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RCCX Genetic Module Theory
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==Conditions associated with RCCX gene mutations== Meglathery states that the following are associated with RCCX gene mutations *[[Ehlers-Danlos syndrome|Ehlers-Danlos Syndrome]], Hypermobility Type (EDS-HT) *[[Chronic fatigue syndrome]] (CFS) / [[Myalgic Encephalomyelitis]] (ME) *[[Fibromyalgia]] (FM) *[[Chronic Lyme disease|Chronic Lyme Disease]], [[Gulf War Illness|Gulf War Syndrome]], Toxic [[Mold illness|Mold]]/[[Biologic Illness]] *[[Mast cell activation syndrome|Mast Cell Activation Syndrome]] (MCAS): [[histamine intolerance]], [[Migraine|migraines]], [[diarrhea]], [[Sinusitis|sinus pain]], [[burning eyes]], [[Fainting|syncope]], [[distractibility]], [[brain fog]], [[Excessive irritability|irritability]], [[interstitial cystitis]], [[hyper-adrenergic POTS]], etc., depending on location of the mast cells *[[Postural orthostatic tachycardia syndrome|Postural Orthostatic Tachycardia]] (POTS) *[[Dysautonomia]] *[[Orthostatic intolerance|Orthostatic Intolerance]], [[low blood volume]] *Pain Syndromes: Neuropathic Pain Syndromes; Chronic Regional Pain Syndrome; [[myofascial pain disorder|Myofascial Pain Disorder]]; Frequent Dislocations; [[Dysmenorrhea]]; Chronic [[Headache]]; [[Migraine]]s; [[interstitial cystitis|Interstitial Cystitis]]; [[Vulvodynia]]; Temporomandibular Joint Disorder (TMJ) *GI Syndromes: [[Irritable bowel syndrome|Irritable Bowel Syndrome]]; [[cyclic vomiting|Cyclical Vomiting]]; [[Gastroparesis]]; [[Food intolerance|Food Intolerance]]; [[intestinal dysbiosis|Gut dysbiosis]]; Candida overgrowth; Leaky Gut Syndrome; Malabsorption Syndromes *Raised Intracranial Pressure Conditions: Pseudotumor Cerebri; [[intercranial hypertension|Benign Intracranial Hypertension]]; Posterior Reversible Encephalopathy; Acquired [[Chiari malformation|Chiari Malformation]] *Neurological Issues: Neuropathies; Pain Syndromes; Uncoordinated Swallow; Vertigo; Central Apnea; Sleep Paralysis; [[Dysautonomia]]; Seizure-Like Episodes; Dystonia; Narcolepsy; [[White Matter Lesions]]; [[Small Fiber Polyneuropathy]] (Erythromelalgia); [[restless leg syndrome|Restless Leg Syndrome]]; Brain Anatomic Abnormalities, e.g., enlarged amygdalae, small anterior cingulate, [[Chiari malformation]], hydrocephalus *Mitochondrial Disorders *Immune Dysregulation: Combined Variable Immunodeficiency Disease (CVID); IgA deficiency; chronic fungal infections; recurrent [[herpes simplex virus]] (HSV) infections; no colds for years; severe bacterial infections; inability to clear chronic bacterial and viral infections ([[Streptococcus|strep]]/Epstein Barr/mycoplasma/chlamydia/candida), dysbiosis; [[small intestine bacterial overgrowth]] (SIBO); classic and non classic autoimmune disorders, e.g., [[multiple sclerosis]] (MS); mixed connective tissue disorders; eosinophilic disorders; high TGF beta; inflammatory conditions (endometriosis); Chronic Inflammatory Response Syndrome (CIRS) *Psychiatric Issues: Dysautonomia (Generalized Anxiety Disorder, ADD, Hyperfocus); Autistic spectrum; Sensory Processing Disorders; Psychosis; Schizophrenia; Chronic [[Stress]]; [[Post-traumatic stress disorder|PTSD]];]] Mood Disorders; Chronic [[Insomnia; Obsessive Compulsive Disorder; Phobias; Paranoid Disorders; Emotional Dysregulation; *Hormonal Disorders: Sex Hormone Disorders (Cystic Ovaries, Acne, Water/Fat-Associated Weight Gain, Breast and Tissue Swelling, Fertility issues, Hot Flashes/Night Sweats; Adrenal Gland Issues (Adrenal Fatigue, [[Addison's Disease]], Cortisol dysregulation, Low Aldosterone); Pituitary Hormone Abnormalities (ACTH, TRH-Mediated Thyroid Disorders); Autoimmune Hormonal Issues ([[Hashimoto's thyroiditis (hypothyroidism)|Hashimotos's Thyroiditis]]) *GU/Renal Issues: Fibromuscular Dysplasia; Diabetes Insipidus; Interstitial Cystitis; Vesicoureteral Reflux (urine backing up into kidneys) *Miscellaneous Issues: Extreme Temperature Dysregulation (with/without Dysautonomia), [[multiple chemical sensitivity]], High Adrenaline/Noradrenaline (norepinephrine) States; Erythromelalgia; Raynaud's Phenomena; Livedo Reticularis; Poor Connective Tissue integrity (dislocations, [[bruising]], bleeding, petechaie, calcific aortic valves, Mitral Valve Prolapse); Dry eyes; Tinnitis; Subcutaneous Adipose Disorders (Lipidema, Dercum's Disease), Left Handedness, Gender Fluidity (LGTBQ); lack of traditional gender roles *Possible other inclusions: Medullary Sponge Kidney; Pyroluria; disorders of copper and zinc regulation; early onset [[Parkinson's disease]]; Ion-Associated Illnesses
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