Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Thyroid hormone
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==Role in other human disease== === ME/CFS === A study of 99 patients with a diagnosis of [[chronic fatigue syndrome]] found similar levels of TSH to healthy controls but lower free triiodothyronine (FT3), total thyroxine (TT4), total triiodothyronine (TT3), %TT3 (4.7%), deiodinase activity, secretory capacity of the thyroid gland, lower 24-h urinary iodine (27.6%), and higher % reverse T3 (rT3). "Low circulating T3 and the apparent shift from T3 to rT3 may reflect more severely depressed tissue T3 levels. The present findings might be in line with recent metabolomic studies pointing at a hypometabolic state."<ref name="Ruiz-NΓΊΓ±ez, 2018" /> === Fibromyalgia === A series of small N trials found significant improvement in [[fibromyalgia]] symptoms in euthyroid patients given T3.<ref>{{Cite journal | last =Lowe | first = John C. | date = 1996-08-10 | title = Results of an Open Trial of T3Therapy with 77 Euthyroid Female Fibromyalgia Patients|url=https://www.tandfonline.com/doi/abs/10.1300/J425v02n01_04?journalCode=wzcb20|journal=Clinical Bulletin of Myofascial Therapy|language=en|volume=2|issue=1|pages=35β37|doi=10.1300/j425v02n01_04|issn=1089-4195}}</ref><ref>{{Cite journal | last =Lowe | first = John C. | last2 = Garrison | first2 = Richard L. | last3 = Reichman | first3=Alan | last4 = Yellin | first4 = Jackie | date = 1997-08-15 | title = Triiodothyronine (T3) Treatment of Euthyroid Fibromyalgia|url=https://www.tandfonline.com/doi/abs/10.1300/J425v02n04_05|journal=Clinical Bulletin of Myofascial Therapy|language=en|volume=2|issue=4 | pages = 71β88|doi=10.1300/j425v02n04_05|issn=1089-4195}}</ref><ref>{{Cite journal | last =Lowe | first = John C. | last2 = Garrison | first2 = Richard L. | last3 = Reichman | first3=Alan J. | last4 = Yellin | first4 = Jackie| last5 = Thompson | first5 = Mervianna | last6 = Kaufman | first6 = Daniel | date = 1996-10-08 | title = Effectiveness and Safety of T3(Triiodothyronine) Therapy for Euthyroid Fibromyalgia|url=https://www.tandfonline.com/doi/abs/10.1300/J425v02n02_04|journal=Clinical Bulletin of Myofascial Therapy|language=en|volume=2|issue=2-3|pages=31β57|doi=10.1300/j425v02n02_04|issn=1089-4195}}</ref><ref>{{Cite journal | last =Lowe | first = Jhon C. | last2 = Reichman | first2=Alan J. | last3 = Yellin | first3 = Jackie | date = 1996-10-08 | title = The Process of Change During T3Treatment for Euthyroid Fibromyalgia|url=https://www.tandfonline.com/doi/abs/10.1300/J425v02n02_07|journal=Clinical Bulletin of Myofascial Therapy|language=en|volume=2|issue=2-3 | pages = 91β124|doi=10.1300/j425v02n02_07|issn=1089-4195}}</ref> === Small intestinal bacterial overgrowth === In one study, 54% of patients with hypothyroidism tested positive for [[small intestinal bacterial overgrowth]] (SIBO) as compared to 5% of controls.<ref>{{Cite journal | last =Lauritano | first = Ernesto Cristiano | date = November 1, 2007 | title = Association between Hypothyroidism and Small Intestinal Bacterial Overgrowth|url=https://academic.oup.com/jcem/article/92/11/4180/2598186|journal=The Journal of Clinical Endocrinology & Metabolism|volume=92|pages=4180β4184|via=}}</ref> SIBO is also associated with Levothyroxine usage,<ref>{{Cite journal | last =Brechmann | first=Thorsten | date = February 2017 | title = Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296200/|journal=World Journal of Gastroenterology|volume=23 | pages = 842β852|via=}}</ref> possibly owing to the secondary hypothyroidism seen in patients who are poor converters.
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs