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T cell immunoreceptor with Ig and ITIM domains
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{{stub}} '''TIGIT''' or '''T Cell Immunoreceptor With Ig And ITIM Domains''', alternatively known as '''WUCAM''' or '''Vstm3''' or '''VSIG9''' is a protein and antibody which has an important role in the immune system.<ref name="Verma2021" /><ref name="PMC7160651">{{Cite journal | title = TIGIT as an emerging immune checkpoint | date = May 2020|url=https://pubmed.ncbi.nlm.nih.gov/31828774/|journal=Clinical and Experimental Immunology|volume=200|issue=2|pages=108–119 | last =Harjunpää | first = H. | author-link = | last2 = Guillerey | first2 = C. | authorlink2 = |pmid=31828774|access-date=|issn=1365-2249|quote=|via=}}</ref> The gene that encodes the TIGIT antibody may also be referred to as TIGIT.<ref name="genecards">{{Cite web|access-date=2022-05-01 | url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TIGIT | title = T cell immunoreceptor with Ig and ITIM domains - Gene card |website=Gene cards}}</ref> ==Function== TIGIT is an emerging immune checkpoint, and a number of drugs targeting TIGIT are undergoing clinical trials for a number of types of [[cancer]].<ref name="PMC7160651" /><ref name="genecards" /> ==ME/CFS== {{See also|Genetics of chronic fatigue syndrome}} ==Fibromyalgia == A 2021 study by Verma et al. using immune profiling that TIGIT may have an important role in [[fibromyalgia]].<ref name="Verma2021" /> ==Notable studies == *2021, Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia<ref name="Verma2021">{{Cite journal | title = Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia | date = 2022-03-04|url=https://journals.lww.com/pain/abstract/9000/unbiased_immune_profiling_reveals_a_natural_killer.97873.aspx|journal=PAIN|volume=|issue=|pages = | last = Verma | first = Vivek | authorlink = | last2 = Drury | first2 = Gillian L. | authorlink2 = | last3 = Parisien | first3=Marc | author-link3 = | last4 = Özdağ Acarli | first4 = Ayşe N. | authorlink4 = | last5 = Al-Aubodah | first5 = Tho-Alfakar | authorlink5 = | last6 = Nijnik | first6 = Anastasia | authorlink6 = | last7 = Wen | first7 = Xia | last8 = Tugarinov | first8 = Nicol | last9 = Verner | first9 = Maria | last10 = Klares | first10 = Richie III | last11 = Linton | first11 = Alexander|language=en-US|doi=10.1097/j.pain.0000000000002498|pmc=8942876|pmid=34913882|access-date=|issn=0304-3959|quote=|via=|pmc-embargo-date=2023-03-24}}</ref> - [https://journals.lww.com/pain/abstract/9000/unbiased_immune_profiling_reveals_a_natural_killer.97873.aspx (Abstract)] ==See also== *[[Natural killer cell]] *[[Immunoglobulin G]] - IgG antibody *[[Fibromyalgia]] ==Learn more== *[https://www.genecards.org/cgi-bin/carddisp.pl?gene=TIGIT TIGIT] - Gene cards ==References== {{reflist}} [[Category:Proteins]] [[Category:Genes]] [[Category:Antibodies]]
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