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Transient receptor potential melastatin 3
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{{stub}} {{NeedsImage}} '''Transient Receptor Potential Melastatin 3''' or '''TRPM3''' is a non-selective [[ion channel]] permeable to both calcium and magnesium. Impaired activity of TRPM3 function is a potential biomarker for [[ME/CFS]].<ref name="Cabanas2019" /> TRPM3 may also be used to refer to the gene for TRPM3. ==Function== ==ME/CFS== ==Notable studies== *2021, Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment<ref name="Cabanas2021">{{Cite journal | title = Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment | date = 2021|url=https://www.frontiersin.org/articles/10.3389/fimmu.2021.687806|journal=Frontiers in Immunology|volume=12|issue= | pages = 687806 | last =Cabanas | first = Helene | author-link = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko|author-link2 = | last3 = Eaton-Fitch | first3 = Natalie | author-link3 = Natalie Eaton-Fitch | last4 = Staines | first4=Donald Ross | authorlink4 = Donald Staines| last5 = Marshall-Gradisnik | first5 = Sonya | authorlink5 = Sonya Marshall-Gradisnik|doi=10.3389/fimmu.2021.687806|pmc=PMC8313851|pmid=34326841|access-date=|issn=1664-3224|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2021.687806/full (Full text)] *2019, Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Cabanas2019">{{Cite journal | last =Cabanas | first = H. | author-link = Hélène Cabanas | last2 = Muraki | first2 = K.|author-link2 = | last3 = Balinas | first3=C. | author-link3 = Cassandra Balinas | last4 = Eaton-Fitch | first4 = N. | authorlink4 = Natalie Eaton-Fitch| last5 = Staines | first5 = D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | authorlink6 = Sonya Marshall-Gradisnik | date = Dec 2019 | title = Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0083-4|journal=Molecular Medicine|language=en|volume=25|issue=14|pages=|doi=10.1186/s10020-019-0083-4|issn=1076-1551|quote=|via=|pmc=|pmid=|access-date=}}</ref> - [https://link.springer.com/article/10.1186/s10020-019-0083-4 (Full text)] * 2019, [[Low dose naltrexone|Naltrexone]] restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients<ref name="Cabanas2019LDN">{{Cite journal | last =Cabanas | first = Helene | author-link = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko|author-link2 = | last3 = Staines | first3=Donald | author-link3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | author-link4 = Sonya Marshall-Gradisnik | date = Oct 14, 2019 | title = Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients|url=https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract|journal=Frontiers in Immunology|volume=|issue=|pages=|doi=10.3389/fimmu.2019.02545|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract (Abstract)] *2018, Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Cabanas2018">{{Cite journal | last =Cabanas | first = Hélène | author-link = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | authorlink2 = Katsuhiko Muraki | last3 = Eaton | first3=Natalie | author-link3 = Natalie Eaton-Fitch | last4 = Balinas | first4=Cassandra | author-link4 = Cassandra Balinas| last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | authorlink6 = Sonya Marshall-Gradisnik | date = 2018-08-14 | title = Loss of Transient Receptor Potential Melastatin 3 ion channel function in Natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092868/|journal=Molecular Medicine|volume=24|issue=2|pages=|doi=10.1186/s10020-018-0046-1|issn=1076-1551|pmc=6092868|pmid=30134818|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092868/#__ffn_sectitle (Full text)] *2018, Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in [[ME/CFS|Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]]<ref name="Marshall2018">{{Cite journal | last =Marshall-Gradisnik | first = Sonya | authorlink = Sonya Marshall-Gradisnik | last2 = Fretel | first2 = Marshall | author-link2 = | last3 = Eaton | first3=Natalie | author-link3 = Natalie Eaton | first4=Helene | last4 = Cabanas | authorlink4 = Hélène Cabanas| last5 = Balinas | first5 = Cassandra | authorlink5 = | last6 = Gopalan | first6 = Vinod | author-link6 = | last7 = Petersen | first7 = Daniel | authorlink7 = Daniel Peterson | last8 = Passmore | first8 = Rachel | last9 = Tang | first9 = Kevin | last10 = Haque | first10 = Mazhar | authorlink10 = | last11 = Lam | first11 = Alfred | authorlink11 = | last12 = Staines | first12 = Donald | authorlink12 = Donald Staines | date = 2018-05-31|access-date=| title=Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|url=http://www.scirp.org/journal/PaperInformation.aspx?PaperID=85005&#abstract|journal=International Journal of Clinical Medicine|language=en|volume=09|issue=05|pages=467|doi=10.4236/ijcm.2018.95040|via=|pmc=|pmid=|quote=}}</ref> - [http://file.scirp.org/Html/11-2101759_85005.htm (Full text)] *2016, Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients<ref name="Marshall2016">{{Cite journal | last =Marshall-Gradisnik | first = S.M. | author-link = Sonya Marshall-Gradisnik | last2 = Chacko | first2 = A. | authorlink2 = A Chacko | last3 = Johnston | first3=S. | author-link3 = Samantha Johnston | last4 = Smith | first4 = P. | authorlink4 = Peter Smith| last5 = Nilius | first5 = B. | authorlink5 = B Nilius | last6 = Staines | first6 = D.R. | authorlink6 = Donald Staines | date = 2016-01-01 | title = Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients|url=https://doi.org/10.4137/III.S37042|journal=Immunology and Immunogenetics Insights|language=en|volume=8|issue=|pages=III.S37042|doi=10.4137/III.S37042|issn=1178-6345|quote=|via=}}</ref> - [https://journals.sagepub.com/doi/full/10.4137/III.S37042 (Full text)] *2016, ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Huth2016">{{Cite journal | last =Huth | first = Teilah Kathryn | author-link = Teilah Huth | last2 = Staines | first2=Donald | authorlink2 = Donald Staines | last3 = Marshall-Gradisnik | first3 = Sonya | author-link3 = Sonya Marshall-Gradisnik | date = 2016-04-21 | title = ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://doi.org/10.1186/s12967-016-0859-z|journal=Journal of Translational Medicine|volume=14|issue=1 | pages = 97|doi=10.1186/s12967-016-0859-z|issn=1479-5876|pmc=4839077|pmid=27098723|quote=|via=}}</ref> - [http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0859-z (Full text) *2016, Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients<ref name="Nguyen2016">{{Cite journal | last =Nguyen | first = T. | author-link = Thao Nguyen | last2 = Staines | first2= D. | authorlink2 = Donald Staines | last3 = Nilius | first3=B. | author-link3 = B Nilius | last4 = Smith | first4 = P. | authorlink4 = Peter Smith| last5 = Marshall-Gradisnik | first5 = S. | authorlink5 = Sonya Marshall-Gradisnik | date = 2016-05-31 | title = Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients|url=https://doi.org/10.1186/s40659-016-0087-2|journal=Biological Research|volume=49|issue=1|pages=27|doi=10.1186/s40659-016-0087-2|issn=0717-6287|pmc=4888729|pmid=27245705|quote=|via=}}</ref> - [https://biolres.biomedcentral.com/articles/10.1186/s40659-016-0087-2 (Full text)] *2015, Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients]<ref name="Marshall2015">{{Cite journal | last =Marshall-Gradisnik | first = Sonya M. | author-link = Sonya Marshall-Gradisnik | last2 = Smith | first2 = Peter | authorlink2 = Peter Smith | last3 = Brenu | first3 = Ekua W. | author-link3 = Ekua Brenu | last4 = Nilius | first4=Bernd | author-link4 = Bernd Nilius| last5 = Ramos | first5 = Sandra B. | authorlink5 = Sandra Ramos | last6 = Staines | first6 = Donald R. | date = 2015-01-01 | title = Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients|url=https://doi.org/10.4137/III.S25147|journal=Immunology and Immunogenetics Insights|language=en|volume=7|issue=|pages=III.S25147|doi=10.4137/III.S25147|issn=1178-6345|quote=|via=}}</ref> - [https://journals.sagepub.com/doi/full/10.4137/III.S25147 (Abstract)] - small study - 115 people with ME/CFS *2015, Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis<ref name="NKcells-2015">{{Cite journal | last =Huth | first = T.K. | authorlink = Teilah Huth | last2 = Brenu | first2 = E.W. | authorlink2 = Ekua Brenu | last3 = Ramos | first3=S. | author-link3 = Sandra Ramos | last4 = Nguyen | first4=T. | authorlink4 = Thao Nguyen| last5 = Broadley | first5 = S. | authorlink5 = Simon Broadley | last6 = Staines | first6 = D. | authorlink6 = Donald Staines | last7 = Marshall‐Gradisnik | first7 = S. | authorlink7 = Sonya Marshall-Gradisnik | date = 2016 | title=Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/sji.12388|journal=Scandinavian Journal of Immunology|language=en|volume=83|issue=1|pages=44–51|doi=10.1111/sji.12388|issn=1365-3083|quote=|via=}}</ref> - [https://onlinelibrary.wiley.com/doi/10.1111/sji.12388/abstract (Abstract) ==News and blogs== * Dec 19, 2019, [http://simmaronresearch.com/2019/12/naltrexone-natural-killer-cells-chronic-fatigue-syndrome/ Finally Found – A Natural Killer Cell Enhancer for ME/CFS?] - Cort Johnson ==See also == *[[Transient receptor potential melastatin 2]] *[[Ion channel]] *[[Diagnostic biomarker]] *[[Natural killer cell]] *[[Plasma]] *[[Ion transportation]] *[[Transient receptor potential]] *[[Channelopathy]] *[[National Centre for Neuroimmunology and Emerging Diseases]] ==Learn more == ==References == {{Reflist}} [[Category:Immunology]] [[Category:Anatomy]] [[Category:Genes]] [[Category:Biochemistry and cell biology]] [[Category:Channelopathy]] [[Category:Energy system]]
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