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===United States=== A 2016 study by the Center for Community Research, DePaul University, compared the mortality in patients with [[myalgic encephalomyelitis]] and [[chronic fatigue syndrome]] to the mortality rates of the general population in the [[United States]]. Four categories for death were examined in detail: all causes combined, suicide, cardiovascular-related and cancer. In this study sample of 56 patients, the most frequent cause of death, as reported by caregivers, was suicide, occurring among 26.8% of patients. When examining suicide rates they found the suicide rate was higher in male ME/CFS patients than females (53.33% male and 46.67% female), which was the only cause of death in this study to display this pattern. Although the mean age of death in individuals with ME and CFS is at a younger age compared to the overall population, only the rate of all causes combined and cardiovascular-related mortality reached statistical significance.<ref name="McManimen, 2016" />
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