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RCCX Genetic Module Theory
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==Theory== [[Sharon Meglathery]] MD, a board certified psychiatrist and previously also board certified in internal medicine, with 20 years of practice experience, developed chronic illnesses in 2009. Her illnesses included, but was not limited to: [[Mast cell activation disorder|mast cell activation syndrome]] (MCAS), [[Postural orthostatic tachycardia syndrome]] (POTS), [[Chronic fatigue syndrome]] (CFS) and raised intracranial pressure (ICP) in the setting of [[Ehlers-Danlos syndrome]], Hypermobility Type (hEDS or EDS-HT). Meglathery was motivated to figure out the basis for all these co-occurring conditions. She carefully examined her patients, herself, the literature and people on the various chronic illness forums to see what characteristics people with these illnesses have in common. She stated that she had found a psychological profile, now dubbed [[CYP21A2 mutation associated psychiatric spectrum|CAPS]] (CYP21A2 mutation associated Psychiatric spectrum) which could predict the development of chronic illness. From there, she was able to assess many of the characteristics of this population and their families. Then, she learned of the unique properties of the RCCX Module and how its genes could explain all of her observations, as well as results of the research since then. Meglathery says the RCCX Theory explains the co-inheritance of a wide range of overlapping chronic medical conditions in individuals and families ([[EDS]]/hypermobility, [[autoimmune disease]], chronic fatiguing illness, psychiatric conditions, autism, etc.). It explains the underlying pathophysiology of [[Chronic fatigue|chronic fatiguing illnesses]] with so many overlapping features ([[Ehlers-Danlos syndrome|EDS]]-HT, [[Chronic fatigue syndrome|CFS]], [[chronic Lyme disease]], [[Fibromyalgia]] (FM), toxic [[mold]], [[Epstein-Barr virus]] infection, [[mast cell activation syndrome]] (MCAS, [[Postural orthostatic tachycardia syndrome|POTS]], etc.) and why many are associated with varying degrees of hypermobility, with the degree of hypermobility unrelated to the degree of physical or psychiatric illness. Meglathery further postulates that CYP21A2 mutations are the genetic diathesis (predisposition to abnormal/diseased medical conditions) which predisposes to all of the psychiatric conditions in the vast majority of affected people.{{citation needed| date = 2021}}
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