MEpedia - User contributions [en]

Bragee ME center Stockholm

2025-10-24T09:48:49Z

BrageeResearch:Updating the activities of the clinic

[[File:BrageeKlinikerLogoWebbJpg.gif|thumb]]

'''Bragee ME center''' in Stockholm, [[Sweden]], was a private and specialized clinic endorsed by the Stockholm County region to help patients with ME/CFS.<ref name="website">{{Cite web | url = https://www.bragee.se/ | title = Rehab för smärta, utmattning och ME/CFS | last = | first = | author-link = | date = | website = Bragee Kliniker|language=sv| archive-url = | archive-date = |url-status = | access-date=2022-02-21}}</ref> The clinic was a national resource with patients from all over Sweden, but seized their clinical activities late 2023. Scientific engagements within the field persist (see below).

==History ==
Bragee ME center started in 2018. By February 2022 around 1600 patients with [[ME/CFS]] were registered at the clinic, all diagnosed according to the [[Canadian Consensus Criteria]] (CCC). Local political initiatives in the Stockholm county resulted in closure of the clinic in December 2023 and patients are since then taken care of by primary care centers.

==Staff==
The center had around 35 employees within various professions, of whom many with scientific experience (PhDs, Associate professors, and Professors).

==Aims==
The clinic, and its staff, had the ambition to develop the clinical care of individuals with ME/CFS and improve understanding of the disease, which included scientific engagements.

==Research ==
In 2018, representatives of the clinic initiated the research network [https://kise.sharepoint.com/teams/GRP_PIAF PIAF] (Pain Inflammation And Fatigue) with monthly meetings at which multinational speakers are invited to present their latest findings and hypotheses in relation to ME/CFS (NB. restricted access, invitation needed). Those meeting are presently at hold.

Two clinical pilot studies were finalized before closing the clinic, and the results from those two studies have been published in scientific peer-reviewed journals (see below). Furthermore, several ongoing scientific projects are ongoing including studies with external collaborators, partly by providing biological material from patients with ME/CFS, following existing ethical regulations including informed consent.

A study supported by the Patient Led Research Col (PLRC) and OMF are currently ongoing (October 2025) that intends to evaluate the clinical outcome of cervical spinal surgery in patients with ME/CFS and radiculopathy.

==Notable studies ==
*2020, Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="IIH2020">{{Cite journal | title = Signs of Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | date = 2020 | url = https://www.frontiersin.org/article/10.3389/fneur.2020.00828 | journal = Frontiers in Neurology | volume = 11 | issue = | pages = | last = Bragée | first = Björn | author-link = Björn Bragée | last2 = Michos | first2 = Anastasios | author-link2 = Anastasios Michos | last3 = Drum | first3 = Brandon | author-link3 = Brandon Drum | last4 = Fahlgren | first4 = Mikael | author-link4 = Mikael Fahlgren | last5 = Szulkin | first5 = Robert | author-link5 = Robert Szulkin | last6 = Bertilson | first6 = Bo C. | author-link6 = Bo Bertilson|doi=10.3389/fneur.2020.00828|pmc=PMC7485557|pmid=32982905|access-date=|issn=1664-2295|quote=|via=}}</ref> - [http://dx.doi.org/10.3389/fneur.2020.00828 (Abstract)]
*2022, Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome<ref>{{Cite journal | title = Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome | date = 2022-10-20 | url = https://www.frontiersin.org/articles/10.3389/fimmu.2022.949787/full | journal = Frontiers in Immunology | volume = 13|pages=949787 | last =Apostolou | first =Eirini | last2=Rizwan | first2 = Muhammad | last3 = Moustardas | first3 = Petros | last4 = Sjögren | first4 = Per | last5 = Bertilson | first5 = Bo Christer | last6 = Bragée | first6 = Björn | last7 = Polo | first7 = Olli | last8 = Rosén | first8 = Anders|doi=10.3389/fimmu.2022.949787|pmc=PMC9630598|pmid=36341457|issn=1664-3224}}</ref>
*2024, Successful Subcutaneous Immunoglobulin Therapy in a Case Series of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref>{{Cite journal|title=Successful Subcutaneous Immunoglobulin Therapy in a Case Series of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|date=2024-07|url=https://doi.org/10.1016/j.clinthera.2024.05.010|journal=Clinical Therapeutics|volume=46|issue=7|pages=597–600|last=Sjogren|first=Per|last2=Bragée|first2=Bjorn|last3=Britton|first3=Sven|doi=10.1016/j.clinthera.2024.05.010|issn=0149-2918}}</ref>
*2025, Beneficial effects of intermittent intravenous saline infusion in dysautonomic patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a case-series<ref>{{Cite journal|title=Beneficial effects of intermittent intravenous saline infusion in dysautonomic patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a case-series|journal=Front Neurol. 2025 Jul 21;16:1601599. doi: 10.3389/fneur.2025.1601599. eCollection 2025.}}</ref>
==Online presence ==
*[https://www.bragee.se/ Website], in Swedish)
==See also ==
*[[Sweden]]

==References ==
{{Reflist}}

[[Category:Swedish clinics]]

Bragee ME center Stockholm

2022-06-27T10:28:17Z

BrageeResearch:/* History */

[[File:BrageeKlinikerLogoWebbJpg.gif|thumb]]

'''Bragee ME center''' in Stockholm, [[Sweden]], is a private and specialized clinic endorsed by the Stockholm County region to help patients with ME/CFS.<ref name="website">{{Cite web|url=https://www.bragee.se/|title=Rehab för smärta, utmattning och ME/CFS|last=|first=|authorlink=|date=|website=Bragee Kliniker|language=sv|archive-url=|archive-date=|url-status=|access-date=2022-02-21}}</ref> The clinic is a national resource and welcomes patients from all over Sweden.

==History ==
Bragee ME center started in 2018. By February 2022 around 1600 patients with [[ME/CFS]] were registered at the clinic, all diagnosed according to the [[Canadian Consensus Criteria]] (CCC).

==Staff==
The center has around 35 employees within various professions, of whom many with scientific experience (PhDs, Associate professors, and Professors).

==Aims==
The clinic, and many of its staff, have the ambition to contribute scientifically to improve the knowledge of the disease.

The clinic aims to explore the potential importance of intracranial pressure abnormalities (see publication below), but also contribute to other aspects of the disease, such as improving diagnostic precision and treatment efficiency.

==Research ==
In 2018, representatives of the clinic initiated the research network [https://kise.sharepoint.com/teams/GRP_PIAF PIAF] (Pain Inflammation And Fatigue) with monthly meetings at which multinational speakers are invited to present their latest findings and hypotheses in relation to ME/CFS (NB. restricted access, invitation needed).

Collaborative studies are ongoing to which the clinic provide material from patients with ME/CFS, following existing ethical regulations including informed consent.

In house placebo-controlled treatment studies were recently initiated.

==Notable studies ==
*2020, Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="IIH2020">{{Cite journal|title=Signs of Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|date=2020|url=https://www.frontiersin.org/article/10.3389/fneur.2020.00828|journal=Frontiers in Neurology|volume=11|issue=|pages=|last=Bragée|first=Björn|author-link=Björn Bragée|last2=Michos|first2=Anastasios|author-link2=Anastasios Michos|last3=Drum|first3=Brandon|author-link3=Brandon Drum|last4=Fahlgren|first4=Mikael|author-link4=Mikael Fahlgren|last5=Szulkin|first5=Robert|author-link5=Robert Szulkin|last6=Bertilson|first6=Bo C.|author-link6=Bo Bertilson|doi=10.3389/fneur.2020.00828|pmc=PMC7485557|pmid=32982905|access-date=|issn=1664-2295|quote=|via=}}</ref> - [http://dx.doi.org/10.3389/fneur.2020.00828 (Abstract)]
==Online presence ==
*[https://www.bragee.se/ Website], in Swedish)
==See also ==
*[[Sweden]]

==References ==
{{Reflist}}

[[Category:Swedish clinics]]

Bragee ME center Stockholm

2022-02-11T09:28:36Z

BrageeResearch:Bragee ME center Stockholm, a clinical and scientific facility for improving care of patients with ME/CFS

[[File:BrageeKlinikerLogoWebbJpg.gif|thumb]]

Bragee ME center in Stockholm, Sweden, is a private and specialized clinic endorsed by the Stockholm County region to help patients with ME/CFS ([https://www.bragee.se/ www.bragee.se], in Swedish). The clinic is a national resource and welcomes patients from all over Sweden. Bragee ME center started in 2018 and has today (February 2022) around 1600 patients with ME/CFS registered at the clinic, all diagnosed according to the Canadian consensus criteria (CCC) and treated according to best clinical practice. The center has around 35 employees within various professions, of whom many with scientific experience (PhDs, Associate professors, and Professors).

The clinic, and many of its staff, have the ambition to contribute scientifically to improve the knowledge of the disease. Collaborative studies are ongoing to which the clinic provide material from patients with ME/CFS, following existing ethical regulations including informed consent. Recently, scientists associated with the clinic published a paper on the potential importance of Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome [[doi: 10.3389/fneur.2020.00828]]. The clinic aims to explore the potential importance of these abnormalities further, but also contribute to other aspects of the disease, such as improving diagnostic precision and treatment efficiency.

In 2018, representatives of the clinic initiated the research network [https://kise.sharepoint.com/teams/GRP_PIAF PIAF] (Pain Inflammation And Fatigue) with monthly meetings at which multinational speakers are invited to present their latest findings and hypotheses in relation to ME/CFS (NB. restricted access, invitation needed).

Olli Polo

2022-02-11T09:21:35Z

BrageeResearch:Link

[[File:Olli Polo.png|200px|right|Source: investinme.org]]
'''Olli Juhani Polo''', MD, PhD, is a Finnish pulmonologist, sleep specialist, docent of physiology and CFS/ME expert working in Stockholm, [[Sweden]]. He was formerly a professor of pulmonology at Tampere university, but lost the professorship in 2014 as a result of official complaints made against him by insurance doctors. He had his own clinic, Unesta, where he mostly treated and studied CFS/ME, [[RLS]] and [[sleep apnea]]. Since 2019 he is clinician at [[Bragee|Bragée ME Center in Stockholm]]. He has also treated [[multiple chemical sensitivity]] and [[mold illness]].

Polo has been treating and studying CFS/ME since 2007, but he lost his license to practice medicine on the private sector in 2017. This decision remains in effect even though just days later a Finnish court decided that the 2014 complaints, on which the legal action was based, were unwarranted in the light of scientific evidence. Polo is still allowed to practice pulmonary medicine at the Tampere university hospital.

Olli Polo is yet to publish a single paper on CFS/ME, though he has published over 100 papers in prominent journals about sleep disorders, particularly RLS, sleep apnea and the effect of menopause on sleep. He has been a speaker at the 2016 [[Invest in ME International ME Conference]] in London and many smaller CFS/ME conferences and events.

Polo's ideas of the causal mechanisms of CFS/ME are focused on the [[sympathetic nervous system]], circadian rhythm and tissue [[hypoxia]]. He believes [[Ehlers-Danlos syndrome]] or a similar type of collagen abnormality underlies virtually every case of CFS/ME. He has documented this in hundreds of patients and the evidence has been the subject of many of his conference speeches.

Polo has developed several experimental medical therapies, as well as utilizing more common treatments like [[LDN]], [[supplemental oxygen]], [[saline]], [[vitamin B12]], [[rotigotine]] and [[pramipexole]]. He believes e.g. most psychiatric drugs, sleeping pills and [[Lyrica]] are harmful in CFS/ME.

Polo has been a vocal advocate for CFS/ME, [[Multiple chemical sensitivity|MCS]] and mold illness in the Finnish media and has been interviewed in TV, radio, online documentaries and many newspaper and magazine articles. This has not always been positively received by his colleagues.

For years Polo applied for permission to run clinical trials on [[Low dose naltrexone|LDN]] and his experimental treatments, but his applications was always turned down. The Finnish regulatory agencies are of the opinion that CFS/ME is such a mild illness that virtually any potential side effect, no matter how minor, would be unacceptable.

In 2017 Polo finally got the permission to run an LDN study. It had just completed enrollment, when he was barred from continuing it due to losing his right to private medical practice. He has, however, compiled a retrospective paper on using LDN in hundreds of his CFS/ME patients.<ref name=":0" />

== Reseach studies ==
* 2019, Dampness and mold hypersensitivity syndrome and vaccination as risk factors for chronic fatigue syndrome<ref>{{Cite journal|last=Tuuminen|first=Tamara|author-link=Tamara Tuuminen|last2=Jääskeläinen|first2=Tiina|author-link2=Tiina Jääskeläinen|last3=Vaali|first3=Kirsi|author-link3=Kirsi Vaali|last4=Polo|first4=Olli|author-link4=Olli Polo|author-link5=|date=Nov 2018|title=Dampness and mold hypersensitivity syndrome and vaccination as risk factors for chronic fatigue syndrome|url=https://linkinghub.elsevier.com/retrieve/pii/S1568997218302660|journal=Autoimmunity Reviews|volume=|issue=|pages=|doi=10.1016/j.autrev.2018.08.004|issn=1568-9972|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/pii/S1568997218302660?via%3Dihub (Full text)]
* 2019, Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)<ref name=":0">{{Cite journal|last=Polo|first=Olli|author-link=Olli Polo|last2=Pesonen|first2=Pia|author-link2=|last3=Tuominen|first3=Essi|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2019-11-19|title=Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)|url=https://www.tandfonline.com/doi/full/10.1080/21641846.2019.1692770|journal=Fatigue: Biomedicine, Health & Behavior|language=en|volume=|issue=|pages=1–11|doi=10.1080/21641846.2019.1692770|issn=2164-1846|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.tandfonline.com/doi/abs/10.1080/21641846.2019.1692770?journalCode=rftg20 (Abstract)]

==Talks and interviews==
*2016, Speaker at the 11th Invest in ME International ME Conference on "Clinical Diagnosis of Myalgic Encephalomyelitis"<ref>{{Cite web|url=http://www.investinme.org/Documents/IIMEC11/IIMEC11%20Conference%20Report.pdf|title=11th Invest in ME – Research International ME Conference 2016|last=Vallings|first=Rosamund|authorlink=Rosamund Vallings|last2=|first2=|authorlink2=|date=2016|website=Invest in ME Research|archive-url=|archive-date=|url-status=|access-date=2019-12-04}}</ref> - [http://www.investinme.org/IIMEC11.shtml#dvd DVD available]
*2017, Speaker at the Care4ME conference in Brussels on sleep and dysautonomia in ME. - [https://www.youtube.com/watch?v=3v-2c2meSxw YouTube video]

==Learn more==
* [http://symposium2014.semmelweis.hu/images/speakers/Polo_Olli.pdf Curriculum Vitae]

==See also==
*[[Invest in ME International ME Conference]]
*[[EUROMENE]]

==References==
<references />
[[Category:Clinicians]]
[[Category:Finnish clinicians]]
[[Category:Researchers]]
[[Category:Finland researchers]]

User:BrageeResearch

2022-02-11T09:16:30Z

BrageeResearch:Introduced links and image

User:BrageeResearch

2022-02-11T09:12:42Z

BrageeResearch:

[[File:BrageeKlinikerLogoWebbJpg.gif|thumb]]

Bragee ME center in Stockholm, Sweden, is a private and specialized clinic endorsed by the Stockholm County region to help patients with ME/CFS (www.bragee.se, in Swedish). The clinic is a national resource and welcomes patients from all over Sweden. Bragee ME center started in 2018 and has today (February 2022) around 1600 patients with ME/CFS registered at the clinic, all diagnosed according to the Canadian consensus criteria (CCC) and treated according to best clinical practice. The center has around 35 employees within various professions, of whom many with scientific experience (PhDs, Associate professors, and Professors).

The clinic, and many of its staff, have the ambition to contribute scientifically to improve the knowledge of the disease. Collaborative studies are ongoing to which the clinic provide material from patients with ME/CFS, following existing ethical regulations including informed consent. Recently, scientists associated with the clinic published a paper on the potential importance of Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome doi: 10.3389/fneur.2020.00828. The clinic aims to explore the potential importance of these abnormalities further, but also contribute to other aspects of the disease, such as improving diagnostic precision and treatment efficiency.

In 2018, representatives of the clinic initiated the research network PIAF (Pain Inflammation And Fatigue) with monthly meetings at which multinational speakers are invited to present their latest findings and hypotheses in relation to ME/CFS (NB. restricted access, invitation needed).

User:BrageeResearch

2022-02-11T09:03:28Z

BrageeResearch:Bragee ME center Stockholm, a clinical and scientific facility for improving care of patients with ME/CFS

[[File:https://me-pedia.org/images/9/94/BrageeKlinikerLogoWebbJpg.gif]]

Bragee ME center in Stockholm, Sweden, is a private and specialized clinic endorsed by the Stockholm County region to help patients with ME/CFS (www.bragee.se, in Swedish). The clinic is a national resource and welcomes patients from all over Sweden. Bragee ME center started in 2018 and has today (February 2022) around 1600 patients with ME/CFS registered at the clinic, all diagnosed according to the Canadian consensus criteria (CCC) and treated according to best clinical practice. The center has around 35 employees within various professions, of whom many with scientific experience (PhDs, Associate professors, and Professors).

The clinic, and many of its staff, have the ambition to contribute scientifically to improve the knowledge of the disease. Collaborative studies are ongoing to which the clinic provide material from patients with ME/CFS, following existing ethical regulations including informed consent. Recently, scientists associated with the clinic published a paper on the potential importance of Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome doi: 10.3389/fneur.2020.00828. The clinic aims to explore the potential importance of these abnormalities further, but also contribute to other aspects of the disease, such as improving diagnostic precision and treatment efficiency.

In 2018, representatives of the clinic initiated the research network PIAF (Pain Inflammation And Fatigue) with monthly meetings at which multinational speakers are invited to present their latest findings and hypotheses in relation to ME/CFS (NB. restricted access, invitation needed).

File:BrageeKlinikerLogoWebbJpg.gif

2022-02-11T08:56:39Z

BrageeResearch:==== Title: BrageeKlinikerLogoWeb ==== ==== Author: Björn Bragee ==== ==== Source: www.bragee.se ==== ==== Other information: none ====

== Summary ==
==== Title: BrageeKlinikerLogoWeb ====

==== Author: Björn Bragee ====

==== Source: www.bragee.se ====

==== Other information: none ====
== Licensing ==
{{CC-by-sa-3.0}}

User:BrageeResearch

2022-02-11T08:45:00Z

BrageeResearch:Bragee ME center Stockholm, a clinical and scientific facility for improving care of patients with ME/CFS

Bragee ME center in Stockholm, Sweden, is a private and specialized clinic endorsed by the Stockholm County region to help patients with ME/CFS (www.bragee.se, in Swedish). The clinic is a national resource and welcomes patients from all over Sweden. Bragee ME center started in 2018 and has today (February 2022) around 1600 patients with ME/CFS registered at the clinic, all diagnosed according to the Canadian consensus criteria (CCC) and treated according to best clinical practice. The center has around 35 employees within various professions, of whom many with scientific experience (PhDs, Associate professors, and Professors).

The clinic, and many of its staff, have the ambition to contribute scientifically to improve the knowledge of the disease. Collaborative studies are ongoing to which the clinic provide material from patients with ME/CFS, following existing ethical regulations including informed consent. Recently, scientists associated with the clinic published a paper on the potential importance of Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome doi: 10.3389/fneur.2020.00828. The clinic aims to explore the potential importance of these abnormalities further, but also contribute to other aspects of the disease, such as improving diagnostic precision and treatment efficiency.

In 2018, representatives of the clinic initiated the research network PIAF (Pain Inflammation And Fatigue) with monthly meetings at which multinational speakers are invited to present their latest findings and hypotheses in relation to ME/CFS (NB. restricted access, invitation needed).