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==Regional studies== ===United States=== A 2016 study by the Center for Community Research, DePaul University, compared the mortality in patients with [[myalgic encephalomyelitis]] and [[chronic fatigue syndrome]] to the mortality rates of the general population in the [[United States]]. Four categories for death were examined in detail: all causes combined, suicide, cardiovascular-related and cancer. In this study sample of 56 patients, the most frequent cause of death, as reported by caregivers, was suicide, occurring among 26.8% of patients. When examining suicide rates they found the suicide rate was higher in male ME/CFS patients than females (53.33% male and 46.67% female), which was the only cause of death in this study to display this pattern. Although the mean age of death in individuals with ME and CFS is at a younger age compared to the overall population, only the rate of all causes combined and cardiovascular-related mortality reached statistical significance.<ref name="McManimen, 2016" /> ===United Kingdom=== A 2016 study by Roberts, et al. examined the mortality rates via electronic clinical records of 2147 people with [[chronic fatigue syndrome]] (as per the [[Oxford definition|Oxford case definition]]) over a seven year period who presented to a specialist clinic that serves London and the south of England.<ref name="Roberts, 2016">{{Cite journal | last1 = Roberts | first1 = Emmert | authorlink1 = | last2 = Wessely | first2 = Simon | authorlink2 = Simon Wessely | last3 = Chalder | first3 = Trudie | authorlink3 = Trudie Chalder | last4 = Chang | first4 = Chin-Kuo | authorlink4 = | last5 = Hotopf | first5 = Matthew | authorlink5 = Matthew Hotopf | title = Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) Register | url = https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)01223-4/fulltext | journal = The Lancet | volume = 387 | issue = 10028 | page = 1638 - 1643 | date = 2016 | pmid = 26873808| doi = 10.1016/S0140-6736(15)01223-4}}</ref> :The researchers found no significant statistical difference in mortality rate for all-cause mortality or cancer-specific mortality in patients with [[chronic fatigue syndrome]] compared with the general population in England and Wales when matched for age and gender. The one category for which a significant increase existed was in suicide-specific mortality. The researchers also, found an increased risk of completed suicide in patients with [[chronic fatigue syndrome]] when compared with a population control. In total, five people died from suicide during the 7-year period.<ref name="Roberts, 2016" /> Kapur and Webb, from the Centre for Suicide Prevention at the University of Manchester, UK commented on the study: "Based on the suicide rate in the general population of England and Wales, the expected number would have been less than one death by suicide. In other words, suicide risk was increased almost seven-fold."<ref name="Kapur, 2016" /> Because of the statistic analysis used, this study is criticized by Dr. [[James Coyne]], an ardent critic of the statistical analysis of the [[PACE trial]]. Please note that several of the researchers who authored this study, authored the [[PACE trial]] study.<ref>{{Cite web |url = https://jcoynester.wordpress.com/2016/02/16/bad-stats-non-sequitur-conclusions-in-lancet-chronic-fatigue-syndromesuicide-study/| title = Bad stats, non sequitur conclusions in Lancet chronic fatigue syndrome/suicide study by Dr. James Coyne | authorlink = James Coyne|first = James C. |last =Coyne | date = 2016-02-16}}</ref> ===Spain=== A 2015 doctoral thesis from [[Spain]] found an increased risk of suicidal ideation in [[ME/CFS]] patients, 12.74% compared to 2.3% in the general Spanish population. This study is believed to be the first that pointed to external factors, such as [[Medical neglect and abuse#medical_neglect|inadequate medical treatment]] and loss of job and relationships, instead of [[depression]] as the reason for suicidal ideation.<ref>{{Citation|lay-url=https://afectadasporlosrecortessanitarios.wordpress.com/2016/05/11/risk-of-suicide-due-to-neglect-amongst-pwme/|trans-title=Risk of Suicide due to Neglect Amongst PWME | website = Plataforma de Afectadas por los Recortes Sanitarios - La PARS|language=es-ES|access-date=2020-07-27 |url=https://web.archive.org/web/20170517091502id_/http://uvadoc.uva.es:80/bitstream/10324/13868/1/Tesis705-150928.pdf | last= Jiménez-Ortiz | first = JJ| title = Depresión y desesperanza en personas enfermas de Encefalomielitis Miálgica/ Síndrome de Fatiga Crónica: Factores de riesgo y de protection| publisher=Universidad de Valladolid | date = 2015}}</ref><ref name="McManimen, 2016" />
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