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Zofin
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'''Zofin''' or '''Organicell Flow''' is an unapproved treatment that has been used on a number of patients severely ill with [[Long COVID|long-lasting COVID-19 symptoms]] under a compassionate use authorization.<ref name="organicell-7May2020">{{Cite web|url=https://organicell.com/2020/05/27/organicell-reports-positive-results-from-compassionate-use-of-organicell-flow-in-severely-ill-covid-19-patients/ | title = Organicell Reports Positive Results from Compassionate Use of Organicell Flow in Severely Ill COVID-19 Patients | last =Organicell | first = |authorlink=| date = May 27, 2020 | website = |language=en-US|archive-url=|archive-date=|url-status=|access-date=2020-12-13}}</ref><ref>{{Cite web|url=https://www.wtoc.com/2020/11/23/savannah-doctor-providing-treatment-long-term-covid-effects/ | title = Savannah doctor providing treatment for long-term COVID-19 effects | last =Caldwell | first = Blair | authorlink=| date = November 23, 2020 | website = WTOC|language=en-US|archive-url=|archive-date=|url-status=|access-date=2020-12-13}}</ref> Zofin is a biological product derived from the human amniotic fluid (HAF) donated from the births of healthy, newborn babies; it is administered by intravenous infusion. Zofin is produced by the company Organicell which states that it "contains over 300 growth factors, [[cytokine]]s, and [[chemokine]]s as well as other extracellular vesicles/nanoparticles derived from amniotic stem and epithelial cells" including the proteins [[CD63]], [[CD81]], and [[CD9]] in addition to high expression of [[CD133]].<ref name="organicell-7May2020" /> ==Theory == According to Organicell, pro-inflammatory cytokines believed to be targeted by Zofin include [[tumor necrosis factor]] (TNF), [[interleukin 6|IL-6]], and [[interleukin 8|IL-8]], and published research states that targeting these may "reduce the severity of symptoms associated with elevated immune response".<ref name="organicell-7May2020" /> ==Theory== ==Evidence== ==Clinicians== ==Risks and safety== Zofin has not yet been approved for use and clinical trials remain ongoing.<ref name="Trial-NCT04384445">https://clinicaltrials.gov/ct2/show/NCT04384445</ref> Risks, side effects and safety are largely unknown. ==Costs and availability== Zofin is not yet an approved drug and availability is limited to special authorizations. ==See also== *[[Long COVID]] *[[COVID-19]] ==Learn more== *[https://organicell.com/2020/05/27/organicell-reports-positive-results-from-compassionate-use-of-organicell-flow-in-severely-ill-covid-19-patients/ Organicell reports positive results from compassionate use of Organicell Flow] - Organicell *[https://clinicaltrials.gov/ct2/show/NCT04384445 Clinical trial NCT04384445] ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Immunomodulators]]
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