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Varicella zoster virus
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==VZV as a cause of ME/CFS == One medical hypothesis states that for some patients, CFS is a result of infection by a neurotropic virus, particularly VZV. Shapiro argues that virtually all CFS symptoms could be produced by infection of the peripheral ganglia. He further argues that the chronic course of CFS could be explained by how infections of the peripheral ganglia can cause long-term nerve dysfunction.<ref>{{Cite journal | date = 2009-11-01 | title = Does varicella-zoster virus infection of the peripheral ganglia cause Chronic Fatigue Syndrome?|url=https://www.sciencedirect.com/science/article/pii/S0306987709003065|journal=Medical Hypotheses|language=en|volume=73|issue=5 | pages = 728β734|doi=10.1016/j.mehy.2009.04.043|issn=0306-9877}}</ref> Dr John Chia says around 1.5% of cases of ME/CFS are due to reactivated varicella zoster virus, and this varicella form of ME/CFS can be very easily treated with antiviral drugs like acyclovir, which can completely cure the ME/CFSΒ in around 3 weeks.<ref>{{Cite web|url=https://www.youtube.com/watch?v=NhU-G0loqtY&t=6m58s | title = ME/CFS Alert With Llewellyn King: Episode 38 - Interview with Dr. John Chia, Part 1. Dec 2012. Timecode: 6:58. | last=Chia | first = John | author-link =| date = |website=|archive-url=|archive-date=|url-status=|access-date=}}</ref> === Studies === A population cohort study followed a group of VZV-infected and non-infected individuals, and found that the incidence of CFS was higher among the VZV-infected cohort. The authors report that the VZV-infected patients that used antiviral treatment had a 15% reduced risk of CFS compared to patients without antiviral treatment. Overall they concluded that VZV infection may be associated with the risk of CFS, even without a comorbidity.<ref>{{Cite journal | last = Kao | first = C.-H. | last2 = Kuo | first2 = C.-N. | last3 = Shen | first3=W.-C. | last4 = Lin | first4=W.-M. | last5 = Chen | first5 = C.-S. | last6 = Chen | first6 = H.-J. | last7 = Yang | first7 = T.-Y. | last8 = Tsai | first8 = S.-Y. | date = 2014-09-01 | title = Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study|url=https://link.springer.com/article/10.1007/s10096-014-2095-x|journal=European Journal of Clinical Microbiology & Infectious Diseases|language=en|volume=33|issue=9|pages=1653β1659|doi=10.1007/s10096-014-2095-x|issn=1435-4373}}</ref>
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