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Thyroid hormone
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=== Peripheral === T4 is a [[prohormone]] and a reservoir for the biologically active T3. T<sub>4</sub> is converted to T3 by deiodinase enzymes. There are three types of deiodinase enzymes: * '''Type 1 (D1)''' deiodinates T4 to the biologically active T3 as well as the hormonally inactive and possibly inhibitory rT3. Breaks down rT3 into T2. Encoded by ''DIO1'' gene''.'' In humans, it is found in liver, kidney, thyroid, and pituitary.<ref name=":0">{{Cite journal | last =Medici | first = Marco | date = March 2017 | title = Genetics of thyroid function|url=https://www.sciencedirect.com/science/article/abs/pii/S1521690X17300301|journal=Best Practice & Research Clinical Endocrinology & Metabolism|volume=31|pages=129-142|via=}}</ref> * '''Type 2 (D2)''' converts T4 into T3, and breaks down rT3 into T2. Encoded by ''DIO2'' gene''.'' In humans, it is found in skeletal muscle, central nervous system, pituitary, thyroid, heart, and brown adipose tissue.<ref name=":0" /> * '''Type 3 (D3)''' produces rT3 from T4, and breaks down T3 into T2. Encoded by ''DIO3'' gene''.'' In humans, it has been found in the central nervous system and placenta in adults and in many additional tissues in the fetus.<ref name=":0" />
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