Wirth-Scheibenbogen hypothesis
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Prof Dr Klaus Wirth and Prof Dr Carmen Scheibenbogen
Theory[edit | edit source]
Evidence[edit | edit source]
Treatment[edit | edit source]
Notable studies[edit | edit source]
Hypothesis[edit | edit source]
- 2020, A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors[1] - (Full text)
- 2021, An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[2] - (Full text)
- 2021, Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[3] - (Full text)
[edit | edit source]
- 2009, Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects[4] - (Abstract)
- 2011, Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome[5] - (Abstract)
- 2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls[6] - (Full text)
See also[edit | edit source]
- Endothelial dysfunction
- Beta 2-adrenergic receptor/ß2-adrenergic receptor (ß2AdR)
- Alfa 2-adrenergic receptors/α2-adrenergic receptors (a2AdR)
- Klaus Wirth
- Carmen Scheibenbogen
Learn more[edit | edit source]
References[edit | edit source]
- ↑ Wirth, Klaus; Scheibenbogen, Carmen (June 1, 2020). "A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors". Autoimmunity Reviews. 19 (6): 102527. doi:10.1016/j.autrev.2020.102527. ISSN 1568-9972.
- ↑ Wirth, Klaus J.; Scheibenbogen, Carmen; Paul, Friedemann (November 22, 2021). "An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of Translational Medicine. 19 (1): 471. doi:10.1186/s12967-021-03143-3. ISSN 1479-5876. PMC 8607226. PMID 34809664.
- ↑ Wirth, Klaus J.; Scheibenbogen, Carmen (April 21, 2021). "Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Journal of Translational Medicine. 19 (1): 162. doi:10.1186/s12967-021-02833-2. ISSN 1479-5876. PMC 8058748. PMID 33882940.
- ↑ Light, Alan R; White, Andrea T; Hughen, Ronald W; Light, Kathleen C (July 31, 2009). "Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects". J Pain. 10 (10): 1099-112. doi:10.1016/j.jpain.2009.06.003. PMID 19647494.
- ↑ Light, Alan R; Bateman, Lucinda; Jo, Daehyun; Hughen, Ronald W; Vanhaitsma, TA; White, Andrea T; Light, Kathleen C (July 13, 2011). "Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome". J Intern Med. 271 (1): 64-81. doi:10.1111/j.1365-2796.2011.02405.x. PMID 21615807.
- ↑ White, Andrea T; Light, Alan R; Hughen, Ronald W; VanHaitsma, Timothy A; Light, Kathleen C (December 30, 2011). "Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls". Psychosom Med. 74 (1): 46-54. doi:10.1097/PSY.0b013e31824152ed. PMID 22210239.