Sleep dysfunction: Difference between revisions

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== See also ==
== See also ==
* [[Buspirone challenge test]] (the degree of prolactin released by buspirone in ME/CFS patients correlates to the degree of shift in their sleep/wake cycle).
* [[Buspirone challenge test]] (the degree of prolactin released by buspirone in ME/CFS patients correlates to the degree of shift in their sleep/wake cycle).
* [[Hypersomnia]]
* [[Insomnia]]
* [[Insomnia]]
* [[Unrefreshing sleep]]
==Learn more==
==Learn more==
*[https://www.drugs.com/condition/insomnia.html Medications for insomnia] - drugs.com
*[https://www.drugs.com/condition/insomnia.html Medications for insomnia] - drugs.com

Revision as of 13:25, February 28, 2021

"Slerp easy" tea bags containing valerian, lemon balm capsules and a bottle of melatonin.

Sleep dysfunction is very common in ME/CFS patients, although it can take a very wide range of forms, with unrefreshing sleep being particularly common. The prevalence of sleep disorders in ME/CFS is estimated at 56%.[1]

Fibromyalgia patients also suffer from sleep disorders.[2]

Types of Sleep dysfunction[edit | edit source]

Some of these sleep dysfunctions include:

Prevalence[edit | edit source]

  • Depending on the criteria used for diagnosis, prevalence can vary greatly.
  • In a 2001 Belgian study, 91.9% of patients meeting the Fukuda criteria and 94.8% of patients meeting the Holmes criteria, in a cohort of 2073 CFS patients, reported sleep disturbances.[7]
  • A 2017 study by Davidson, et al, found up to 96.8% of people with CFS report unrefreshing sleep and many describe changes in sleep over the course of their illness.[8]

According to the published evidence, the mean prevalence of sleep disorders in patients with CFS is estimated at 56%.[9]

Year N Prevalence Sleep disorders included
Krupp et al.[10] 1993 16 62% OSAHS, PLMD, narcolepsy, hypersomnia
Morriss et al.[11] 1993 12 58% Maintenance insomnia
Buchwald et al.[12] 1994 59 81% OSAHS, hypersomnia
Le Bon et al.[13] 2000 53 46% OSAHS
Fossey et al.[14] 2004 37 58% OSAHS, narcolepsy
Reeves et al.[15] 2006 43 25% OSAHS, PLMD
Majer et al.[16] 2007 35 30% OSAHS, PLMD, ISS
Libman et al.[17] 2009 66 68% OSAHS
Creti et al.[18] 2010 49 69% OSAHS, PLMD
65% Chronic insomnia
Mean 56.2%

Symptom recognition[edit | edit source]

Sleep dysfunction is a core requirement to meet the diagnostic criteria for ME/CFS according to the 2003 Canadian Consensus Criteria,[19] the 2007 Nightingale definition,[20] and the 2015 Institute of Medicine report.[21]

Sleep dysfunction is an optional symptom in the 1988 Holmes criteria,[22] the 1991 Oxford criteria,[23] the 1994 Fukuda criteria,[24] the 2005 Reeves criteria,[25] the 2007 NICE guidelines,[26] the 2012 International Consensus Criteria.[27], and the 2014 London criteria.[28]

Sleep dysfunction is not a criteria listed for diagnosis with the 1986 Ramsay definition.[29]

Notable studies[edit | edit source]

  • 2007, Paradoxical NREMS Distribution in “Pure” Chronic Fatigue Patients: A Comparison with Sleep Apnea-Hypopnea Patients and Healthy Control Subjects[30] - (Abstract)
  • 2012, Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review[31] - (Full Text)
  • 2017, Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)[32] - (Full text)
  • 2018, Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[33] - (Full Text)
  • 2018, The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis[34] - (Abstract)
  • 2018, Association of sleep disorders, chronic pain, and fatigue with survival in patients with chronic kidney disease: A meta-analysis of clinical trials[35] - (Abstract)

Treatment[edit | edit source]

Treatment can include non-benzodiazepine hypnotics, or benzodiazepine hypnotics (benzos), other sedatives, sedating antidepressants, cannabiniods (CBD), melatonin, vitamin B12, meditation and good sleep hygiene practices.

Medications, including:

Supplements and natural remedies include :No pages meet these criteria.

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Chronic fatigue syndrome and sleep disorders: Clinical associations and diagnostic difficulties". Neurología (English Edition). 33 (6): 385–394. July 1, 2018. doi:10.1016/j.nrleng.2015.11.020. ISSN 2173-5808.
  2. "Fibromyalgia Sufferers Have Difficulty Maintaining Continuous Sleep, Study Says". National Pain Report. March 25, 2016. Retrieved August 20, 2018. Cite has empty unknown parameter: |dead-url= (help)
  3. "Symptoms of ME/CFS – American ME and CFS Society". ammes.org. Retrieved August 29, 2018.
  4. "The role of insomnia in the treatment of chronic fatigue". Journal of Psychosomatic Research. 78 (5): 427–432. May 1, 2015. doi:10.1016/j.jpsychores.2014.11.022. ISSN 0022-3999.
  5. Viola-Saltzman, Mari; Watson, Nathaniel F.; Bogart, Andy; Goldberg, Jack; Buchwald, Dedra (October 15, 2010). "High prevalence of restless legs syndrome among patients with fibromyalgia: a controlled cross-sectional study". Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine. 6 (5): 423–427. ISSN 1550-9389. PMID 20957840.
  6. Cambras, Trinitat; Castro-Marrero, Jesús; Zaragoza, Maria Cleofé; Díez-Noguera, Antoni; Alegre, José (June 6, 2018). "Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis". PLOS ONE. 13 (6): e0198106. doi:10.1371/journal.pone.0198106. ISSN 1932-6203. PMID 29874259.
  7. De Becker, Pascale; McGregor, Neil; De Meirleir, Kenny (December 2001). "A definition‐based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome". Journal of Internal Medicine. 250 (3): 234–240. doi:10.1046/j.1365-2796.2001.00890.x.
  8. Davidson, Sean L.; Gotts, Zoe M.; Ellis, Jason G.; Newton, Julia L. (March 2017), "Two year follow-up of sleep diaries and polysomnography in chronic fatigue syndrome: a cohort study", Fatigue: Biomedicine, Health & Behavior, doi:10.1080/21641846.2017.1297280
  9. "Chronic fatigue syndrome and sleep disorders: Clinical associations and diagnostic difficulties". Neurología (English Edition). 33 (6): 385–394. July 1, 2018. doi:10.1016/j.nrleng.2015.11.020. ISSN 2173-5808.
  10. Krupp, Lauren B.; Jandorf, L.; Coyle, P. K.; Mendelson, W. B. (May 1, 1993). "Sleep disturbance in chronic fatigue syndrome". Journal of Psychosomatic Research. 37 (4): 325–331. doi:10.1016/0022-3999(93)90134-2. ISSN 0022-3999.
  11. Morriss, R.; Sharpe, M.; Sharpley, A. L.; Cowen, P. J.; Hawton, K.; Morris, J. (May 1, 1993). "Abnormalities of sleep in patients with the chronic fatigue syndrome". British Medical Journal. 306 (6886): 1161–1164. doi:10.1136/bmj.306.6886.1161. ISSN 0959-8138. PMID 8499816.
  12. Buchwald, Dedra; Pascualy, Ralph; Bombardier, Charles; Kith, Phalla (January 1, 1994). "Sleep Disorders in Patients with Chronic Fatigue". Clinical Infectious Diseases. 18 (Supplement_1): S68–S72. doi:10.1093/clinids/18.supplement_1.s68. ISSN 1537-6591.
  13. Le Bon, O.; Fischler, B.; Hoffmann, G.; Murphy, J. R.; De Meirleir, K.; Cluydts, R.; Pelc, I. (2000). "How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome?". Sleep research online: SRO. 3 (2): 43–48. ISSN 1096-214X. PMID 11382899.
  14. Fossey, Myrtis; Libman, Eva; Bailes, Sally; Baltzan, Marc; Schondorf, Ronald; Amsel, Rhonda; Fichten, Catherine S. (December 1, 2004). "Sleep Quality and Psychological Adjustment in Chronic Fatigue Syndrome". Journal of Behavioral Medicine. 27 (6): 581–605. doi:10.1007/s10865-004-0004-y. ISSN 1573-3521.
  15. Reeves, William C.; Heim, Christine; Maloney, Elizabeth M.; Youngblood, Laura Solomon; Unger, Elizabeth R.; Decker, Michael J.; Jones, James F.; Rye, David B. (November 16, 2006). "Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study". BMC Neurology. 6 (1): 41. doi:10.1186/1471-2377-6-41. ISSN 1471-2377. PMC 1660569. PMID 17109739.
  16. Majer, Matthias; Jones, James F.; Unger, Elizabeth R.; Youngblood, Laura Solomon; Decker, Michael J.; Gurbaxani, Brian; Heim, Christine; Reeves, William C. (December 5, 2007). "Perception versus polysomnographic assessment of sleep in CFS and non-fatigued control subjects: results from a population-based study". BMC Neurology. 7 (1): 40. doi:10.1186/1471-2377-7-40. ISSN 1471-2377. PMC 2231384. PMID 18053240.
  17. Libman, Eva; Creti, Laura; Baltzan, Marcel; Rizzo, Dorrie; Fichten, Catherine S.; Bailes, Sally (October 26, 2009). "Sleep Apnea and Psychological Functioning in Chronic Fatigue Syndrome:". Journal of Health Psychology. doi:10.1177/1359105309344895.
  18. Creti, Laura; Libman, Eva; Baltzan, Marcel; Rizzo, Dorrie; Bailes, Sally; Fichten, Catherine S. (May 11, 2010). "Impaired Sleep in Chronic Fatigue Syndrome: How Is It Best Measured?". Journal of Health Psychology. doi:10.1177/1359105309355336.
  19. Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip (2003). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of Chronic Fatigue Syndrome. 11 (1): 7–115. doi:10.1300/j092v11n01_02. ISSN 1057-3321.
  20. "The Nightingale, Myalgic Encephalomyelitis (M.E.) Definition" (PDF). investinme.org. January 2007. Cite has empty unknown parameter: |dead-url= (help)
  21. "Proposed Diagnostic Criteria for ME/CFS". nationalacademies.org. 2015. Cite has empty unknown parameter: |dead-url= (help)
  22. Holmes, G. P.; Kaplan, J. E.; Gantz, N. M.; Komaroff, A. L.; Schonberger, L. B.; Straus, S. E.; Jones, J. F.; Dubois, R. E.; Cunningham-Rundles, C. (1988). "Chronic fatigue syndrome: a working case definition". Annals of Internal Medicine. 108 (3): 387–389. ISSN 0003-4819. PMID 2829679.
  23. Sharpe, M. C.; Archard, L. C.; Banatvala, J. E.; Borysiewicz, L. K.; Clare, A. W.; David, A.; Edwards, R. H.; Hawton, K. E.; Lambert, H. P. (1991). "A report--chronic fatigue syndrome: guidelines for research". Journal of the Royal Society of Medicine. 84 (2): 118–121. ISSN 0141-0768. PMID 1999813.
  24. Fukuda, K.; Straus, S. E.; Hickie, I.; Sharpe, M. C.; Dobbins, J. G.; Komaroff, A. (December 15, 1994). "The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group". Annals of Internal Medicine. 121 (12): 953–959. ISSN 0003-4819. PMID 7978722.
  25. Reeves, William C.; Wagner, Dieter; Nisenbaum, Rosane; Jones, James F.; Gurbaxani, Brian; Solomon, Laura; Papanicolaou, Dimitris A.; Unger, Elizabeth R.; Vernon, Suzanne D. (December 15, 2005). "Chronic fatigue syndrome--a clinically empirical approach to its definition and study". BMC medicine. 3: 19. doi:10.1186/1741-7015-3-19. ISSN 1741-7015. PMID 16356178.
  26. "Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy): diagnosis and management | Guidance and guidelines | NICE". www.nice.org.uk. August 2007. Retrieved August 29, 2018. Cite has empty unknown parameter: |dead-url= (help)
  27. Carruthers, B. M.; Sande, M. I. van de; Meirleir, K. L. De; Klimas, N. G.; Broderick, G.; Mitchell, T.; Staines, D.; Powles, A. C. P.; Speight, N. (October 1, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4). doi:10.1111/j.1365-2796.2011.02428.x/full. ISSN 1365-2796.
  28. "ME/CFS Medical Update (Layman's version) Winter 2001". www.axfordsabode.org.uk. Retrieved August 29, 2018.
  29. "Ramsay's Definition of M.E., 1986". www.cfids-me.org. Retrieved August 29, 2018.
  30. Bon, Olivier Le; Neu, Daniel; Valente, Filomena; Linkowski, Paul (2007). "Paradoxical NREMS Distribution in "Pure" Chronic Fatigue Patients". Journal of Chronic Fatigue Syndrome. 14 (2): 45–59. doi:10.1300/j092v14n02_05. ISSN 1057-3321.
  31. Jackson, ML; Bruck, D (2012), "Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review, Journal of Clinical Sleep Medicine", Journal of Clinical Sleep Medicine, 8 (6): 719-28, doi:10.5664/jcsm.2276
  32. Josev, Elisha K.; Jackson, Melinda L.; Bei, Bei; Trinder, John; Harvey, Adrienne; Clarke, Cathriona; Snodgrass, Kelli; Scheinberg, Adam; Knight, Sarah J. (September 15, 2017). "Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)". Journal of Clinical Sleep Medicine. 13 (09): 1057–1066. doi:10.5664/jcsm.6722. ISSN 1550-9389. PMC 5566461. PMID 28760189.
  33. Cambras, T.; Castro-Marrero, J.; Zaragoza, MC.; Díez-Noguera, A.; Alegre, J. (2018), "Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis", PLoS ONE, 13 (6): e0198106, doi:10.1371/journal.pone.0198106
  34. Morris, Gerwyn; Stubbs, Brendon; Köhler, Cristiano A.; Walder, Ken; Slyepchenko, Anastasiya; Berk, Michael; Carvalho, André F. (2018), "The putative role of Oxidative Stress and Inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders : Focus on Chronic Fatigue Syndrome, Bipolar Disorder and Multiple Sclerosis", Sleep Med Reviews, doi:10.1016/j.smrv.2018.03.007, PMID 29759891
  35. Yang, Xiu Hong; Zhang, Bao Long; Gu, Yan Hong; Zhan, Xiao Li; Guo, Li Li; Jin, Hui Min (2018). "Association of sleep disorders, chronic pain, and fatigue with survival in patients with chronic kidney disease: a meta-analysis of clinical trials". Sleep Medicine. 51: 59–65. doi:10.1016/j.sleep.2018.06.020. ISSN 1389-9457.
  36. "ME/CFS South Australia Inc: Survey results - insomnia". www.sacfs.asn.au. Retrieved February 11, 2021.
  37. "Melatonin for Sleep: Does It Work?". www.hopkinsmedicine.org. Retrieved February 11, 2021.
  38. Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6