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==NHS definition== {{Quote box|quote=A sustained and marked exacerbation of symptoms lasting longer than a [[flare-up]] and needing a substantial and sustained adjustment to the person's [[energy management]]. It may not be clear in the early stages of a symptom exacerbation whether it is a flare‑up or a relapse. Relapses can lead to a long-term reduction in the person's energy limits.<ref name="ng206" /> | author=ME/CFS:diagnosis and management. NICE guideline (2021). | title=Relapse}} The UK's [[National Health Service]] definition of a relapse can be found within the 2021 [[NICE guidelines]].<ref name="ng206">{{Cite web|url=https://www.nice.org.uk/guidance/ng206/chapter/recommendations#terms-used-in-this-guideline | title = Myalgic Encephalomyelitis (or Encephalopathy)/Chronic Fatigue Syndrome:diagnosis and management. NICE guideline. | last=NICE Guideline Development Group | first = | authorlink = |publisher=[[National Institute for Health and Care Excellence]] | date = 2021-10-29}}</ref>
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