MEpedia - User contributions [en]

Oxford criteria

2018-11-29T20:16:38Z

AlisonOrr:/* PDF for Oxford Definition CFS and PIFS */ Corrected link to https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1293107/pdf/jrsocmed00127-0072.pdf

The '''Oxford criteria''' are a set of criteria for the diagnosis [[Chronic Fatigue Syndrome]] published in 1991 by a group mostly consisting of psychiatrists.<ref name=":0" /> They identify two broad syndromes and are used primarily for research purposes.<ref>[http://www.meassociation.org.uk/about/the-symptoms-and-diagnosis-of-mecfs Symptoms and diagnosis of ME/CFS - ME Association]</ref> The Oxford criteria was used for [[PACE trial]] participation.<ref>[http://www.wolfson.qmul.ac.uk/current-projects/pace-trial#patients Pace Trial - Centre for Psychiatry - QMUL]</ref><ref>[http://www.meassociation.org.uk/2011/02/pace-study-trial-%e2%80%93-medical-research-council-uk-news-report-18-february-2011/ PACE study results – Medical Research Council (UK) news report, 18 February 2011 - ME Association]</ref>

==Authors==
[[Michael Sharpe]], [[Len Archard]], [[Jangu Banatvala]], [[Leszek Borysiewicz]], [https://en.wikipedia.org/wiki/Anthony_Clare Anthony Clare], [[Anthony David]], [[Richard Edwards]], [[Keith Hawton]], [[Harold Lambert]], [[Russell Lane]]

==Definition==

===Chronic fatigue syndrome===

* [[fatigue]] is the principal symptom: it is severe, disabling and affects physical and mental functioning; it should have been present for a minimum of 6 months during which it was present for more than 50% of the time.
* other symptoms may be present: particularly [[myalgia]], [[mood swings]] and [[sleep disturbance]]s.
* definite onset of symptoms, not life-long.
* exclusions: patients with established medical conditions known to produce [[Chronic fatigue (symptom)|chronic fatigue]]; also patients with a current diagnosis of [[schizophrenia]], [[Bipolar disorder|bipolar disorder (manic depressive illness)]], [[substance abuse]], [[eating disorder]] or proven organic brain disease.

===[[Post-infectious Fatigue Syndrome]] (PIFS)===

A sub-type of [[CFS]] which either follows an infection or is associated with a current infection (although whether such associated infection is of aetiological significance (i.e. whether it is the cause of the symptoms) is a topic for research).

To meet the research criteria for PIFS patients must:
* i. fulfil the criteria for CFS as defined above (i.e. the Oxford definition)
* ii. should also fulfil the following additional criteria:
* (a) There is definite evidence of infection at onset or presentation (a patient’s self-report is unlikely to be sufficiently reliable).
* (b) the syndrome is present for a minimum of 6 months after onset of infection.
* (c) the infection has been corroborated by laboratory evidence.

===PDF for Oxford Definition CFS and PIFS===

PDF: '''[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1293107/pdf/jrsocmed00127-0072.pdf A report - chronic fatigue syndrome: guidelines for research]''' - ''Journal of the Royal Society of Medicine'' - Volume 84 February 1991 118-121<ref name=":0">[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1293107/ A report - chronic fatigue syndrome: guidelines for research Journal of the Royal Society of Medicine Volume 84 February 1991 118-121]</ref>

==Criticisms==
*[[How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?]] For every 15 patients selected under Oxford criteria, 14 will be false positives when compared to [[Canadian Consensus Criteria]]. The [[Pace trial]] and [[FINE trial]] used Oxford criteria.
*[[Post-exertional malaise]] is not a listed symptom. When this symptom is not mandatory, patients with [[Chronic Fatigue]] and not the grossly misnamed disease [[Chronic Fatigue Syndrome]] are swept into the study.
*Depression is not an absolute exception for a possible cause of Chronic Fatigue (not to be confused with Chronic Fatigue Syndrome.) This allows for patients with depression to be misdiagnosed with [[CFS]].<ref>[http://arthritis.about.com/od/fatigue/f/chronicfatigue.htm Chronic Fatigue Versus Chronic Fatigue Syndrome - About.com HEALTH By: Carol Eustice]</ref>
*Many psychiatric disorders are not excluded. Although schizophrenia, substance abuse, bipolar disorder, eating disorders, and verified organic brain disorders are excluded from diagnosis in the Oxford criteria, anxiety disorders, depressive disorders, and hyperventilation can be included. This allows for a more heterogeneous patient sample which can render clinical study results indeterminate.<ref name="Njoku, 2016" />

*'''US NIH Report Calls for UK Definition of ME/CFS to be Scrapped''' - ''The Argus Report'' By: Penny Swift.

:''Excerpt''
::The [https://en.wikipedia.org/wiki/National_Institutes_of_Health United States National Institutes of Health] (NIH) has issued a draft report that highlights the dire need for scientific research that will help find a cure for the millions of people suffering from myalgic encephalomyelitis/chronic fatigue syndrome ([[ME/CFS]]) worldwide. The report also highlights the fact that the decades-old UK Royal Society of Medicine’s '''Oxford criteria''' for ME/CFS are severely “flawed,” and that continuing to use these criteria may “cause harm.” Further, the NIH report says that the Royal Society definition should “be retired” and replaced with a single case definition agreed to by the ME/CFS community.<ref>[http://theargusreport.com/us-nih-report-calls-uk-definition-mecfs-scrapped/ US NIH Report Calls for UK Definition of ME/CFS to be Scrapped - The Argus Report By: Penny Swift]</ref>

* Dr [James Baraniuk] published in July 2017 [http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1353578?journalCode=rftg20 'Chronic fatigue syndrome prevalence is grossly overestimated using Oxford criteria compared to Centers for Disease Control (Fukuda) criteria in a US population study'.]

==Learn more==
*2016, [http://occupyme.net/2016/08/16/ahrq-evidence-review-changes-its-conclusions/ AHRQ Evidence Review Changes Its Conclusions]

==See also==
*[[FINE trial]]
*[[PACE trial]]

==References==
<references>
<ref name="Njoku, 2016">{{citation
| author = [[Mary Gloria Njoku| Mary Gloria C. Njoku]]
| title = Myalgic, Encephalomyelitis/Chronic Fatigue Syndrome: History, Diagnostic Criteria and Prevalence
| type = ebook
| date = 2016
| ISBN = 978-1-4689-7326-6
}}</ref>
</references>

[[Category:Definitions]]

Oxford criteria

2018-11-29T20:14:13Z

AlisonOrr:/* PDF for Oxford Definition CFS and PIFS */ Hyperlink created for https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1293107

The '''Oxford criteria''' are a set of criteria for the diagnosis [[Chronic Fatigue Syndrome]] published in 1991 by a group mostly consisting of psychiatrists.<ref name=":0" /> They identify two broad syndromes and are used primarily for research purposes.<ref>[http://www.meassociation.org.uk/about/the-symptoms-and-diagnosis-of-mecfs Symptoms and diagnosis of ME/CFS - ME Association]</ref> The Oxford criteria was used for [[PACE trial]] participation.<ref>[http://www.wolfson.qmul.ac.uk/current-projects/pace-trial#patients Pace Trial - Centre for Psychiatry - QMUL]</ref><ref>[http://www.meassociation.org.uk/2011/02/pace-study-trial-%e2%80%93-medical-research-council-uk-news-report-18-february-2011/ PACE study results – Medical Research Council (UK) news report, 18 February 2011 - ME Association]</ref>

==Authors==
[[Michael Sharpe]], [[Len Archard]], [[Jangu Banatvala]], [[Leszek Borysiewicz]], [https://en.wikipedia.org/wiki/Anthony_Clare Anthony Clare], [[Anthony David]], [[Richard Edwards]], [[Keith Hawton]], [[Harold Lambert]], [[Russell Lane]]

==Definition==

===Chronic fatigue syndrome===

* [[fatigue]] is the principal symptom: it is severe, disabling and affects physical and mental functioning; it should have been present for a minimum of 6 months during which it was present for more than 50% of the time.
* other symptoms may be present: particularly [[myalgia]], [[mood swings]] and [[sleep disturbance]]s.
* definite onset of symptoms, not life-long.
* exclusions: patients with established medical conditions known to produce [[Chronic fatigue (symptom)|chronic fatigue]]; also patients with a current diagnosis of [[schizophrenia]], [[Bipolar disorder|bipolar disorder (manic depressive illness)]], [[substance abuse]], [[eating disorder]] or proven organic brain disease.

===[[Post-infectious Fatigue Syndrome]] (PIFS)===

A sub-type of [[CFS]] which either follows an infection or is associated with a current infection (although whether such associated infection is of aetiological significance (i.e. whether it is the cause of the symptoms) is a topic for research).

To meet the research criteria for PIFS patients must:
* i. fulfil the criteria for CFS as defined above (i.e. the Oxford definition)
* ii. should also fulfil the following additional criteria:
* (a) There is definite evidence of infection at onset or presentation (a patient’s self-report is unlikely to be sufficiently reliable).
* (b) the syndrome is present for a minimum of 6 months after onset of infection.
* (c) the infection has been corroborated by laboratory evidence.

===PDF for Oxford Definition CFS and PIFS===

PDF: '''[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1293107 A report - chronic fatigue syndrome: guidelines for research]''' - ''Journal of the Royal Society of Medicine'' - Volume 84 February 1991 118-121<ref name=":0">[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1293107/ A report - chronic fatigue syndrome: guidelines for research Journal of the Royal Society of Medicine Volume 84 February 1991 118-121]</ref>

==Criticisms==
*[[How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?]] For every 15 patients selected under Oxford criteria, 14 will be false positives when compared to [[Canadian Consensus Criteria]]. The [[Pace trial]] and [[FINE trial]] used Oxford criteria.
*[[Post-exertional malaise]] is not a listed symptom. When this symptom is not mandatory, patients with [[Chronic Fatigue]] and not the grossly misnamed disease [[Chronic Fatigue Syndrome]] are swept into the study.
*Depression is not an absolute exception for a possible cause of Chronic Fatigue (not to be confused with Chronic Fatigue Syndrome.) This allows for patients with depression to be misdiagnosed with [[CFS]].<ref>[http://arthritis.about.com/od/fatigue/f/chronicfatigue.htm Chronic Fatigue Versus Chronic Fatigue Syndrome - About.com HEALTH By: Carol Eustice]</ref>
*Many psychiatric disorders are not excluded. Although schizophrenia, substance abuse, bipolar disorder, eating disorders, and verified organic brain disorders are excluded from diagnosis in the Oxford criteria, anxiety disorders, depressive disorders, and hyperventilation can be included. This allows for a more heterogeneous patient sample which can render clinical study results indeterminate.<ref name="Njoku, 2016" />

*'''US NIH Report Calls for UK Definition of ME/CFS to be Scrapped''' - ''The Argus Report'' By: Penny Swift.

:''Excerpt''
::The [https://en.wikipedia.org/wiki/National_Institutes_of_Health United States National Institutes of Health] (NIH) has issued a draft report that highlights the dire need for scientific research that will help find a cure for the millions of people suffering from myalgic encephalomyelitis/chronic fatigue syndrome ([[ME/CFS]]) worldwide. The report also highlights the fact that the decades-old UK Royal Society of Medicine’s '''Oxford criteria''' for ME/CFS are severely “flawed,” and that continuing to use these criteria may “cause harm.” Further, the NIH report says that the Royal Society definition should “be retired” and replaced with a single case definition agreed to by the ME/CFS community.<ref>[http://theargusreport.com/us-nih-report-calls-uk-definition-mecfs-scrapped/ US NIH Report Calls for UK Definition of ME/CFS to be Scrapped - The Argus Report By: Penny Swift]</ref>

* Dr [James Baraniuk] published in July 2017 [http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1353578?journalCode=rftg20 'Chronic fatigue syndrome prevalence is grossly overestimated using Oxford criteria compared to Centers for Disease Control (Fukuda) criteria in a US population study'.]

==Learn more==
*2016, [http://occupyme.net/2016/08/16/ahrq-evidence-review-changes-its-conclusions/ AHRQ Evidence Review Changes Its Conclusions]

==See also==
*[[FINE trial]]
*[[PACE trial]]

==References==
<references>
<ref name="Njoku, 2016">{{citation
| author = [[Mary Gloria Njoku| Mary Gloria C. Njoku]]
| title = Myalgic, Encephalomyelitis/Chronic Fatigue Syndrome: History, Diagnostic Criteria and Prevalence
| type = ebook
| date = 2016
| ISBN = 978-1-4689-7326-6
}}</ref>
</references>

[[Category:Definitions]]

Forward-ME

2018-09-14T12:52:14Z

AlisonOrr:/* Members and Associates */ re-edited link for Nina Muirhead

[[File:Forward-ME logo.gif|right|thumb]]

'''Forward-ME''' is a grouping of British ME/CFS charities founded and led by Margaret [[Countess of Mar]]. Its web site lists [http://www.forward-me.org.uk/LinkedOrganisations.htm its members].

==Members and Associates==
* [[Margaret of Mar, 31st Countess of Mar|Countess of Mar]] (Chairman)
* [[Carol Monaghan]] (MP) Vice Chairman
* [[Nigel Speight|Dr Nigel Speight]]
* [[William Weir|Dr William Weir]]
* [http://www.buckshealthcare.nhs.uk/Our%20clinical%20services/Consultants%20and%20clinical%20teams/muirhead-nina.htm Dr Nina Muirhead]
The members all participate in the meetings convened by Forward-ME.<ref>[http://www.forward-me.org.uk/LinkedOrganisations.htm]</ref>
*[[ME Association]] ([http://www.MEAssociation.org.uk website])
*[[ME Research UK]] ([http://www.meresearch.org.uk website])
*[[Action for ME]] ([http://www.AfME.org.uk website])
*[[The Young ME Sufferers Trust]] ([http://www.tymestrust.org website])
*[[reMemberCFS]] ([http://www.remembercfs.org.uk website])
*[[Blue Ribbon for awareness of ME]] ([http://www.Brame.org website])
*[[Neurological Alliance]] ([http://www.neural.org.uk website])
*[[ME Trust]] ([http://www.metrust.org.uk website])
*[[25% ME Group]] ([http://www.25megroup.org website])
*[[The MEAction Network|MEAction]] ([http://meaction.net website])

==Aims==
Forward-ME consists of charities and voluntary organisations invited by the Countess of Mar to meet several times a year. The aim of Forward-ME is to promote effective joint working by ME and CFS organisations to maximise impact on behalf of all people with ME and CFS in the UK. Forward-ME exists to improve recognition, understanding, research, management, support and information for everyone whose life is affected by ME and CFS.<ref>[http://www.forward-me.org.uk/default.htm Foward-ME - Welcome]</ref>

==Minutes==
The full list of minutes can be found [http://www.forward-me.org.uk/Minutes.htm here].
*2014, [http://www.forward-me.org.uk/25th%20June%202014.htm Minutes of the Meeting held in the Television Interview Room House of Lords]

==Notable People==
*The [[Countess of Mar]] is the founder and chairman of Forward-ME.

==History==
Forward-ME was first convened by the Countess of Mar in October 2008. Meetings have taken place several times yearly since.<ref>[http://www.forward-me.org.uk/Minutes.htm Forward-ME - Minutes of Meetings]</ref>

==Online Presence==
*[http://www.forward-me.org.uk/default.htm Website]

==See Also==
*[[European ME Alliance]]
*[[Countess of Mar]]
*[[All-Party Parliamentary Group on Myalgic Encephalomyelitis]]

==References==
<references />

[[Category:Patient groups]]
[[Category:British patient groups]]

Forward-ME

2018-09-14T12:47:21Z

AlisonOrr:/* Members */ Added Associates from the Forward-ME website

Forward-ME

2018-09-14T12:38:21Z

AlisonOrr:/* Members */ Added up to date url

[[File:Forward-ME logo.gif|right|thumb]]

'''Forward-ME''' is a grouping of British ME/CFS charities founded and led by Margaret [[Countess of Mar]]. Its web site lists [http://www.forward-me.org.uk/LinkedOrganisations.htm its members].

==Members==
The members all participate in the meetings convened by Forward-ME.<ref>[http://www.forward-me.org.uk/LinkedOrganisations.htm]</ref>
*[[ME Association]] ([http://www.MEAssociation.org.uk website])
*[[ME Research UK]] ([http://www.meresearch.org.uk website])
*[[Action for ME]] ([http://www.AfME.org.uk website])
*[[The Young ME Sufferers Trust]] ([http://www.tymestrust.org website])
*[[reMemberCFS]] ([http://www.remembercfs.org.uk website])
*[[Blue Ribbon for awareness of ME]] ([http://www.Brame.org website])
*[[Neurological Alliance]] ([http://www.neural.org.uk website])
*[[ME Trust]] ([http://www.metrust.org.uk website])
*[[25% ME Group]] ([http://www.25megroup.org website])
*[[The MEAction Network|MEAction]] ([http://meaction.net website])

==Aims==
Forward-ME consists of charities and voluntary organisations invited by the Countess of Mar to meet several times a year. The aim of Forward-ME is to promote effective joint working by ME and CFS organisations to maximise impact on behalf of all people with ME and CFS in the UK. Forward-ME exists to improve recognition, understanding, research, management, support and information for everyone whose life is affected by ME and CFS.<ref>[http://www.forward-me.org.uk/default.htm Foward-ME - Welcome]</ref>

==Minutes==
The full list of minutes can be found [http://www.forward-me.org.uk/Minutes.htm here].
*2014, [http://www.forward-me.org.uk/25th%20June%202014.htm Minutes of the Meeting held in the Television Interview Room House of Lords]

==Notable People==
*The [[Countess of Mar]] is the founder and chairman of Forward-ME.

==History==
Forward-ME was first convened by the Countess of Mar in October 2008. Meetings have taken place several times yearly since.<ref>[http://www.forward-me.org.uk/Minutes.htm Forward-ME - Minutes of Meetings]</ref>

==Online Presence==
*[http://www.forward-me.org.uk/default.htm Website]

==See Also==
*[[European ME Alliance]]
*[[Countess of Mar]]
*[[All-Party Parliamentary Group on Myalgic Encephalomyelitis]]

==References==
<references />

[[Category:Patient groups]]
[[Category:British patient groups]]

Forward-ME

2018-09-14T12:31:17Z

AlisonOrr:/* Members */

[[File:Forward-ME logo.gif|right|thumb]]

'''Forward-ME''' is a grouping of British ME/CFS charities founded and led by Margaret [[Countess of Mar]]. Its web site lists [http://www.forward-me.org.uk/LinkedOrganisations.htm its members].

==Members==
The members all participate in the meetings convened by Forward-ME.<ref>[http://www.forward-me.org.uk/LinkedOrganisations.htm Forward-ME - Linked Organisations]</ref>
*[[ME Association]] ([http://www.MEAssociation.org.uk website])
*[[ME Research UK]] ([http://www.meresearch.org.uk website])
*[[Action for ME]] ([http://www.AfME.org.uk website])
*[[The Young ME Sufferers Trust]] ([http://www.tymestrust.org website])
*[[reMemberCFS]] ([http://www.remembercfs.org.uk website])
*[[Blue Ribbon for awareness of ME]] ([http://www.Brame.org website])
*[[Neurological Alliance]] ([http://www.neural.org.uk website])
*[[ME Trust]] ([http://www.metrust.org.uk website])
*[[25% ME Group]] ([http://www.25megroup.org website])
*[[The MEAction Network|MEAction]] ([http://meaction.net website])

==Aims==
Forward-ME consists of charities and voluntary organisations invited by the Countess of Mar to meet several times a year. The aim of Forward-ME is to promote effective joint working by ME and CFS organisations to maximise impact on behalf of all people with ME and CFS in the UK. Forward-ME exists to improve recognition, understanding, research, management, support and information for everyone whose life is affected by ME and CFS.<ref>[http://www.forward-me.org.uk/default.htm Foward-ME - Welcome]</ref>

==Minutes==
The full list of minutes can be found [http://www.forward-me.org.uk/Minutes.htm here].
*2014, [http://www.forward-me.org.uk/25th%20June%202014.htm Minutes of the Meeting held in the Television Interview Room House of Lords]

==Notable People==
*The [[Countess of Mar]] is the founder and chairman of Forward-ME.

==History==
Forward-ME was first convened by the Countess of Mar in October 2008. Meetings have taken place several times yearly since.<ref>[http://www.forward-me.org.uk/Minutes.htm Forward-ME - Minutes of Meetings]</ref>

==Online Presence==
*[http://www.forward-me.org.uk/default.htm Website]

==See Also==
*[[European ME Alliance]]
*[[Countess of Mar]]
*[[All-Party Parliamentary Group on Myalgic Encephalomyelitis]]

==References==
<references />

[[Category:Patient groups]]
[[Category:British patient groups]]

Forward-ME

2018-09-14T12:28:45Z

AlisonOrr:/* Members */

[[File:Forward-ME logo.gif|right|thumb]]

'''Forward-ME''' is a grouping of British ME/CFS charities founded and led by Margaret [[Countess of Mar]]. Its web site lists [http://www.forward-me.org.uk/LinkedOrganisations.htm its members].

==Members==
The members all participate in the meetings convened by Forward-ME.<ref>[http://www.forward-me.org.uk/LinkedOrganisations.htm Forward-ME - Linked Organisations]</ref>
*[[ME Association]] ([http://www.MEAssociation.org.uk website])
*[[ME Research UK]] ([http://www.meresearch.org.uk website])
*[[Action for ME]] ([http://www.AfME.org.uk website])
*[[The Young ME Sufferers Trust]] ([http://www.tymestrust.org website])
*[[reMemberCFS]] ([http://www.remembercfs.org.uk website])
*[[Blue Ribbon for awareness of ME]] ([http://www.Brame.org website])
*[[Neurological Alliance]] ([http://www.neural.org.uk website])
*[[ME Trust]] ([http://www.metrust.org.uk website])
*[[25% ME Group]] ([http://www.25megroup.org website])
*[[Health Equality for ME]] ([http://meaction.net website])

==Aims==
Forward-ME consists of charities and voluntary organisations invited by the Countess of Mar to meet several times a year. The aim of Forward-ME is to promote effective joint working by ME and CFS organisations to maximise impact on behalf of all people with ME and CFS in the UK. Forward-ME exists to improve recognition, understanding, research, management, support and information for everyone whose life is affected by ME and CFS.<ref>[http://www.forward-me.org.uk/default.htm Foward-ME - Welcome]</ref>

==Minutes==
The full list of minutes can be found [http://www.forward-me.org.uk/Minutes.htm here].
*2014, [http://www.forward-me.org.uk/25th%20June%202014.htm Minutes of the Meeting held in the Television Interview Room House of Lords]

==Notable People==
*The [[Countess of Mar]] is the founder and chairman of Forward-ME.

==History==
Forward-ME was first convened by the Countess of Mar in October 2008. Meetings have taken place several times yearly since.<ref>[http://www.forward-me.org.uk/Minutes.htm Forward-ME - Minutes of Meetings]</ref>

==Online Presence==
*[http://www.forward-me.org.uk/default.htm Website]

==See Also==
*[[European ME Alliance]]
*[[Countess of Mar]]
*[[All-Party Parliamentary Group on Myalgic Encephalomyelitis]]

==References==
<references />

[[Category:Patient groups]]
[[Category:British patient groups]]