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RCCX Genetic Module Theory
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==Common mechanism== According to Meglathery, the most compelling piece of evidence that all of these conditions have a common mechanism is the psychological profile 'CAPS' which is universally present and allows prediction of who is at risk for developing chronic illness. CAPS is very often associated with hypermobility, but not always. It is very clear that CYP21A2 mutations are responsible for both CAPS and chronic illness (medical and psychiatric), whether or not they have the often accompanying TNXB mutation (which brings with it complications of musculoskeletal/structural issues and TGF beta). Interestingly, a very large study<ref name="Cederlof2016" /> involving the Swedish registry (1,780 with EDS, 1,722 siblings of EDS patients, 10,019 with hypermobility syndrome and 11,082 hypermobility siblings) showed a substantially higher risk for autism spectrum, bipolar disorder, ADHD and depression in EDS patients, hypermobility syndrome patients and their non-affected siblings. This study confirms Meglathery's observation that psychological issues in hypermobile people are rampant, and not dependent on the presence or degree of individual hypermobility, but rather the presence of hypermobility within the family. A seven year study demonstrated that therapy was very helpful in decreasing issues with schizophrenia. Meglathery believes therapy decreased the patients' acute stress response, which decreased the stress burden and subsequently decreased the aberrations which happen when 21-hydroxylase is overwhelmed in someone carrying a CYP21A2 mutation. Characterizing RCCX variances may be the direct way to provide genetic tests for who is at risk for chronic illness. Effective prevention and treatments would follow naturally from this. These conditions can occur due to other genes, but they occur without these clusters. For example, MCAS has many triggers and POTS often is associated with the vasodilating effects of excessive liberation of histamine. Also, it is important to remember that there are quite a few downstream issues which affect all of these conditions and muddy the waters. For example, most people with the RCCX gene module have raised intracranial pressure which affects pituitary hormones, making hormonal issues appear to be secondary rather than primary. Also, because of C4, and possibly other causes of autoimmune issues, there are also autoimmune hormone disorders.
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