvalueschart-gradedexercise.png|thumb|200x200px]]
'''Graded exercise therapy''' (GET) is a form of physical therapy for the treatment of [[chronic fatigue syndrome]] (CFS) where physical activity is gradually increased over time, regardless of how the patient is feeling and ignoring any increased symptoms or new symptoms. GET was offered as a primary treatment for [[ME/CFS]] to [[UK]] patients by the [[National Health Service]] (NHS), as specified in the [[NICE guidelines]] from 2007-2021, but the GET recommendation was removed by the 2021 [[NICE guidelines]] update because of high rates of harm.<ref name="ng206">{{Cite web | url=https://www.nice.org.uk/guidance/ng206 | title = Myalgic Encephalomyelitis (or Encephalopathy)/Chronic Fatigue Syndrome:diagnosis and management. NICE guideline. | last = NICE Guideline Development Group | first = | authorlink = | publisher = [[National Institute for Health and Care Excellence]] | date = 2021-10-29}}</ref> The use of Graded Exercise Therapy as a treatment is based on the disputed [[deconditioning]] hypothesis, and the highly controversial [[biopsychosocial model]] (BPS) of ME/CFS.<ref name=":0" />

Alternative names used for graded exercise therapy include [[graded activity management|'''Graded Activity Management''']] (GAM), and '''Graded Activity Therapy''' (GAT).<ref name="SharpeCampling">{{Cite book | title = Chronic Fatigue Syndrome | pages = 157|isbn=978-0-19-157971-4|edition=|volume=|language=en|title-link=| url = https://books.google.co.uk/books?id=DTefP_zDgyQC&pg=PT157&lpg=PT157&dq=%22graded+activity+therapy%22|access-date= | date = 2008-07-02| publisher = OUP Oxford | last = Campling | first = Frankie | authorlink = | last2 = Sharpe | first2 = Michael | authorlink2 = Michael Sharpe|veditors=|others=|doi=|oclc=|quote=GET is similar in many ways to CBT, but it concentrates more on changing coping behaviour rather than thinking. It might be better called graded activity therapy.|archive-url=|archive-date=|location=|editor-last = }}</ref><ref name="southtees2018">{{Cite web | url=https://www.southtees.nhs.uk/content/uploads/Session-1-full-updated-summer-2018-1.pdf | date = 2018 | website = South Tees Hospitals NHS Foundation | title = Group Rehabilitation Programme for people with CFS / ME. SESSION 1 | last = South Tees Specialist CFS/ME Service|at=Slide 17|access-date=2021-11-03|quote=GRADED EXERCISE THERAPY = GRADED ACTIVITY THERAPY}}</ref><ref name="elft">{{Cite web | url=https://www.elft.nhs.uk/service/419/Bedfordshire-Chronic-Fatigue-Service | title = ELFT - Services - Bedfordshire Chronic Fatigue Service | last = | first = | authorlink = | date = 2021-10-30 | website = East London NHS|archive-url=|archive-date=|url-status=|access-date=2021-11-03|quote=NICE recommended Cognitive Behaviour Therapy (CBT) and Graded Activity Management (GAM)}}</ref>

Graded Activity Therapy is defined in several different ways:
* As identical to graded exercise therapy,<ref name="SharpeCampling" /><ref name="southtees2018" /> or
* As the same approach but including [[cognitive dysfunction|cognitive / mental activity]] as well as physical activity<ref name="Cheshire2020">{{Cite journal | last = Cheshire | first = Anna | last2 = Ridge | first2 = Damien | last3 = Clark | first3 = Lucy | last4 = White | first4 = Peter | date = 2020-01-30 | title = Guided graded Exercise Self-help for chronic fatigue syndrome: patient experiences and perceptions| url = https://doi.org/10.1080/09638288.2018.1499822|journal=Disability and Rehabilitation|volume=42|issue=3 | pages = 368–377|doi=10.1080/09638288.2018.1499822|issn=0963-8288|pmid=30325677}}</ref><ref name="srft">{{Cite web | url=https://www.srft.nhs.uk/EasysiteWeb/getresource.axd?AssetID=56453&type=full&servicetype=Inline | date = 2018 | title = Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalopathy (ME) Management Programme|website=Salford Royal NHS Foundation Trust | last = |access-date=2021-11-03|quote=Scheduling Rest and Activity<br />The aim of cognitive-behaviour and graded activity therapy is not simply to be more active, but to make activity and rest consistent, rather than symptom dependent. By doing this you will be able to gradually increase your ability to carry out everyday activities while slowly cutting down on excessive rest.}}</ref>

== Evidence ==

=== Patient reports of harm ===
Clinical trials have resulted in mixed results.<ref name=":0" /><ref name=":1" /><ref name=":5" /> Surveys of patients conducted by patient charities have universally found Graded Exercise Therapy to be harmful, although a minority of patients found it helped them or simply ineffective.<ref name=":2" /><ref name=":3" /> A number of severely ill patients have reported that starting Graded Exercise Therapy with moderate symptoms cause a severe escalation of symptoms, leaving them permanently worse. Two highly influential peer-reviewed articles often used to support the use of Graded Exercise Therapy, the [[Cochrane]] review and the [[PACE trial]], have had widescale calls for retraction based on criticism of the scientific method and standards used.<ref name=":5" />

[[Robin Brown]], a British doctor with ME/CFS has created petition that many thousands have signed calling for GET and related [[Cognitive behavioral therapy|CBT]] to be removed from the UK treatment guidelines immediately.<ref>{{Cite web | url=https://www.change.org/p/nice-stop-harming-me-cfs-patients-take-cbt-get-out-of-me-cfs-guidelines-now | title = NICE stop harming ME/CFS patients - Take CBT and GET out of the CFS guidelines NOW! {{!}} Sign the Petition | last = Brown | first = Robin | authorlink = Robin Brown | date = |website=Change.org|language=en-GB|archive-url=|archive-date=|access-date=2018-11-13}}</ref>

=== Physical fitness unchanged ===
A number of studies by proponents of GET have found that it did not improve fitness, when self-rated perception of fatigue did improve after GET, no improvements in exercise capacity were statistically significant.<ref name=":0" /><ref>{{Cite journal | last = Moss-Morris | first = Rona | authorlink = Rona Moss-Morris | last2 = Sharon | first2 = Cynthia | authorlink2 = Cynthia Sharon | last3 = Tobin | first3 = Roseanne | authorlink3 = Roseanne Tobin | last4 = Baldi | first4 = James C. | authorlink4 = James Baldi | authorlink5 = | date = Mar 2005 | title = A Randomized Controlled Graded Exercise Trial for Chronic Fatigue Syndrome: Outcomes and Mechanisms of Change| url = https://journals.sagepub.com/doi/abs/10.1177/1359105305049774|journal=Journal of Health Psychology|language=en|volume=10|issue=2 | pages = 245–259|doi=10.1177/1359105305049774|issn=1359-1053|quote=|via=}}</ref><ref name=":4" /> The controversial PACE trial's 6 minute walk test results showed those successfully completing GET were unable to walk as far as older patients awaiting a lung transplant or those with heart failure; data that was omitted from the original trial report.<ref name=":4" />

==Patient analysis of PACE results==
[[Graham McPhee]] and others created videos investigating the PACE trial data in relation to GET.<ref>{{Cite web | url=https://vimeo.com/21850334 | title = PACEindividuals|website=Vimeo|language=en|access-date=2018-10-13}}</ref><ref>{{Cite web | url=https://vimeo.com/21852891 | title = PACEgraph|website=Vimeo|language=en|access-date=2018-10-13}}</ref> Several re-analyses of the PACE trial results have been published since the detailed PACE trial data was released into the public domain.<ref name=":4" />

==Fear of exercise==
The [[PACE Trial Management Group|PACE trial investigators]] have stated that they believe a significant maintaining factor in the persistence of ME/CFS is fear of [[exercise]].<ref>{{Cite journal | last = Torjesen | first = Ingrid | date = 2015-10-28 | title = Tackling fear about exercise produces long term benefit in chronic fatigue syndrome| url = https://www.bmj.com/content/351/bmj.h5771|journal=BMJ|language=en|volume=351 | pages = h5771|doi=10.1136/bmj.h5771|issn=1756-1833|pmid=26511755}}</ref> This claim has been criticized as unsupported by trial results.<ref>{{Cite journal | date = 2018-10-13 | title = Objective measures found a lack of improvement for CBT & GET in the PACE Trial: subjective improvements may simply represent response biases or placebo effects in this non-blinded trial| url = https://www.bmj.com/content/350/bmj.h227/rr-10|journal=The BMJ|language=en}}</ref> A study by [[Jo Nijs|Nijs]] et al. in 2004 concluded:

{{Quote box|quote=These results indicate a lack of correlation between kinesiophobia and exercise capacity, activity limitations, or participation restrictions, at least in patients with [[chronic fatigue syndrome |CFS]] who are experiencing widespread [[myalgia |muscle]] or [[arthralgia |joint pain]]. | title = Chronic Fatigue Syndrome: Lack of Association between Pain-Related Fear of Movement and Exercise Capacity and Disability|source=Jo Nij, Katrien Vanherberghen, William Duquet & Kenny De Meirleir (2004)}}

==Doctors who are patients with ME/CFS==
[[File:GET-CBT-ME-chronicfatiguesyndrome.jpeg|alt=Graded exercise therapy and CBT. "As a physician bedridden with myalgic encephalomyelitis (ME) for more than a decade who is totally dependent on others, all thanks to a major relapse caused by GET, I am in a unique position to answer how harmful GET and cognitive behavioral therapy (CBT) really are. The basis of these therapies is false illness beliefs, meaning that it is all in the mind. These beliefs ignore all of the evidence that ME is a physical disease, such as intracellular immune dysfunctions, which not only restrict exercise capacity but also worsen with exercise (2)." - Maik Speedy (2015). Annals of Internal Medicine.|upright=1|thumb|right|Graded exercise therapy caused a permanent relapse that left Dr [[Maik Speedy]] bedridden.]]<br />
A number of doctors diagnosed with ME/CFS have shared their personal experiences of [[graded exercise therapy]] or have spoken out against GET to both other doctors and patients. These include:
* [[Robin Brown]], author of [[M.E. and Me: A Doctor's Struggle with Chronic Fatigue Syndrome]]
* [[Nina Muirhead]], a British surgeon
* [[Maik Speedy]], who became [[Severe and very severe ME|severely ill]] as a result of GET and has not improved since
* [[Mark Vink]], a former marathon runner, GP, and Dutch national hockey captain with [[severe and very severe ME#verysevere|very severe ME]], who published a study demonstrating his body responded to walking down the hall to the toilet in a similar way to elite athletes in competition<br style="clear:both">

==NICE's 2019 patient survey ==
An independent patient survey of UK patients was comissioned by [[NICE]] in 2019, as part of the [[NHS]] guideline review process.<ref name="OxBrookesSummary">{{Cite web | url= https://meassociation.org.uk/wp-content/uploads/NICE-Patient-Survey-Outcomes-CBT-and-GET-Executive-Summary-from-Forward-ME-03.04.19.pdf | type=pdf | date = 2019-04-03 | title = Forward-ME Executive Summary|website=ME Association | last = Forward-ME | authorlink = Forward-ME}}</ref>

{| class="wikitable"
! colspan="4" class="center" | Effects of GET on ME/CFS
|-
!
! improved
! no change
! worsened
|-
| physical health
| 13%
| 12%
| 67%
|-
| mental health
| 13%
| 26%
| 53%
|}

{| class="wikitable"
|-
! colspan="3" class="center" |ME/CFS symptoms after GET
|-
!
!yes
!no
|-
| one of more symptoms worsened because of GET
|81%
|13%
|-
| new symptom(s) developed because of GET
| 37%
|
|}

{| class="wikitable"
|-
! colspan="3" class="center" |Patient had severe ME/CFS
|-
| before treatment
|13%
|-
| after treatment
| 35%
|-
|}

== Articles explaining GET not appropriate for ME/CFS ==
* 2005, [http://stonebird.co.uk/GET.pdf Issues relating to Severe ME And Graded Exercise]<ref>{{Cite web | url=http://stonebird.co.uk/GET.pdf | title=Issues relating to Severe ME And Graded Exercise | last = Crowhurst | first = Greg | authorlink=Greg Crowhurst | date = Sep 3, 2005 | website = Stonebird|archive-url=|archive-date=|access-date=}}</ref>
* 2016, [https://undark.org/article/chronic-fatigue-graded-exercise-pace/ Worse Than the Disease: A popular therapy for chronic fatigue syndrome made many patients worse. Adding insult to injury, research supporting it is now unraveling.]<ref name=":6" />
* 2017, [https://www.buzzfeed.com/camillamaxted/this-is-why-i-quit-exercise-therapy This is why I quit Exercise Therapy]<ref>{{Cite news | url=https://www.buzzfeed.com/camillamaxted/this-is-why-i-quit-exercise-therapy | title = This Is Why I Quit Exercise Therapy | last = Maxted | first = Camilla | date = Aug 6, 2017|work=BuzzFeed|access-date=2018-11-29|archive-url=|archive-date=|language=en|quote=}}</ref>
* 2017, [http://journals.sagepub.com/doi/full/10.1177/1359105317697323 Do graded activity therapies cause harm in chronic fatigue syndrome?]<ref>{{Cite journal | last = Kindlon | first = Tom | date = 2017-03-20 | title = Do graded activity therapies cause harm in chronic fatigue syndrome?| url = http://journals.sagepub.com/doi/full/10.1177/1359105317697323|journal=Journal of Health Psychology|language=en|volume=22|issue=9 | pages = 1146–1154|doi=10.1177/1359105317697323|issn=1359-1053}}</ref>
*2018, [https://repository.uel.ac.uk/download/b9ef0ae9a8494102fe0bfface6eb12d5651bc78be4eda0401b72d1896cb16858/137216/2012_Goudsmit_etal_Pacing.doc Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document]<ref name="Goudsmit2018Pacing">{{Cite journal | last = Goudsmit | first = Ellen M. | authorlink = Ellen Goudsmit | last2 = Nijs | first2 = Jo | authorlink2 = Jo Nijs | last3 = Jason | first3 = Leonard A. | authorlink3 = Leonard Jason | last4 = Wallman | first4 = Karen E. | authorlink4 = | date = 2011-12-19 | title = Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document| url = https://dx.org/10.3109/09638288.2011.635746|journal=Disability and Rehabilitation|volume=34|issue=13 | pages = 1140–1147|doi=10.3109/09638288.2011.635746|issn=0963-8288|pmc=|pmid=|access-date=|quote=|via=}}</ref>
::''Describing graded exercise in comparison with symptom-contingent graded exercise therapy or pacing''
* 2019, [https://blogs.bmj.com/medical-humanities/2019/07/04/why-graded-exercise-therapy-and-cognitive-behaviour-therapy-are-controversial-in-chronic-fatigue-syndrome/ Why Graded Exercise Therapy and Cognitive Behaviour Therapy are Controversial in Chronic Fatigue Syndrome]<ref name="Tack2019">{{Cite web | url=https://blogs.bmj.com/medical-humanities/2019/07/04/why-graded-exercise-therapy-and-cognitive-behaviour-therapy-are-controversial-in-chronic-fatigue-syndrome/ | title = Why Graded Exercise Therapy and Cognitive Behaviour Therapy are Controversial in Chronic Fatigue Syndrome | last = Michiel | first = Tack | authorlink = Michiel Tack | date = Jul 4, 2019 | website = BMJ Medical Humanities Blog|language=en-US|archive-url=|archive-date=|access-date=2019-07-09}}</ref>

==Criticism==
*2008, [https://meassociation.org.uk/2008/05/mea-position-on-graded-exercise-therapy-get/ ME Association position on graded exercise therapy (GET)]<ref name="MEA2007">{{Cite web | url=https://meassociation.org.uk/2008/05/mea-position-on-graded-exercise-therapy-get/ | title = ME Association position on graded exercise therapy (GET) | last = The ME Association | first = | authorlink = ME Association | date = 2008-05-11 | website = ME Association|language=en-GB|archive-url=|archive-date=|access-date=2020-09-19}}</ref> - [[ME Association]]
*2010, At the [[Invest in ME International ME Conference]] Doctor [[Paul Cheney]] said "The whole idea that you can take a disease like this and exercise your way to health is foolishness. It is insane".<ref>{{Cite news | url=https://paradigmchange.me/me/exercise-quotes/ | title = Quotes About Exercise Intolerance from M.E. Experts|work=Myalgic Encephalomyelitis|access-date=2018-10-13|language=en-US}}</ref>
*2011, [http://iacfsme.org/PDFS/Reporting-of-Harms-Associated-with-GET-and-CBT-in.aspx Reporting of Harms Associated with Graded Exercise Therapy and Cognitive Behavioural Therapy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]<ref name=":2">{{Cite web | url=http://iacfsme.org/PDFS/Reporting-of-Harms-Associated-with-GET-and-CBT-in.aspx | title = Bulletin of the IACFS/ME 59 Reporting of Harms Associated with Graded Exercise Therapy and Cognitive Behavioural Therapy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | last = Kindlon | first = Tom | authorlink = Tom Kindlon | date = |website=IACFSME|archive-url=|archive-date=|access-date=}}</ref>
*2011, Health-related quality of life in patients with chronic fatigue syndrome: group [[Cognitive behavioral therapy|cognitive behavioural therapy]] and graded exercise versus usual treatment. A randomised controlled trial with 1 year of follow-up<ref>{{Cite journal | last = Núñez | first = Montserrat | authorlink = Montserrat Núñez | last2 = Fernández-Solà | first2 = Joaquim | authorlink2 = | last3 = Nuñez | first3 = Esther | authorlink3 = | last4 = Fernández-Huerta | first4 = José-Manuel | authorlink4 = | last5 = Godás-Sieso | first5 = Teresa | authorlink5 = | last6 = Gomez-Gil | first6 = Esther | authorlink6 = | date = Mar 2011 | title = Health-related quality of life in patients with chronic fatigue syndrome: group cognitive behavioural therapy and graded exercise versus usual treatment. A randomised controlled trial with 1 year of follow-up | url =http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.467.4965&rep=rep1&type=pdf|journal=Clinical Rheumatology|volume=30|issue=3 | pages = 381–389|doi=10.1007/s10067-010-1677-y|issn=1434-9949|pmid=21234629|quote=|via=}}</ref> [http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.467.4965&rep=rep1&type=pdf (Full Text)]
*2015, [http://www.meassociation.org.uk/wp-content/uploads/2015-ME-Association-Illness-Management-Report-No-decisions-about-me-without-me-30.05.15.pdf ME/CFS Illness Management Survey Results “No decisions about me without me”]<ref name=":3">{{Cite web | url=http://www.meassociation.org.uk/wp-content/uploads/2015-ME-Association-Illness-Management-Report-No-decisions-about-me-without-me-30.05.15.pdf | title=ME/CFS Illness Management Survey Results - “No decisions about me without me” Part 1 | last = | first = | date = May 2015 | website = meassociation.org|archive-url=|archive-date=|access-date=}}</ref>
*2016, Do graded activity therapies cause harm in chronic fatigue syndrome?<ref>{{Cite journal | last = Kindlon | first = Tom | date = 2017-03-20 | title = Do graded activity therapies cause harm in chronic fatigue syndrome?| url = http://journals.sagepub.com/doi/full/10.1177/1359105317697323|journal=Journal of Health Psychology|language=en|volume=22|issue=9 | pages = 1146–1154|doi=10.1177/1359105317697323|issn=1359-1053|quote= | author-link = Tom Kindlon|via=}}</ref> [https://journals.sagepub.com/doi/full/10.1177/1359105317697323 (Full Text)] - Tom Kindlon
*2016, Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial<ref name=":4">{{Cite journal | last = Wilshire | first = Carolyn | last2 = Kindlon | first2 = Tom | last3 = Matthees | first3 = Alem | last4 = McGrath | first4 = Simon | date = 2016-12-14 | title = Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial| url = http://www.tandfonline.com/doi/full/10.1080/21641846.2017.1259724|journal = Fatigue: Biomedicine, Health & Behavior |language=en|volume=5|issue=1 | pages = 43–56|doi=10.1080/21641846.2017.1259724|issn=2164-1846}}</ref> [http://www.tandfonline.com/doi/full/10.1080/21641846.2017.1259724 (Full Text)]
*2016, [https://undark.org/article/chronic-fatigue-graded-exercise-pace/ Worse Than the Disease: A popular therapy for chronic fatigue syndrome made many patients worse. Adding insult to injury, research supporting it is now unraveling.]<ref name=":6">{{Cite news | url=https://undark.org/article/chronic-fatigue-graded-exercise-pace/ | title = For Chronic Fatigue Syndrome Sufferers, a Dubious Treatment Unravels | last = Tuller | first = David | date = 2016-10-27|work=Undark|access-date=2018-11-27|archive-url=|archive-date=|language=en-US | authorlink = David Tuller}}</ref>
*2017, Bias, misleading information and lack of respect for alternative views have distorted perceptions of [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] and its treatment<ref>{{Cite journal | last1 = Goudsmit | first1 = Ellen M | authorlink1=Ellen Goudsmit | last2 = Howes | first2 = Sandra | authorlink2 = Sandra Howes | title =Bias, misleading information and lack of respect for alternative views have distorted perceptions of myalgic encephalomyelitis/chronic fatigue syndrome and its treatment|journal=J Health Psychol|volume=22|issue=9 | page = 1159-1167 | date = 2017|pmid=|doi=10.1177/1359105317707216}}</ref> [http://journals.sagepub.com/doi/full/10.1177/1359105317707216 (Full Text)]
*2017, [https://www.nytimes.com/2017/03/18/opinion/sunday/getting-it-wrong-on-chronic-fatigue-syndrome.html Getting it wrong on chronic fatigue syndrome]<ref>{{Cite news | url=https://www.nytimes.com/2017/03/18/opinion/sunday/getting-it-wrong-on-chronic-fatigue-syndrome.html | title = Opinion {{!}} Getting It Wrong on Chronic Fatigue Syndrome | last = Rehmeyer | first = Julie | date = 2018-03-18|work=New York Times|access-date=2018-11-27|archive-url=|archive-date=| publisher = New York Times | last2 = Tuller | first2 = David|publication-date=Jul 2018|language=en | authorlink = Julie Rehmeyer | authorlink2 = David Tuller}}</ref>
*2018, Rethinking the treatment of Chronic Fatigue Syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT<ref>{{Cite journal | last = Wilshire | first = Carolyn E. | authorlink = Carolyn Wilshire | last2 = Kindlon | first2 = Tom | authorlink2 = Tom Kindlon | last3 = Courtney | first3 = Robert | authorlink3 = Robert Courtney | last4 = Matthees | first4 = Alem | authorlink4 = Alem Matthees | last5 = Tuller | first5 = David | authorlink5 = David Tuller | last6 = Geraghty | first6 = Keith | authorlink6 = Keith Geraghty | last7 = Levin | first7 = Bruce | authorlink7 = Bruce Levin | date = 2018-03-22 | title = Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT| url = https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-018-0218-3|journal=BMC Psychology|language=en|volume=6|issue=1 | pages = |doi=10.1186/s40359-018-0218-3|issn=2050-7283|pmc=5863477|pmid=29562932|quote=|via=}}</ref> [https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-018-0218-3 (Full Text)]
*2018, Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review<ref name=":5">{{Cite journal | last = Vink | first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Alexandra | authorlink2 = Alexandra Vink-Niese | date = 2018-10-08 | title = Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176540/|journal=Health Psychology Open|volume=5|issue=2 | pages = |doi=10.1177/2055102918805187|issn=2055-1029|pmc=|pmid=30305916|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176540/ (Full Text)]
*2018, [https://healthycontrolblog.wordpress.com/2018/11/29/my-complaint-to-the-cochrane-governing-board-about-the-cochrane-review-of-exercise-for-chronic-fatigue-syndrome/ My complaint to the Cochrane Governing Board about the Cochrane review of Exercise for chronic fatigue syndrome]<ref>{{Cite news | url=https://healthycontrolblog.wordpress.com/2018/11/29/my-complaint-to-the-cochrane-governing-board-about-the-cochrane-review-of-exercise-for-chronic-fatigue-syndrome/ | title = My complaint to the Cochrane Governing Board about the Cochrane review of Exercise for chronic fatigue syndrome | last = Struthers | first = Caroline | date = 2018-11-29|work=Healthy Control|access-date=2018-11-29|archive-url=|archive-date=|language=en-US|quote= | author-link = Caroline Struthers}}</ref> - Caroline Struthers
*2019, [https://www.meassociation.org.uk/2019/04/forward-me-and-oxford-brookes-university-announce-results-of-patient-survey-on-cbt-and-get-in-me-cfs-03-april-2019/ Forward-ME and Oxford Brookes University announce the results of patient survey on CBT and GET in ME/CFS]<ref name="OxBrookesMEA">{{Cite web | url=https://www.meassociation.org.uk/2019/04/forward-me-and-oxford-brookes-university-announce-results-of-patient-survey-on-cbt-and-get-in-me-cfs-03-april-2019 | date = 2019-04-03 | title = Forward-ME and Oxford Brookes University announce the results of patient survey on CBT and GET in ME/CFS|website=ME Association | last = Forward-ME | authorlink = Forward-ME | last2 = Oxford Brookes University|access-date= | first = | first2 = | authorlink2 = |archive-url=|archive-date=}}</ref>- Survey commissioned by NICE to help inform the review of the UK's ME/CFS treatment guidelines
::Survey results showed the effects of GET were:
::*Physical health deteriorated in 67% of ME/CFS patients as a result of GET
::*Physical health improved in 13% of ME/CFS patients as a result of GET
::*One or more symptoms worsened in 81% because of GET, particularly [[pain]] and [[fatigue]]
::*One or more new symptoms developed in 37% because of GET
::*No symptoms worsened for 13% because of GET
::*Mental health deteriorated in 53% of ME/CFS patients as a result of GET
::*Mental health improved in 13% of ME/CFS patients as a result of GET
*2020, [https://meassociation.org.uk/wp-content/uploads/ForwardME-Letter-re-Covid-19-Management-and-Exercise-Caution-27.08.20.pdf Letter re Covid-19 Management and Exercise Caution]<ref name="GETcovidForwardME">{{Cite web | url=https://meassociation.org.uk/wp-content/uploads/ForwardME-Letter-re-Covid-19-Management-and-Exercise-Caution-27.08.20.pdf | date = 2020-08-27 | last = Forward-ME | authorlink = Forward-ME| title = Letter re Covid-19 Management and Exercise Caution}}</ref> - [[Forward-ME]]

==CDC withdrawal of GET treatment ==

July 3, 2017, The [[Centers for Disease Control and Prevention]]'s (CDC) website Chronic Fatigue Syndrome page has been changed to "[[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] (ME/CFS)" and GET and CBT recommendations have been removed.<ref>[http://www.virology.ws/2017/07/10/trial-by-error-the-cdc-drops-cbtget/ Trial By Error: The CDC Drops CBT/GET - Virology Blog]</ref><ref>[https://www.cdc.gov/me-cfs/index.html Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - CDC.gov]</ref>

==StopGET petitions==

A number of different patients and patient charities have created <nowiki>#stopGET</nowiki> petitions to campaign for an end to graded exercise therapy treatment in [[ME/CFS]]:
* Stop GET trials - MEAction<ref>{{Cite news | url=https://my.meaction.net/petitions/stop-graded-exercise-therapy-trials-for-me-cfs | title = STOP GRADED EXERCISE THERAPY TRIALS FOR ME/CFS|work=#MEAction|access-date=2018-10-20|language=en}}</ref>
* Stop harming ME/CFS patients - take CBT/GET out of NICE guidelines NOW. - [[Robin Brown|Dr. Hng's]] [[United Kingdom|UK]] petition to stop GET and CBT
* The NICE guideline for CFS/ME is not fit for purpose and needs a complete revision - a petition the ME Association delivered to Andrew Dillon at NICE
* Suspend all trials of graded exercise therapy in children and adults with ME/CFS - [[UK]] parliament petition (archived)<ref>{{Cite news | url=https://petition.parliament.uk/petitions/166601 | title = Archived Petition: Suspend all trials of graded exercise therapy in children and adults with ME/CFS|work=Petitions - UK Government and Parliament|access-date=2018-10-20|language=en-GB}}</ref>

== GET after COVID-19 ==
Concerns have been raised about the potential harms of graded exercise therapy to patients who have developed fatigue or other symptoms after COVID-19, patients needing rehabilitation after COVID-19, and patients who may develop postviral ME/CFS after COVID-19.<ref name="GETcovidForwardME" />

{{See also|Post-COVID-19 illness||Long COVID|}}

==Notable studies==
*2004, Chronic Fatigue Syndrome: Lack of Association between Pain-Related Fear of Movement and Exercise Capacity and Disability <ref>{{Cite journal | last = Nijs | first = Jo | author-link =Jo Nijs | last2 = Vanherberghen | first2 = Katrien | authorlink2 = Katrien Vanherberghen | last3 = Duquet | first3 = William | authorlink3 = William Duquet | last4 = De Meirleir | first4 = Kenny | authorlink4 = Kenny De Meirleir | date = 2004-08-01 | title = Chronic Fatigue Syndrome: Lack of Association Between Pain-Related Fear of Movement and Exercise Capacity and Disability| url = https://doi.org/10.1093/ptj/84.8.696|journal=Physical Therapy|language=en|volume=84|issue=8 | pages = |doi=10.1093/ptj/84.8.696|issn=1538-6724|quote=These results indicate a lack of correlation between kinesiophobia and exercise capacity, activity limitations, or participation restrictions, at least in patients with CFS who are experiencing widespread muscle or joint pain.|via=}}</ref> [https://academic.oup.com/ptj/article/84/8/696/2857531 (Full Text)]
*2009, A review on cognitive behavorial therapy (CBT) and graded exercise therapy (GET) in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS): CBT/GET is not only ineffective and not evidence-based, but also potentially harmful for many patients with ME/CFS<ref name=":0">{{Cite journal | last = Twisk | first = Frank N.M. | last2 = Maes | first2 = Michael | date = 2009 | title = A review on cognitive behavorial therapy (CBT) and graded exercise therapy (GET) in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS): CBT/GET is not only ineffective and not evidence-based, but also potentially harmful for many patients with ME/CFS| url = https://www.ncbi.nlm.nih.gov/m/pubmed/19855350/|journal=Neuro Endocrinology Letters|volume=30|issue=3 | pages = 284–299|issn=0172-780X|pmid=19855350}}</ref> [https://www.ncbi.nlm.nih.gov/m/pubmed/19855350/ (Abstract)]
*2016, Exercise therapy for chronic fatigue syndrome<ref name=":1">{{Cite journal | last = Larun | first = Lillebeth | last2 = Brurberg | first2 = Kjetil G. | last3 = Odgaard‐Jensen | first3 = Jan | last4 = Price | first4 = Jonathan R. | date = 2016 | title=Exercise therapy for chronic fatigue syndrome| url = https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003200.pub5/abstract|journal=Cochrane Database of Systematic Reviews|language=en|issue=6|doi=10.1002/14651858.CD003200.pub5|issn=1465-1858}}</ref> [https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003200.pub5/abstract (Full Text)]
*2016, Neurocognitive improvements after best-practice intervention for chronic fatigue syndrome: Preliminary evidence of divergence between objective indices and subjective perceptions.<ref>{{Cite journal | last = Cvejic | first = Erin | last2 = Lloyd | first2 = Andrew R. | last3 = Vollmer-Conna | first3 = Uté | date = 2016 | title=Neurocognitive improvements after best-practice intervention for chronic fatigue syndrome: Preliminary evidence of divergence between objective indices and subjective perceptions| url = https://www.ncbi.nlm.nih.gov/pubmed/26995250|journal=Comprehensive Psychiatry|volume=66 | pages = 166–175|doi=10.1016/j.comppsych.2016.02.002|issn=1532-8384|pmid=26995250|via=}}</ref> [[pubmed:26995250|(Abstract)]]
*2017, PACE investigators' response is misleading regarding patient survey results<ref>{{Cite journal | last = Kirke | first = Karen D | authorlink = | date = 2017-05-11 | title = PACE investigators’ response is misleading regarding patient survey results| url = https://doi.org/10.1177/1359105317703787|journal=Journal of Health Psychology|language=en|volume=22|issue=9 | pages = 1168–1176|doi=10.1177/1359105317703787|issn=1359-1053|quote=|via=}}</ref> [https://doi.org/10.1177%2F1359105317703787 (Full Text)]
*2018, Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT <ref>{{Cite journal | last = Wilshire | first = Carolyn E. | authorlink = Carolyn Wilshire | last2 = Kindlon | first2 = Tom | authorlink2 = Tom Kindlon | last3 = Courtney | first3 = Robert | authorlink3 = Robert Courtney | last4 = Matthees | first4 = Alem | authorlink4 = Alem Matthees | last5 = Tuller | first5 = David | authorlink5 = David Tuller | last6 = Geraghty | first6 = Keith | authorlink6 = Keith Geraghty | last7 = Levin | first7 = Bruce | authorlink7 = | date = 2018-03-22 | title = Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT| url = https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-018-0218-3|journal=BMC Psychology|language=en|volume=6|issue=1 | pages = |doi=10.1186/s40359-018-0218-3|issn=2050-7283|quote=|via=}}</ref> [https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-018-0218-3 (Full Text)]

* 2019, Evaluation of a survey exploring the experiences of adults and children with ME/CFS who have participated in CBT and GET interventional programmes. FINAL REPORT<ref name="OxfordBrookesSurvey">{{Cite web | url = https://www.meassociation.org.uk/wp-content/uploads/NICE-Patient-Survey-Outcomes-CBT-and-GET-Final-Consolidated-Report-03.04.19.pdf | title =Evaluation of a survey exploring the experiences of adults and children with ME/CFS who have participated in CBT and GET interventional programmes. FINAL REPORT | last = Oxford Clinical Allied Technology and Trials Services Unit (OxCATTS)|location=Oxford Brookes University | date = Feb 27, 2019}}</ref> [https://www.meassociation.org.uk/wp-content/uploads/NICE-Patient-Survey-Outcomes-CBT-and-GET-Final-Consolidated-Report-03.04.19.pdf (Full text)]

==Learn more==
*[https://blogs.plos.org/absolutely-maybe/2019/02/08/consumer-contested-evidence-why-the-me-cfs-exercise-dispute-matters-so-much/ Consumer contested evidence: Why the ME/CFS exercise dispute matters so much] - [[Hilda Bastian]], 2019
* [http://anilvanderzee.com/for-patients-with-cfs-going-to-the-bathroom-is-similar-to-running-a-marathon/ For patients with CFS, going to the bathroom is similar to running a marathon.] - Anil van der Zee
* [https://www.buzzfeed.com/camillamaxted/this-is-why-i-quit-exercise-therapy This is why I quit Exercise Therapy] - Camilla Maxted, Buzzfeed
*[https://www.nhsinform.scot/illnesses-and-conditions/brain-nerves-and-spinal-cord/chronic-fatigue-syndrome-cfs Chronic fatigue syndrome - GET, CBT and Counselling] - NHS Scotland (2020)

==See also==
*[[Biopsychosocial model|Biopsychosocial model]]
*[[Cognitive behavioral therapy]]
*[[Deconditioning]]
*[[Exercise]]
*[[Illness beliefs]]
*[[Intimidation and bullying of PACE trial critics]]
*[[PACE trial]]
*[[Post-exertional malaise]]
*[[Strength Training]]

==References==
{{Reflist}}

[[Category:Exercise treatments]]
[[Category:Psychological paradigm]]
[[Category:Potential treatments]]
[[Category:Psychological and behavioral therapies]]

Colin Tait

2025-07-22T14:28:31Z

DarthNZ:Details of my Research Added.

Colin Tait (Darth Vader), Nelson, New Zealand. BE Mech(1982), 1st Class Honours, Cant, NZ.

Discovered 2007 that CFS/Long Covid is Chronic Human Hibernation. Has developed 2 Effective Treatments for CFS/LC late 2005 to June 2025, mainly High Dose, 6 Month, Vitamin D Pulse Therapy.

==Online Presence==

*Website     : [https://WikiSite.info/Cfs/Main_Page WikiSite.info/Cfs/Main_Page]
* LinkedIn   : [https://www.linkedin.com/in/colin-tait-239a5528a linkedin.com/in/colin-tait-239a5528a]
*Facebook : [https://www.facebook.com/darth.vader.822072 facebook.com/darth.vader.822072] (Auckland, NZ).

*Email        : DarthVaderNZ02@gmail.com

==See also==
*[[New Zealand]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

Colin Tait

2025-07-22T14:19:14Z

DarthNZ:Blank Lines Removed. Spaces Added.

Colin Tait (Darth Vader), Nelson, New Zealand. BE Mech(1982), 1st Class Honours, Cant, NZ. Hopefully more Content on the way, especially a summary of my Research (DarthNZ 15:00 B22 Jul 2025 (UTC)).

==Online Presence==

*Website     : [https://WikiSite.info/Cfs/Main_Page WikiSite.info/Cfs/Main_Page]
* LinkedIn   : [https://www.linkedin.com/in/colin-tait-239a5528a linkedin.com/in/colin-tait-239a5528a]
*Facebook : [https://www.facebook.com/darth.vader.822072 facebook.com/darth.vader.822072] (Auckland, NZ).

*Email        : DarthVaderNZ02@gmail.com

==See also==
*[[New Zealand]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

Colin Tait

2025-07-22T14:15:49Z

DarthNZ:Content Added.

Colin Tait (Darth Vader), Nelson, New Zealand. BE Mech(1982), 1st Class Honours, Cant, NZ. Hopefully more Content on the way, especially a summary of my Research (DarthNZ 15:00 B22 Jul 2025 (UTC)).

==Online Presence==

*Website : [https://WikiSite.info/Cfs/Main_Page WikiSite.info/Cfs/Main_Page]
* LinkedIn   : [https://www.linkedin.com/in/colin-tait-239a5528a linkedin.com/in/colin-tait-239a5528a]
*Facebook : [https://www.facebook.com/darth.vader.822072 facebook.com/darth.vader.822072] (Auckland, NZ).

*Email : DarthVaderNZ02@gmail.com

==See also==
*[[New Zealand]]

[[Category:Researchers]]
[[Category:New Zealand researchers]]

Colin Tait

2025-07-22T14:01:49Z

DarthNZ:Page Created. Link Test.

[https://www.facebook.com/darth.vader.822072 facebook.com/darth.vader.822072]

Rosamund Vallings

2025-07-22T12:52:50Z

DarthNZ:Blank deleted.

[[File:Rosamund Vallings.png |thumb|right|Source:www.stuff.co.nz]]
'''Rosamund Vallings''', MD, MNZM, MB, BS, is one of [[New Zealand]]’s leading authorities on Chronic Fatigue Syndrome. She served voluntarily for over 27 years as President of the [[Associated New Zealand ME Society]] (ANZMES) and later as Medical Adviser and Committee Member.<ref>http://www.howickhealth.co.nz/CFS.aspx</ref><ref>{{Cite web|url=http://www.drvallings.co.nz/about-ros.html| title = Dr. Rosamund Vallings|website=drvallings.co.nz|access-date=2020-04-28}}</ref>Retired from Clinical Practice at the end of Jan 2022. <ref> [https://www.howickhealth.co.nz/blog/post/142022/doctors--update/ https://www.howickhealth.co.nz/blog/post/142022/doctors--update/] </ref>

She is one of the authors of the 2011 case definition, [[International Consensus Criteria]]<ref>{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> and the 2017 Pediatric Primer for Physicians.<ref name="Rowe2017"/>

==Awards==
*2008, Member of the New Zealand Order of Merit in the New Year honours list (MNZM)<ref>{{Cite web|url=https://dpmc.govt.nz/publications/new-year-honours-list-2008| title = New Year Honours List 2008 | website = Department of the Prime Minister and Cabinet (DPMC)|access-date=2020-04-28}}</ref>
*2011, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]]<ref>{{Cite web|url=http://www.scoop.co.nz/stories/GE1611/S00077/dr-vallings-winning-nelson-gantz-clinicians-award.htm| title = Dr Vallings winning Nelson Gantz Clinicians Award | last = | first = | author-link =| date = Nov 17, 2016 | website = Scoop News|archive-url=|archive-date=|url-status=|access-date=2019-07-22 }}</ref><ref>{{Cite web|url=https://www.iacfsme.org/iacfs-me-awardees| title = IACFS/ME Awardees|website=
IACFS/ME|access-date=2020-04-23}}</ref>
*2019, Finalist for the Metlifecare Senior New Zealander of the Year<ref>{{Cite web|url=https://nzawards.org.nz/news/2019-new-zealander-year-awards-finalists-confirmed/| title = 2019 New Zealander of the Year Awards finalists confirmed|website=nzawards.org.nz|access-date=2020-04-28}}</ref>

==Committees and boards==

===International Consensus Criteria===
Dr. Vallings was one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref>

===IACFS/ME Primer (2014)===
Dr Vallings was one of the authors of the 2014 [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|IACFSME]] Primer for Clinical Practitioners.<ref name="Primer2014">{{Citation | date = 2014 |url=https://www.massmecfs.org/images/pdf/Primer_2014.pdf| title = Chronic Fatigue Syndrome Myalgic Encephalomyelitis Primer for Clinical Practitioners | last1 = ((International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis)) | author-link = International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | last2 = Friedberg | first2 = Fred | authorlink2 = Fred Friedberg | last3 = Bateman | first3 = Lucinda | authorlink3 = Lucinda Bateman | last4 = Bested | first4 = Alison C | authorlink4 = Alison Bested | last5 = Davenport | first5 = Todd | authorlink5 = Todd Davenport | last6 = Friedman | first6 = Kenneth J | authorlink6 = Kenneth Friedman | last7 = Gurwitt | first7 = Alan R | authorlink7 = Alan Gurwitt | last8 = Jason | first8 = Leonard A | authorlink8 = Leonard Jason | last9 = Lapp | first9 = Charles W | authorlink9 = Charles Lapp | last10 = Stevens | first10 = Staci R | authorlink10 = Staci Stevens | last11 = Underhill | first11 = Rosemary A | authorlink11 = Rosemary Underhill | last12 = Vallings | first12 = Rosamund | authorlink12 = Rosamund Vallings|location=Chicago, USA|publisher= International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis}}</ref>
===Pediatric Primer (2017)===
Dr. Vallings was one of the authors of the 2017 Pediatric Primer for Physicians published in ''Frontiers in Pediatrics.''
* ''Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer'' by [[Peter C. Rowe|Peter Rowe]], [[Rosemary Underhill|Rosemary A. Underhill]], [[Kenneth Friedman|Kenneth J. Friedman]], [[Alan Gurwitt]], [[Marvin Medow|Marvin S. Medow]], [[Malcolm Schwartz|Malcolm S. Schwartz]], [[Nigel Speight]], [[Julian Stewart|Julian M. Stewart]], Rosamund Vallings and [[Katherine Rowe|Katherine S. Rowe]]<ref name="Rowe2017">{{Citation | last1 = Rowe | first1 = Peter C. | authorlink = Peter Rowe | last2 = Underhill | first2 = Rosemary A. | authorlink2 = Rosemary Underhill | last3 = Friedman | first3 = Kenneth J. | authorlink3 = Kenneth Friedman | last4 = Gurwitt | first4 = Alan | authorlink4 = Alan Gurwitt | last5 = Medow | first5 = Marvin S. | authorlink5 = Marvin Medow | last6 = Schwartz | first6 = Malcolm S. | authorlink6 = Malcolm Schwartz | last7 = Speight | first7 = Nigel | authorlink7 = Nigel Speight | last8 = Stewart | first8 = Julian M. | authorlink8 = Julian Stewart | last9 = Vallings | first9 = Rosamund | authorlink9=Rosamund Vallings | last10 = Rowe | first10 = Katherine S. | authorlink10=Katherine Rowe| title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer|journal=Frontiers in Pediatrics|volume=5|issue=|pages=121 | date =2017|pmid= |doi= 10.3389/fped.2017.00121}}</ref> - [http://journal.frontiersin.org/article/10.3389/fped.2017.00121/full (Full Text)]

==Advocacy==
===Open Letter to ''The Lancet''===

In response to ''The Lancet''<nowiki/>'s publication of the controversial [[PACE trial]] in 2011, three [[open letter to the Lancet |open letters to the editor of ''The Lancet'']] urged the [[Richard Horton|editor, Richard Horton,]] to commission a fully independent review of the [[PACE trial]]. In 2016, Dr. Vallings, along with 41 colleagues in the [[ME/CFS]] field, signed the second letter. In 2018, Dr. Vallings, along with over 100 colleagues signed a third letter.
*February 10, 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog]
*July 9, 2018, [http://www.virology.ws/2018/07/10/trial-by-error-yet-another-appeal-to-the-lancet-with-more-on-board/ Trial By Error: Yet Another Appeal to The Lancet, With More On Board]

==Articles==
*2004, AACFS 7th International Conference - Conference Reports<ref>{{Cite journal | last = Vallings | first = Rosamund | date = Jan 2004| title = AACFS 7th International Conference|url=http://www.tandfonline.com/doi/full/10.1300/J092v12n04_06|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=12|issue=4 | pages = 61–79|doi=10.1300/J092v12n04_06|issn=1057-3321|quote=|via=}}</ref>
*2004, Hypnosis in the Management of Chronic Fatigue Syndrome<ref>{{Cite journal | last = Vallings | first = Rosamund | date = Jan 2004| title = Hypnosis in the Management of Chronic Fatigue Syndrome|url=http://www.tandfonline.com/doi/full/10.1300/J092v12n04_04|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=12|issue=4|pages=37–46|doi=10.1300/J092v12n04_04|issn=1057-3321|quote=|via=}}</ref>
*2015 [http://anzmes.org.nz/wp-content/uploads/2015/06/10th-Invest-in-ME-International-ME-Conference-Ros-Vallings.pdf Invest in ME Conference Report, by Dr. Rosamund Vallings]
*2016, [http://anzmes.org.nz/wp-content/uploads/2016/06/Invest-in-ME-Conf-2016-by-ROS-Letterhead-1.pdf Invest in ME C11 2016 Conference Report, by Dr. Rosamund Vallings]
*2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Tate2019">{{Cite journal | last = Tate | first = Warren | authorlink = Warren Tate | last2 = Ryan | first2 = Margaret | authorlink2 = Margaret Ryan | last3 = Vallings | first3 = Rosamund | author-link3 = Rosamund Vallings | last4 = Helliwell | first4 = Amber | author-link4 = Amber Helliwell| last5 = Mackay | first5 = Angus | authorlink5 = Angus Mackay | last6 = Edgar | first6 = Christina | authorlink6 = Christina Edgar | last7 = Noble | first7 = Alex | authorlink7 = Alex Noble | last8 = Sweetman | first8 = Eiren | authorlink8 = Eiren Sweetman | date = Jul 2019| title = Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.mdpi.com/2075-4418/9/3/73|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 73|doi=10.3390/diagnostics9030073|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/3/73 (Full text)]

==Talks and interviews==
* 2010, [https://www.youtube.com/watch?v=02d6II-lmSE Dr Ros Vallings on ME/CFS and XMRV]
* 2013, [https://vimeo.com/89223289 Presentation by Dr Ros Vallings at seminar held by Emerge Australia (formerly ME/CFS Australia (Victoria))]
* 2013, [https://www.youtube.com/watch?v=ez9Gx5qdf58 Dr Ros Vallings talks about M.E. and feelings of isolation]
* 2014, [https://www.youtube.com/watch?v=H9ZqGKxNpB8 CFS/ME lecture | Dr Ros Vallings | Sep-2014]

==Books==
*2013, [[Chronic Fatigue Syndrome M.E.: Symptoms, Diagnosis, Management]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2013 | title = Chronic Fatigue Syndrome M.E.: Symptoms, Diagnosis, Management | publisher =Calico Publishing Ltd | asin = B00DVX59DQ}}</ref>
*2015, [[Managing ME/CFS: A guide for young people]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2015 | title = Managing ME/CFS: A guide for young people | publisher = Calico Publishing | asin = B0118NVEBG}}</ref>
*2017, [[The Pocket Guide to Chronic Fatigue Syndrome/ME: Key Facts and Tips for Improved Health]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2015 | title = The Pocket Guide to Chronic Fatigue Syndrome/ME | publisher =Calico Publishing Ltd | isbn = 9781877429231}}</ref>

== Research studies ==
* 2019, Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome<ref>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Ryan | first2 = Margaret | authorlink2 = Margaret Ryan | last3 = Edgar | first3 = Christina | authorlink3 = Christina Edgar | last4 = Mackay | first4 = Angus | authorlink4 = Angus Mackay | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | authorlink6 = Warren Tate | date = Jan 2019| title = Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome|url=https://journals.sagepub.com/doi/abs/10.1177/2058738418820402|journal=International Journal of Immunopathology and Pharmacology|volume=33|issue=|pages=|doi=10.1177/2058738418820402|quote=|via=}}</ref> - [https://journals.sagepub.com/doi/10.1177/2058738418820402 (Full text)]
* 2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Noble | first2 = Alex | authorlink2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = Mackay | first4 = Angus | authorlink4 = Angus Mackay| last5 = Helliwell | first5 = Amber | author-link5 = Amber Helliwell | last6 = Vallings | first6 = Rosamund | authorlink6 = Rosamund Vallings | last7 = Ryan | first7 = Margaret | authorlink7 = | last8 = Tate | first8 = Warren | authorlink8 = Warren Tate | date = 2019-07-10| title = Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.mdpi.com/2075-4418/9/3/73|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 73|doi=10.3390/diagnostics9030073|issn=2075-4418|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/3/73/htm (Full text)]
*2020, A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction<ref name=Sweetman2020>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Kleffmann | first2 = Torsten | author-link2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = de Lange | first4 = Michel | authorlink4 = | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | authorlink6 = Warren Tate | date = 2020-09-24| title = A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction|url=https://doi.org/10.1186/s12967-020-02533-3|journal=Journal of Translational Medicine|volume=18|issue=1|pages=365|doi=10.1186/s12967-020-02533-3|issn=1479-5876|pmc = 7512220|pmid=|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02533-3 (Full text)]

==Learn more==
*Nov 20, 2016, [http://www.times.co.nz/front-page-feature/doctor-wins-international-award.html ''Doctor wins international award'' in Times Live New Zealand]

==See also==
*[[Associated New Zealand ME Society]]
*[[Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer]]
*[[New Zealand]]
*[[Richie Barnett]]

==References==
{{reflist}}
[[Category:Clinicians]]
[[Category:New Zealand clinicians]]
[[Category:Authors]]
[[Category:Psychological paradigm critics]]
[[Category:PACE trial critics]]

Rosamund Vallings

2025-07-22T11:31:42Z

DarthNZ:ref improved.

Rosamund Vallings

2025-07-22T11:30:28Z

DarthNZ:ref improved.

[[File:Rosamund Vallings.png |thumb|right|Source:www.stuff.co.nz]]
'''Rosamund Vallings''', MD, MNZM, MB, BS, is one of [[New Zealand]]’s leading authorities on Chronic Fatigue Syndrome. She served voluntarily for over 27 years as President of the [[Associated New Zealand ME Society]] (ANZMES) and later as Medical Adviser and Committee Member.<ref>http://www.howickhealth.co.nz/CFS.aspx</ref><ref>{{Cite web|url=http://www.drvallings.co.nz/about-ros.html| title = Dr. Rosamund Vallings|website=drvallings.co.nz|access-date=2020-04-28}}</ref>Retired from Clinical Practice at the end of Jan 2022. <ref> [https://www.howickhealth.co.nz/blog/post/142022/doctors--update/ |https://www.howickhealth.co.nz/blog/post/142022/doctors--update/] </ref>

She is one of the authors of the 2011 case definition, [[International Consensus Criteria]]<ref>{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> and the 2017 Pediatric Primer for Physicians.<ref name="Rowe2017"/>

==Awards==
*2008, Member of the New Zealand Order of Merit in the New Year honours list (MNZM)<ref>{{Cite web|url=https://dpmc.govt.nz/publications/new-year-honours-list-2008| title = New Year Honours List 2008 | website = Department of the Prime Minister and Cabinet (DPMC)|access-date=2020-04-28}}</ref>
*2011, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]]<ref>{{Cite web|url=http://www.scoop.co.nz/stories/GE1611/S00077/dr-vallings-winning-nelson-gantz-clinicians-award.htm| title = Dr Vallings winning Nelson Gantz Clinicians Award | last = | first = | author-link =| date = Nov 17, 2016 | website = Scoop News|archive-url=|archive-date=|url-status=|access-date=2019-07-22 }}</ref><ref>{{Cite web|url=https://www.iacfsme.org/iacfs-me-awardees| title = IACFS/ME Awardees|website=
IACFS/ME|access-date=2020-04-23}}</ref>
*2019, Finalist for the Metlifecare Senior New Zealander of the Year<ref>{{Cite web|url=https://nzawards.org.nz/news/2019-new-zealander-year-awards-finalists-confirmed/| title = 2019 New Zealander of the Year Awards finalists confirmed|website=nzawards.org.nz|access-date=2020-04-28}}</ref>

==Committees and boards==

===International Consensus Criteria===
Dr. Vallings was one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref>

===IACFS/ME Primer (2014)===
Dr Vallings was one of the authors of the 2014 [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|IACFSME]] Primer for Clinical Practitioners.<ref name="Primer2014">{{Citation | date = 2014 |url=https://www.massmecfs.org/images/pdf/Primer_2014.pdf| title = Chronic Fatigue Syndrome Myalgic Encephalomyelitis Primer for Clinical Practitioners | last1 = ((International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis)) | author-link = International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | last2 = Friedberg | first2 = Fred | authorlink2 = Fred Friedberg | last3 = Bateman | first3 = Lucinda | authorlink3 = Lucinda Bateman | last4 = Bested | first4 = Alison C | authorlink4 = Alison Bested | last5 = Davenport | first5 = Todd | authorlink5 = Todd Davenport | last6 = Friedman | first6 = Kenneth J | authorlink6 = Kenneth Friedman | last7 = Gurwitt | first7 = Alan R | authorlink7 = Alan Gurwitt | last8 = Jason | first8 = Leonard A | authorlink8 = Leonard Jason | last9 = Lapp | first9 = Charles W | authorlink9 = Charles Lapp | last10 = Stevens | first10 = Staci R | authorlink10 = Staci Stevens | last11 = Underhill | first11 = Rosemary A | authorlink11 = Rosemary Underhill | last12 = Vallings | first12 = Rosamund | authorlink12 = Rosamund Vallings|location=Chicago, USA|publisher= International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis}}</ref>
===Pediatric Primer (2017)===
Dr. Vallings was one of the authors of the 2017 Pediatric Primer for Physicians published in ''Frontiers in Pediatrics.''
* ''Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer'' by [[Peter C. Rowe|Peter Rowe]], [[Rosemary Underhill|Rosemary A. Underhill]], [[Kenneth Friedman|Kenneth J. Friedman]], [[Alan Gurwitt]], [[Marvin Medow|Marvin S. Medow]], [[Malcolm Schwartz|Malcolm S. Schwartz]], [[Nigel Speight]], [[Julian Stewart|Julian M. Stewart]], Rosamund Vallings and [[Katherine Rowe|Katherine S. Rowe]]<ref name="Rowe2017">{{Citation | last1 = Rowe | first1 = Peter C. | authorlink = Peter Rowe | last2 = Underhill | first2 = Rosemary A. | authorlink2 = Rosemary Underhill | last3 = Friedman | first3 = Kenneth J. | authorlink3 = Kenneth Friedman | last4 = Gurwitt | first4 = Alan | authorlink4 = Alan Gurwitt | last5 = Medow | first5 = Marvin S. | authorlink5 = Marvin Medow | last6 = Schwartz | first6 = Malcolm S. | authorlink6 = Malcolm Schwartz | last7 = Speight | first7 = Nigel | authorlink7 = Nigel Speight | last8 = Stewart | first8 = Julian M. | authorlink8 = Julian Stewart | last9 = Vallings | first9 = Rosamund | authorlink9=Rosamund Vallings | last10 = Rowe | first10 = Katherine S. | authorlink10=Katherine Rowe| title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer|journal=Frontiers in Pediatrics|volume=5|issue=|pages=121 | date =2017|pmid= |doi= 10.3389/fped.2017.00121}}</ref> - [http://journal.frontiersin.org/article/10.3389/fped.2017.00121/full (Full Text)]

==Advocacy==
===Open Letter to ''The Lancet''===

In response to ''The Lancet''<nowiki/>'s publication of the controversial [[PACE trial]] in 2011, three [[open letter to the Lancet |open letters to the editor of ''The Lancet'']] urged the [[Richard Horton|editor, Richard Horton,]] to commission a fully independent review of the [[PACE trial]]. In 2016, Dr. Vallings, along with 41 colleagues in the [[ME/CFS]] field, signed the second letter. In 2018, Dr. Vallings, along with over 100 colleagues signed a third letter.
*February 10, 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog]
*July 9, 2018, [http://www.virology.ws/2018/07/10/trial-by-error-yet-another-appeal-to-the-lancet-with-more-on-board/ Trial By Error: Yet Another Appeal to The Lancet, With More On Board]

==Articles==
*2004, AACFS 7th International Conference - Conference Reports<ref>{{Cite journal | last = Vallings | first = Rosamund | date = Jan 2004| title = AACFS 7th International Conference|url=http://www.tandfonline.com/doi/full/10.1300/J092v12n04_06|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=12|issue=4 | pages = 61–79|doi=10.1300/J092v12n04_06|issn=1057-3321|quote=|via=}}</ref>
*2004, Hypnosis in the Management of Chronic Fatigue Syndrome<ref>{{Cite journal | last = Vallings | first = Rosamund | date = Jan 2004| title = Hypnosis in the Management of Chronic Fatigue Syndrome|url=http://www.tandfonline.com/doi/full/10.1300/J092v12n04_04|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=12|issue=4|pages=37–46|doi=10.1300/J092v12n04_04|issn=1057-3321|quote=|via=}}</ref>
*2015 [http://anzmes.org.nz/wp-content/uploads/2015/06/10th-Invest-in-ME-International-ME-Conference-Ros-Vallings.pdf Invest in ME Conference Report, by Dr. Rosamund Vallings]
*2016, [http://anzmes.org.nz/wp-content/uploads/2016/06/Invest-in-ME-Conf-2016-by-ROS-Letterhead-1.pdf Invest in ME C11 2016 Conference Report, by Dr. Rosamund Vallings]
*2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Tate2019">{{Cite journal | last = Tate | first = Warren | authorlink = Warren Tate | last2 = Ryan | first2 = Margaret | authorlink2 = Margaret Ryan | last3 = Vallings | first3 = Rosamund | author-link3 = Rosamund Vallings | last4 = Helliwell | first4 = Amber | author-link4 = Amber Helliwell| last5 = Mackay | first5 = Angus | authorlink5 = Angus Mackay | last6 = Edgar | first6 = Christina | authorlink6 = Christina Edgar | last7 = Noble | first7 = Alex | authorlink7 = Alex Noble | last8 = Sweetman | first8 = Eiren | authorlink8 = Eiren Sweetman | date = Jul 2019| title = Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.mdpi.com/2075-4418/9/3/73|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 73|doi=10.3390/diagnostics9030073|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/3/73 (Full text)]

==Talks and interviews==
* 2010, [https://www.youtube.com/watch?v=02d6II-lmSE Dr Ros Vallings on ME/CFS and XMRV]
* 2013, [https://vimeo.com/89223289 Presentation by Dr Ros Vallings at seminar held by Emerge Australia (formerly ME/CFS Australia (Victoria))]
* 2013, [https://www.youtube.com/watch?v=ez9Gx5qdf58 Dr Ros Vallings talks about M.E. and feelings of isolation]
* 2014, [https://www.youtube.com/watch?v=H9ZqGKxNpB8 CFS/ME lecture | Dr Ros Vallings | Sep-2014]

==Books==
*2013, [[Chronic Fatigue Syndrome M.E.: Symptoms, Diagnosis, Management]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2013 | title = Chronic Fatigue Syndrome M.E.: Symptoms, Diagnosis, Management | publisher =Calico Publishing Ltd | asin = B00DVX59DQ}}</ref>
*2015, [[Managing ME/CFS: A guide for young people]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2015 | title = Managing ME/CFS: A guide for young people | publisher = Calico Publishing | asin = B0118NVEBG}}</ref>
*2017, [[The Pocket Guide to Chronic Fatigue Syndrome/ME: Key Facts and Tips for Improved Health]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2015 | title = The Pocket Guide to Chronic Fatigue Syndrome/ME | publisher =Calico Publishing Ltd | isbn = 9781877429231}}</ref>

== Research studies ==
* 2019, Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome<ref>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Ryan | first2 = Margaret | authorlink2 = Margaret Ryan | last3 = Edgar | first3 = Christina | authorlink3 = Christina Edgar | last4 = Mackay | first4 = Angus | authorlink4 = Angus Mackay | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | authorlink6 = Warren Tate | date = Jan 2019| title = Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome|url=https://journals.sagepub.com/doi/abs/10.1177/2058738418820402|journal=International Journal of Immunopathology and Pharmacology|volume=33|issue=|pages=|doi=10.1177/2058738418820402|quote=|via=}}</ref> - [https://journals.sagepub.com/doi/10.1177/2058738418820402 (Full text)]
* 2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Noble | first2 = Alex | authorlink2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = Mackay | first4 = Angus | authorlink4 = Angus Mackay| last5 = Helliwell | first5 = Amber | author-link5 = Amber Helliwell | last6 = Vallings | first6 = Rosamund | authorlink6 = Rosamund Vallings | last7 = Ryan | first7 = Margaret | authorlink7 = | last8 = Tate | first8 = Warren | authorlink8 = Warren Tate | date = 2019-07-10| title = Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.mdpi.com/2075-4418/9/3/73|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 73|doi=10.3390/diagnostics9030073|issn=2075-4418|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/3/73/htm (Full text)]
*2020, A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction<ref name=Sweetman2020>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Kleffmann | first2 = Torsten | author-link2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = de Lange | first4 = Michel | authorlink4 = | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | authorlink6 = Warren Tate | date = 2020-09-24| title = A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction|url=https://doi.org/10.1186/s12967-020-02533-3|journal=Journal of Translational Medicine|volume=18|issue=1|pages=365|doi=10.1186/s12967-020-02533-3|issn=1479-5876|pmc = 7512220|pmid=|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02533-3 (Full text)]

==Learn more==
*Nov 20, 2016, [http://www.times.co.nz/front-page-feature/doctor-wins-international-award.html ''Doctor wins international award'' in Times Live New Zealand]

==See also==
*[[Associated New Zealand ME Society]]
*[[Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer]]
*[[New Zealand]]
*[[Richie Barnett]]

==References==
{{reflist}}
[[Category:Clinicians]]
[[Category:New Zealand clinicians]]
[[Category:Authors]]
[[Category:Psychological paradigm critics]]
[[Category:PACE trial critics]]

Rosamund Vallings

2025-07-22T11:27:53Z

DarthNZ:Dr Ros Vallings retired. ref.

[[File:Rosamund Vallings.png |thumb|right|Source:www.stuff.co.nz]]
'''Rosamund Vallings''', MD, MNZM, MB, BS, is one of [[New Zealand]]’s leading authorities on Chronic Fatigue Syndrome. She served voluntarily for over 27 years as President of the [[Associated New Zealand ME Society]] (ANZMES) and later as Medical Adviser and Committee Member.<ref>http://www.howickhealth.co.nz/CFS.aspx</ref><ref>{{Cite web|url=http://www.drvallings.co.nz/about-ros.html| title = Dr. Rosamund Vallings|website=drvallings.co.nz|access-date=2020-04-28}}</ref>Retired from Clinical Practice at the end of Jan 2022. <ref> [https://www.howickhealth.co.nz/blog/post/142022/doctors--update/] </ref>

She is one of the authors of the 2011 case definition, [[International Consensus Criteria]]<ref>{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> and the 2017 Pediatric Primer for Physicians.<ref name="Rowe2017"/>

==Awards==
*2008, Member of the New Zealand Order of Merit in the New Year honours list (MNZM)<ref>{{Cite web|url=https://dpmc.govt.nz/publications/new-year-honours-list-2008| title = New Year Honours List 2008 | website = Department of the Prime Minister and Cabinet (DPMC)|access-date=2020-04-28}}</ref>
*2011, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]]<ref>{{Cite web|url=http://www.scoop.co.nz/stories/GE1611/S00077/dr-vallings-winning-nelson-gantz-clinicians-award.htm| title = Dr Vallings winning Nelson Gantz Clinicians Award | last = | first = | author-link =| date = Nov 17, 2016 | website = Scoop News|archive-url=|archive-date=|url-status=|access-date=2019-07-22 }}</ref><ref>{{Cite web|url=https://www.iacfsme.org/iacfs-me-awardees| title = IACFS/ME Awardees|website=
IACFS/ME|access-date=2020-04-23}}</ref>
*2019, Finalist for the Metlifecare Senior New Zealander of the Year<ref>{{Cite web|url=https://nzawards.org.nz/news/2019-new-zealander-year-awards-finalists-confirmed/| title = 2019 New Zealander of the Year Awards finalists confirmed|website=nzawards.org.nz|access-date=2020-04-28}}</ref>

==Committees and boards==

===International Consensus Criteria===
Dr. Vallings was one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref>

===IACFS/ME Primer (2014)===
Dr Vallings was one of the authors of the 2014 [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|IACFSME]] Primer for Clinical Practitioners.<ref name="Primer2014">{{Citation | date = 2014 |url=https://www.massmecfs.org/images/pdf/Primer_2014.pdf| title = Chronic Fatigue Syndrome Myalgic Encephalomyelitis Primer for Clinical Practitioners | last1 = ((International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis)) | author-link = International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | last2 = Friedberg | first2 = Fred | authorlink2 = Fred Friedberg | last3 = Bateman | first3 = Lucinda | authorlink3 = Lucinda Bateman | last4 = Bested | first4 = Alison C | authorlink4 = Alison Bested | last5 = Davenport | first5 = Todd | authorlink5 = Todd Davenport | last6 = Friedman | first6 = Kenneth J | authorlink6 = Kenneth Friedman | last7 = Gurwitt | first7 = Alan R | authorlink7 = Alan Gurwitt | last8 = Jason | first8 = Leonard A | authorlink8 = Leonard Jason | last9 = Lapp | first9 = Charles W | authorlink9 = Charles Lapp | last10 = Stevens | first10 = Staci R | authorlink10 = Staci Stevens | last11 = Underhill | first11 = Rosemary A | authorlink11 = Rosemary Underhill | last12 = Vallings | first12 = Rosamund | authorlink12 = Rosamund Vallings|location=Chicago, USA|publisher= International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis}}</ref>
===Pediatric Primer (2017)===
Dr. Vallings was one of the authors of the 2017 Pediatric Primer for Physicians published in ''Frontiers in Pediatrics.''
* ''Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer'' by [[Peter C. Rowe|Peter Rowe]], [[Rosemary Underhill|Rosemary A. Underhill]], [[Kenneth Friedman|Kenneth J. Friedman]], [[Alan Gurwitt]], [[Marvin Medow|Marvin S. Medow]], [[Malcolm Schwartz|Malcolm S. Schwartz]], [[Nigel Speight]], [[Julian Stewart|Julian M. Stewart]], Rosamund Vallings and [[Katherine Rowe|Katherine S. Rowe]]<ref name="Rowe2017">{{Citation | last1 = Rowe | first1 = Peter C. | authorlink = Peter Rowe | last2 = Underhill | first2 = Rosemary A. | authorlink2 = Rosemary Underhill | last3 = Friedman | first3 = Kenneth J. | authorlink3 = Kenneth Friedman | last4 = Gurwitt | first4 = Alan | authorlink4 = Alan Gurwitt | last5 = Medow | first5 = Marvin S. | authorlink5 = Marvin Medow | last6 = Schwartz | first6 = Malcolm S. | authorlink6 = Malcolm Schwartz | last7 = Speight | first7 = Nigel | authorlink7 = Nigel Speight | last8 = Stewart | first8 = Julian M. | authorlink8 = Julian Stewart | last9 = Vallings | first9 = Rosamund | authorlink9=Rosamund Vallings | last10 = Rowe | first10 = Katherine S. | authorlink10=Katherine Rowe| title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer|journal=Frontiers in Pediatrics|volume=5|issue=|pages=121 | date =2017|pmid= |doi= 10.3389/fped.2017.00121}}</ref> - [http://journal.frontiersin.org/article/10.3389/fped.2017.00121/full (Full Text)]

==Advocacy==
===Open Letter to ''The Lancet''===

In response to ''The Lancet''<nowiki/>'s publication of the controversial [[PACE trial]] in 2011, three [[open letter to the Lancet |open letters to the editor of ''The Lancet'']] urged the [[Richard Horton|editor, Richard Horton,]] to commission a fully independent review of the [[PACE trial]]. In 2016, Dr. Vallings, along with 41 colleagues in the [[ME/CFS]] field, signed the second letter. In 2018, Dr. Vallings, along with over 100 colleagues signed a third letter.
*February 10, 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog]
*July 9, 2018, [http://www.virology.ws/2018/07/10/trial-by-error-yet-another-appeal-to-the-lancet-with-more-on-board/ Trial By Error: Yet Another Appeal to The Lancet, With More On Board]

==Articles==
*2004, AACFS 7th International Conference - Conference Reports<ref>{{Cite journal | last = Vallings | first = Rosamund | date = Jan 2004| title = AACFS 7th International Conference|url=http://www.tandfonline.com/doi/full/10.1300/J092v12n04_06|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=12|issue=4 | pages = 61–79|doi=10.1300/J092v12n04_06|issn=1057-3321|quote=|via=}}</ref>
*2004, Hypnosis in the Management of Chronic Fatigue Syndrome<ref>{{Cite journal | last = Vallings | first = Rosamund | date = Jan 2004| title = Hypnosis in the Management of Chronic Fatigue Syndrome|url=http://www.tandfonline.com/doi/full/10.1300/J092v12n04_04|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=12|issue=4|pages=37–46|doi=10.1300/J092v12n04_04|issn=1057-3321|quote=|via=}}</ref>
*2015 [http://anzmes.org.nz/wp-content/uploads/2015/06/10th-Invest-in-ME-International-ME-Conference-Ros-Vallings.pdf Invest in ME Conference Report, by Dr. Rosamund Vallings]
*2016, [http://anzmes.org.nz/wp-content/uploads/2016/06/Invest-in-ME-Conf-2016-by-ROS-Letterhead-1.pdf Invest in ME C11 2016 Conference Report, by Dr. Rosamund Vallings]
*2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Tate2019">{{Cite journal | last = Tate | first = Warren | authorlink = Warren Tate | last2 = Ryan | first2 = Margaret | authorlink2 = Margaret Ryan | last3 = Vallings | first3 = Rosamund | author-link3 = Rosamund Vallings | last4 = Helliwell | first4 = Amber | author-link4 = Amber Helliwell| last5 = Mackay | first5 = Angus | authorlink5 = Angus Mackay | last6 = Edgar | first6 = Christina | authorlink6 = Christina Edgar | last7 = Noble | first7 = Alex | authorlink7 = Alex Noble | last8 = Sweetman | first8 = Eiren | authorlink8 = Eiren Sweetman | date = Jul 2019| title = Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.mdpi.com/2075-4418/9/3/73|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 73|doi=10.3390/diagnostics9030073|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/3/73 (Full text)]

==Talks and interviews==
* 2010, [https://www.youtube.com/watch?v=02d6II-lmSE Dr Ros Vallings on ME/CFS and XMRV]
* 2013, [https://vimeo.com/89223289 Presentation by Dr Ros Vallings at seminar held by Emerge Australia (formerly ME/CFS Australia (Victoria))]
* 2013, [https://www.youtube.com/watch?v=ez9Gx5qdf58 Dr Ros Vallings talks about M.E. and feelings of isolation]
* 2014, [https://www.youtube.com/watch?v=H9ZqGKxNpB8 CFS/ME lecture | Dr Ros Vallings | Sep-2014]

==Books==
*2013, [[Chronic Fatigue Syndrome M.E.: Symptoms, Diagnosis, Management]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2013 | title = Chronic Fatigue Syndrome M.E.: Symptoms, Diagnosis, Management | publisher =Calico Publishing Ltd | asin = B00DVX59DQ}}</ref>
*2015, [[Managing ME/CFS: A guide for young people]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2015 | title = Managing ME/CFS: A guide for young people | publisher = Calico Publishing | asin = B0118NVEBG}}</ref>
*2017, [[The Pocket Guide to Chronic Fatigue Syndrome/ME: Key Facts and Tips for Improved Health]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2015 | title = The Pocket Guide to Chronic Fatigue Syndrome/ME | publisher =Calico Publishing Ltd | isbn = 9781877429231}}</ref>

== Research studies ==
* 2019, Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome<ref>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Ryan | first2 = Margaret | authorlink2 = Margaret Ryan | last3 = Edgar | first3 = Christina | authorlink3 = Christina Edgar | last4 = Mackay | first4 = Angus | authorlink4 = Angus Mackay | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | authorlink6 = Warren Tate | date = Jan 2019| title = Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome|url=https://journals.sagepub.com/doi/abs/10.1177/2058738418820402|journal=International Journal of Immunopathology and Pharmacology|volume=33|issue=|pages=|doi=10.1177/2058738418820402|quote=|via=}}</ref> - [https://journals.sagepub.com/doi/10.1177/2058738418820402 (Full text)]
* 2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Noble | first2 = Alex | authorlink2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = Mackay | first4 = Angus | authorlink4 = Angus Mackay| last5 = Helliwell | first5 = Amber | author-link5 = Amber Helliwell | last6 = Vallings | first6 = Rosamund | authorlink6 = Rosamund Vallings | last7 = Ryan | first7 = Margaret | authorlink7 = | last8 = Tate | first8 = Warren | authorlink8 = Warren Tate | date = 2019-07-10| title = Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.mdpi.com/2075-4418/9/3/73|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 73|doi=10.3390/diagnostics9030073|issn=2075-4418|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/3/73/htm (Full text)]
*2020, A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction<ref name=Sweetman2020>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Kleffmann | first2 = Torsten | author-link2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = de Lange | first4 = Michel | authorlink4 = | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | authorlink6 = Warren Tate | date = 2020-09-24| title = A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction|url=https://doi.org/10.1186/s12967-020-02533-3|journal=Journal of Translational Medicine|volume=18|issue=1|pages=365|doi=10.1186/s12967-020-02533-3|issn=1479-5876|pmc = 7512220|pmid=|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02533-3 (Full text)]

==Learn more==
*Nov 20, 2016, [http://www.times.co.nz/front-page-feature/doctor-wins-international-award.html ''Doctor wins international award'' in Times Live New Zealand]

==See also==
*[[Associated New Zealand ME Society]]
*[[Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer]]
*[[New Zealand]]
*[[Richie Barnett]]

==References==
{{reflist}}
[[Category:Clinicians]]
[[Category:New Zealand clinicians]]
[[Category:Authors]]
[[Category:Psychological paradigm critics]]
[[Category:PACE trial critics]]

Rosamund Vallings

2025-07-22T11:24:25Z

DarthNZ:Retired from Clinical Practice.

[[File:Rosamund Vallings.png |thumb|right|Source:www.stuff.co.nz]]
'''Rosamund Vallings''', MD, MNZM, MB, BS, is one of [[New Zealand]]’s leading authorities on Chronic Fatigue Syndrome. She served voluntarily for over 27 years as President of the [[Associated New Zealand ME Society]] (ANZMES) and later as Medical Adviser and Committee Member.<ref>http://www.howickhealth.co.nz/CFS.aspx</ref><ref>{{Cite web|url=http://www.drvallings.co.nz/about-ros.html| title = Dr. Rosamund Vallings|website=drvallings.co.nz|access-date=2020-04-28}}</ref>Retired from Clinical Practice at the end of Jan 2022. <ref> </ref>

She is one of the authors of the 2011 case definition, [[International Consensus Criteria]]<ref>{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> and the 2017 Pediatric Primer for Physicians.<ref name="Rowe2017"/>

==Awards==
*2008, Member of the New Zealand Order of Merit in the New Year honours list (MNZM)<ref>{{Cite web|url=https://dpmc.govt.nz/publications/new-year-honours-list-2008| title = New Year Honours List 2008 | website = Department of the Prime Minister and Cabinet (DPMC)|access-date=2020-04-28}}</ref>
*2011, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]]<ref>{{Cite web|url=http://www.scoop.co.nz/stories/GE1611/S00077/dr-vallings-winning-nelson-gantz-clinicians-award.htm| title = Dr Vallings winning Nelson Gantz Clinicians Award | last = | first = | author-link =| date = Nov 17, 2016 | website = Scoop News|archive-url=|archive-date=|url-status=|access-date=2019-07-22 }}</ref><ref>{{Cite web|url=https://www.iacfsme.org/iacfs-me-awardees| title = IACFS/ME Awardees|website=
IACFS/ME|access-date=2020-04-23}}</ref>
*2019, Finalist for the Metlifecare Senior New Zealander of the Year<ref>{{Cite web|url=https://nzawards.org.nz/news/2019-new-zealander-year-awards-finalists-confirmed/| title = 2019 New Zealander of the Year Awards finalists confirmed|website=nzawards.org.nz|access-date=2020-04-28}}</ref>

==Committees and boards==

===International Consensus Criteria===
Dr. Vallings was one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref>

===IACFS/ME Primer (2014)===
Dr Vallings was one of the authors of the 2014 [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|IACFSME]] Primer for Clinical Practitioners.<ref name="Primer2014">{{Citation | date = 2014 |url=https://www.massmecfs.org/images/pdf/Primer_2014.pdf| title = Chronic Fatigue Syndrome Myalgic Encephalomyelitis Primer for Clinical Practitioners | last1 = ((International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis)) | author-link = International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | last2 = Friedberg | first2 = Fred | authorlink2 = Fred Friedberg | last3 = Bateman | first3 = Lucinda | authorlink3 = Lucinda Bateman | last4 = Bested | first4 = Alison C | authorlink4 = Alison Bested | last5 = Davenport | first5 = Todd | authorlink5 = Todd Davenport | last6 = Friedman | first6 = Kenneth J | authorlink6 = Kenneth Friedman | last7 = Gurwitt | first7 = Alan R | authorlink7 = Alan Gurwitt | last8 = Jason | first8 = Leonard A | authorlink8 = Leonard Jason | last9 = Lapp | first9 = Charles W | authorlink9 = Charles Lapp | last10 = Stevens | first10 = Staci R | authorlink10 = Staci Stevens | last11 = Underhill | first11 = Rosemary A | authorlink11 = Rosemary Underhill | last12 = Vallings | first12 = Rosamund | authorlink12 = Rosamund Vallings|location=Chicago, USA|publisher= International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis}}</ref>
===Pediatric Primer (2017)===
Dr. Vallings was one of the authors of the 2017 Pediatric Primer for Physicians published in ''Frontiers in Pediatrics.''
* ''Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer'' by [[Peter C. Rowe|Peter Rowe]], [[Rosemary Underhill|Rosemary A. Underhill]], [[Kenneth Friedman|Kenneth J. Friedman]], [[Alan Gurwitt]], [[Marvin Medow|Marvin S. Medow]], [[Malcolm Schwartz|Malcolm S. Schwartz]], [[Nigel Speight]], [[Julian Stewart|Julian M. Stewart]], Rosamund Vallings and [[Katherine Rowe|Katherine S. Rowe]]<ref name="Rowe2017">{{Citation | last1 = Rowe | first1 = Peter C. | authorlink = Peter Rowe | last2 = Underhill | first2 = Rosemary A. | authorlink2 = Rosemary Underhill | last3 = Friedman | first3 = Kenneth J. | authorlink3 = Kenneth Friedman | last4 = Gurwitt | first4 = Alan | authorlink4 = Alan Gurwitt | last5 = Medow | first5 = Marvin S. | authorlink5 = Marvin Medow | last6 = Schwartz | first6 = Malcolm S. | authorlink6 = Malcolm Schwartz | last7 = Speight | first7 = Nigel | authorlink7 = Nigel Speight | last8 = Stewart | first8 = Julian M. | authorlink8 = Julian Stewart | last9 = Vallings | first9 = Rosamund | authorlink9=Rosamund Vallings | last10 = Rowe | first10 = Katherine S. | authorlink10=Katherine Rowe| title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer|journal=Frontiers in Pediatrics|volume=5|issue=|pages=121 | date =2017|pmid= |doi= 10.3389/fped.2017.00121}}</ref> - [http://journal.frontiersin.org/article/10.3389/fped.2017.00121/full (Full Text)]

==Advocacy==
===Open Letter to ''The Lancet''===

In response to ''The Lancet''<nowiki/>'s publication of the controversial [[PACE trial]] in 2011, three [[open letter to the Lancet |open letters to the editor of ''The Lancet'']] urged the [[Richard Horton|editor, Richard Horton,]] to commission a fully independent review of the [[PACE trial]]. In 2016, Dr. Vallings, along with 41 colleagues in the [[ME/CFS]] field, signed the second letter. In 2018, Dr. Vallings, along with over 100 colleagues signed a third letter.
*February 10, 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog]
*July 9, 2018, [http://www.virology.ws/2018/07/10/trial-by-error-yet-another-appeal-to-the-lancet-with-more-on-board/ Trial By Error: Yet Another Appeal to The Lancet, With More On Board]

==Articles==
*2004, AACFS 7th International Conference - Conference Reports<ref>{{Cite journal | last = Vallings | first = Rosamund | date = Jan 2004| title = AACFS 7th International Conference|url=http://www.tandfonline.com/doi/full/10.1300/J092v12n04_06|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=12|issue=4 | pages = 61–79|doi=10.1300/J092v12n04_06|issn=1057-3321|quote=|via=}}</ref>
*2004, Hypnosis in the Management of Chronic Fatigue Syndrome<ref>{{Cite journal | last = Vallings | first = Rosamund | date = Jan 2004| title = Hypnosis in the Management of Chronic Fatigue Syndrome|url=http://www.tandfonline.com/doi/full/10.1300/J092v12n04_04|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=12|issue=4|pages=37–46|doi=10.1300/J092v12n04_04|issn=1057-3321|quote=|via=}}</ref>
*2015 [http://anzmes.org.nz/wp-content/uploads/2015/06/10th-Invest-in-ME-International-ME-Conference-Ros-Vallings.pdf Invest in ME Conference Report, by Dr. Rosamund Vallings]
*2016, [http://anzmes.org.nz/wp-content/uploads/2016/06/Invest-in-ME-Conf-2016-by-ROS-Letterhead-1.pdf Invest in ME C11 2016 Conference Report, by Dr. Rosamund Vallings]
*2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Tate2019">{{Cite journal | last = Tate | first = Warren | authorlink = Warren Tate | last2 = Ryan | first2 = Margaret | authorlink2 = Margaret Ryan | last3 = Vallings | first3 = Rosamund | author-link3 = Rosamund Vallings | last4 = Helliwell | first4 = Amber | author-link4 = Amber Helliwell| last5 = Mackay | first5 = Angus | authorlink5 = Angus Mackay | last6 = Edgar | first6 = Christina | authorlink6 = Christina Edgar | last7 = Noble | first7 = Alex | authorlink7 = Alex Noble | last8 = Sweetman | first8 = Eiren | authorlink8 = Eiren Sweetman | date = Jul 2019| title = Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.mdpi.com/2075-4418/9/3/73|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 73|doi=10.3390/diagnostics9030073|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/3/73 (Full text)]

==Talks and interviews==
* 2010, [https://www.youtube.com/watch?v=02d6II-lmSE Dr Ros Vallings on ME/CFS and XMRV]
* 2013, [https://vimeo.com/89223289 Presentation by Dr Ros Vallings at seminar held by Emerge Australia (formerly ME/CFS Australia (Victoria))]
* 2013, [https://www.youtube.com/watch?v=ez9Gx5qdf58 Dr Ros Vallings talks about M.E. and feelings of isolation]
* 2014, [https://www.youtube.com/watch?v=H9ZqGKxNpB8 CFS/ME lecture | Dr Ros Vallings | Sep-2014]

==Books==
*2013, [[Chronic Fatigue Syndrome M.E.: Symptoms, Diagnosis, Management]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2013 | title = Chronic Fatigue Syndrome M.E.: Symptoms, Diagnosis, Management | publisher =Calico Publishing Ltd | asin = B00DVX59DQ}}</ref>
*2015, [[Managing ME/CFS: A guide for young people]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2015 | title = Managing ME/CFS: A guide for young people | publisher = Calico Publishing | asin = B0118NVEBG}}</ref>
*2017, [[The Pocket Guide to Chronic Fatigue Syndrome/ME: Key Facts and Tips for Improved Health]]<ref>{{Cite book | last = Vallings | first = Rosamund | date = 2015 | title = The Pocket Guide to Chronic Fatigue Syndrome/ME | publisher =Calico Publishing Ltd | isbn = 9781877429231}}</ref>

== Research studies ==
* 2019, Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome<ref>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Ryan | first2 = Margaret | authorlink2 = Margaret Ryan | last3 = Edgar | first3 = Christina | authorlink3 = Christina Edgar | last4 = Mackay | first4 = Angus | authorlink4 = Angus Mackay | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | authorlink6 = Warren Tate | date = Jan 2019| title = Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome|url=https://journals.sagepub.com/doi/abs/10.1177/2058738418820402|journal=International Journal of Immunopathology and Pharmacology|volume=33|issue=|pages=|doi=10.1177/2058738418820402|quote=|via=}}</ref> - [https://journals.sagepub.com/doi/10.1177/2058738418820402 (Full text)]
* 2019, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Noble | first2 = Alex | authorlink2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = Mackay | first4 = Angus | authorlink4 = Angus Mackay| last5 = Helliwell | first5 = Amber | author-link5 = Amber Helliwell | last6 = Vallings | first6 = Rosamund | authorlink6 = Rosamund Vallings | last7 = Ryan | first7 = Margaret | authorlink7 = | last8 = Tate | first8 = Warren | authorlink8 = Warren Tate | date = 2019-07-10| title = Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.mdpi.com/2075-4418/9/3/73|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 73|doi=10.3390/diagnostics9030073|issn=2075-4418|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/3/73/htm (Full text)]
*2020, A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction<ref name=Sweetman2020>{{Cite journal | last = Sweetman | first=Eiren | authorlink = Eiren Sweetman | last2 = Kleffmann | first2 = Torsten | author-link2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = de Lange | first4 = Michel | authorlink4 = | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | authorlink6 = Warren Tate | date = 2020-09-24| title = A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction|url=https://doi.org/10.1186/s12967-020-02533-3|journal=Journal of Translational Medicine|volume=18|issue=1|pages=365|doi=10.1186/s12967-020-02533-3|issn=1479-5876|pmc = 7512220|pmid=|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02533-3 (Full text)]

==Learn more==
*Nov 20, 2016, [http://www.times.co.nz/front-page-feature/doctor-wins-international-award.html ''Doctor wins international award'' in Times Live New Zealand]

==See also==
*[[Associated New Zealand ME Society]]
*[[Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer]]
*[[New Zealand]]
*[[Richie Barnett]]

==References==
{{reflist}}
[[Category:Clinicians]]
[[Category:New Zealand clinicians]]
[[Category:Authors]]
[[Category:Psychological paradigm critics]]
[[Category:PACE trial critics]]