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The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
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==Contents== *i. Magnetic Resonance Imaging ([[MRI]]) *ii. Dedication: Dr. John Richardson *iv-viii. Brain Imaging Illustrations *ix. Foreword *x. Preface: Unravelling the Enigma *xiv. In Appreciation ===Section 1: A Road Map to M.E. / CFS / [[Postviral fatigue syndrome|PVFS]] / [[Chronic Fatigue Immune Dysfunction Syndrome|CFIDS]]=== *Chapter 1: The Disease of a Thousand Names *Chapter 2: The Definitions of M.E./CFS, A Review *Chapter 3: A Description of Patients, [[Borys Chabursky]], Byron Hyde, M.D., [[Anil Jain]], M.D. *Chapter 4: General Information, Post Infectious, Acute Onset M.E./CFS, Byron Hyde, M.D., [[Sheila Bastien]], Ph.D, Anil Jain, M.D. *Chapter 5: Clinical Observations of CNS Dysfunction in Post-Infectious, Acute Onset M.E./CFS, Byron Hyde, M.D., Anil Jain, M.D. *Chapter 6: M.E./CFS: The Physical Signs of Disease, Byron Hyde, M.D., Anil Jain, M.D. ===Section 2: Opening Remarks of the Honorary Chairmen=== *Chapter 7: Myalgic Encephalomyelitis, Then and Now, An Epidemiological Introduction, A. Melvin Ramsay, M.B., [[Betty Dowsett]], M.B. *Chapter 8: M.E., The Epidemiological and Clinical Observations of a Rural Practitioner, [[John Richardson]], M.B., B.S. ===Section 3: Opening Remarks of some of the Chairmen=== *Chapter 9: The Myalgic Encephalomyelitis Syndrome, [[John Murdoch]], M.D., Ph.D: New Zealand *Chapter 10: "Spasmophilia" and/or "Myalgic Encephalomyelitis", [[Henri Rubinstein]], M.D.: France *Chapter 11: [[Tapanui Flu]] (A quest for a diagnosis), [[Peter Snow]], M.B., ChB, FRNZCSP: New Zealand :Chairman J.E. Banatvala, MA., M.D., MRCP, FRCPath: England :Chairman [[Alan Smith]], M.D.: South Africa ===Section 4: An Historical Review of M.E./CFS Like Disease=== *Chapter 12: Myalgic Encephalomyelitis (Chronic Fatigue Syndrome): An Historical Perspective, Byron Hyde, M.D. ===Section 5: The Twentieth Century History of M.E./CFS=== *Chapter 13: The [[1934 Los Angeles atypical polio outbreak|1934 Los Angeles County Hospital Epidemic]], [[A.G. Gilliam]], M.D., reviewed by [[Byron Hyde]], M.D. *Chapter 14: [[The Clinical Syndrome Variously Called Benign Myalgic Encephalomyelitis, Iceland Disease and Epidemic Neuromyasthenia]], [[Donald Acheson|E.D. Acheson]], D.M., MRCP *Chapter 15: [[Epidemic Neuromyasthenia - Clinical Syndrome?]], [[Donald A. Henderson]], M.D., MPH and [[Alexis Shelokov]], M.D. *Chapter 16: A Bibliography of M.E./CFS Epidemics, Public Domain ===Section 6: The Epidemiology and Methodology of M.E./CFS=== *Chapter 17: Epidemiolgic and Immunologic Findings in Clusters of Chronic Fatigue Syndrome, [[Seymour Grufferman]], M.D., Dr. PH *Chapter 18: Epidemiologic Aspects of CFS/M.E., [[Paul Levine|Paul H. Levine]], M.D. ===Section 7: Children and Students with M.E./CFS=== *Chapter 19: Children with M.E./CFIDS: Overview and Review of the Literature, [[David S. Bell]], M.D., FAAP ===Section 8: General Review=== *Chapter 20: A Multidisciplinary Approach to Investigating and Treating Patients with Chronic Fatigue, [[Richard H.T. Edwards]], Ph.D., FRCP *Chapter 21: A Review of M.E. / CFIDS / PVFS in America, [[Anthony Komaroff]], M.D. *Chapter 22: [[Post-Viral Fatigue Syndrome]] Research in Glasgow, A Review, Nightingale Research Foundation ===Section 9: Evaluating the M.E./CFS Patient=== *Chapter 23: How do I Diagnose a Patient with Chronic Fatigue Syndrome?, Jay Goldstein, M.D. *Chapter 24: The Evaluation of Adults with Chronic Fatigue: A Review of Laboratory and Psychological Findings, [[Dedra Buchwald]], M.D. *Chapter 25: Chronic Fatigue of Nasal Origin: Possible Confusion with Chronic Fatigue Syndrome, [[Alexander Chester III]], M.D., FACP ===Section 10: The Infectious Origins of M.E./CFS=== *Chapter 26: Possible Role for [[Epstein-Barr virus|Epstein-Barr Virus]] (EBV) in the Chronic Fatigue Syndrome (CFS), [[James Jones]], M.D. *Chapter 27: Detection of Viral Related Sequences in CFS Patients Using the Polymerase Chain Reaction, [[W. John Martin]], M.D., Ph.D ====Subsection A: The Enteroviral Theories==== *Chapter 28: Myalgic Encephalomyelitis (M.E.) - A Persistent Enteroviral Infection?, [[E.G. Dowsett]], M.B., [[A.M. Ramsay]], M.B. et al *Chapter 29: Virology Laboratory Diagnosis of Chronic Fatigue Syndrome, [[Bernadette McLaughlin]], M.D. *Chapter 30: The Immunosuppressive Effects of Group B [[Coxsackievirus]] Infections, [[Mauro Bendinelli]], M.D., Ph.D., [[Donatella Matteuci]], BS *Chapter 31: Evidence of Chronic [[Enterovirus]] Infection in M.E., [[James F. Mowbray]], FRCP *Chapter 32: Chronic Enterovirus Infection in Patients with PVFS, [[Galal Yousef]], M.D. et al ====Subsection B: The Retroviral Theories==== *Chapter 33: A [[Retrovirus]] Aetiology for CFS?, [[Michael J. Holmes]], M.D. *Chapter 34: Viral Infection in CFS Patients, W. John Martin, M.D., Ph.D *Chapter 35: The Search for a Retrovirus in CFS/CFIDS, [[Elaine DeFreitas]], Ph.D, [[Hiroshi Terunuma]], M.D., Ph.D. *Chapter 36: The Search for a Retrovirus in M.E./CFS, A Review, Byron Hyde, M.D. ===Section 11: The Skeletal Muscle As Target=== *Chapter 37: Molecular Virology of Muscle Disease: Persistent Virus Infection of Muscle in Patients with Postviral Fatigue Syndrome, [[Leonard C. Archard]], PhD, [[Louise Cunningham]], Ph.D. *Chapter 38: Neuromuscular Abnormalities in Patients with CFS, [[Carolyn L. Warner]], M.D. et al *Chapter 39: An Account of 100 Muscle Biopsies in Epidemic M.E., [[David Doyle]], M.D. *Chapter 40: Whole Body and Muscle Protein Synthesis in Myalgic Encephalomyelitis, [[David Halliday]], M.D., [[P.J. Pacy]], M.D. *Chapter 41: Exercise Testing in Patients with Chronic Fatigue Syndrome, [[David McCluskey]], M.D., [[M. Riley]], M.D. ===Section 12: The Heart As Target=== *Chapter 42: Cardiac and Cardiovascular Aspects of M.E./CFS, A Review, Byron Hyde, M.D., Anil Jain, M.D. ===Section 13: Neurology=== *Chapter 43: The Differential Diagnosis Between Multiple Sclerosis and Chronic Fatigue Postviral Syndrome, [[Charles M. Poser]], M.D. *Chapter 44: Neurological Features of M.E., [[Russell J.M. Lane]], M.D. *Chapter 45: CFS: Limbic Encephalopathy in a Dysfunctional Neuroimmune Network, Jay Goldstein, M.D. ===Section 14: M.E./CFS and the Peripheral Nervous System=== *Chapter 46: An Historical Review of the Electromyographic Features of Post-Infectious M.E./CFS, Byron Hyde, M.D., [[Alberto Marinacci]], M.D. and [[Karl Von Hagen]], M.D. *Chapter 47: Evidence for Organic Disturbance in the Post Viral Fatigue Syndrome: Neurophysiological Studies, [[Goran A. Jamal]], M.D., Ph.D. ===Section 15: M.E./CFS and Central Nervous System Injury=== *Chapter 48: Magnetic Resonance in the Diagnosis of M.E./CFS, A Review, Byron Hyde, M.D., [[Royce Biddle]], M.D., [[Thomas McNamara]], M.D. *Chapter 49: Study of Cerebral Perfusion by NeuroSPECT in Patients with CFS, [[Ismael Mena]], M.D., [[Javier Villanueva-Meyer]], M.D. *Chapter 50: Multi-modality Sensory and Auditory Cognitive Event-Related Potentials in M.E. and M.S., [[Deepak Prasher]], M.D., and [[Leslie Findley]], M.D. ===Section 16: Neuropsychological Changes in M.E./CFS=== *Chapter 51: Patterns of Neuropsychological Abnormalities and Cognitive Impairment in Adults and Children, [[Sheila Bastien]], Ph.D *Chapter 52: The MMPI as an Aid to CFS Diagnosis, [[Linda Iger]], Ph.D *Chapter 53: Is There a CFS Dementia?, [[Curt A. Sandman]], Ph.D *Chapter 54: Physical and Psychosocial Functioning in Chronic Fatigue Syndrome, [[Diane L. Cookfair]], Ph.D et al ===Section 17: Psychiatry in M.E./CFS=== *Chapter 55: Depression / Somatization Explanations for the Chronic Fatigue Syndrome: A Critical Review, [[Donald G. Dutton]], Ph.D *Chapter 56: The Psychiatric Status of Patients with the Chronic Fatigue Syndrome, [[Ian Hickie]], M.D. et al ===Section 18: Food Intolerance in M.E./CFS=== *Chapter 57: The Role of Food Intolerance in CFS, [[Robert Loblay]], M.D., Ph.D., [[Anne R. Swain]], Ph.D ===Section 19: Immunology=== *Chapter 58: Immunological Abnormalities in Patients with CFS, [[Andrew Lloyd]], M.D. et al *Chapter 59: Recent Developments in Immunological Aspects of CFS, [[Sudhir Gupta]], M.D., Ph.D. *Chapter 60: Host Factors Affecting the Course and Outcome of Viral Disease, [[Roger M. Loria]], Ph.D. (See also Chapter 74: The Role of Thymic Infections, Nathan Trainin, M.D. and Chapter 28: M.E. - A Persistent Enteroviral Infection, Betty Dowsett, M.D.) *Chapter 61: Abnormalities of [[Natural killer cell|Natural Killer (NK) Cell]] Numbers and Function in Patients with Chronic Fatigue Immune Dysfunction Syndrome (CFIDS), [[Hugh Pross]], M.D., Ph.D, FRCPC ===Section 20: Blood Cell Changes=== *Chapter 62: Opioid-Mediated Monocyte Dysfunction in the CFS, [[Jesus Prieto]], M.D. et al *Chapter 63: Paired, Age, Sex and Ethnically Matched Studies of Peripheral Blood Leucocyte Profiles in Early CFS, [[Michael Holmes]], M.D. et al *Chapter 64: Working Towards a Diagnostic Aid in CFS: Analysis of Peripheral Blood Leucocyte Profiles by Radial Plot, [[John Cross]], Ph.D et al *Chapter 65: The Role of Nondiscocytic Erythrocytes in the Pathogenesis of M.E./CFS, [[Len O. Simpson]], Ph.D. *Chapter 66: Differentiation Between M.S. and M.E., [[E.J. Field]], M.D., FRCP ===Section 21: New Investigation Techniques=== *Chapter 67: Biochemical Defects in the 2-5A Synthetase/RNAse L Pathway Associated with CFS with Encephalopathy, [[Robert J. Suhadolnik]], Ph.D et al *Chapter 68: Evidence for [[T-Cell]] Activation by Soluble IL-2-R and T8-R in the Chronic Fatigue Syndrome, [[Paul R. Cheney]], M.D., Ph.D (See also Chapter 64: Working Towards..., John Cross, Ph.D) ===Section 22: Treatment=== *Chapter 69: Intravenous Immunoglobulin Therapy in Patients with CFS, Andrew Lloyd, M.D. et al *Chapter 70: Essential Fatty Acid Therapy for M.E., [[Michael D. Winther]], M.D. *Chapter 71: Clinical Improvements Obtained with [[Ampligen]] in Patients with Severe CFS and Associated Encephalopathy, [[Daniel L. Peterson]], M.D. et al *Chapter 72: Immunological Therapy with Transfer Factor, [[Andrew Lloyd]], M.D. et al *Chapter 73: The Florence Nightingale Disease: A Multisystem Experiment of Nature: A 50 Patient Five Year Analysis, [[H. Hugh Fudenberg]], M.D. *Chapter 74: The Role of Thymic Hormones in Viral Infections, [[Nathan Trainin]], M.D. et al (See also Chapter 23: How I Diagnose..., Jay Goldstein, M.D.) ===Section 23: Fibrositis / Fibromyalgia=== *Chapter 75: Fibrositis / Fibromyalgia Syndrome, [[I. Jon Russell]], M.D., Ph.D ===Section 24: Conclusions=== *Summary *Addendum I - [[Jay Goldstein|Jay A. Goldstein]], M.D. *Addendum II - [[Linda Iger]], Ph.D *Addendum III - [[Harvey Moldofsky]], M.D. *Addendum IV - [[David C. Poskanzer]], M.D., M.P.H. *Addendum V - [[Alfredo Sadun|Alfredo A. Sadun]], M.D., Ph.D, [[Pravin Dugel|Pravin U. Dugel]], M.D. *Addendum VI - [[Bjorn Sigurdsson]], M.D., Ph.D
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