Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Tumor necrosis factor alpha
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==Notable studies== *2016, [http://www.jni-journal.com/action/showFullTextImages?pii=S0165-5728%2816%2930449-0 Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women]<blockquote>"ABSTRACT: ''Objective'' - Poor sleep quality has been linked to inflammatory processes and worse disease outcomes in the context of many chronic illnesses, but less is known in conditions such as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). This study examines the relationships between sleep quality, pro-inflammatory cytokines, and CFS/ME symptoms. ''Methods'' - Sixty women diagnosed with CFS/ME were assessed using the Pittsburgh Sleep Quality Index (PSQI), Fatigue Symptom Inventory (FSI) and Center for Disease Control and Prevention (CDC)-based CFS/ME symptom questionnaires. Circulating plasma pro-inflammatory cytokine levels were measured by ELISA. Multiple regression analyses examined associations between sleep, cytokines and symptoms, controlling for age, education, and body mass index. ''Results'' - Poor sleep quality (PSQI global score) was associated with greater pro-inflammatory cytokine levels: [[Interleukin 1 beta|interleukin-1Ξ²]] (IL-1Ξ²) (Ξ²β =β 0.258, pβ =β 0.043), [[Interleukin 6|IL-6]] (Ξ²β =β 0.281, pβ =β 0.033), and [tumor necrosis factor-alpha (TNF-Ξ±) (Ξ²β =β 0.263, pβ =β 0.044). Worse sleep quality related to greater fatigue severity (Ξ²β =β 0.395, pβ =β 0.003) and fatigue-related interference with daily activities (Ξ²β =β 0.464, pβ <β 0.001), and more severe and frequent CDC-defined core CFS/ME symptoms (Ξ²β =β 0.499, pβ <β 0.001, and Ξ²β =β 0.556, pβ <β 0.001, respectively). ''Conclusions'' - Results underscore the importance of managing sleep-related difficulties in this patient population. Further research is needed to identify the etiology of sleep disruptions in CFS/ME and mechanistic factors linking sleep quality to symptom severity and inflammatory processes."<ref>{{Citation | last1 = Milrad | first1 = Sara F. | last2 = Hall | first2 = Daniel L. | last3 = Jutagir | first3 = Devika R. | last4 = Lattie|first4 = Emily G. | last5 = Ironson | first5 = Gail H. | last6 = Wohlgemuth | first6 = William | last7 = Vera Nunez | first7 = Maria | authorlink7 = Maria Vera | last8 = Garcia | first8 = Lina | last9 = Czaja | first9 = Sara J. | last10 = Perdomo | first10 = Dolores M. | last11 = Fletcher | first11 = Mary Ann | authorlink11 =Mary Ann Fletcher | last12 = Klimas | first12 = Nancy| authorlink12=Nancy Klimas | last13 = Antoni | first13 = Michael H. | authorlink13=Michael Antoni | title = Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women|journal= Journal of Neuroimmunology| volume = 0 | issue = 0 | page = | date = 2016|doi= 10.1016/j.jneuroim.2016.12.008}}</ref></blockquote> *1999, [https://www.ncbi.nlm.nih.gov/pubmed/10535608 TNF-alpha and chronic fatigue syndrome]<blockquote>"ABSTRACT: Based upon the clinical presentation of chronic fatigue syndrome (CFS), we hypothesized that proinflammatory cytokines may play a role in the pathogenesis of the disease. We therefore undertook a retrospective cross-sectional study to examine the role of TNF-alpha in patients with CFS. Our results suggest a significant increase serum TNF-alpha in patients with CFS (P<0.0001) compared to non-CFS controls. This study supports the further examination of the role of proinflammatory mediators in CFS. Furthermore, the clinical testing of TNF-alpha blockers and other antiinflammatory agents for the treatment of this disease is warranted."<ref name="Moss, 1999" /></blockquote> *1994, [https://www.ncbi.nlm.nih.gov/pubmed/8148443 Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression]<blockquote>"ABSTRACT: Among a group of 70 individuals who met the criteria established by the Centers for Disease Control and Prevention (Atlanta) for chronic fatigue syndrome (CFS), 12%-28% had serum levels exceeding 95% of control values for tumor necrosis factor (TNF) alpha, TNF-beta, [[Interleukin 1 alpha|interleukin (IL) 1 alpha]], [[Interleukin 2|IL-2]], soluble IL-2 receptor (sIL-2R), or [[neopterin]]; overall, 60% of patients had elevated levels of one or more of the nine soluble [[immune mediator]]s tested. Nevertheless, only the distributions for circulating levels of TNF-alpha and [[TNF-beta]] differed significantly in the two populations. In patients with CFS--but not in controls--serum levels of TNF-alpha, IL-1 alpha, [[Interleukin 4|IL-4]], and sIL-2R correlated significantly with one another and (in the 10 cases analyzed) with relative amounts (as compared to beta-globin or beta-actin) of the only mRNAs detectable by reverse transcriptase-coupled polymerase chain reaction in [[Peripheral blood mononuclear cell|peripheral-blood mononuclear cells]]: TNF-beta, unspliced and spliced; [[Interleukin 1 beta|IL-1 beta]], lymphocyte fraction; and IL-6 (in order of appearance). These findings point to polycellular activation and may be relevant to the etiology and nosology of CFS."<ref>{{Citation | last1 = Patarca | first1 = Roberto | authorlink1 = Roberto Patarca-Montero | last2 = Klimas | first2 = Nancy | authorlink2 = Nancy Klimas | last3 = Lugtendorf | first3 = S | authorlink3 = | last4 = Antoni|first4 = Michael H. | authorlink4 = Michael Antoni | last5 = Fletcher | first5 = Mary Ann|authorlink5 = Mary Ann Fletcher | title = Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression| journal = Clinical Infectious Diseases| volume = 18 | issue = | page = S147-53 | date = 1994 | pmid = 8148443}}</ref></blockquote>
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs