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Sirtuin 1
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==Notable studies == *2018, PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle<ref name="Wu2018">{{Cite journal | title = PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle:| date = 2018-10-04|url=https://www.bdd.rdplf.org/index.php/EBR/article/view/10353|journal=Exercise Biochemistry Review|volume=1|issue=4 | last = Wu | first = Fangnan | last2 = Huder | first2 = Chaolu | last3 = Tian | first3=Zhenjun|language=en|doi=10.14428/ebr.v1i4.10353|issn=2593-7588}}</ref> - Conference proceedings [https://www.bdd.rdplf.org/index.php/EBR/article/view/10353 (Abstract)] ::This refers to mice exhausted by excessive activity, which is an exclusion for [[chronic fatigue syndrome]]. ::Results Compared with C group, CFS group appeared serious damage caused by fighting, and the concentration of serum testosterone decreased significantly (p<0.01 or p<0.05) while cortisol concentration increased significantly (p<0.01 or p<0.05). Regarding antioxidant stress system indexes, the expression of MDA, T-SOD and GSH-PX significantly increased (p<0.05). The concentration of MEK and SIRT3 decreased significantly (p<0.01 or p<0.05). Compared with CFS group, VD intervention group (bVD, mVD and aVD) showed less damage caused by fighting and significantly lighter body weight (p<0.05), and the concentration of serum testosterone increased significantly (p<0.05) while that of cortisol decreased significantly (p<0.01 or p<0.05). The expression of MDA decreased significantly (p<0.05), on the countrary, T-AOC, T-SOD and GSH-PX increased significantly (p<0.05). The expressions of MEK, p-ERK/ERK, SIRT1 and SIRT3 were significantly upregulated (p<0.01 or p<0.05). *2016, Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample<ref name="Iacob, 2016">{{Cite journal | last1 = Iacob | first1 = E | authorlink1 = | last2 = Light | first2 = AR | authorlink2 = Alan Light | last3 = Donaldson | first3 = GW | authorlink3 =| last4 = Okifuji | first4 = A | authorlink4 = | last5 = Hughen | first5 = RW | authorlink5 = | last6 = White | first6 = AT | authorlink6 = | last7 = Light | first7 = K | authorlink7 = Kathleen Light| title = Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample| journal = Arthritis Care and Research | volume = 68 | issue = 1 | page = 132-40 | url = https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.22639 | pmc = PMC4684820 | date = 2016 | pmid = 26097208 | doi = 10.1002/acr.22639}}</ref> [https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.22639 (Full text)] *2015, Novel Associations of F2-Isoprostanes, F3- Isoprostanes and Isofurans in Older Adults with Chronic Fatigue Syndrome: An Exploratory Study<ref name="Kubow2015">{{Cite journal | last = Kubow|first =Stan | last2 =Sorenson | first2 =Matthew | last3 =Alkazemi | first3 = Dalal | first4 = Jackson L II | last4 = Roberts | last5 = Adamski | first5 = Katherine Naselli | last6 = Jason | first6 = Leonard | author-link6 = Leonard Jason | date = 2015 | title = Novel Associations of F2-Isoprostanes, F3- Isoprostanes and Isofurans in Older Adults with Chronic Fatigue Syndrome: An Exploratory Study|journal =Clinical Research: Open Access|volume = 1|issue = |pages =1-4 | doi = 10.16966/clroa.103 | url = https://www.researchgate.net/profile/Leonard-Jason/publication/281108522_Novel_Associations_of_F2-Isoprostanes_F3-_Isoprostanes_and_Isofurans_in_Older_Adults_with_Chronic_Fatigue_Syndrome_An_Exploratory_Study/links/55d5da0b08ae9d659489544d/Novel-Associations-of-F2-Isoprostanes-F3-Isoprostanes-and-Isofurans-in-Older-Adults-with-Chronic-Fatigue-Syndrome-An-Exploratory-Study.pdf}}</ref> - [https://www.sciforschenonline.org/journals/clinical-research/article-data/CLROA-1-103/CLROA-1-103.pdf (Full Text)] *2011, Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome<ref name="Jason2011HDAC">{{Cite journal | title = Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome | date = 2011-11-01|url=https://www.sciencedirect.com/science/article/pii/S0889159111001255|journal=Brain, Behavior, and Immunity|volume=25|issue=8|pages=1544β1547 | last= Jason | first = Leonard | authorlink = Leonard Jason | last2 = Sorenson | first2 = Matthew | author-link2 = Matthew Sorenson | last3 = Sebally | first3 = Kebba | authorlink3 = | last4 = Alkazemi | first4 = Dalal | authorlink4 = | last5 = Lerch | first5 = Athena | authorlink5 = | last6 = Porter | first6 = Nicole | author-link6 = Nicole Porter | last7 = Kubow | first7 = Stan|language=en|doi=10.1016/j.bbi.2011.04.007|pmc=|pmid=|access-date=|issn=0889-1591|quote=|via=}}</ref> [https://www.sciencedirect.com/science/article/abs/pii/S0889159111001255 (Full text)]
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