Yasuyoshi Watanabe

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Yasuyoshi Watanabe, MD, PhD, is the Director of RIKEN BDR-DAIKIN Collaboration Center at RIKEN Center for Life Science Technologies, Kobe City, Hyogo, Japan.[1] He is a Professor, Department of Physiology, Osaka City Graduate School of Medicine, Osaka City, Japan, where his specialties are fatigue science and molecular neuroimaging.[2]

Dr. Watanabe serves as an associate editor of the journal Fatigue: Biomedicine, Health & Behavior.[3]

IOM Committee on Diagnostic Criteria for ME/CFS[edit | edit source]

Dr Watanabe was a reviewer for the 2015 report produced by the Institute of Medicine's Committee on Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.[4]

Book chapter[edit | edit source]

  • 2020, Integrated Imaging on Fatigue and Chronic Fatigue, a chapter in the book, Make Life Visible[5] - (Full chapter)

Notable studies[edit | edit source]

  • 2006, Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study[6] - (Full text)
  • 2010, A new hypothesis of chronic fatigue syndrome: Co-conditioning theory[7] - (Abstract)
  • 2011, Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome – A 6-month follow-up study[8] - (Abstract)
  • 2013, Neurocognitive impairment in childhood chronic fatigue syndrome[9] - (Full Text)
  • 2014, Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study[10] - (Full Text)
  • 2015, Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome[11] - (Full Text)
  • 2015, Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder[12] - (Full Text)
  • 2016, Neural effect of physical fatigue on mental fatigue: a magnetoencephalography study[13] - (Abstract)
  • 2016, Roles of the right dorsolateral prefrontal cortex during physical fatigue: a magnetoencephalographic study[2] - (Abstract)
  • 2016, Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome[14] - (Abstract)
  • 2016, Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles[15] - (Full Text)
  • 2016, Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome[16] - (Full text)
  • 2018, History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[17] - (Abstract)
  • 2018, Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[18] - (Abstract)
  • 2018, Brain Science on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[19] - (Abstract)
  • 2018, Association of Fatigue and Stress With Gray Matter Volume[20] - (Full text)
  • 2019, Decreased alpha-band oscillatory brain activity prior to movement initiated by perception of fatigue sensation[21] - (Full text)
  • 2020, Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population - (Full text)
  • 2020, Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome[22] - (Full text)
  • 2021, Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[23] - (Full text)

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "Laboratory for Pathophysiological and Health Science | RIKEN". riken.jp. Retrieved October 31, 2019.
  2. ↑ 2.0 2.1 Tanaka, Masaaki; Ishii, Akira; Watanabe, Yasuyoshi (July 2, 2016). "Roles of the right dorsolateral prefrontal cortex during physical fatigue: a magnetoencephalographic study". Fatigue: Biomedicine, Health & Behavior. 4 (3): 146–157. doi:10.1080/21641846.2016.1175179. ISSN 2164-1846.
  3. ↑ "Fatigue: Biomedicine, Health & Behavior". tandfonline.com. Retrieved October 31, 2019.
  4. ↑ "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness" (PDF). National Academies Press. 2015. Retrieved October 31, 2019.
  5. ↑ Watanabe, Yasuyoshi; Tanaka, Masaaki; Ishii, Akira; Mizuno, Kei; Sasaki, Akihiro; Yamano, Emi; Cui, Yilong; Fukuda, Sanae; Kataoka, Yosky (2020). Toyama, Yoshiaki; Miyawaki, Atsushi; Nakamura, Masaya; Jinzaki, Masahiro (eds.). "Integrated Imaging on Fatigue and Chronic Fatigue". Make Life Visible. Singapore: Springer Singapore: 227–233. doi:10.1007/978-981-13-7908-6_23. ISBN 9789811379079.
  6. ↑ Tanaka, Masaaki; Sadato, Norihiro; Okada, Tomohisa; Mizuno, Kei; Sasabe, Tetsuya; Tanabe, Hiroki C; Saito, Daisuke N; Onoe, Hirotaka; Kuratsune, Hirohiko (February 22, 2006). "Reduced responsiveness is an essential feature of chronic fatigue syndrome: A fMRI study". BMC Neurology. 6 (1): 9. doi:10.1186/1471-2377-6-9. ISSN 1471-2377. PMC 1397862. PMID 16504053.
  7. ↑ Tanakaa, Masaaki; Watanabe, Yasuyoshi (August 1, 2010). "A new hypothesis of chronic fatigue syndrome: Co-conditioning theory". Medical Hypotheses. 75 (2): 244–249. doi:10.1016/j.mehy.2010.02.032. ISSN 0306-9877.
  8. ↑ Kawatani, Junko; Mizuno, Kei; Shiraishi, Seishi; Takao, Miyuki; Joudoi, Takako; Fukuda, Sanae; Watanabe, Yasuyoshi; Tomoda, Akemi (November 2011). "Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome--a 6-month follow-up study". Brain & Development. 33 (10): 832–841. doi:10.1016/j.braindev.2010.12.009. ISSN 1872-7131. PMID 21530119.
  9. ↑ Mizuno, Kei; Tanaka, Masaaki; Tanabe, Hiroki C.; Joudoi, Takako; Kawatani, Junko; Shigihara, Yoshihito; Tomoda, Akemi; Miike, Teruhisa; Imai-Matsumura, Kyoko (2015). "Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome". NeuroImage: Clinical. 9: 355–368. doi:10.1016/j.nicl.2015.09.001. PMC 4589845. PMID 26594619.
  10. ↑ Nakatomi, Y.; Mizuno, K.; Ishii, A.; Wada, Y.; Tanaka, M.; Tazawa, S.; Onoe, K.; Fukuda, S.; Kawabe, J.; Takahashi, Kazuhiro; Kataoka, Yosky; Shiomi, Susumu; Yamaguti, Kouzi; Masaaki, Inaba; Kuratsune, Hirohiko; Watanabe, Yasuyoshi (June 1, 2014). "Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study". Journal of Nuclear Medicine. 55 (6): 945–950. doi:10.2967/jnumed.113.131045. ISSN 0161-5505.
  11. ↑ Mizuno, Kei; Tanaka, Masaaki; Tanabe, Hiroki C.; Joudoi, Takako; Kawatani, Junko; Shigihara, Yoshihito; Tomoda, Akemi; Miike, Teruhisa; Imai-Matsumura, Kyoko; Sadatod, Norihiro; Watanabe, Yasuyoshi (2015). "Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome". NeuroImage: Clinical. 9: 355–368. doi:10.1016/j.nicl.2015.09.001. PMC 4589845. PMID 26594619.
  12. ↑ Tanaka, Masaaki; Tajima, Seiki; Mizuno, Kei; Ishii, Akira; Konishi, Yukuo; Miike, Teruhisa; Watanabe, Yasuyoshi (November 2015). "Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder". The Journal of Physiological Sciences. 65 (6): 483–498. doi:10.1007/s12576-015-0399-y. ISSN 1880-6546. PMC 4621713. PMID 26420687.
  13. ↑ Tanaka, Masaaki; Ishii, Akira; Watanabe, Yasuyoshi (April 2, 2016). "Neural effect of physical fatigue on mental fatigue: a magnetoencephalography study". Fatigue: Biomedicine, Health & Behavior. 4 (2): 104–114. doi:10.1080/21641846.2016.1167471. ISSN 2164-1846.
  14. ↑ Fukuda, S; Nojima, J; Kajimoto, O; Yamaguti, K; Nakatomi, Y; Kuratsune, H; Watanabe, Y (April 29, 2016), "Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome", BioFactors (Oxford, England), doi:10.1002/biof.1293, PMID 27125909
  15. ↑ Yamano, Emi; Sugimoto, Masahiro; Hirayama, Akiyoshi; Kume, Satoshi; Yamato, Masanori; Jin, Guanghua; Tajima, Seiki; Goda, Nobuhito; Iwai, Kazuhiro; Fukuda, Sanae; Yamaguti, Kouzi; Kuratsune, Hirohiko; Soga, Tomoyoshi; Watanabe, Yasuyoshi; Kataoka, Yosky (2016), "Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles", Scientific Reports, 6 (34990), doi:10.1038/srep34990, PMID 27725700
  16. ↑ Mizuno, Kei; Kawatani, Junko; Tajima, Kanako; Sasaki, Akihiro T.; Yoneda, Tetsuya; Komi, Masanori; Hirai, Toshinori; Tomoda, Akemi; Joudoi, Takako; Watanabe, Yasuyoshi (February 2016). "Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome". NeuroImage: Clinical. 12: 600–606. doi:10.1016/j.nicl.2016.09.016. PMC 5043413. PMID 27709065.
  17. ↑ 渡辺, 恭良; 倉恒, 弘彦 (January 1, 2018), 特集 筋痛性脳脊髄炎/慢性疲労症候群の今 筋痛性脳脊髄炎/慢性疲労症候群研究の潮流, 株式会社医学書院, doi:10.11477/mf.1416200943, retrieved October 31, 2019
  18. ↑ Nakatomi, Y; Kuratsune, H; Watanabe, Y (2018), "Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Brain Nerve, 70 (1): 19–25, doi:10.11477/mf.1416200945, PMID 29348371
  19. ↑ 渡辺, 恭良 (November 1, 2018), 増大特集 脳科学で解き明かす精神神経症候 筋痛性脳脊髄炎/慢性疲労症候群の脳科学研究, 株式会社医学書院, doi:10.11477/mf.1416201164, retrieved October 31, 2019
  20. ↑ Kokubun, Keisuke; Nemoto, Kiyotaka; Oka, Hiroki; Fukuda, Hiroki; Yamakawa, Yoshinori; Watanabe, Yasuyoshi (July 24, 2018). "Association of Fatigue and Stress With Gray Matter Volume". Frontiers in Behavioral Neuroscience. 12: 154. doi:10.3389/fnbeh.2018.00154. ISSN 1662-5153. PMC 6066525. PMID 30087602.
  21. ↑ Ishii, Akira; Matsuo, Takashi; Nakamura, Chika; Uji, Masato; Yoshikawa, Takahiro; Watanabe, Yasuyoshi (December 2019). "Decreased alpha-band oscillatory brain activity prior to movement initiated by perception of fatigue sensation". Scientific Reports. 9 (1): 4000. doi:10.1038/s41598-019-40605-7. ISSN 2045-2322. PMC 6408540. PMID 30850665.
  22. ↑ Eguchi, Akiko; Fukuda, Sanae; Kuratsune, Hirohiko; Nojima, Junzo; Nakatomi, Yasuhito; Watanabe, Yasuyoshi; Feldstein, Ariel E. (February 2020). "Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome". Brain, Behavior, and Immunity. 84: 106–114. doi:10.1016/j.bbi.2019.11.015. PMC 7010541. PMID 31759091.
  23. ↑ Yamano, Emi; Watanabe, Yasuyoshi; Kataoka, Yosky (March 26, 2021). "Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". International Journal of Molecular Sciences. 22 (7): 3423. doi:10.3390/ijms22073423. ISSN 1422-0067. PMID 33810365.

National Academy of Medicine (NAM) - An American non-profit, non-governmental organization which provides expert advice to governmental agencies on issues relating to biomedical science, medicine and health. Formerly known as the Institute of Medicine (IOM).

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue (CF) - Persistent and abnormal fatigue is a symptom, not an illness. It may be caused by depression, multiple sclerosis, fibromyalgia, chronic fatigue syndrome or many other illnesses. The term "chronic fatigue" should never be confused with the disease chronic fatigue syndrome.

cognition Thought processes, including attention, reasoning, and memory.

cognition Thought processes, including attention, reasoning, and memory.

stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.

extracellular vesicle An extracellular vesicle (sometimes abbreviated EV) is a piece of a cell that has broken off and formed a separate membrane-bound vesicle. A membrane-bound vesicle is like a bubble, or like a mini-cell, in that it has a membrane surrounding some liquid. An extracellular vesicle may also contain some parts of the cell from which the extracellular vesicle arose. There are currently two types of extracellular vesicles: "exosomes" and "microvesicles". An "exosome" is an extracellular vesicle that began inside the cell as an intracellular vesicle known as an "endosome". A "microvesicle" is an extracellular vesicle that begins at the cell surface, and pinches off the cell's own membrane to form a separate vesicle. (Learn more: journals.physiology.org)

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

physiological Concerning living organisms, such as cells or the human body.  Physio logical (as in physio) is not to be confused with psych ological (emotional stress).

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