Systemic Exertion Intolerance Disease: Difference between revisions

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'''Systemic Exertion Intolerance Disease''' (SEID) was the new name proposed at the same time as the diagnostic criteria developed by the [[National Academy of Medicine]] (NAM) (formerly the Institute of Medicine, IOM) published on February 10, 2015. The report was titled ''Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness'', and is also referred to as the [[Institute of Medicine report]].
The '''current CDC [[Myalgic Encephalomyelitis]]/<wbr>[[Chronic Fatigue Syndrome]]''' diagnostic criteria is also known as the '''Systemic Exertion Intolerance Disease''' (SEID) criteria; SEID was a the new name proposed for chronic fatigue syndrome which is not in use.<ref name="beyondMECFS" /><ref name="CDC2020">{{Cite web|url=https://www.cdc.gov/me-cfs/index.html | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | last = | first =  | author-link =| date = 2021-11-16|website=CDC|language=en-us|archive-url=|archive-date=|url-status=|access-date=2021-12-23}}</ref>


The IOM diagnostic criteria requires [[chronic fatigue]] (CF); [[post-exertional malaise]] (PEM); [[unrefreshing sleep]]; and [[Cognitive dysfunction|cognitive impairment]] and/or [[orthostatic intolerance]] (OI).<ref name=":2">{{Cite web|url= https://www.nap.edu/resource/19012/MECFS_DiagnosticAlgorithm.jpg|title=Diagnostic Algorithm for ME/CFS|last=|first=|authorlink=|last2=|first2=|authorlink2=|date=2015|website=nap.edu|archive-url=|archive-date=|dead-url=|access-date=}}</ref> It is also useful for a more severe presentation of the disease; symptom severity and other symptoms are outlined in the Institute of Medicine report.<ref>{{Cite book|url=https://www.nap.edu/read/19012/chapter/7|title=Read "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness" at NAP.edu|last=|first=|publisher=National Academies of Medicine|year=2015|isbn=|editor-link=|location=|pages=141-162|language=en|chapter=5|quote=|editor-last2=|editor-link2=}}</ref>  
'''The proposed name and acronym SEID is meant to hone in on key aspects of'' ME/CFS''.''' '''''S'''ystemic'' would give credence to the disease being body wide.  '''''E'''xertion '''I'''ntolerance'' would key doctors into understanding that the patient cannot tolerate exertion.<ref>{{Cite book | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness|isbn=978-0-309-31689-7|url=http://www.ncbi.nlm.nih.gov/books/NBK274235/ | date = 2015 | publisher=National Academies Press (US) | last =Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | last2 = Board on the Health of Select Populations | last3 = Institute of Medicine|location=Washington (DC)|series=The National Academies Collection: Reports funded by National Institutes of Health|pmid=25695122}}</ref> '''''D'''isease'' gave the self-explanatory label of being an organic biological disease.<ref name="beyondMECFS" />


Adults can be diagnosed at six months of illness and [[Pediatric myalgic encephalomyelitis and chronic fatigue syndrome|pediatric]] cases are diagnosed at three months.
The SEID diagnostic criteria and name were first proposed and published by an Institute of Medicine committee on [[Myalgic Encephalomyelitis]]/<wbr>[[Chronic Fatigue Syndrome]] (ME/CFS) in 2015, at the request of the CDC.<ref name="beyondMECFS" />
[[File:Morgan Fairchild.png |300px|thumb|right|[[Morgan Fairchild]] is an [[United States|American]] actress of film and television. She was diagnosed with [[chronic fatigue syndrome]] (CFS) in 1989. On March 25, 2015, she gave a [https://www.youtube.com/watch?v=lWTF80daWtw speech] during the [[IOM]] briefing of the rollout of SEID where she says compared to others suffering with [[ME/CFS]] she has a mild case]]
 
==<span id="CDC">Symptoms</span>==
The latest '''CDC ME/CFS''' diagnostic criteria were adopted in 2017, the suggested name of SEID is not used by the CDC.
 
===Core symptoms===
* [[Greatly lowered ability to do activities that were usual before the illness]]. This drop in activity level occurs along with [[fatigue]] and must last six months or longer. People with ME/CFS have fatigue that is very different from just being tired. The fatigue of ME/CFS:
**Can be severe.
**Is not a result of unusually difficult activity.
**Is not relieved by sleep or rest.
**Was not a problem before becoming ill (not life-long).
* [[post-exertional malaise]] (PEM)
* [[unrefreshing sleep]]; '''''and'''''
'''''either'''''
* [[Cognitive dysfunction|impaired memory or ability to concentrate]]
'''''or'''''
* [[orthostatic intolerance]] (symptoms that occur when standing upright)<ref name="CDC-criteria">{{Cite web|url=https://www.cdc.gov/me-cfs/symptoms-diagnosis/symptoms.html | title = Symptoms {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|website=[[Centers for Disease Control and Prevention]] | date = Jan 27, 2021|access-date = 2022-01-03}}</ref><ref name="criteria">{{Cite book|chapter-url=https://www.nap.edu/read/19012/chapter/9|chapter=Proposed Diagnostic Criteria for ME/CFS | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness | last =IOM (Institute of Medicine) | first = | authorlink = Institute of Medicine | last2 = Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | first2 =  | date = 2015 | page=210|publisher=National Academies Press|location=Washington, D.C.|isbn=978-0-309-31689-7|archive-url=|archive-date=|url-status=|access-date=2022-01-03}}</ref><ref name="CDC-IOM-SEIDcriteria">{{Cite web|url=https://www.cdc.gov/me-cfs/healthcare-providers/diagnosis/iom-2015-diagnostic-criteria.html | title = IOM 2015 Diagnostic Criteria {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|website=[[Centers for Disease Control and Prevention]] | date = Jan 27, 2021|access-date = 2021-02-25}}</ref><ref name="algorithm">{{Cite web|url= https://www.nap.edu/resource/19012/MECFS_DiagnosticAlgorithm.jpg | title = Diagnostic Algorithm for ME/CFS | last =Institute of Medicine | first = | authorlink = Institute of Medicine | date = 2015 | website = nap.edu|archive-url=|archive-date=|url-status=|access-date=}}</ref>
 
===Other Common Symptoms===
Many people with ME/CFS also have other symptoms, such as:


==Authors==
*[[Pain not caused by injury]]: The type of pain, where it occurs, and how severe it is varies. The most common types of pain in ME/CFS are:
[[File:Rosa SEID.JPG|400px|thumb|Rosa age 25 in 1986 and mildly ill with [[ME/CFS]]. Rosa believes she then met the SEID criteria developed in 2015 and this is when she first read about [[Post-exertional malaise|PEM]]. She became worse over the years and in 2003 was diagnosed and disabled with [[chronic fatigue syndrome]] (CFS) which was the name for ME/CFS at the time. Rosa now meets the [[CCC]] criteria with PEM "[[Canadian Consensus Criteria#Definition|option]]". ME/CFS onset was [[Pediatric myalgic encephalomyelitis and chronic fatigue syndrome|age 17]] and [[fibromyalgia]] since puberty]]
**[[Myalgia|Muscle pain]] and aches
The committee on the Diagnostic Criteria for [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] (ME/CFS) consisted of [[Ellen Wright Clayton]], [[Margarita Alegría]], [[Lucinda Bateman]], [[Lily Chu]], [[Charles Cleeland]], [[Ronald Davis]], [[Betty Diamond]], [[Theodore Ganiats]], [[Betsy Keller]], [[Nancy Klimas]], [[A Martin Lerner]], [[Cynthia Mulrow]], [[Benjamin Natelson]], [[Peter Rowe]], and [[Michael Shelanski]].
**[[Arthralgia|Joint pain]] without swelling or redness
**[[Headache]]s, either new or worsening
Some people with ME/CFS may also have:
*[[Tender lymph nodes]] in their neck or armpits
*A [[sore throat]] that happens often
*[[Digestive problems|Digestive issues]], like [[irritable bowel syndrome]]
*[[Chill]]s and [[night sweats]]
*[[Allergy|Allergies]] and sensitivities to foods, odors, chemicals, light, or noise
*[[Paresis|Muscle weakness]]
*[[Dyspnea|Shortness of breath]]
*[[arrhythmia|Irregular heartbeat]]<ref name="CDC-criteria"/>


==Development==
===Notes===
In 2014, the [[U.S. Department of Health and Human Services]] (HHS), the [[National Institutes of Health]] (NIH), the [[Agency for Healthcare Research and Quality]] (AHRQ), the [[Centers for Disease Control & Prevention]] (CDC), the [[Food and Drug Administration]] (FDA), and the [[Social Security Administration]] (SSA) asked the [[Institute of Medicine]] (IOM) to convene an expert committee to examine the evidence base for [[ME/CFS]]. In ''Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness'', the committee proposes new diagnostic criteria that will facilitate timely diagnosis and care and enhance understanding among health care providers and the public. These criteria, based on expert analysis and the most up-to-date scientific literature, are streamlined for practical use in the clinical setting. The IOM committee also recommends that the name of the disease be changed—from ME/CFS to systemic exertion intolerance disease (SEID)—to more accurately capture the central characteristics of the illness.<ref>{{Cite web|url= https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf|title=Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness|last=|first=|date=|website=nap.edu|page=5|archive-url=https://web.archive.org/web/20170615034241/https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf|archive-date=2017-06-15|dead-url=|access-date=}}</ref>
Orthostatic intolerance is also useful for a more severe presentation of the disease; symptom severity and other symptoms are outlined in the [[Institute of Medicine report]].<ref>{{Cite book | url =https://www.nap.edu/read/19012/chapter/5\ | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness | last = | first = |publisher=National Academies of Medicine| year = 2015 |isbn=|editor-link=|location=|pages=141-162|language=en|chapter=5|quote=|editor-last2=|editor-link2=}}</ref>  


'''The proposed name and acronym SEID is meant to hone in on key aspects of''' ME/CFS'''.''' '''''S'''ystemic'' would give credence to the disease being body wide.  '''''E'''xertion '''I'''ntolerance'' would key doctors into understanding that the patient CAN NOT tolerate exertion of any kind; physical, cognitive or emotional.<ref>{{Cite news|url=http://www.shoutoutaboutme.com/about-mecfs/seid-diagnostic-criteria-proposed/|title=NIH/IOM 2015 Definition (SEID)|last=Logan|first=Russell|date=Jan 3, 2015|work=Shoutout about ME|access-date=2018-09-03|archive-url=|archive-date=|dead-url=|language=en-us}}</ref> (Intolerance is well understood in the medical field in that there is a medical problem. Other diseases, such as gluten intolerance, is a serious medical condition; gluten CAN NOT be consumed.) '''''D'''isease'' gave the self-explanatory label of being an organic biological disease.
Adults can be diagnosed at six months of illness and [[Pediatric myalgic encephalomyelitis and chronic fatigue syndrome|pediatric]] cases are diagnosed at three months.


==Diagnostic criteria==
==Diagnostic criteria for clinicians==
[[File:SEID algorithm.JPG|400px|thumb|right|Diagnostic Algorithm<ref name=":2" />]]
[[File:SEID algorithm.JPG|400px|thumb|right|Diagnostic Algorithm<ref name="algorithm" />]]
'''Diagnosis requires that the patient have the following three symptoms:'''
'''Diagnosis requires that the patient have the following three symptoms:'''


1. A substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities, that persists for more than 6 months and is accompanied  
1. [[substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities|A substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities]], that [[lasts longer than 6 months|persists for more than 6 months]] and is accompanied  
by [[Chronic fatigue|fatigue, which is often profound, is of new or definite onset (not lifelong), is not the result of ongoing excessive exertion, and is not substantially alleviated by rest]], and
by [[Chronic fatigue|fatigue]], which is often profound, is of new or definite onset (not lifelong), is not the result of ongoing excessive exertion, and is not substantially alleviated by rest, and


2. [[Post-exertional malaise]],* and
2. [[Post-exertional malaise]],* and
Line 32: Line 60:
2. [[Orthostatic intolerance]]
2. [[Orthostatic intolerance]]


: * Frequency and severity of symptoms should be assessed. The diagnosis of ME/CFS (SEID) should be questioned if patients do not have these symptoms at least half of the time with moderate, substantial, or severe intensity.<ref>{{Cite web|url= https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf|title=Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness|last=|first=|date=2015|website=nap.edu|archive-url=https://web.archive.org/web/20170615034241/https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf|archive-date=2017-06-15|dead-url=|access-date=}}</ref>
: * Frequency and severity of symptoms should be assessed. The diagnosis of ME/CFS (SEID) should be questioned if patients do not have these symptoms at least half of the time with moderate, substantial, or severe intensity.<ref>{{Cite web|url= https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness | last = | first = | date = 2015 | website = nap.edu|archive-url=https://web.archive.org/web/20170615034241/https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf|archive-date=2017-06-15|url-status=|access-date=}}</ref><ref>{{Cite web|url=https://www.nap.edu/resource/19012/MECFS_ProposedDiagnosticCriteria.jpg | title = New diagnostic criteria {{!}} IOM 2015 Diagnostic Criteria {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|website=[[Centers for Disease Control and Prevention]] | date = Jan 27, 2021|access-date = 2022-01-03}}</ref>


===Centers for Disease Control and Prevention (CDC) website===
===Centers for Disease Control and Prevention (CDC) website===


:Note: The name "Systemic Exertion Intolerance Disease" (SEID) has not been adopted but the new diagnostic criteria have been incorporated into the [[Centers for Disease Control and Prevention]] (CDC) ME/CFS website under the tab [https://www.cdc.gov/me-cfs/healthcare-providers/diagnosis/iom-2015-diagnostic-criteria.html IOM 2015 Diagnostic Criteria].<ref>{{Cite web|url=https://www.cdc.gov/me-cfs/healthcare-providers/diagnosis/iom-2015-diagnostic-criteria.html|title=IOM 2015 Diagnostic Criteria  {{!}} Diagnosis {{!}} Healthcare Providers {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) {{!}} CDC|date=2018-07-10|website=www.cdc.gov|language=en-us|access-date=2018-09-03}}</ref>
:Note: The name "Systemic Exertion Intolerance Disease" (SEID) has not been adopted but the new diagnostic criteria have been incorporated into the [[Centers for Disease Control and Prevention]] (CDC) [https://www.cdc.gov/me-cfs/healthcare-providers/diagnosis/iom-2015-diagnostic-criteria.html ME/CFS website].<ref>{{Cite web|url=https://www.cdc.gov/me-cfs/healthcare-providers/diagnosis/iom-2015-diagnostic-criteria.html | title = IOM 2015 Diagnostic Criteria  {{!}} Diagnosis {{!}} Healthcare Providers {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | date = 2018-07-10 | website = [[Centers for Disease Control and Prevention]]|language=en-us|access-date=2018-09-03}}</ref>
 
==Background==
The name and diagnostic criteria for Systemic Exertion Intolerance Disease were the result of the report ''Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness'', and is also referred to as the [[Institute of Medicine report]], which was published by the [[National Academy of Medicine]] (NAM) (formerly the Institute of Medicine, IOM) on February 10, 2015. The.<ref name="beyondMECFS" />
 
==People ==
[[File:Morgan Fairchild.png |300px|thumb|right|[[Morgan Fairchild]] is an [[United States|American]] actress of film and television. She was diagnosed with [[chronic fatigue syndrome]] (CFS) in 1989.]]
On March 25, 2015, [[Morgan Fairchild]] gave a [https://www.youtube.com/watch?v=lWTF80daWtw speech] during the [[IOM]] briefing of the rollout of SEID where she said that compared to others suffering with [[ME/CFS]] she has a mild case.
{{clear}}


== SEID vs Other criteria ==
==Development==
The SEID criteria are the most symptom liberal of the valid ''disease'' definition criteria. The [[Canadian Consensus Criteria]] (CCC) are for ME/CFS, and [[International Consensus Criteria]] (ICC) are for ME.<ref>{{Cite journal|last=Chu|first=Lily|last2=Norris|first2=Jane L.|last3=Valencia|first3=Ian J.|last4=Montoya|first4=Jose G.|date=2017-03-13|title=Patients diagnosed with Myalgic encephalomyelitis/chronic fatigue syndrome also fit systemic exertion intolerance disease criteria|url=http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1299079?journalCode=rftg20|journal=Fatigue: Biomedicine, Health & Behavior|language=en|volume=5|issue=2|pages=114–128|doi=10.1080/21641846.2017.1299079|issn=2164-1846}}</ref>  
In 2014, the [[U.S. Department of Health and Human Services]] (HHS), the [[National Institutes of Health]] (NIH), the [[Agency for Healthcare Research and Quality]] (AHRQ), the [[Centers for Disease Control and Prevention]] (CDC), the [[Food and Drug Administration]] (FDA), and the [[Social Security Administration]] (SSA) asked the [[Institute of Medicine]] (IOM) to convene an expert committee to examine the evidence base for [[ME/CFS]]. In ''Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness'', the committee proposes new diagnostic criteria that will facilitate timely diagnosis and care and enhance understanding among health care providers and the public. These criteria, based on expert analysis and the most up-to-date scientific literature, are streamlined for practical use in the clinical setting. The IOM committee also recommends that the name of the disease be changed—from ME/CFS to systemic exertion intolerance disease (SEID)—to more accurately capture the central characteristics of the illness.<ref name="beyondMECFS">{{Cite web|url= https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness | last = | first = | date = |website=nap.edu | page = 5|archive-url=https://web.archive.org/web/20170615034241/https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf|archive-date=2017-06-15|url-status=|access-date=}}</ref>


The IOM report calls for the "retirement" of the [[Oxford criteria]] for [[chronic fatigue syndrome]] (CFS).<ref>{{Cite web|url=http://theargusreport.com/us-nih-report-calls-uk-definition-mecfs-scrapped/|title=US NIH Report Calls for UK Definition of ME/CFS to be Scrapped|last=Swift|first=Penny|date=|website=theargusreport.com|language=en-US|archive-url=|archive-date=|dead-url=|access-date=2018-09-03}}</ref> The  [[Fukuda criteria]] are also for CFS.
==Authors ==
The committee on the Diagnostic Criteria for [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] (ME/CFS) consisted of [[Ellen Wright Clayton]], [[Margarita Alegría]], [[Lucinda Bateman]], [[Lily Chu]], [[Charles Cleeland]], [[Ronald Davis]], [[Betty Diamond]], [[Theodore Ganiats]], [[Betsy Keller]], [[Nancy Klimas]], [[A Martin Lerner]], [[Cynthia Mulrow]], [[Benjamin Natelson]], [[Peter Rowe]], and [[Michael Shelanski]].


Comparison chart of the [[International Consensus Criteria|ICC]] and SEID: [https://d3n8a8pro7vhmx.cloudfront.net/meadvocacy/pages/22/attachments/original/1531592663/ICC_compared_to_IOM.pdf?1531592663 ICC compared to IOM (SEID)].<ref>{{Cite web|url=https://d3n8a8pro7vhmx.cloudfront.net/meadvocacy/pages/22/attachments/original/1531592663/ICC_compared_to_IOM.pdf?1531592663|title=International Consensus Criteria (ICC) vs Systemic Exertion Intolerance Disease (SEID)|last=|first=|authorlink=|last2=|first2=|authorlink2=|date=|website=cloudfront.net|publisher=MEadvocacy.org|archive-url=|archive-date=|dead-url=|access-date=}}</ref>
==SEID differences from other criteria ==
The SEID criteria are the most symptom liberal of the valid ''disease'' definition criteria. The [[Canadian Consensus Criteria]] (CCC) are for ME/CFS, and [[International Consensus Criteria]] (ICC) are for ME.<ref>{{Cite journal | last =Chu | first = Lily | last2 = Norris | first2=Jane L. | last3 = Valencia | first3=Ian J. | last4 = Montoya | first4 = Jose G. | date = 2017-03-13 | title = Patients diagnosed with Myalgic encephalomyelitis/chronic fatigue syndrome also fit systemic exertion intolerance disease criteria|url=http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1299079?journalCode=rftg20|journal = Fatigue: Biomedicine, Health & Behavior |language=en|volume=5|issue=2|pages=114–128|doi=10.1080/21641846.2017.1299079|issn=2164-1846}}</ref>
 
The IOM report calls for the "retirement" of the [[Oxford criteria]] for [[chronic fatigue syndrome]] (CFS).<ref>{{Cite web|url=http://theargusreport.com/us-nih-report-calls-uk-definition-mecfs-scrapped/ | title = US NIH Report Calls for UK Definition of ME/CFS to be Scrapped | last =Swift | first=Penny | date = |website=theargusreport.com|language=en-US|archive-url=|archive-date=|url-status=|access-date=2018-09-03}}</ref> The  [[Fukuda criteria]] are also for CFS.
 
Comparison chart of the [[International Consensus Criteria|ICC]] and SEID: [https://d3n8a8pro7vhmx.cloudfront.net/meadvocacy/pages/22/attachments/original/1531592663/ICC_compared_to_IOM.pdf?1531592663 ICC compared to IOM (SEID)].<ref>{{Cite web|url=https://d3n8a8pro7vhmx.cloudfront.net/meadvocacy/pages/22/attachments/original/1531592663/ICC_compared_to_IOM.pdf?1531592663 | title = International Consensus Criteria (ICC) vs Systemic Exertion Intolerance Disease (SEID) | last = | first = | author-link =| date = |website=cloudfront.net|publisher=MEadvocacy.org|archive-url=|archive-date=|url-status=|access-date=}}</ref>


== Criticism ==
== Criticism ==
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* the missing of [[immune system]] from diagnostic criteria
* the missing of [[immune system]] from diagnostic criteria
* unclear and broad criterion of the main symptom of post-exertional malaise
* unclear and broad criterion of the main symptom of post-exertional malaise
* absence of important symptoms like [[pain]]
* absence of important symptoms like [[pain]], which is listed as a "common symptom" but not is a diagnostic symptom
* missing exclusions, for example [[POTS]]
* missing exclusions, for example [[Postural orthostatic tachycardia syndrome|POTS]]
*laboratory tests results are missing<ref name="Jason, Sunnquist, Gleason, Fox, 2017" /><ref name="Twisk3DistinctEntities" /><ref name=":1" /><ref name="Jason, Sunn, 2015" /><ref name=":3" /><ref name=":4" />
*laboratory tests results are missing<ref name="Jason, Sunnquist, Gleason, Fox, 2017" /><ref name="Twisk3DistinctEntities" /><ref name="TwiskAccurate" /><ref name="Jason, Sunn, 2015" /><ref name=":3" /><ref name=":4" />


ME was the original name for CFS; the names are often used interchangeably or with the acronym ME/CFS.<ref name=":0">{{Cite news|url=https://www.verywellhealth.com/myalgic-encephalomyelitis-me-715663|title=Myalgic Encephalomyelitis or Chronic Fatigue Syndrome|last=Dellwo|first=Adrienne|authorlink=Adrienne Dellwo|date=Nov 24, 2018|work=Verywell Health|access-date=2018-11-28|archive-url=|archive-date=|dead-url=|quote=|author-link=}}</ref> The name SEID, although giving credence to the fact that patients are intolerant to [[exertion]], does not capture the debilitating [[central nervous system]] (CNS) symptoms patients experience as the name ME does.
[[myalgic encephalomyelitis|Myalgic Encephalomyelitis]] (ME) was the original name for CFS; the names are often used interchangeably or with the acronym ME/CFS.<ref name="Nicholson, 2016">{{Cite journal | last1 = Nicholson | first1 = Laura | authorlink1 = | last2 = Brown | first2 = Abigail | authorlink2 = Abigail Brown | last3 = Jason | first3 = Leonard A. | authorlink3 = Leonard Jason | last4 = Ohanian | first4 = Diana | authorlink4 = Diana Ohanian
| last5 = O'Connor | first5 = Kelly | authorlink5 = | title = Educational Priorities for Healthcare Providers and Name Suggestions for Chronic Fatigue Syndrome: Including the Patient Voice| journal = Clin Res Open Access | volume = 2 | issue = | page = | date = 2016 | pmid =  
| doi = 10.16966/2469-6714.112}}</ref> The name SEID, although giving credence to the fact that patients are intolerant to [[exertion]], has been criticized for  not capturing the debilitating [[central nervous system]] (CNS) symptoms patients experience as the name ME does.


[[Frank Twisk|Twisk]] (2017) stated that ME and CFS are different illnesses, with ME being a neuromuscular disease and CFS being a partially overlapping fatigue-based illness, and that it was not possible to replace both ME and CFS with a single diagnostic entity. Twisk also stated that SEID included some patients that did not meet either ME or CFS diagnostic criteria.<ref name=":1">{{Cite journal|last=Twisk|first=Frank N. M.|author-link=Frank Twisk|author-link2=|author-link3=|author-link4=|author-link5=|date=Jun 27, 2017|title=An Accurate Diagnosis of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome  requires strict Clinical Case definitions and Objective Test Methods|url=https://www.researchgate.net/profile/Frank_Twisk/publication/318463814_An_Accurate_Diagnosis_of_Myalgic_Encephalomyelitis_and_Chronic_Fatigue_Syndrome_requires_strict_Clinical_Case_definitions_and_Objective_Test_Methods/links/596ca586aca2728ca689c2fa/An-Accurate-Diagnosis-of-Myalgic-Encephalomyelitis-and-Chronic-Fatigue-Syndrome-requires-strict-Clinical-Case-definitions-and-Objective-Test-Methods.pdf|journal=Journal of Medical Diagnostic Methods|volume=6|issue=3|pages=|doi=10.4172/2168-9784.1000249|quote=|via=l}}</ref>
[[Frank Twisk|Twisk]] (2017) stated that ME and CFS are different illnesses,  
with ME being a neuromuscular disease and CFS being a partially overlapping fatigue-based illness, and that it was not possible to replace both ME and CFS with a single diagnostic entity. Twisk also stated that SEID included some patients that did not meet either ME or CFS diagnostic criteria.<ref name="TwiskAccurate">{{Cite journal | last = Twisk | first = Frank N.M. | authorlink = Frank Twisk | date = Jun 27, 2017 | title = An Accurate Diagnosis of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome  requires strict Clinical Case definitions and Objective Test Methods|url=https://www.researchgate.net/profile/Frank_Twisk/publication/318463814_An_Accurate_Diagnosis_of_Myalgic_Encephalomyelitis_and_Chronic_Fatigue_Syndrome_requires_strict_Clinical_Case_definitions_and_Objective_Test_Methods/links/596ca586aca2728ca689c2fa/An-Accurate-Diagnosis-of-Myalgic-Encephalomyelitis-and-Chronic-Fatigue-Syndrome-requires-strict-Clinical-Case-definitions-and-Objective-Test-Methods.pdf|journal=Journal of Medical Diagnostic Methods|volume=6|issue=3|pages=|doi=10.4172/2168-9784.1000249|quote=|via=l}}</ref>


== Clinicians guide ==
== Clinicians guide ==
Line 63: Line 108:
===Centers for Disease Control and Prevention (CDC) website===
===Centers for Disease Control and Prevention (CDC) website===


: Note: This clinicians guide has been incorporated into the CDC's ME/CFS website under the tab [https://www.cdc.gov/me-cfs/healthcare-providers/index.html Information for Healthcare Providers] under the "Resources" heading with a page disclaimer: "The findings and conclusions in these documents are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC)."<ref>{{Cite web|url=https://www.cdc.gov/me-cfs/healthcare-providers/index.html|title=Information for Healthcare Providers {{!}} ME/CFS {{!}} CDC|date=2018-07-10|website=www.cdc.gov|language=en-us|access-date=2018-09-03}}</ref>
: Note: This clinicians guide has been incorporated into the CDC's ME/CFS website under the tab [https://www.cdc.gov/me-cfs/healthcare-providers/index.html Information for Healthcare Providers] under the "Resources" heading with a page disclaimer: "The findings and conclusions in these documents are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC)."<ref>{{Cite web|url=https://www.cdc.gov/me-cfs/healthcare-providers/index.html | title = Information for Healthcare Providers {{!}} ME/CFS {{!}} CDC | date = 2018-07-10 | website = [[Centers for Disease Control and Prevention]]|language=en-us|access-date=2018-09-03}}</ref>


== The Institute of Medicine report ==
== The Institute of Medicine report ==
Line 71: Line 116:
===Read the report===
===Read the report===
*[https://www.nap.edu/resource/19012/MECFS_KeyFacts.pdf Key facts] (two pages)
*[https://www.nap.edu/resource/19012/MECFS_KeyFacts.pdf Key facts] (two pages)
*[https://www.nap.edu/resource/19012/MECFS_ReportBrief.pdf Report brief] (four pages)
*[https://www.nap.edu/resource/19012/MECFS_ReportBrief.pdf Report brief] (four pages)
*[https://www.nap.edu/catalog/19012/beyond-myalgic-encephalomyelitischronic-fatigue-syndrome-redefining-an-illness Download full report] (282 pages)
*[https://www.nap.edu/catalog/19012/beyond-myalgic-encephalomyelitischronic-fatigue-syndrome-redefining-an-illness Download full report] (282 pages)
*[https://www.nap.edu/resource/19012/MECFS_DiagnosticAlgorithm.jpg Diagnostic Algorithm Chart]
*[https://www.nap.edu/resource/19012/MECFS_DiagnosticAlgorithm.jpg Diagnostic Algorithm Chart]
Line 92: Line 137:
**[http://www.nap.edu/read/19012/chapter/15 Biographical Sketches of Committee Members, Consultants, and Staff]
**[http://www.nap.edu/read/19012/chapter/15 Biographical Sketches of Committee Members, Consultants, and Staff]


 
*[https://www.youtube.com/watch?v=Uj1l-tmkRvw "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness" Official video presentation]
[https://www.youtube.com/watch?v=Uj1l-tmkRvw "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness" Official video presentation]


== Videos ==
== Videos ==
Line 99: Line 143:
:[[CDC]] Posted Video - Dr. [[John Iskander]] of CDC interviews Dr. [[Anthony Komaroff]] (Feb 17, 2016)
:[[CDC]] Posted Video - Dr. [[John Iskander]] of CDC interviews Dr. [[Anthony Komaroff]] (Feb 17, 2016)


*[https://www.youtube.com/watch?v=ZW2Tcsp75a0 SMCI IOM Briefing in Washington, D.C. Full Coverage]<ref>{{Cite web|url=https://www.youtube.com/watch?v=ZW2Tcsp75a0|title=SMCI IOM Briefing in Washington, D.C. Full Coverage|last=|first=|date=Mar 25, 2015|website=YouTube|publisher=SolveCFS|archive-url=|archive-date=|dead-url=|access-date=}}</ref>
*[https://www.youtube.com/watch?v=ZW2Tcsp75a0 SMCI IOM Briefing in Washington, D.C. Full Coverage]<ref>{{Cite web|url=https://www.youtube.com/watch?v=ZW2Tcsp75a0 | title = SMCI IOM Briefing in Washington, D.C. Full Coverage | last = | first = | date = Mar 25, 2015 | website = YouTube|publisher=SolveCFS|archive-url=|archive-date=|url-status=|access-date=}}</ref>
:[[Carol Head]] of [[Solve ME/CFS]], Dr. [[Ellen Wright Clayton]] and [https://en.wikipedia.org/wiki/Morgan_Fairchild Morgan Fairchild]
:[[Carol Head]] of [[Solve ME/CFS]], Dr. [[Ellen Wright Clayton]] and [https://en.wikipedia.org/wiki/Morgan_Fairchild Morgan Fairchild]


*[https://www.youtube.com/watch?v=X4Tnt2d-5S8 New Clinical Definitions for ME/CFS - Dr. Lucinda Bateman]<ref>{{Cite web|url=https://www.youtube.com/watch?v=X4Tnt2d-5S8|title="New Clinical Definitions for ME/CFS" Dr. Lucinda Bateman|last=Bateman|first=Lucinda|date=Mar 8, 2015|website=YouTube|publisher=Bateman Horne Center|archive-url=|archive-date=|dead-url=|access-date=}}</ref>  
*[https://www.youtube.com/watch?v=X4Tnt2d-5S8 New Clinical Definitions for ME/CFS - Dr. Lucinda Bateman]<ref>{{Cite web|url=https://www.youtube.com/watch?v=X4Tnt2d-5S8 | title = "New Clinical Definitions for ME/CFS" Dr. Lucinda Bateman | last =Bateman | first = Lucinda | date = Mar 8, 2015 | website = YouTube|publisher=Bateman Horne Center|archive-url=|archive-date=|url-status=|access-date=}}</ref>  
:Dr. [[Lucinda Bateman]] of [[Bateman Horne Center]] discusses. (Mar 8, 2015)
:Dr. [[Lucinda Bateman]] of [[Bateman Horne Center]] discusses. (Mar 8, 2015)


==Notable studies==
==Notable studies==
* 2015, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556426/pdf/nihms699325.pdf Chronic Fatigue Syndrome versus Systemic Exertion Intolerance Disease]<ref name="Jason, Sunn, 2015" />
* 2015, Chronic Fatigue Syndrome versus Systemic Exertion Intolerance Disease<ref name="Jason, Sunn, 2015" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556426/pdf/nihms699325.pdf (Full text)]
* 2015, Unintended Consequences of not Specifying Exclusionary Illnesses for Systemic Exertion Intolerance Disease<ref name=":3">{{Cite journal|last=Jason|first=Leonard A.|author-link=Leonard Jason|last2=Sunnquist|first2=Madison|author-link2=Madison Sunnquist|last3=Kot|first3=Bobby|author-link3=Bobby Kot|last4=Brown|first4=Abigail|author-link4=Abigail Brown|last5=|last7=|last8=|date=Jun 23, 2015|title=Unintended Consequences of not Specifying Exclusionary Illnesses for Systemic Exertion Intolerance Disease|url=https://www.mdpi.com/2075-4418/5/2/272|journal=Diagnostics|language=en|volume=5|issue=2|pages=272–286|doi=10.3390/diagnostics5020272|quote=|via=}}</ref> [https://www.mdpi.com/2075-4418/5/2/272/htm (Full text)]
* 2015, Unintended Consequences of not Specifying Exclusionary Illnesses for Systemic Exertion Intolerance Disease<ref name=":3">{{Cite journal | last= Jason | first = Leonard A. | author-link = Leonard Jason | last2 = Sunnquist | first2 = Madison | authorlink2 = Madison Sunnquist | last3 = Kot | first3=Bobby | author-link3 = Bobby Kot | last4 = Brown | first4 = Abigail | authorlink4 = Abigail Brown | date = Jun 23, 2015 | title = Unintended Consequences of not Specifying Exclusionary Illnesses for Systemic Exertion Intolerance Disease|url=https://www.mdpi.com/2075-4418/5/2/272|pmid=26854153|pmc=PMC4666441|journal=Diagnostics|language=en|volume=5|issue=2|pages=272–286|doi=10.3390/diagnostics5020272|quote=|via=}}</ref> [https://www.mdpi.com/2075-4418/5/2/272/htm (Full text)]
* 2016, Replacing Myalgic Encephalomyelitis and Chronic Fatigue Syndrome with Systemic Exercise Intolerance Disease Is Not the Way forward<ref name=":4">{{Cite journal|last=Twisk|first=Frank N. M.|author-link=Frank Twisk|last2=|first2=|author-link2=|author-link3=|author-link4=|author-link5=|date=Feb 6, 2016|title=Replacing Myalgic Encephalomyelitis and Chronic Fatigue Syndrome with Systemic Exercise Intolerance Disease Is Not the Way forward|url=https://www.mdpi.com/2075-4418/6/1/10|journal=Diagnostics|language=en|volume=6|issue=1|pages=10|doi=10.3390/diagnostics6010010|quote=|via=}}</ref> [https://www.mdpi.com/2075-4418/6/1/10 (Full text)]
* 2016, Replacing Myalgic Encephalomyelitis and Chronic Fatigue Syndrome with Systemic Exercise Intolerance Disease Is Not the Way forward<ref name=":4">{{Cite journal | last = Twisk | first = Frank N.M. | authorlink = Frank Twisk|pmid=26861399|pmc=PMC4808825 | date = Feb 6, 2016 | title = Replacing Myalgic Encephalomyelitis and Chronic Fatigue Syndrome with Systemic Exercise Intolerance Disease Is Not the Way forward | url =https://www.mdpi.com/2075-4418/6/1/10|journal=Diagnostics|language=en|volume=6|issue=1|pages=10|doi=10.3390/diagnostics6010010|quote=|via=}}</ref> [https://www.mdpi.com/2075-4418/6/1/10 (Full text)]
* 2016, Systemic exertion intolerance disease diagnostic criteria applied on an adolescent chronic fatigue syndrome cohort: evaluation of subgroup differences and prognostic utility<ref name="SEIDAsprusten">{{Cite journal|last=Asprusten|first=Tarjei Tørre|author-link=Tarjei Asprusten|last2=Sulheim|first2=Dag|author-link2=Dag Sulheim|last3=Fagermoen|first3=Even|author-link3=Even Fagermoen|last4=Winger|first4=Anette|author-link4=Anette Winger|last5=Skovlund|first5=Eva|author-link5=Eva Skovlund|last6=Wyller|first6=Vegard Bruun|author-link6=Vegard Bruun Wyller|last7=|first7=|last8=|first8=|date=2018-03-16|title=Systemic exertion intolerance disease diagnostic criteria applied on an adolescent chronic fatigue syndrome cohort: evaluation of subgroup differences and prognostic utility|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887832/|journal=BMJ Paediatrics Open|volume=2|issue=1|pages=|doi=10.1136/bmjpo-2017-000233|issn=2399-9772|pmc=5887832|pmid=29637195|access-date=|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887832/ (Full text)]
* 2016, Systemic exertion intolerance disease diagnostic criteria applied on an adolescent chronic fatigue syndrome cohort: evaluation of subgroup differences and prognostic utility<ref name="SEIDAsprusten">{{Cite journal | last = Asprusten | first = Tarjei Tørre | authorlink = Tarjei Asprusten | last2 = Sulheim | first2 = Dag | authorlink2 = Dag Sulheim | last3 = Fagermoen | first3=Even | author-link3 = Even Fagermoen | last4 = Winger | first4 = Anette | authorlink4 = Anette Winger | last5 = Skovlund | first5 = Eva | authorlink5 = Eva Skovlund | last6 = Wyller | first6 = Vegard Bruun | authorlink6 = Vegard Bruun Wyller|pmc=PMC5887832 | date =2018-03-16 | title = Systemic exertion intolerance disease diagnostic criteria applied on an adolescent chronic fatigue syndrome cohort: evaluation of subgroup differences and prognostic utility|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887832/|journal=BMJ Paediatrics Open|volume=2|issue=1|pages=|doi=10.1136/bmjpo-2017-000233|issn=2399-9772|pmid=29637195|access-date=|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887832/ (Full text)]
* 2017, [http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1299079?journalCode=rftg20& Patients diagnosed with Myalgic encephalomyelitis/chronic fatigue syndrome also fit systemic exertion intolerance disease criteria]<ref name="Chu, 2017" />
* 2017, Patients diagnosed with Myalgic encephalomyelitis/chronic fatigue syndrome also fit systemic exertion intolerance disease criteria<ref name="Chu, 2017" /> [http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1299079?journalCode=rftg20& (Full text)]


==Letters and commentary==
==Letters and commentary==
*2017, An Accurate Diagnosis of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome  requires strict Clinical Case definitions and Objective Test Methods<ref name=":1" /> [https://www.researchgate.net/profile/Frank_Twisk/publication/318463814_An_Accurate_Diagnosis_of_Myalgic_Encephalomyelitis_and_Chronic_Fatigue_Syndrome_requires_strict_Clinical_Case_definitions_and_Objective_Test_Methods/links/596ca586aca2728ca689c2fa/An-Accurate-Diagnosis-of-Myalgic-Encephalomyelitis-and-Chronic-Fatigue-Syndrome-requires-strict-Clinical-Case-definitions-and-Objective-Test-Methods.pdf (Full text)]
*2017, An Accurate Diagnosis of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome  requires strict Clinical Case definitions and Objective Test Methods<ref name="TwiskAccurate" /> [https://www.researchgate.net/profile/Frank_Twisk/publication/318463814_An_Accurate_Diagnosis_of_Myalgic_Encephalomyelitis_and_Chronic_Fatigue_Syndrome_requires_strict_Clinical_Case_definitions_and_Objective_Test_Methods/links/596ca586aca2728ca689c2fa/An-Accurate-Diagnosis-of-Myalgic-Encephalomyelitis-and-Chronic-Fatigue-Syndrome-requires-strict-Clinical-Case-definitions-and-Objective-Test-Methods.pdf (Full text)]
*2017, [http://www.tandfonline.com/doi/full/10.1080/21641846.2017.1362750 Article commentary - Differences of opinion on systemic exercise intolerance disease are not ‘mistakes’: a rejoinder to Jason Sunnquist, Gleason and Fox]<ref name="Chu, Valencia, Montoya, 2017" />
*2017, [http://www.tandfonline.com/doi/full/10.1080/21641846.2017.1362750 Article commentary - Differences of opinion on systemic exercise intolerance disease are not ‘mistakes’: a rejoinder to Jason Sunnquist, Gleason and Fox]<ref name="Chu, Valencia, Montoya, 2017" />
*2017, [http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1362780 Article commentary - Mistaken conclusions about systemic exercise intolerance disease being comparable to research case definitions of CFS: A rebuttal to Chu et al.]<ref name="Jason, Sunnquist, Gleason, Fox, 2017" />
*2017, [http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1362780 Article commentary - Mistaken conclusions about systemic exercise intolerance disease being comparable to research case definitions of CFS: A rebuttal to Chu et al.]<ref name="Jason, Sunnquist, Gleason, Fox, 2017" />
*2018, Myalgic Encephalomyelitis, chronic fatigue syndrome, and Systemic Exertion Intolerance Disease: Three distinct clinical entities<ref name="Twisk3DistinctEntities">{{Cite journal|last=Twisk|first=Frank N. M.|author-link=Frank Twisk|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Jun 2018|title=Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities|url=https://www.mdpi.com/2078-1547/9/1/19|journal=Challenges|language=en|volume=9|issue=1|pages=19|doi=10.3390/challe9010019|pmc=|pmid=|access-date=Sep 1, 2018|quote=|via=}}</ref> [https://www.mdpi.com/2078-1547/9/1/19/pdf (Full text)]
*2018, Myalgic Encephalomyelitis, chronic fatigue syndrome, and Systemic Exertion Intolerance Disease: Three distinct clinical entities<ref name="Twisk3DistinctEntities">{{Cite journal | last = Twisk | first = Frank N.M. | authorlink = Frank Twisk | date = Jun 2018 | title = Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities|url=https://www.mdpi.com/2078-1547/9/1/19|journal=Challenges|language=en|volume=9|issue=1|pages=19|doi=10.3390/challe9010019|pmc=|pmid=|access-date=Sep 1, 2018|quote=|via=}}</ref> [https://www.mdpi.com/2078-1547/9/1/19/pdf (Full text)]


==In popular culture==
==In popular culture==
Line 126: Line 170:
* [[Myalgic encephalomyelitis]]
* [[Myalgic encephalomyelitis]]


*[[NIH Post-Infectious ME/CFS Study]] - [[SEID]] will be used in this study.<ref>{{Cite news|url=http://www.meaction.net/2016/02/09/positive-answers-to-initial-questions-re-nih-clinical-center-protocol/|title=Positive Answers to Initial Questions re NIH Clinical Center Protocol - #MEAction|last=Alexander Miller|first=Courtney|date=2016-02-09|work=#MEAction|access-date=2018-09-03|archive-url=|archive-date=|dead-url=|language=en-US}}</ref>
*[[NIH Post-Infectious ME/CFS Study]] - [[SEID]] will be used in this study.<ref>{{Cite news | url=http://www.meaction.net/2016/02/09/positive-answers-to-initial-questions-re-nih-clinical-center-protocol/ | title = Positive Answers to Initial Questions re NIH Clinical Center Protocol - #MEAction | last = Alexander Miller | first = Courtney | date = 2016-02-09|work=#MEAction|access-date=2018-09-03|archive-url=|archive-date=|url-status=|language=en-US}}</ref>
*[[Pediatric myalgic encephalomyelitis and chronic fatigue syndrome]]
*[[Pediatric myalgic encephalomyelitis and chronic fatigue syndrome]]
*[[Prognosis for myalgic encephalomyelitis and chronic fatigue syndrome]]
*[[Prognosis for myalgic encephalomyelitis and chronic fatigue syndrome]]
Line 132: Line 176:


===Generally accepted criteria for diagnosing ME/CFS and ME ===
===Generally accepted criteria for diagnosing ME/CFS and ME ===
*[[Canadian Consensus Criteria]] (CCC)<ref name="Carruthers, 2003">{{Citation
*[[Canadian Consensus Criteria]] (CCC)<ref name="Carruthers, 2003">{{Citation | last1 = Carruthers | first1 = Bruce M. | authorlink1 = Bruce Carruthers  
| last1   = Carruthers   | first1 = Bruce M.     | authorlink1 = Bruce Carruthers  
| last2 = Jain | first2 = Anil Kumar | authorlink2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | authorlink4 = Daniel Peterson
| last2   = Jain         | first2 = Anil Kumar   | authorlink2 = Anil Kumar Jain
| last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas
| last3   = De Meirleir   | first3 = Kenny L.     | authorlink3 = Kenny De Meirleir
| last6 = Lerner | first6 = A. Martin | authorlink6 = Martin Lerner
| last4   = Peterson     | first4 = Daniel L.     | authorlink4 = Daniel Peterson
| last7 = Bested | first7 = Alison C. | authorlink7 = Alison Bested | last8 = Flor-Henry | first8 = Pierre | authorlink8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip| authorlink9 = Pradip Joshi | last10  = Powles | first10 = AC Peter | authorlink10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | authorlink11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I.  | authorlink12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols | journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid = | doi = 10.1300/J092v11n01_02
| last5   = Klimas       | first5 = Nancy G.     | authorlink5 = Nancy Klimas
| url = http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf }}</ref>  A diagnosis of moderate and severe forms of [[ME/CFS]] are accurately made using this criterion. Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.
| last6   = Lerner       | first6 = A. Martin     | authorlink6 = Martin Lerner
*[[International Consensus Criteria]] (ICC)<ref>{{Cite journal | last =Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3=Kenny L. | author-link3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | authorlink8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref>  This criterion will accurately diagnose [[myalgic encephalomyelitis]] (ME). There is no requirement that the individual have symptoms for a specified period of time for diagnosis, as opposed to CCC, [[Fukuda criteria|Fukuda]], and [[Systemic Exertion Intolerance Disease|SEID]], which all require 6 months in adults.
| last7   = Bested       | first7 = Alison C.     | authorlink7 = Alison Bested
*[[Systemic Exertion Intolerance Disease]] (SEID)<ref>{{Cite web|url=https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness | last =Clayton | first = Ellen Wright | date = 2015 | website = nap.edu|archive-url=|archive-date=|url-status=|access-date= | authorlink = Ellen Wright Clayton | last2 = Alegria | first2 = Margarita | authorlink2 = Margarita Alegría | authorlink3 = Lucinda Bateman | authorlink4 = Lily Chu | authorlink5 = Charles Cleeland | authorlink6 = Ronald Davis | authorlink7 = Betty Diamond | authorlink8 = Theodore Ganiats | authorlink9=Betsy Keller | last3 = Bateman | first3 = Lucinda | last4 = Chu | first4 = Lily | last5 = Cleeland | first5 = Charles | last6 = Davis | first6 = Ronald | last7 = Diamond | first7 = Betty | last8 = Ganiats | first8 = Theodore | last9 = Keller | first9 = Betsy | last10 = Klimas | first10 = Nancy | authorlink10=Nancy Klimas | last11 = Lerner | first11 = A Martin | authorlink11=Martin Lerner | last12 = Mulrow | first12 = Cynthia | authorlink12=Cynthia Mulrow | last13 = Natelson | first13 = Benjamin | authorlink13 = Benjamin Natelson | last14 = Rowe | first14 = Peter | authorlink14=Peter Rowe | last15 = Shelanski | first15 = Michael | authorlink15=Michael Shelanski}}</ref> ME/CFS ([[Systemic Exertion Intolerance Disease|SEID]]) is accurately diagnosed when the [[Systemic Exertion Intolerance Disease#Diagnostic criteria|core symptoms]] are met. The [[Institute of Medicine report]] as a whole is a comprehensive review of the medical literature available at time of publication (2015). Adults can be diagnosed at [[lasts longer than 6 months|6 months]] while [[lasts longer than 3 months for children or adolescents|pediatric cases are diagnosed at three months]].
| last8   = Flor-Henry   | first8 = Pierre       | authorlink8 = Pierre Flor-Henry  
| last9   = Joshi         | first9 = Pradip       | authorlink9 = Pradip Joshi
| last10  = Powles       | first10 = A C Peter   | authorlink10 = A C Peter Powles
| last11 = Sherkey       | first11 = Jeffrey A.   | authorlink11 = Jeffrey Sherkey
| last12 = van de Sande | first12 = Marjorie I.  | authorlink12 = Marjorie van de Sande
| title   = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols
| journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | page = 7-115
| date   = 2003
| pmid   =  
| doi     = 10.1300/J092v11n01_02
| url     = http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf
}}</ref>  A diagnosis of moderate and severe forms of [[ME/CFS]] are accurately made using this criterion. Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.
*[[International Consensus Criteria]] (ICC)<ref>{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref>  This criterion will accurately diagnose [[myalgic encephalomyelitis]] (ME). There is no requirement that the individual have symptoms for a specified period of time for diagnosis, as opposed to CCC, [[Fukuda criteria|Fukuda]], and [[Systemic Exertion Intolerance Disease|SEID]], which all require 6 months in adults.
*[[Systemic Exertion Intolerance Disease]] (SEID)<ref>{{Cite web|url=https://www.nap.edu/resource/19012/MECFScliniciansguide.pdf|title=Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness|last=Clayton|first=Ellen Wright|date=2015|website=nap.edu|archive-url=|archive-date=|dead-url=|access-date=|authorlink=Ellen Wright Clayton|last2=Alegria|first2=Margarita|authorlink2=Margarita Alegría|authorlink3=Lucinda Bateman|authorlink4=Lily Chu|authorlink5=Charles Cleeland|authorlink6=Ronald Davis|authorlink7=Betty Diamond|authorlink8=Theodore Ganiats|authorlink9=Betsy Keller|authors=|last3=Bateman|first3=Lucinda|last4=Chu|first4=Lily|last5=Cleeland|first5=Charles|last6=Davis|first6=Ronald|last7=Diamond|first7=Betty|last8=Ganiats|first8=Theodore|last9=Keller|first9=Betsy|last10=Klimas|first10=Nancy|authorlink10=Nancy Klimas|last11=Lerner|first11=A Martin|authorlink11=Martin Lerner|last12=Mulrow|first12=Cynthia|authorlink12=Cynthia Mulrow|last13=Natelson|first13=Benjamin|authorlink13=Benjamin Natelson|last14=Rowe|first14=Peter|authorlink14=Peter Rowe|last15=Shelanski |first15=Michael|authorlink15=Michael Shelanski}}</ref> ME/CFS ([[Systemic Exertion Intolerance Disease|SEID]]) is accurately diagnosed when the [[Systemic Exertion Intolerance Disease#Diagnostic criteria|core symptoms]] are met. The [[Institute of Medicine report]] as a whole is a comprehensive review of the medical literature available at time of publication (2015). Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.


==Learn more==
==Learn more==
*2015, [https://www.newscientist.com/article/dn26945-chronic-fatigue-syndrome-gets-yet-another-name/ Chronic fatigue syndrome gets yet another name]<ref>{{Cite news|url=https://www.newscientist.com/article/dn26945-chronic-fatigue-syndrome-gets-yet-another-name/|title=Chronic fatigue syndrome gets yet another name|last=Coghlan|first=Andy|date=Feb 10, 2015|work=New Scientist|access-date=2018-09-03|archive-url=|archive-date=|dead-url=|language=en-US}}</ref>
*2015, [https://www.newscientist.com/article/dn26945-chronic-fatigue-syndrome-gets-yet-another-name/ Chronic fatigue syndrome gets yet another name]<ref>{{Cite news | url=https://www.newscientist.com/article/dn26945-chronic-fatigue-syndrome-gets-yet-another-name/ | title = Chronic fatigue syndrome gets yet another name | last =Coghlan | first = Andy | date = Feb 10, 2015 |work=New Scientist|access-date=2018-09-03|archive-url=|archive-date=|url-status=|language=en-US}}</ref>
*2015, [http://www.asianjournalofpsychiatry.com/article/S1876-2018(16)30248-9/abstract Systemic Exercise Intolerance Disease: What’s in a name?]<ref>{{Cite journal|last=Sen|first=Mahadev Singh|last2=Sahoo|first2=Swapnajeet|last3=Aggarwal|first3=Shivali|last4=Singh|first4=Shubh Mohan|date=2016|title=Systemic exercise intolerance disease: What’s in a name?|url=http://www.asianjournalofpsychiatry.com/article/S1876-2018(16)30248-9/abstract|journal=Asian Journal of Psychiatry|language=English|volume=22|pages=157–158|doi=10.1016/j.ajp.2016.06.003|issn=1876-2018|via=}}</ref>
*2015, [http://www.asianjournalofpsychiatry.com/article/S1876-2018(16)30248-9/abstract Systemic Exercise Intolerance Disease: What’s in a name?]<ref>{{Cite journal | last =Sen | first = Mahadev Singh | last2 = Sahoo | first2 = Swapnajeet | last3 = Aggarwal | first3 = Shivali | last4 = Singh | first4 = Shubh Mohan | date = 2016 | title=Systemic exercise intolerance disease: What’s in a name?|url=http://www.asianjournalofpsychiatry.com/article/S1876-2018(16)30248-9/abstract|journal=Asian Journal of Psychiatry|language=English|volume=22|pages=157–158|doi=10.1016/j.ajp.2016.06.003|issn=1876-2018|via=}}</ref>
*2018, [https://youtu.be/RC9TjgE_PlU?t=89 Diagnosis and Management of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome]<ref>{{Cite web|url=https://youtu.be/RC9TjgE_PlU?t=89|title=Diagnosis and Management of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome|last=Kaufman|first=David|date=Oct 16, 2018|website=YouTube|publisher=Unrest Film|archive-url=|archive-date=|dead-url=|access-date=|quote=Part of the Unrest Continuing Education module.|at=1:29}}</ref> (Notes the IOM report's diagnostic criteria.)
*2018, [https://youtu.be/RC9TjgE_PlU?t=89 Diagnosis and Management of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome]<ref>{{Cite web|url=https://youtu.be/RC9TjgE_PlU?t=89 | title = Diagnosis and Management of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome | last = Kaufman | first = David | date = Oct 16, 2018 | website = YouTube|publisher=Unrest Film|archive-url=|archive-date=|url-status=|access-date=|quote=Part of the Unrest Continuing Education module.|at=1:29}}</ref> (Notes the IOM report's diagnostic criteria.)


== References ==
== References ==
<references>
<references>
<ref name="Chu, 2017">{{Citation
<ref name="Chu, 2017">{{Citation | last1 = Chu | first1 = Lily | authorlink1 = Lily Chu
| last1   = Chu               | first1 = Lily                 | authorlink1 = Lily Chu
| last2 = Norris | first2 = Jane | authorlink2 = Jane Norris | last3 = Valencia | first3 = Ian J. | authorlink3 = | last4 = Montoya | first4 = Jose G. | authorlink4 = Jose Montoya | title = Patients diagnosed with Myalgic encephalomyelitis/chronic fatigue syndrome also fit systemic exertion intolerance disease criteria | journal = Fatigue: Biomedicine, Health & Behavior | volume = 5 | issue = | page = | date = 2017
| last2   = Norris             | first2 = Jane                 | authorlink2 = Jane Norris
| doi = 10.1080/21641846.2017.1299079 }}</ref>
| last3   = Valencia           | first3 = Ian J.               | authorlink3 =  
<ref name="Chu, Valencia, Montoya, 2017">{{Citation | last1 = Chu | first1 = Lily | authorlink1 = Lily Chu
| last4   = Montoya           | first4 = Jose G.             | authorlink4 = Jose Montoya  
| last2 = Valencia | first2 = Ian J. | authorlink2 = | last3 = Montoya | first3 = Jose G. | authorlink3 = Jose Montoya | title = Differences of opinion on systemic exercise intolerance disease are not ‘mistakes’: a rejoinder to Jason Sunnquist, Gleason and Fox | journal = Fatigue: Biomedicine, Health & Behavior | volume = | issue = | page = | date = 2017
| title   = Patients diagnosed with Myalgic encephalomyelitis/chronic fatigue syndrome also fit systemic exertion intolerance disease criteria
| doi = 10.1080/21641846.2017.1362750 }}</ref>
| journal = Fatigue: Biomedicine, Health & Behavior   | volume = 5   | issue =   | page =  
<ref name="Jason, Sunn, 2015">{{Citation | last1 = Jason | first1 = L.A. | authorlink1 = Leonard Jason
| date   = 2017
| last2 = Sunnquist | first2 = M. | authorlink2 = Madison Sunnquist | last3 = Brown | first3 = A. | authorlink3 = | last4 = Newton | first4 = J.L. | authorlink4 = Julia Newton
| doi     = 10.1080/21641846.2017.1299079
| last5 = Strand | first5 = E.B. | authorlink5 = Elin Strand
}}
| last6 = Vernon | first6 = S.D. | authorlink6 = Suzanne Vernon | title = Chronic fatigue syndrome versus systemic exertion intolerance disease | journal = Fatigue: Biomedicine, Health & Behavior | volume = 3 | issue = 3  | page = 127-141 | date = 2015 | pmid = | doi = 10.1080/21641846.2015.1051291 }}</ref>
</ref>
<ref name="Jason, Sunnquist, Gleason, Fox, 2017">{{Citation | last1 = Jason | first1 = Leonard A. | authorlink1 = Leonard Jason
<ref name="Chu, Valencia, Montoya, 2017">{{Citation
| last2 = Sunnquist | first2 = Madison | authorlink2 = Madison Sunnquist | last3 = Gleason | first3 = Kristen | authorlink3 = Kristen Gleason | last4 = Fox | first4 = Pamela| authorlink4 = Pamela Fox | title = Mistaken conclusions about systemic exercise intolerance disease being comparable to research case definitions of CFS: A rebuttal to Chu et al. | journal = Fatigue: Biomedicine, Health & Behavior | volume = | issue = | page = | date = 2017 | pmid = | doi = 10.1080/21641846.2017.1362780 }}</ref>
| last1   = Chu               | first1 = Lily                 | authorlink1 = Lily Chu
| last2   = Valencia           | first2 = Ian J.               | authorlink2 =  
| last3   = Montoya           | first3 = Jose G.             | authorlink3 = Jose Montoya
| title   = Differences of opinion on systemic exercise intolerance disease are not ‘mistakes’: a rejoinder to Jason Sunnquist, Gleason and Fox
| journal = Fatigue: Biomedicine, Health & Behavior   | volume =   | issue =   | page =  
| date   = 2017
| doi     = 10.1080/21641846.2017.1362750
}}
</ref>
<ref name="Jason, Sunn, 2015">{{Citation
| last1   = Jason             | first1 = L.A.               | authorlink1 = Leonard Jason
| last2   = Sunnquist         | first2 = M.                 | authorlink2 = Madison Sunnquist
| last3   = Brown             | first3 = A.                 | authorlink3 =  
| last4   = Newton           | first4 = J.L.               | authorlink4 = Julia Newton
| last5   = Strand           | first5 = E.B.               | authorlink5 = Elin Strand
| last6   = Vernon           | first6 = S.D.               | authorlink6 = Suzanne Vernon  
| title   = Chronic fatigue syndrome versus systemic exertion intolerance disease
| journal = Fatigue: Biomedicine, Health & Behavior   | volume = 3   | issue = 3  | page = 127-141
| date   = 2015
| pmid   =  
| doi     = 10.1080/21641846.2015.1051291
}}</ref>
<ref name="Jason, Sunnquist, Gleason, Fox, 2017">{{Citation
| last1   = Jason             | first1 = Leonard A.         | authorlink1 = Leonard Jason
| last2   = Sunnquist         | first2 = Madison           | authorlink2 = Madison Sunnquist
| last3   = Gleason           | first3 = Kristen           | authorlink3 = Kristen Gleason
| last4   = Fox               | first4 = Pamela             | authorlink4 = Pamela Fox
| title   = Mistaken conclusions about systemic exercise intolerance disease being comparable to research case definitions of CFS: A rebuttal to Chu et al.
| journal = Fatigue: Biomedicine, Health & Behavior   | volume =   | issue =   | page =  
| date   = 2017
| pmid   =  
| doi     = 10.1080/21641846.2017.1362780
}}
</ref>
</references>
</references>



Latest revision as of 23:24, April 2, 2023

The current CDC Myalgic Encephalomyelitis/Chronic Fatigue Syndrome diagnostic criteria is also known as the Systemic Exertion Intolerance Disease (SEID) criteria; SEID was a the new name proposed for chronic fatigue syndrome which is not in use.[1][2]

The proposed name and acronym SEID is meant to hone in on key aspects of ME/CFS. Systemic would give credence to the disease being body wide. Exertion Intolerance would key doctors into understanding that the patient cannot tolerate exertion.[3] Disease gave the self-explanatory label of being an organic biological disease.[1]

The SEID diagnostic criteria and name were first proposed and published by an Institute of Medicine committee on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in 2015, at the request of the CDC.[1]

Symptoms[edit | edit source]

The latest CDC ME/CFS diagnostic criteria were adopted in 2017, the suggested name of SEID is not used by the CDC.

Core symptoms[edit | edit source]

either

or

Other Common Symptoms[edit | edit source]

Many people with ME/CFS also have other symptoms, such as:

Some people with ME/CFS may also have:

Notes[edit | edit source]

Orthostatic intolerance is also useful for a more severe presentation of the disease; symptom severity and other symptoms are outlined in the Institute of Medicine report.[8]

Adults can be diagnosed at six months of illness and pediatric cases are diagnosed at three months.

Diagnostic criteria for clinicians[edit | edit source]

Diagnostic Algorithm[7]

Diagnosis requires that the patient have the following three symptoms:

1. A substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities, that persists for more than 6 months and is accompanied by fatigue, which is often profound, is of new or definite onset (not lifelong), is not the result of ongoing excessive exertion, and is not substantially alleviated by rest, and

2. Post-exertional malaise,* and

3. Unrefreshing sleep*

At least one of the two following manifestations is also required:

1. Cognitive impairment* or

2. Orthostatic intolerance

* Frequency and severity of symptoms should be assessed. The diagnosis of ME/CFS (SEID) should be questioned if patients do not have these symptoms at least half of the time with moderate, substantial, or severe intensity.[9][10]

Centers for Disease Control and Prevention (CDC) website[edit | edit source]

Note: The name "Systemic Exertion Intolerance Disease" (SEID) has not been adopted but the new diagnostic criteria have been incorporated into the Centers for Disease Control and Prevention (CDC) ME/CFS website.[11]

Background[edit | edit source]

The name and diagnostic criteria for Systemic Exertion Intolerance Disease were the result of the report Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness, and is also referred to as the Institute of Medicine report, which was published by the National Academy of Medicine (NAM) (formerly the Institute of Medicine, IOM) on February 10, 2015. The.[1]

People[edit | edit source]

Morgan Fairchild is an American actress of film and television. She was diagnosed with chronic fatigue syndrome (CFS) in 1989.

On March 25, 2015, Morgan Fairchild gave a speech during the IOM briefing of the rollout of SEID where she said that compared to others suffering with ME/CFS she has a mild case.

Development[edit | edit source]

In 2014, the U.S. Department of Health and Human Services (HHS), the National Institutes of Health (NIH), the Agency for Healthcare Research and Quality (AHRQ), the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), and the Social Security Administration (SSA) asked the Institute of Medicine (IOM) to convene an expert committee to examine the evidence base for ME/CFS. In Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness, the committee proposes new diagnostic criteria that will facilitate timely diagnosis and care and enhance understanding among health care providers and the public. These criteria, based on expert analysis and the most up-to-date scientific literature, are streamlined for practical use in the clinical setting. The IOM committee also recommends that the name of the disease be changed—from ME/CFS to systemic exertion intolerance disease (SEID)—to more accurately capture the central characteristics of the illness.[1]

Authors[edit | edit source]

The committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) consisted of Ellen Wright Clayton, Margarita Alegría, Lucinda Bateman, Lily Chu, Charles Cleeland, Ronald Davis, Betty Diamond, Theodore Ganiats, Betsy Keller, Nancy Klimas, A Martin Lerner, Cynthia Mulrow, Benjamin Natelson, Peter Rowe, and Michael Shelanski.

SEID differences from other criteria[edit | edit source]

The SEID criteria are the most symptom liberal of the valid disease definition criteria. The Canadian Consensus Criteria (CCC) are for ME/CFS, and International Consensus Criteria (ICC) are for ME.[12]

The IOM report calls for the "retirement" of the Oxford criteria for chronic fatigue syndrome (CFS).[13] The Fukuda criteria are also for CFS.

Comparison chart of the ICC and SEID: ICC compared to IOM (SEID).[14]

Criticism[edit | edit source]

The main criticisms are:

  • the missing of nervous system symptoms from diagnostic criteria, when ME/CFS is a neurological disease
  • the missing of immune system from diagnostic criteria
  • unclear and broad criterion of the main symptom of post-exertional malaise
  • absence of important symptoms like pain, which is listed as a "common symptom" but not is a diagnostic symptom
  • missing exclusions, for example POTS
  • laboratory tests results are missing[15][16][17][18][19][20]

Myalgic Encephalomyelitis (ME) was the original name for CFS; the names are often used interchangeably or with the acronym ME/CFS.[21] The name SEID, although giving credence to the fact that patients are intolerant to exertion, has been criticized for not capturing the debilitating central nervous system (CNS) symptoms patients experience as the name ME does.

Twisk (2017) stated that ME and CFS are different illnesses, with ME being a neuromuscular disease and CFS being a partially overlapping fatigue-based illness, and that it was not possible to replace both ME and CFS with a single diagnostic entity. Twisk also stated that SEID included some patients that did not meet either ME or CFS diagnostic criteria.[17]

Clinicians guide[edit | edit source]

The Report Guide for Clinicians explains the core symptoms, additional symptoms, diagnostic criteria and more. (Feb 10, 2015)

Centers for Disease Control and Prevention (CDC) website[edit | edit source]

Note: This clinicians guide has been incorporated into the CDC's ME/CFS website under the tab Information for Healthcare Providers under the "Resources" heading with a page disclaimer: "The findings and conclusions in these documents are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC)."[22]

The Institute of Medicine report[edit | edit source]

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness

Read the report[edit | edit source]

Videos[edit | edit source]

CDC Posted Video - Dr. John Iskander of CDC interviews Dr. Anthony Komaroff (Feb 17, 2016)
Carol Head of Solve ME/CFS, Dr. Ellen Wright Clayton and Morgan Fairchild
Dr. Lucinda Bateman of Bateman Horne Center discusses. (Mar 8, 2015)

Notable studies[edit | edit source]

  • 2015, Chronic Fatigue Syndrome versus Systemic Exertion Intolerance Disease[18] (Full text)
  • 2015, Unintended Consequences of not Specifying Exclusionary Illnesses for Systemic Exertion Intolerance Disease[19] (Full text)
  • 2016, Replacing Myalgic Encephalomyelitis and Chronic Fatigue Syndrome with Systemic Exercise Intolerance Disease Is Not the Way forward[20] (Full text)
  • 2016, Systemic exertion intolerance disease diagnostic criteria applied on an adolescent chronic fatigue syndrome cohort: evaluation of subgroup differences and prognostic utility[25] (Full text)
  • 2017, Patients diagnosed with Myalgic encephalomyelitis/chronic fatigue syndrome also fit systemic exertion intolerance disease criteria[26] (Full text)

Letters and commentary[edit | edit source]

In popular culture[edit | edit source]

A February 2016 comic strip referred to SEID and implied it is simply tiredness. See: Blondie comic

See also[edit | edit source]

Generally accepted criteria for diagnosing ME/CFS and ME[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 1.3 1.4 "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness" (PDF). nap.edu. p. 5. Archived from the original (PDF) on June 15, 2017.
  2. "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". CDC. November 16, 2021. Retrieved December 23, 2021.
  3. Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine (2015). Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. The National Academies Collection: Reports funded by National Institutes of Health. Washington (DC): National Academies Press (US). ISBN 978-0-309-31689-7. PMID 25695122.
  4. 4.0 4.1 "Symptoms | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Centers for Disease Control and Prevention. January 27, 2021. Retrieved January 3, 2022.
  5. IOM (Institute of Medicine); Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (2015). "Proposed Diagnostic Criteria for ME/CFS". Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. Washington, D.C.: National Academies Press. p. 210. ISBN 978-0-309-31689-7. Retrieved January 3, 2022.
  6. "IOM 2015 Diagnostic Criteria | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Centers for Disease Control and Prevention. January 27, 2021. Retrieved February 25, 2021.
  7. 7.0 7.1 Institute of Medicine (2015). "Diagnostic Algorithm for ME/CFS". nap.edu.
  8. "5". Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. National Academies of Medicine. 2015. pp. 141–162.
  9. "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness" (PDF). nap.edu. 2015. Archived from the original (PDF) on June 15, 2017.
  10. "New diagnostic criteria | IOM 2015 Diagnostic Criteria | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Centers for Disease Control and Prevention. January 27, 2021. Retrieved January 3, 2022.
  11. "IOM 2015 Diagnostic Criteria | Diagnosis | Healthcare Providers | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Centers for Disease Control and Prevention. July 10, 2018. Retrieved September 3, 2018.
  12. Chu, Lily; Norris, Jane L.; Valencia, Ian J.; Montoya, Jose G. (March 13, 2017). "Patients diagnosed with Myalgic encephalomyelitis/chronic fatigue syndrome also fit systemic exertion intolerance disease criteria". Fatigue: Biomedicine, Health & Behavior. 5 (2): 114–128. doi:10.1080/21641846.2017.1299079. ISSN 2164-1846.
  13. Swift, Penny. "US NIH Report Calls for UK Definition of ME/CFS to be Scrapped". theargusreport.com. Retrieved September 3, 2018.
  14. "International Consensus Criteria (ICC) vs Systemic Exertion Intolerance Disease (SEID)" (PDF). cloudfront.net. MEadvocacy.org.
  15. 15.0 15.1 Jason, Leonard A.; Sunnquist, Madison; Gleason, Kristen; Fox, Pamela (2017), "Mistaken conclusions about systemic exercise intolerance disease being comparable to research case definitions of CFS: A rebuttal to Chu et al.", Fatigue: Biomedicine, Health & Behavior, doi:10.1080/21641846.2017.1362780
  16. 16.0 16.1 Twisk, Frank N.M. (June 2018). "Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities". Challenges. 9 (1): 19. doi:10.3390/challe9010019. Retrieved September 1, 2018.
  17. 17.0 17.1 17.2 Twisk, Frank N.M. (June 27, 2017). "An Accurate Diagnosis of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome requires strict Clinical Case definitions and Objective Test Methods" (PDF). Journal of Medical Diagnostic Methods. 6 (3). doi:10.4172/2168-9784.1000249 – via l.
  18. 18.0 18.1 Jason, L.A.; Sunnquist, M.; Brown, A.; Newton, J.L.; Strand, E.B.; Vernon, S.D. (2015), "Chronic fatigue syndrome versus systemic exertion intolerance disease", Fatigue: Biomedicine, Health & Behavior, 3 (3): 127-141, doi:10.1080/21641846.2015.1051291
  19. 19.0 19.1 Jason, Leonard A.; Sunnquist, Madison; Kot, Bobby; Brown, Abigail (June 23, 2015). "Unintended Consequences of not Specifying Exclusionary Illnesses for Systemic Exertion Intolerance Disease". Diagnostics. 5 (2): 272–286. doi:10.3390/diagnostics5020272. PMC 4666441. PMID 26854153.
  20. 20.0 20.1 Twisk, Frank N.M. (February 6, 2016). "Replacing Myalgic Encephalomyelitis and Chronic Fatigue Syndrome with Systemic Exercise Intolerance Disease Is Not the Way forward". Diagnostics. 6 (1): 10. doi:10.3390/diagnostics6010010. PMC 4808825. PMID 26861399.
  21. Nicholson, Laura; Brown, Abigail; Jason, Leonard A.; Ohanian, Diana; O'Connor, Kelly (2016). "Educational Priorities for Healthcare Providers and Name Suggestions for Chronic Fatigue Syndrome: Including the Patient Voice". Clin Res Open Access. 2 (1). doi:10.16966/2469-6714.112.
  22. "Information for Healthcare Providers | ME/CFS | CDC". Centers for Disease Control and Prevention. July 10, 2018. Retrieved September 3, 2018.
  23. "SMCI IOM Briefing in Washington, D.C. Full Coverage". YouTube. SolveCFS. March 25, 2015.
  24. Bateman, Lucinda (March 8, 2015). ""New Clinical Definitions for ME/CFS" Dr. Lucinda Bateman". YouTube. Bateman Horne Center.
  25. Asprusten, Tarjei Tørre; Sulheim, Dag; Fagermoen, Even; Winger, Anette; Skovlund, Eva; Wyller, Vegard Bruun (March 16, 2018). "Systemic exertion intolerance disease diagnostic criteria applied on an adolescent chronic fatigue syndrome cohort: evaluation of subgroup differences and prognostic utility". BMJ Paediatrics Open. 2 (1). doi:10.1136/bmjpo-2017-000233. ISSN 2399-9772. PMC 5887832. PMID 29637195.
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