Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Rare and uncommon symptoms
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
Rare and uncommon symptoms of [[myalgic encephalomyelitis]] (ME) are those not listed the diagnostic criteria, and are more likely to occur or more likely to be problematic in people with [[Severe and very severe ME|severe or very severe ME]].<ref name="Becker2001">{{Cite journal | last = De Becker | first=P. | last2 = McGregor | first2 = N. | last3 = De Meirleir | first3 = K. | date = 2001-09-15| title = A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome|url=https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2001.00890.x|journal=Journal of Internal Medicine|volume=250|issue=3|pages=234β240|doi=10.1046/j.1365-2796.2001.00890.x|issn=0954-6820|pmc=|pmid=|quote= | author-link = Pascale De Becker | authorlink2 = Neil McGregor|access-date= | authorlink3 = Kenny De Meirleir | authorlink4 = | authorlink5 = |via=}}</ref><ref name="Jason2014">{{Cite journal | last= Jason | first = Leonard A. | last2 = Sunnquist | first2 = Madison | last3 = Brown | first3 = Abigail | last4 = Evans | first4 = Meredyth | last5 = Vernon | first5 = Suzanne D. | last6 = Furst | first6 = Jacob | last7 = Simonis | first7 = Valerie | date = 2014-01-01| title = Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912876/|journal=Fatigue: biomedicine, health & behavior|volume=2|issue=1 | pages = 40β56|doi=10.1080/21641846.2013.862993|issn=2164-1846|pmc=3912876|pmid=24511456|quote= | author-link = Leonard Jason | author-link2 = Madison Sunnquist|access-date= | authorlink3 = Abigail Brown | author-link4 = Meredyth Evans | author-link5 = Suzanne Vernon|via=}}</ref> Rare symptoms that can be particularly problematic include: * periodic [[paralysis]] or [[Paresis|partial paralysis]]<ref name=":3" /><ref name="ICC" /> * chewing [[Dysphagia|swallowing]] and digesting food<ref name=":3" /><ref name=":5" /> * seizure-like phenomena, or complete or partial [[Seizure|seizures]]<ref name="HFME" /><ref name="CCC" /><ref name=":6">{{Cite web|url=http://www.investinme.org/Article-020%20What%20is%20ME%20What%20is%20CFS.shtml| title = Invest in ME Research - UK Charity for Myalgic Encephalomyelitis What is ME?|website=[[Invest in ME Research]]|access-date=2018-10-16}}</ref> * [[cardiovascular]] symptoms like [[heart palpitation]]s * nocturnal [[diarrhea]], bladder and bowel control problems<ref name=":5" /> * [[blackouts]] or loss of consciousness<ref name="HFME">{{Cite web|url=https://www.hfme.org/themesymptomlist.htm| title = The comprehensive M.E. symptom list | last = Bassett | first=Jodi | date = 2012 | website = The Hummingbirds' Foundation|archive-url=https://web.archive.org/web/20180330194015/http://www.hfme.org/themesymptomlist.htm|archive-date=2018-03-30|url-status=|access-date=2018-10-07|authorlink=Jodi Bassett}}</ref><ref>{{Cite news | url=https://25megroup.org/me/symptoms| title = Symptoms - 25% M.E. Group|work=25% M.E. Group|access-date=2018-10-07|language=en-US}}</ref><ref name="Becker2001" /><ref name="CCC">{{Cite journal | last = Carruthers | first = Bruce M. | last2 = Jain | first2 = Anil Kumar | last3 = De Meirleir | first3 = Kenny L. | last4 = Peterson | first4 = Daniel L. | last5 = Klimas | first5 = Nancy G. | last6 = Lerner | first6 = A. Martin | last7 = Bested | first7 = Alison C. | last8 = Flor-Henry | first8 = Pierre | last9 = Joshi | first9 = Pradip | date = May 2002| title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Clinical Working Case Definition, Diagnostic and Treatment Protocols|url=http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf#page=10|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=11|issue=1 | pages = 7β115|doi=10.1300/j092v11n01_02|issn=1057-3321|via=|pmc=|pmid=|quote= | author-link = Bruce Carruthers | authorlink2 = Anil Kumar Jain|access-date= | authorlink3 = Kenny De Meirleir | authorlink4 = Daniel Peterson | author-link5 = Nancy Klimas | authorlink6 = A Martin Lerner | authorlink7 = Alison Bested | authorlink8 = Pierre Flor-Henry | authorlink9 = Pradip Joshi}}</ref><ref>{{Cite journal | last = Amano | first = Keiko | last2 = Yanagihori | first2 = Ryoko | last3 = Tei | first3 = Chuwa | date = 2015-05-13| title = Waon Therapy is Effective as the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://www.jstage.jst.go.jp/article/onki/78/3/78_285/_pdf|journal=The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine|language=en|volume=78|issue=3|pages=|doi=10.11390/onki.78.285|issn=0029-0343|via=}}</ref><ref name=":3">{{Cite journal | last = Crowhurst | first=Greg | date = 28 February 2005| title = Supporting people with severe myalgic encephalomyelitis|url=http://me-foreningen.dk/wp-content/uploads/2016/10/Crowhurst-Severely-affected-i-Nursing-Standard.pdf|journal=Nursing Standard (Royal College of Nursing (Great Britain): 1987)|volume=19|issue=21|pages=38β43|doi=10.7748/ns2005.02.19.21.38.c3796|issn=0029-6570|pmid=15727017|via=|pmc=|quote= | author-link = Greg Crowhurst}}</ref> ==Sensory problems== Sensory problems including noise and light sensitivity ([[tinnitus]], [[hyperacusis]], severe [[photophobia]]) are relatively common but may be undercognised; the most commonly used diagnostic criteria do not include any sensory symptoms.<ref name="fukuda1994">{{Cite journal | last = Fukuda | first = K. | authorlink = Keiji Fukuda | last2 = Straus | first2 = S.E. | authorlink2 = Stephen Straus | last3 = Hickie | first3 = I. | authorlink3 = Ian Hickie | last4 = Sharpe | first4 = M.C. | authorlink4 = Michael Sharpe | last5 = Dobbins | first5 = J.G. | authorlink5 = James Dobbins | last6 = Komaroff | first6 = A. | authorlink6 = Anthony Komaroff | date = 1994-12-15| title = The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group | url =https://www.researchgate.net/profile/Michael_Sharpe2/publication/247808895_The_Chronic_Fatigue_Syndrome_A_Comprehensive_Approach_to_Its_Definition_and_Study/links/0c96053201643bfc4b000000/The-Chronic-Fatigue-Syndrome-A-Comprehensive-Approach-to-Its-Definition-and-Study.pdf|journal=Annals of Internal Medicine|volume=121|issue=12 | pages = 953β959|issn=0003-4819|pmid=7978722|via=|publisher=American College of Physicians}}</ref><ref name="CDC2020TREAT">https://www.cdc.gov/me-cfs/symptoms-diagnosis/symptoms.html</ref><ref name=":6" /><ref name="CCC" /><ref name="CCC" /> ==Symptom recognition== === Paralysis === [[Paralysis]] is recognized under ''Motor and Balance'' symptoms in the [[Canadian Consensus Criteria]] (CCC) (Appendix 4). Chewing and swallowing difficulties. Paralysis is not recognized in the [[International Consensus Criteria]], (ICC) but the [[Ion transportation|ion transport]] and [[channelopathy]] impairments that cause it are mentioned in the ''pathophysiology'' section, and the ''response to exercise'' section.<ref name="ICC">{{citation | last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | authorlink7 = Donald Staines | last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles | last9 = Speight | first9 = N | authorlink9 = Nigel Speight | last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman | last12 = Bell | first12 = DS | authorlink12 = David Bell | last13 = Carlo-Stella | first13 = N | authorlink13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | authorlink14 = John Chia | last15 = Darragh | first15 = A | authorlink15 = Austin Darragh | last16 = Gerken | first16 = A | authorlink16 = Anne Gerken | last17 = Jo | first17 = D | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = DP | authorlink18= Donald Lewis | last19 = Light | first19 = AR | authorlink19 = Alan Light | last20 = Light | first20 = KC | authorlink20= Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012 | isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}</ref> === Chewing and swallowing problems === Chewing and swallowing problems are sometimes caused by paralysis, especially facial paralysis. Some patients are too weak to chew, eat or digest food normally and need a feeding tube.<ref>{{Cite journal | last = Hanson | first = Maureen R. | last2 = Giloteaux | first2 = Ludovic | date = 2017 | title=The gut microbiome in Myalgic Encephalomyelitis|url=http://www.biochemist.org/bio/03902/0010/039020010.pdf|journal=Biochemist|volume=39|issue=2|pages=10-13|via=| doi = | pmc = | pmid = | quote = | authorlink = Maureen Hanson}}</ref><ref name="HFME" /> Problems with fine motor control of the hands can also affect eating.<ref name=":3" /><ref>{{Cite web|url=https://www.mesupport.co.uk/index.php?page=the-symptoms-of-m-e| title = The Symptoms of Myalgic Encephalomyelitis - M.E. Support | last = Sargent | first = Louise | date = |website=mesupport.co.uk|language=en|archive-url=|archive-date=|url-status=|access-date=2018-10-16}}</ref> === Nocturnal diarrhea === Nightime diarrhea and delayed emptying of the upper gastricintestinal tract were found in some CFS patients, although vomiting was much rarer in the same study.<ref name=":5">{{Cite journal | last = Burnet | first = Richard B | last2 = Chatterton | first2 = Barry E | date = December 2004| title = Gastric emptying is slow in chronic fatigue syndrome|url=https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-4-32|journal=BMC Gastroenterology|language=en|volume=4|issue=1|pages=|doi=10.1186/1471-230x-4-32|issn=1471-230X|pmc=544348|pmid=15619332|via=}}</ref> Difficulties with bladder or bowel control have also been identified.<ref name=":6" /> === Seizure-like symptoms === [[Seizure|Seizure-like symptoms]] are described as resulting from hypersensitivity to even low levels of a stimulus (to light, noise, chemicals, etc).<ref>{{Cite journal | last = Chaudhury | first = Suprakash | date = 2014-07-01| title = Cognitive impairments in chronic fatigue syndrome|url=http://www.mjdrdypu.org/article.asp?issn=0975-2870;year=2014;volume=7;issue=4;spage=422;epage=424;aulast=Chaudhury|journal=Medical Journal of Dr. D.Y. Patil University|language=en|volume=7|issue=4}}</ref> Seizure-like symptoms are included in the ''[[Nervous system|Nervous System]]'' symptoms in the Canadian Consensus Criteria (Appendix 4).<ref name="CCC" />{{Rp|102-103}} ==Prevalence== {| class="wikitable alternance sortable mw-collapsible" style="background:white" !Symptom !Prevalence % !International Criteria !Canadian Criteria !Fukuda criteria !Rare |- |paralysis | |no |yes |no |yes |- |Sight loss - partial or complete (amaurosis) |15.5 |no - motor disturbances recognized |no - visual changes only |no |yes |- |visible muscle wasting | |no |no |no |yes |- |sleeping all day/awake all night (also reversal) |14 |yes |yes |no |yes |- |[[syncope|fainting]] (syncope) |14.9 |no |no |no |yes |- |seizure-like symptoms | |no |yes |no |yes |- |[[hyperacusis]] (severe noise severe) | |yes, neurosensory |yes |no |no |- |severe [[photophobia]] (severe light sensitivity) |70-76%<ref name="Becker2001" /><ref name="CCC" />{{Rp|101}} |yes, neurosensory |yes |no |no |- |[[tinnitus]] |52-58%<ref name="Becker2001" /><ref name="CCC" />{{Rp|101}} |no |no |no |no |} ==Notable studies== ===Castro-Marrero et al. 2017=== [https://www.sciencedirect.com/science/article/pii/S0033318217301184 Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study]<ref name="Castro2017">https://www.sciencedirect.com/science/article/pii/S0033318217301184</ref> * 1757 Spanish subjects who met both the 1994 CDC/Fukuda definition and Canadian Consensus Criteria for CFS/ME. Table 2 gives prevelance of each ME/CFS symptom in the Canadian Consensus Criteria ===Jason et. al 2014=== [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912876/ Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis] * 236 patients completed the DePaul Symptom Questionnaire, rating the frequency and severity of 54 symptoms, compared to controls. ===de Becker et al. 2010=== [https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2001.00890.x A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome] * A study of 2073 patients complaining of chronic fatigue (CF) in Brussels. Table 1 and Table 2 show the how many patients had each symptom according to whether they met the Fukuda criteria, the Holmes criteria or had chronic fatigue without CFS. 1578 CFS patients fulfilled the Fukuda criteria (called the "CFS group") and 951 (60.3% of the CFS group) fulfilled the Holmes criteria. The Holmes definition was found to be better than the Fukuda at differentiated CFS patients from the patients with Chronic Fatigue without CFS. ==See also== * [[Fukuda criteria]] * [https://www.cdc.gov/me-cfs/pdfs/wichita-data-access/si-scoring-algorithm.pdf Common Symptoms - CDC Symptom Inventory for CFS Scoring] * [[International Consensus Criteria|International Consensus Criteria]] * [[Canadian Consensus Criteria]] * [[Common symptoms in ME/CFS]] * [[Severe and very severe ME|Severe and very severe M.E.]] ==Learn == * [https://www.hfme.org/PDF/Comprehensive_ME_Symptom_List.pdf Hummingbird Foundation: Comprehensive list of M.E.Symptoms] * [http://me-foreningen.dk/wp-content/uploads/2016/10/Crowhurst-Severely-affected-i-Nursing-Standard.pdf Supporting people with severe Myalgic Encephalomyelitis] - [[Greg Crowhurst]], Nursing Times * [http://stonebird.co.uk/Care%20Sheets.pdf Supporting someone with Severe ME sufferer: basic information that carers should find-out] Greg Crowhurst (2010) * [https://25megroup.org/me/symptoms Severe M.E. symptoms] - 25% Group * [https://www.actionforme.org.uk/uploads/pdfs/my-life-stopped-severe-ME-report.pdf Severe M.E.: Time to Deliver] - Action for M.E. * [http://www.investinme.org/Article-020%20What%20is%20ME%20What%20is%20CFS.shtml What is M.E?] - Invest in M.E. Research * ==References== {{reflist}} [[Category:Signs and symptoms]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Citation
(
edit
)
Template:Cite journal
(
edit
)
Template:Cite news
(
edit
)
Template:Cite web
(
edit
)
Template:Main other
(
edit
)
Template:Reflist
(
edit
)
Template:Rp
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:No globals
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs