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Stephen Holgate
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[[File:Stephen Holgate.png|200px|thumb|right|Source:ME Association]] Professor '''Stephen Holgate''' was the Chair of the [[UK CFS/ME Research Collaborative]] 2013-2020 and chair of the MRC-led [[ME expert group]] 2008-2011<ref>{{Cite web|url=https://meassociation.org.uk/wp-content/uploads/PSMB-Paper-CFS-M.E.-Final-24.04.18.pdf | title = Rising to the challenge of understanding the mechanisms of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/M.E.) | last = | first = | author-link =| date = 2018 | website = The ME association|archive-url=|archive-date=|url-status=|access-date=}}</ref>. He is Medical Research Council Clinical Professor of Immunopharmacology and Honorary Consultant Physician within Medicine at the University of Southampton, Southampton, England.<ref>http://www.southampton.ac.uk/medicine/about/staff/sth.page</ref> He was knighted for services to medical research in the 2020 Queen's Birthday Honours List.<ref>{{Cite web|url=https://www.southampton.ac.uk/news/2020/10/stephen-holgate-queens-birthday-honours.page | title = Professor Stephen Holgate receives Knighthood in the Queen’s Birthday Honours List {{!}} University of Southampton | last = | first = | author-link =| date = |website=southampton.ac.uk|archive-url=|archive-date=|url-status=|access-date=2020-10-13}}</ref> Bio in ''Nature Reviews'': "He received his medical degree from the University of London, [[United Kingdom|UK]], M.D. by thesis and D.Sc. from the University of Southampton. From 1978 to 1980 he spent a postdoctoral fellowship at Harvard Medical School, Cambridge, Massachusetts, US, researching inflammatory mechanisms. His current research is directed towards the pathophysiology of [[asthma]] and allied disorders, with a special interest in understanding how environmental exposures such as allergens, [[virus]] infections and air pollutants interact with the airways in the induction and exacerbation of asthma."<ref>http://www.kcl.ac.uk/innovation/groups/projects/cfs/publications/assets/2011/Holgatecomplexillness.pdf</ref> Having chaired the UK CFS/ME Research Collaborative since its inception in 2013, he has stated that he wants to develop a "dream team" of the best researchers working on the [[UK CFS/ME Research Collaborative]]. One the projects launched by the Collaborative was the [[Grand Challenge]], called such because its goal was to study ten thousand patients.<ref>{{Cite web|url=https://www.meaction.net/2016/04/28/professor-stephen-holgate-uk-has-dream-team-for-grand-challenge/ | title = Professor Stephen Holgate: UK has “dream team” for Grand Challenge | date = 2016-04-28 | website = #MEAction Network|language=en-US|access-date=2020-10-13}}</ref> He believes that [[ME/CFS]] could have twelve to fifteen different ‘causal pathways’ and that may be the reason it has been so hard to decipher.<ref>{{Cite web|url=https://forums.phoenixrising.me/threads/a-dozen-different-diseases-stephen-holgate-calls-for-radical-change-in-me-cfs-research.24763/ | title = A Dozen Different Diseases? Stephen Holgate Calls for Radical Change in ME/CFS Research | website = Phoenix Rising ME/CFS Forums|language=en-US|access-date=2020-10-13}}</ref> ==Articles== *2011, [http://www.kcl.ac.uk/innovation/groups/projects/cfs/publications/assets/2011/Holgatecomplexillness.pdf Chronic fatigue syndrome: understanding a complex illness.]<ref name=":0">{{Cite journal | last = Holgate | first = Stephen T. | author-link = Stephen Holgate | last2 = Komaroff | first2 = Anthony L. | authorlink2 = Anthony Komaroff | last3 = Mangan | first3=Dennis | author-link3 = | last4 = Wessely | first4 = Simon | authorlink4 = Simon Wessely | date = Sep 2011 | title = Chronic fatigue syndrome: understanding a complex illness|url=http://www.nature.com/articles/nrn3087|journal=Nature Reviews Neuroscience|language=en|volume=12|issue=9|pages=539–544|doi=10.1038/nrn3087|issn=1471-003X|pmc=|pmid=|access-date=|quote=|via=}}</ref> *2013, [http://phoenixrising.me/archives/18222 A Dozen Different Diseases? Stephen Holgate Calls for Radical Change in ME/CFS Research] *2013, [http://www.forward-me.org.uk/2nd%20July%202013.htm Forward ME Minutes of the Meeting 2 Jul 2013 - Professor Stephen Holgate invited to speak]. *2013, [http://www.southampton.ac.uk/news/2013/04/patients-with-chronic-fatigue.page Patients with chronic fatigue use additional areas of brain when using memory] *2013, [http://phoenixrising.me/archives/16786 Launch of inclusive UK CFS/ME Research Collaborative] *[https://thewire.in/health/fighting-over-fatigue-will-this-chronic-syndrome-ever-be-taken-seriously 2015, Fighting Over Fatigue: Will This Chronic Syndrome Ever Be Taken Seriously?]<ref>{{Cite web|url=https://thewire.in/health/fighting-over-fatigue-will-this-chronic-syndrome-ever-be-taken-seriously | title = Fighting Over Fatigue: Will This Chronic Syndrome Ever Be Taken Seriously?|website=The Wire|access-date=2021-08-17}}</ref> ==Notable studies== *2003, Identification of novel expressed sequences, up‐regulated in the leucocytes of chronic fatigue syndrome patients - https://pubmed.ncbi.nlm.nih.gov/14519154/ *2005, [[Gene expression]] in peripheral [[blood]] mononuclear cells from patients with chronic fatigue syndrome<ref>{{Cite journal | last = Kaushik | first = N | author-link = | last2 = Fear | first2 = D | authorlink2 = | last3 = Richards | first3=S C M | authorlink3 = | last4 = McDermott | first4 = C R | authorlink4 = | last5 = Nuwaysir | first5 = E F | authorlink5 = | last6 = Kellam | first6 = P | authorlink6 = | last7 = Harrison | first7 = T J | last8 = Wilkinson | first8 = RJ | last9 = Tyrrell | first9 = D A J | last10 = Holgate | first10 = S T | authorlink10 = Stephen Holgate | last11 = Kerr | first11 = JR | authorlink11 = Jonathan Kerr | date = 2005-08-01 | title = Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome|url=http://jcp.bmj.com/cgi/doi/10.1136/jcp.2005.025718|journal=Journal of Clinical Pathology|language=en|volume=58|issue=8 | pages = 826–832|doi=10.1136/jcp.2005.025718|issn=0021-9746|pmc=1770875|pmid=16049284|quote=|via=}}</ref> - [http://jcp.bmj.com/content/67/12/1078 (Full Text)] *2008, Gene Expression Subtypes in Patients with [[ME/CFS|Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]]<ref name="Kerr, 2008" /> [https://academic.oup.com/jid/article/197/8/1171/903299 (Full Text)] *2011, [[Chronic fatigue syndrome]]: understanding a complex illness<ref name=":0" /> - [http://www.ncbi.nlm.nih.gov/pubmed/21792218 (Abstract)] ==Talks and interviews== *2013, [https://www.youtube.com/watch?v=uZV49dGf12c Prof Stephen Holgate, Chair of the UK CFS/M.E. Research Collaborative, gives the keynote speech at our 2013 AGM and research conference in London.] *2014, [https://www.youtube.com/watch?v=1nixGEMjBxc Edinburgh M.E. Self-help Group (edmesh) Open Meeting May 2014 - Stephen Holgate Speaking] *2015, [https://www.youtube.com/watch?v=69Jz43kSQX0 UK CFS/M.E. Research Collaborative Science Conference Day 1] *2016, [https://www.youtube.com/watch?v=SbF-Pl_qp8Y UK CFS/ME Research Collaborative Conference, Welcome address] *2018, [https://www.youtube.com/watch?v=AK5UONg0diM&list=PLJV2oZMsotONY3AEkA-c3kVFjtVokLBD7 UK CFS/ME Research Collaborative Conference, Welcome address] ==Controversy== Stephen Holgate supported and endorsed the controversial online CBT therapy for children research, the [[FITNET trial]], led by [[Esther Crawley]] in 2016 which got a lot of media promotion. Dr Esther Crawley claimed that many children could be cured by this & professor Holgate called it the type of high quality research we needed more of <ref>{{Cite news | url=https://www.bbc.com/news/health-37822068 | title = Landmark chronic fatigue trial could treat two-thirds | date = 2016-11-01|work=BBC News|access-date=2021-08-22|language=en-GB}}</ref> Professor Holgate was a cosignatory of the infamous 2012 letter in the Independent<ref>{{Cite web|url=https://www.independent.co.uk/voices/letters/ios-letters-emails-online-postings-2-december-2012-8373777.html | title = IoS letters, emails & online postings (2 December 2012) | date = 2012-12-08 | website = The Independent|language=en|access-date=2021-08-24}}</ref> in support of [[Simon Wessely]]’s CFS <nowiki/>work & his receipt of the Maddox prize for bravery in the “controversial” Chronic Fatigue Syndrome field. ==Learn more== *[http://www.southampton.ac.uk/medicine/about/staff/sth.page Sethphen Holgate's Faculty page at University of Southampton] *[[UK CFS/ME Research Collaborative]] *[[Grand Challenge]] ==References== <references> <ref name="Kerr, 2008">{{Citation | last1 = Kerr | first1 = Jonathan R | authorlink1 = Jonathan Kerr | last2 = Petty | first2 = Robert | authorlink2 = | last3 = Burke | first3 = Beverley | authorlink3 = | last4 = Gough | first4 = John | authorlink4 = | last5 = Fear | first5 = David | authorlink5 = | last6 = Sinclair | first6 = Lindsey I | authorlink6 = | last7 = Mattey | first7 = Derek L | authorlink7 = | last8 = Richards | first8 = Selwyn C | authorlink8 = | last9 = Montgomery | first9 = Jane | authorlink9 = | last10 = Baldwin | first10 = Don A | authorlink10 = | last11 = Kellam | first11 = Paul | authorlink11 = | last12 = Harrison | first12 = Tim J | authorlink12 = | last13 = Griffin | first13 = George E | authorlink13 = | last14 = Main | first14 = Janice | authorlink14 = | last15 = Enlander | first15 = Derek | authorlink15 = Derek Enlander | last16 = Nutt | first16 = David J | authorlink16 = | last17 = Holgate | first17 = Stephen T | authorlink17 = Stephen Holgate | title = Gene Expression Subtypes in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | journal = The Journal of Infectious Diseases | volume = 197 | issue = 8 | page = 1171–1184 | date = 15 April 2008 | pmid = | doi = 10.1086/533453 }}</ref> </references> [[Category:Researchers]] [[Category:UK researchers]]
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