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Quotes from critics of the PACE trial
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===Dr [[David Tuller]] and [[Julie Rehmeyer]]=== Public health expert Dr Tuller and ME/CFS patient [[Julie Rehmeyer]] are both journalists who have written critically about the PACE authors' claims regarding the safety of [[Graded exercise therapy]]:<ref name="Tuller20160107" /> <blockquote>"The study’s primary case definition for identifying participants, called the Oxford criteria, was extremely broad; it required only six months of medically unexplained fatigue, with no other symptoms necessary. Indeed, 16% of the participants didn’t even have exercise intolerance—now recognized as the primary symptom of ME/CFS".</blockquote> <blockquote>"After the trial began, the researchers tightened their definition of harms, just as they had relaxed their methods of assessing improvement."</blockquote> <blockquote>"[T]he study was unblinded, so both participants and therapists knew the treatment being administered. Many participants were probably aware that the researchers themselves favored graded exercise therapy and another treatment, cognitive behavior therapy, which also involved increasing activity levels. Such information has been shown in other studies to lead to efforts to cooperate, which in this case could lead to lowered reporting of harms."</blockquote>
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