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STIMULATE-ICP
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'''STIMULATE-ICP''' or '''Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways''' is a large research consortium running a number of trials to improve the diagnosis, treatment and care of [[Long COVID]] patients.<ref name="overview">{{Cite web|url=https://www.arc-nt.nihr.ac.uk/research/projects/stimulate-icp-improving-diagnosis-treatment-and-care-of-long-covid/ | title = STIMULATE-ICP: Understanding long COVID to improve diagnosis, treatment and care|website=ARC North Thames|access-date=2022-01-03}}</ref><ref name="pressJul2021">{{Cite web|url=https://www.arc-nt.nihr.ac.uk/news-and-events/2021/july/new-clinical-trial-aims-to-improve-diagnosis-treatment-and-rehabilitation-of-long-covid/ | title = New clinical trial aims to improve diagnosis, treatment and rehabilitation of long COVID|website=ARC North Thames|access-date=2022-01-03}}</ref> ==Aims== According to STIMULATE-ICP: "The overall programme aims to work out what long COVID is, how to diagnose it and how to manage it. The team will interview patients and health professionals and analyse data from NHS records,to inform understanding of patterns of long COVID and the outcomes of current clinical practice. Researchers will work alongside patients to improve access to care and support, and to address care inequalities."<ref name="overview" /> ==Consortium members == Over 30 different researchers and 30 different organizations are involved, including the [[LongCovidSOS]] and [[UK Doctors #Longcovid]] long COVID patient groups and the British Heart Foundation charity, a number of British universities and UK NHS hospital trusts, plus several industry partners.<ref name="overview" /> ==Clinical trials == A number of different clinical trials will be run by STIMULATE-ICP, involving over 4,500 patients, and will include: * a new care pathway, with "enhanced rehabilitation" using the '[[Living with COVID Recovery Programme|Living with COVID Recovery]]' digital platform * a drug trial testing several different drugs, including: ** [[Famotidine]]/[[Loratidine]]: These [[anti-histamine]]s may reduce the "persistent inflammation" found in some Long COVID patients that is related to [[mast cell activation disorder|mast cell activation]] (MCAS or MCAD) and the release of histamine.<ref name="faq">{{Cite web|url=https://www.stimulate-icp.org/faq | title = FAQ | last = | first = | authorlink = | date = |website=STIMULATE-ICP|archive-url=|archive-date=|url-status=|access-date=2022-01-03}}</ref> **[[Rivaroxaban]]: "[[Microclots|Micro-clots]]" in the circulation of people with Long COVID may be reducing oxygen available to large muscles during [[exercise]]. The anti-clotting drug [[rivaroxaban]] may address the the [[post-exertional malaise]] found in some people with long COVID<ref name="faq" /> **[[Colchicine]]: This anti-inflammatory may reduce inflammation around the lining of the heart ([[pericarditis]]) and lungs ([[pleuritis]]). Colchicine is also used for pericarditis and may reduce [[chest pain]] and [[Dyspnea|breathlessness]] (dyspnea) in Long COVID.<ref name="faq" /> * a "usual care" pathway<ref name="overview" /> ==Notable people== ===Lead investigators === *[[Amitava Banerjee]] - University College London *[[Melissa Heightman]] - University College London Hospitals NHS Foundation Trust<ref name="overview" /> ===Other investigators === *[[Elizabeth Murray]] - lead for the [[Living with COVID Recovery Programme]]<ref name="ARC2022">{{Cite web|url=https://www.arc-nt.nihr.ac.uk/research/projects/covid-19-research/ | title = COVID-19 research|website=ARC North Thames|access-date=2022-01-03}}</ref> *[[Paula Lorgelly]]<ref name="overview" /> ==News articles and interviews == * Jul 2021, [https://www.arc-nt.nihr.ac.uk/news-and-events/2021/july/new-clinical-trial-aims-to-improve-diagnosis-treatment-and-rehabilitation-of-long-covid/ New clinical trial aims to improve diagnosis, treatment and rehabilitation of long COVID] - National Institute of Health Research ==Notable studies== ==Funding== ==Online presence== *[https://www.stimulate-icp.org Website] ==See also== *[[Microclots]] *[[Long COVID]] ==Learn more== *[https://www.arc-nt.nihr.ac.uk/research/projects/stimulate-icp-improving-diagnosis-treatment-and-care-of-long-covid/ STIMULATE-ICP: Understanding long COVID to improve diagnosis, treatment and care] *[https://www.stimulate-icp.org/faq Frequently asked questions] - STIMULATE-ICP ==References== {{reflist}} [[Category:Research initiatives]] [[Category:British research initiatives]] [[Category:Long COVID research initiatives]]
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