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Randomized controlled trial
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=== Weighting === RCTs are not automatically of equal standing, and [[systematic review]]s assign a weighting to RCTs, which effectively ranks some RCTs as more significant than others.<ref name="2armed" /> The [[GRADE framework]] is a standardised way developed to compare different RCTs by assessing a number of factors from the trials, in order to provide an independent, systematic review of exercise. Both [[Cochrane]] and the systematic reviews created for the UK's [[NICE guidelines]] use the GRADE framework. The largest RCT of [[ME/CFS]] treatments to date is the highly controversial [[PACE trial]]. The PACE trial had significantly more participants than any other RCTs of [[graded exercise therapy]] and [[cognitive behavioral therapy]], for example the [[FINE trial]] tested the same treatments in severely ill patients but had far less participants. The FINE trial reported a null effect for the treatments, but the PACE trial reported a moderately positive result. The [[Cochrane]] systematic review of exercise as a therapy for CFS assigned a higher weight to the PACE trial results compared to the smaller FINE trial.
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