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Quotes from critics of the PACE trial
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===[[James Coyne|Professor James Coyne]]=== Professor Coyne is Professor of Health Psychology, University Medical Center, Groningen and University of the Netherlands; Distinguished Visiting Professor at the Institute for Health Policy, Rutgers, the State University of New Jersey; and Professor Emeritus of Psychology in the Department of Psychiatry, University of Pennsylvania. He is one of the most cited psychologists in the academic literature. <blockquote>"The data presented are uninterpretable. We can temporarily suspend critical thinking and some basic rules for conducting randomized trials (RCTs), follow-up studies, and analyzing the subsequent data. Even if we do, we should reject some of the interpretations offered by the PACE investigators as unfairly spun to fit what [is] already a distorted positive interpretation of the results."<ref name="Coyne20151029po">{{cite web | last1 = Coyne | first1 = James | authorlink1 = James Coyne | url = http://blogs.plos.org/blog/2015/10/29/uninterpretable-fatal-flaws-in-pace-chronic-fatigue-syndrome-follow-up-study/ | title = Uninterpretable: Fatal flaws in PACE Chronic Fatigue Syndrome follow-up study | journal = PLoS One Blog | date = Oct 29, 2015 | archive-url = https://web.archive.org/web/20160506070934/https://blogs.plos.org/blog/2015/10/29/uninterpretable-fatal-flaws-in-pace-chronic-fatigue-syndrome-follow-up-study/ | archive-date = May 6, 2016 }}</ref></blockquote> <blockquote>"The self-report measures do not necessarily capture subjective experience, only forced choice responses to a limited set of statements."<ref name="Coyne20151029po" /></blockquote> <blockquote>"One of the two outcome measures, the physical health scale of the SF-36 requires forced choice responses to a limited set of statements selected for general utility across all mental and physical conditions."<ref name="Coyne20151029po" /></blockquote> <blockquote>"The validity [of the] other primary outcome measure, the [[Chalder fatigue scale|Chalder Fatigue Scale]] depends heavily on research conducted by this investigator group and has inadequate validation of its sensitivity to change in objective measures of functioning."<ref name="Coyne20151029po" /></blockquote> Professor Coyne gave a public talk criticising the PACE trial in Edinburgh in November 2015. Video footage is available<ref name="Coyne20151116-v1" /><ref name="Coyne20151116-v2" /><ref name="Coyne20151116-v3" />, as are a slide show<ref name="Coyne20151116-ss">{{cite web | last1 = Coyne | first1 = James | authorlink1 = James Coyne | url = http://www.slideshare.net/jamesccoyne/edinburgh-skeptics-in-the-pub-talk-on-pace-chronic-fatigue-trial | title = A skeptical look at the PACE chronic fatigue trial - slide show | place = Edinburgh | date = Nov 16, 2015 | via = Slideshare }}</ref> full and an edited transcripts,<ref name="Coyne20151116-tf" /><ref name="Coyne20151116-ts" /><ref name="Coyne20151116-tl" /> and an audio recording.<ref name="Coyne20151116-au" /> He spoke again about the PACE study in Belfast in February 2016 where he described it as "a wasteful trainwreck of a study".<ref name="Coyne20160208-v">{{cite web | last1 = Coyne | first1 = James | authorlink1 = James Coyne | url = https://www.youtube.com/watch?v=8jHRNxMOAjA&feature=youtu.be | title = The scandal of the Β£5m PACE trial for ME | date = Feb 8, 2016 | website = YouTube }}</ref><ref name="Coyne20160208-ss">{{cite web | last1 = Coyne | first1 = James | authorlink1 = James Coyne | url = http://www.slideshare.net/jamesccoyne/the-scandal-of-the-5m-pace-chronic-fatigue-trial | title = The scandal of the Β£5m PACE trial for ME - slide show | date = Feb 8, 2016 }}</ref> Professor Coyne has questioned whether the PACE trial paper could ever have been properly peer-reviewed, given the large number of study authors and the small world of British science.<ref name="Coyne20151125">{{cite web | last1 = Coyne | first1 = James | authorlink1 = James Coyne | url = http://blogs.plos.org/mindthebrain/2015/11/25/was-independent-peer-review-of-the-pace-trial-articles-possible/#.VlW9QYj8_5o.twitter | title = Was independent peer review of the PACE trial articles possible? | website = MindTheBrain Blog | date = Nov 25, 2015 }}</ref>
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