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Research bias in ME/CFS
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=== PACE trial === Davenport et al. (2018) state the lack of [[randomized controlled trial]]s in [[ME/CFS]] research mean that an evidence-based model can be unduly influenced by a very small number of studies, for example the [[PACE trial]] found that treating ME/CFS with [[graded exercise therapy]] or [[cognitive behavioral therapy]] did not result in clinically significant improvements - but this trial heavily influenced the clinical use of those treatments.<ref name="Davenport2018" /> The PACE trial was so problematic that it was used an the example for Prof. [[Bruce Levin|Bruce Levin's]] presentation ''How Not To Conduct A Randomized Clinical Trial'', and [[The Lancet]] received [[Open letter to the Lancet|open letters]] signed by over 100 people, including researchers and academics, calling for the trial to be retracted.
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