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Postviral fatigue syndrome
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===Psychosocial factors determine persistent fatigue but not ME/CFS === Studies that looked at a broader definition of fatigue after an [[Epstein-Barr virus|EBV]] infection have reached different conclusions. Candy et al. (2003) for example found that persistent fatigue six months after infectious mononucleosis was predicted by certain illness perceptions such as the belief that the illness would take more than one month to recover from and would have serious consequences.<ref>{{Cite journal | last = Candy | first = B. | last2 = Chalder | first2 = T. | last3 = Cleare | first3 = A.J. | last4 = Peakman | first4 = A. | last5 = Skowera | first5 = A. | last6 = Wessely | first6 = S. | last7 = Weinman | first7 = J. | last8 = Zuckerman | first8 = M. | last9 = Hotopf | first9 = M. | date = Jul 2003 | title = Predictors of fatigue following the onset of infectious mononucleosis|url=https://www.ncbi.nlm.nih.gov/pubmed/12877399|journal=Psychological Medicine|volume=33|issue=5 | pages = 847–855|issn=0033-2917|pmid=12877399 | author-link = | author-link2 = Trudie Chalder|via= | authorlink6 = Simon Wessely}}</ref> [[Rona Moss-Morris|Moss-Morris]] et al. followed-up on 246 patients with [[Mononucleosis|glandular fever]] from [[New Zealand]]. After six months, 7.8% still reported severe fatigue. [[Depression]], [[anxiety]] and [[perfectionism]] were associated with persistent complaints though perceived stress and limiting activity were not.<ref>{{Cite journal | last = Moss-Morris | first = R. | last2 = Spence | first2 = M.J. | last3 = Hou | first3 = R. | date = May 2011 | title = The pathway from glandular fever to chronic fatigue syndrome: can the cognitive behavioural model provide the map?|url=https://www.ncbi.nlm.nih.gov/pubmed/20663256|journal=Psychological Medicine|volume=41|issue=5|pages=1099–1107|doi=10.1017/S003329171000139X|issn=1469-8978|pmid=20663256|quote= | author-link = Rona Moss-Morris|via=}}</ref> A [[Norway|Norwegian]] study found that [[fatigue]] after acute EBV was predicted by variables related to symptoms and negative emotions instead of immune processes.<ref>{{Cite journal | last = Pedersen | first = Maria | authorlink = Maria Pedersen | last2 = Asprusten | first2 = Tarjei Tørre | last3 = Godang | first3 = Kristin | last4 = Leegaard | first4 = Truls Michael | last5 = Osnes | first5 = Liv Toril | last6 = Skovlund | first6 = Eva | last7 = Tjade | first7 = Trygve | last8 = Øie | first8 = Merete Glenne | last9 = Wyller | first9 = Vegard Bruun Bratholm| date = 2018-09-25 | title = Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study|url=https://www.ncbi.nlm.nih.gov/pubmed/30261303|journal=Brain, Behavior, and Immunity|doi=10.1016/j.bbi.2018.09.023|issn=1090-2139|pmid=30261303}}</ref> These findings would later be disrupted, and [[Personality traits and patient attitudes in ME/CFS|patient attitudes beliefs]] are no longer considered influence outcomes.<ref name="canadianconsensus-CCC">{{Citation | last1 = Carruthers | first1 = Bruce M. | authorlink1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | authorlink2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | authorlink4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | authorlink6 = Martin Lerner | last7 = Bested | first7 = Alison C. | authorlink7 = Alison Bested | last8 = Flor-Henry | first8 = Pierre | authorlink8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip | authorlink9 = Pradip Joshi | last10 = Powles | first10 = AC Peter | authorlink10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | authorlink11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I. | authorlink12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols | journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid = | doi = 10.1300/J092v11n01_02 | url = http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf }}</ref><ref name="ICC2011primer">{{citation | last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | authorlink7 = Donald Staines | last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles | last9 = Speight | first9 = N | authorlink9 = Nigel Speight | last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman | last12 = Bell | first12 = DS | authorlink12 = David Bell | last13 = Carlo-Stella | first13 = N | authorlink13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | authorlink14 = John Chia | last15 = Darragh | first15 = A | authorlink15 = Austin Darragh | last16 = Gerken | first16 = A | authorlink16 = Anne Gerken | last17 = Jo | first17 = D | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = DP | authorlink18 = Donald Lewis | last19 = Light | first19 = AR | authorlink19 = Alan Light | last20 = Light | first20 = KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012 | isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}</ref> {{See also|Biopsychosocial model}}
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