Transforming growth factor beta: Difference between revisions
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TGF-β is disturbed in [[Marfan’s syndrome]] and [[Loeys–Dietz syndrome]]. | TGF-β is disturbed in [[Marfan’s syndrome]] and [[Loeys–Dietz syndrome]]. | ||
It activates [[fibroblast]] proliferation<ref>{{Cite journal|last=Strutz|first=Frank|last2=Zeisberg|first2=Michael|last3=Renziehausen|first3=Anja|last4=Raschke|first4=Birgit|last5=Becker|first5=Volker|last6=Van Kooten|first6=Cees|last7=Müller|first7=Gerhard A.|date=2001-02-01|title=TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)|url=http://www.sciencedirect.com/science/article/pii/S0085253815475076|journal=Kidney International|volume=59|issue=2|pages=579–592|doi=10.1046/j.1523-1755.2001.059002579.x|issn=0085-2538}}</ref> and stimulates fibroblasts to release [[connective tissue growth factor]] (CTGF).<ref>{{Cite journal|last=Grotendorst|first=Gary R.|date=1997-09-01|title=Connective tissue growth factor: a mediator of TGF-β action on fibroblasts|url=http://www.sciencedirect.com/science/article/pii/S1359610197000105|journal=Cytokine & Growth Factor Reviews|volume=8|issue=3|pages=171–179|doi=10.1016/S1359-6101(97)00010-5|issn=1359-6101}}</ref> | |||
== References == | == References == | ||
Revision as of 19:15, September 9, 2019
Transforming growth factor beta (TGF-β ) is a cytokine secreted by many types of cells including macrophages.
TGF-β is disturbed in Marfan’s syndrome and Loeys–Dietz syndrome.
It activates fibroblast proliferation[1] and stimulates fibroblasts to release connective tissue growth factor (CTGF).[2]
References[edit | edit source]
- ↑ Strutz, Frank; Zeisberg, Michael; Renziehausen, Anja; Raschke, Birgit; Becker, Volker; Van Kooten, Cees; Müller, Gerhard A. (February 1, 2001). "TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)". Kidney International. 59 (2): 579–592. doi:10.1046/j.1523-1755.2001.059002579.x. ISSN 0085-2538.
- ↑ Grotendorst, Gary R. (September 1, 1997). "Connective tissue growth factor: a mediator of TGF-β action on fibroblasts". Cytokine & Growth Factor Reviews. 8 (3): 171–179. doi:10.1016/S1359-6101(97)00010-5. ISSN 1359-6101.
