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Tryptase alpha/beta 1
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'''Tryptase alpha/beta 1''' or '''TPSAB1''' is a protein-encoding gene for [[tryptase]].<ref name="genecards">{{Cite web|website=Gene cards|access-date=2022-04-03 | url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TPSAB1&keywords=TPSAB1 | title = Tryptase alpha/beta 1 Gene}}</ref> ==Function== ==Hereditary alpha tryptasemia syndrome== Extra copies of the TPSAB1 gene is known as '''familial hypertryptasemia''' (FHT) or '''hereditary alpha tryptasemia''' (HβΊT or HAT) and is one of several possible causes for increased [[tryptase]] production.<ref name="Lyons2016">{{Cite journal | title = Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features | date = 2018-08-01|url=https://www.sciencedirect.com/science/article/pii/S0889856118300298|journal=Immunology and Allergy Clinics of North America|volume=38|issue=3|pages=483β495 | last =Lyons | first = Jonathan J.|series=Mastocytosis|language=en|doi=10.1016/j.iac.2018.04.003|pmc=PMC6411063|pmid=30007465|issn=0889-8561}}</ref> HAT is common and often does not cause illness.<ref name="Lyons2016"/> '''Hereditary alpha tryptasemia syndrome''' (HATS) is a recently discovered multi-systemic illness involving an increased number of TPSAB1 genes with a cluster of symptoms similar to those found in [[mast cell activation syndrome|MCAS]]. {{See also|Hereditary alpha tryptasemia syndrome}} {{See also|Mast cell activation syndrome}} ==Other symptoms and diseases== The TPSAB1 has also been implicated in [[pruritus]], medically unexplained (functional) [[digestive problems|gastrointestinal symptoms]] and in.<ref name="niaid-FAQ">{{Cite web | title = Hereditary Alpha Tryptasemia Syndrome FAQ|website=[[National Institute of Allergy and Infectious Diseases]] | date = Oct 17, 2016|url=https://www.niaid.nih.gov/research/hereditary-alpha-tryptasemia-faq}}</ref><ref name="Lyons2016"/> ==ME/CFS== ==See also== *[[Hereditary alpha tryptasemia syndrome]] *[[Mast cell activation syndrome]] ==Learn more== *[https://www.genecards.org/cgi-bin/carddisp.pl?gene=TPSAB1 TPSAB1 Gene] - Gene cards *[https://www.niaid.nih.gov/research/hereditary-alpha-tryptasemia-faq Hereditary Alpha Tryptasemia Syndrome FAQ] - National Institute of Allergy and Infectious Diseases ==References== {{reflist}} [[Category:Proteins]] [[Category:Genes]] [[Category:Biochemistry and cell biology]]
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