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RituxME
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'''RituxME''' is a clinical trial of the [[rituximab]] ME/CFS research group at the Dept. of Oncology and Medical Physics at Haukeland University Hospital, Bergen, Norway. Senior Consultant [[Øystein Fluge]] and Professor [[Olav Mella]] are the study supervisors.<ref>http://www.helse-bergen.no/en/OmOss/Avdelinger/kreft/forsking-fagutvikling/Sider/Forsking-p%C3%A5-ME.aspx</ref> The final study, published in 2019, showed no overall improvement.<ref name="Fluge2019"/> ==Notable studies== ==Evidence== *2023, Endothelial dysfunction in ME/CFS patients<ref name="Sandvik2023">{{Cite journal|title=Endothelial dysfunction in ME/CFS patients|date=2023-02-02|url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280942|journal=PLOS ONE|volume=18|issue=2|pages=e0280942|last=Sandvik|first=Miriam Kristine|last2=Sørland|first2=Kari|last3=Leirgul|first3=Elisabeth|last4=Rekeland|first4=Ingrid Gurvin|last5=Stavland|first5=Christina Særsten|last6=Mella|first6=Olav|last7=Fluge|first7=Øystein|language=en|doi=10.1371/journal.pone.0280942|pmc=PMC9894436|pmid=36730360|issn=1932-6203}}</ref> - [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280942 (Full text)] ::A substudy showing improvement in post-occlusive reactive hyperemia (PORH) but not Flow-Mediated Dilation (FMD) after 18 months rituximab, no changes in symptoms *2019, [[B cell|B-Lymphocyte]] Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial<ref name="Fluge2019">{{Cite journal | last = Fluge | first=Øystein | authorlink = Øystein Fluge | last2 = Rekeland | first2 = Ingrid G. | last3 = Lien | first3 = Katarina | last4 = Thürmer | first4 = Hanne| last5 = Borchgrevink | first5 = Pette C. | last6 = Schäfer | first6 = Christoph | last7 = Sørland | first7 = Kari | last8 = Aßmus | first8 = Jörg | last9 = Ktoridou-Valen | first9 = Irini | last10 = Mella | first10 = Olav | authorlink10 = Olav Mella | date = 2019-04-02 | title = B-Lymphocyte Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial|url=http://annals.org/article.aspx?doi=10.7326/M18-1451|journal=Annals of Internal Medicine|language=en|doi=10.7326/M18-1451|issn=0003-4819}}</ref> - [https://www.clinicaltherapeutics.com/article/S0149-2918(19)30163-8/fulltext (Full text)] *2016, Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome.<ref name="Lunde2016">[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161226 Lunde S, Kristoffersen EK, Sapkota D, Risa K, Dahl O, Bruland O, et al. (2016) Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome. PLoS ONE 11(8): e0161226. doi:10.1371/journal.pone.0161226]</ref> - [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161226 (Full text)] *2015, B-Lymphocyte Depletion in Myalgic Encephalopathy/ Chronic Fatigue Syndrome. An Open-Label Phase II Study with Rituximab Maintenance Treatment<ref name="Fluge2015">http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129898</ref> - [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129898 (Full text)] ==See also == *[[Rituximab]] *[[Øystein Fluge]] *[[Olav Mella]] ==Learn more== *20 Oct 2016, [https://www.youtube.com/watch?v=cPlhjgXRKlE The RituxME and [[CycloME]] studies – Ongoing Clinical Research in the ME/CFS Research Group] *[https://helse-bergen.no/seksjon-engelsk/seksjon/Cancer%20Treatment%20and%20Medical%20Physics/Sider/RituxME.aspx RituxME website] ==References== {{Reflist}} [[Category:Notable studies]]
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