Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Tryptophan
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
'''Tryptophan''' is an essential [[amino acid]] and is used in the body to help make the B vitamin [[niacin]], the hormone [[melatonin]], and the [[neurotransmitter]] [[serotonin]].<ref>{{Cite web|url=https://medlineplus.gov/ency/article/002332.htm | title = Tryptophan: MedlinePlus Medical Encyclopedia|website=medlineplus.gov|language=en|access-date=2019-04-16}}</ref> L-tryptophan was formerly used as a dietary supplement to help relieve [[insomnia]] and [[depression]].<ref>{{Cite web|url=https://www.merriam-webster.com/dictionary/L-tryptophan | title = Definition of L-TRYPTOPHAN|website=Merrian-Webster Dictionary|language=en|access-date=2018-11-17}}</ref> There is insufficient evidence for the use of L-tryptophan to improve sleep or depression.<ref>{{Cite web|url=https://medlineplus.gov/druginfo/natural/326.html | title = L-Tryptophan: MedlinePlus Supplements|website=medlineplus.gov|language=en|access-date=2018-11-17}}</ref> ==Importance to ME/CFS== By mediating tryptophan catabolism, the enzyme [[indoleamine-2,3-dioxygenase]] (IDO) has a complex role in immunoregulation in infection and autoimmunity.<ref>{{Cite journal | last =Bozza | first = Silvia | last2 = Fallarino | first2 = Francesca | last3 = Pitzurra | first3 = Lucia | last4 = Zelante | first4 = Teresa| last5 = Montagnoli | first5 = Claudia | last6 = Bellocchio | first6 = Silvia | last7 = Mosci | first7 = Paolo | last8 = Vacca | first8 = Carmine | last9 = Puccetti | first9 = Paolo | last10 = Romani | first10 = Luigina | date = Mar 2005 | title = A Crucial Role for Tryptophan Catabolism at the Host/Candida albicans Interface|url=http://www.jimmunol.org/content/174/5/2910.long|journal=Journal of Immunology|volume=174|issue=5|pages=2910-2918|doi=10.4049/jimmunol.174.5.2910|issn=|quote=|via=}}</ref> The [[ME/CFS Severely Ill, Big Data Study]] of found IDO genes defects in most of the small group with severe ME that was studied, which may prevent people with ME/CFS from metabolising tryptophan, leading to increased levels in patients.<ref name="whatsnext"/> [[Ronald Davis|Dr. Ron Davis]], speaking about tryptophan being available on the market, has made it clear that self experimentation can be very dangerous.<ref name="whatsnext">{{Cite web|url=https://youtu.be/pFzOrknOylA?list=PLl4AfLZNZEQPxjqF4ojAO3wdCFMeriNBK&t=663 | title = Ronald W. Davis, PhD {{!}} What's next? | last =Davis | first = Ronald | authorlink=Ronald Davis | date = Nov 7, 2018 | website = YouTube|publisher=Open Medicine Foundation - OMF|archive-url=|archive-date=|url-status=|access-date=}}</ref> ==Learn more== The 15th Conference of the International Society of Tryptophan Research was held at The University of Shiga Prefecture, which is situated in Hikone city, 30 miles east of Kyoto, Japan. The conference was a venue for tryptophan research including cancer, immunology, neuroscience, pathology, pharmacology, physiology, clinical diagnosis, nutrition, food science, analytical chemistry and L- tryptophan metabolism.<ref>http://www.istry2018.com/</ref> ==Notable studies== * 2010, Sex differences in plasma prolactin response to tryptophan in chronic fatigue syndrome patients with and without comorbid [[fibromyalgia]]<ref>{{Cite journal | last =Weaver | first = Shelley A. | last2 = Janal | first2 = Malvin N. | last3 = Aktan | first3=Nadine | last4 = Ottenweller | first4=John E. | last5 = Natelson | first5 = Benjamin H. | date = May 2010 | title = Sex differences in plasma prolactin response to tryptophan in chronic fatigue syndrome patients with and without comorbid fibromyalgia|url=https://www.ncbi.nlm.nih.gov/pubmed/20384451|journal=Journal of Women's Health (2002)|volume=19|issue=5 | pages = 951β958|doi=10.1089/jwh.2009.1697|issn=1931-843X|pmc=2875960|pmid=20384451|quote= | author-link = Shelley Weaver | authorlink2 = Malvin Janal | author-link3 = Nadine Aktan | authorlink4 = John Ottenweller | authorlink5 = Benjamin Natelson|via=}}</ref> ([https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875960/ Full text]) * 2011, [[Kynurenine pathway hypothesis|Kynurenine pathway Hypothesis]]: The nature of the chronic Fatigue syndrome (cFs) Revisited<ref>{{Cite journal | last =Blankfield | first=Adele | author-link = Adele Blankfield | date = 2011-07-31 | title = Kynurenine pathway Hypothesis: The nature of the chronic Fatigue syndrome (cFs) Revisited | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195222/|journal=International Journal of Tryptophan Research : IJTR|volume=4|issue=|pages=47β48|doi=10.4137/IJTR.S7898|issn=1178-6469|pmc=3195222|pmid=22084603|quote=|via=}}</ref> ([https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195222/ Full text]) * 2012, A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)<ref>{{Cite journal | last =Blankfield | first=Adele | author-link = Adele Blankfield | date = 2012-09-17 | title = A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460668/|journal=International Journal of Tryptophan Research : IJTR|volume=5|issue=|pages=27β32|doi=10.4137/IJTR.S10085|issn=1178-6469|pmc=3460668|pmid=23032646|quote=|via=}}</ref> ([https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460668/ Full text]) * 2014, Tryptophan depletion in chronic fatigue syndrome, a pilot cross-over study<ref>{{Cite journal | last = The | first = Gerard K. H. | last2 = Verkes | first2 = Robbert J. | last3 = Fekkes | first3=Durk | last4 = Bleijenberg | first4 = Gijs| last5 = van der Meer | first5 = Jos W.M. | last6 = Buitelaar | first6 = Jan K. | date = 2014-09-16 | title = Tryptophan depletion in chronic fatigue syndrome, a pilot cross-over study|url=https://www.ncbi.nlm.nih.gov/pubmed/25227994|journal=BMC research notes|volume=7 | pages = 650|doi=10.1186/1756-0500-7-650|issn=1756-0500|pmc=4176591|pmid=25227994|issue=|quote= | author-link = Gerard The | authorlink2 = Robbert Verkes | author-link3 = Durk Fekkes | authorlink4 = Gijs Bleijenberg | authorlink5 = Jos van der Meer|via= | authorlink6 = Jan Buitelaar}}</ref> ([https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176591/ Full text]) * 2014, Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome<ref>{{Cite journal | last = Anderson | first = G. | last2 = Berk | first2 = M. | last3 = Maes | first3=M. | date = Feb 2014 | title = Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/23952563|journal=Acta Psychiatrica Scandinavica|volume=129|issue=2 | pages = 83β97|doi=10.1111/acps.12182|issn=1600-0447|pmid=23952563}}</ref> ([[pubmed:23952563|Abstract]]) * 2014, Physiosomatic complaints, immune-inflammatory pathways, and serotonin-related mood symptoms: relevance for tryptophan-related challenge procedures and clinical considerations with respect to the DSM-V<ref>{{Cite journal | last =von Polier | first=G. G. | last2 = Zepf | first2 = F. D. | date = Feb 2014 | title = Physiosomatic complaints, immune-inflammatory pathways, and serotonin-related mood symptoms: relevance for tryptophan-related challenge procedures and clinical considerations with respect to the DSM-V|url=https://www.ncbi.nlm.nih.gov/pubmed/24117193|journal=Acta Psychiatrica Scandinavica|volume=129|issue=2 | pages = 98β99|doi=10.1111/acps.12197|issn=1600-0447|pmid=24117193}}</ref> (Comment on 2014, "Biological phenotypes underpin...") * 2016, The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders<ref>{{Cite journal | last =Morris | first = Gerwyn | last2 = Carvalho | first2 = AndrΓ© F. | last3 = Anderson | first3=George | last4 = Galecki | first4 = Piotr | last5 = Maes | first5 = Michael | date = 2016 | title=The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders|url=https://www.ncbi.nlm.nih.gov/pubmed/26667000|journal=Current Pharmaceutical Design|volume=22|issue=8 | pages = 963β977|issn=1873-4286|pmid=26667000|quote= | author-link = Gerwyn Morris | authorlink2 = AndrΓ© Carvalho | author-link3 = George Anderson | authorlink4 = Piotr Galecki | authorlink5 = Michael Maes|via=}}</ref> ([[pubmed:26667000|Abstract]]) ==See also == *[[Metabolic trap]] *[[Kynurenine]] *[[Kynurenine pathway]] *[[Amino acid]] ==References== {{Reflist}} {{stub}} [[Category:Amino acids]] [[Category:Biochemistry and cell biology]] [[Category:Depression alternative treatments]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Asbox
(
edit
)
Template:Cite journal
(
edit
)
Template:Cite web
(
edit
)
Template:Full stop
(
edit
)
Template:Full stop character
(
edit
)
Template:GetFallback
(
edit
)
Template:Help improve text
(
edit
)
Template:LangSwitch
(
edit
)
Template:Main other
(
edit
)
Template:No fullstop
(
edit
)
Template:No fullstop/first
(
edit
)
Template:Reflist
(
edit
)
Template:Str endswith
(
edit
)
Template:Stub
(
view source
) (semi-protected)
Template:Stub text
(
edit
)
Template:Uselang
(
edit
)
Module:Arguments
(
edit
)
Module:Asbox
(
edit
)
Module:Buffer
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:Navbar
(
edit
)
Module:No globals
(
edit
)
Module:String
(
edit
)
This page is a member of 2 hidden categories:
Category:All stub articles
Category:Stub pages last edited in 2023
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs