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Postviral fatigue syndrome
(section)
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===ME/CFS cases decrease over time=== A study in the Chicago area showed that the percentage of patients meeting ME/CFS criteria after infectious mononucleosis decreases as time moves on. While 13% met ME/CFS criteria at the six-month time interval, this decreased to 7% at 12 months and only 4% at 24 months.<ref>{{Cite journal | last = Katz | first = Ben Z. | last2 = Jason | first2 = Leonard A. | date = Feb 2013 | title = Chronic fatigue syndrome following infections in adolescents|url=https://www.ncbi.nlm.nih.gov/pubmed/23263024|journal=Current Opinion in Pediatrics|volume=25|issue=1 | pages = 95β102|doi=10.1097/MOP.0b013e32835c1108|issn=1531-698X|pmid=23263024|quote= | author-link = Ben Katz | authorlink2 = Leonard Jason|via=}}</ref> The most important predictors of ME/CFS caseness were [[Autonomic nervous system|autonomic]] symptoms and days spent in bed since mono.<ref>{{Cite journal | last= Jason | first = Leonard A. | last2 = Katz | first2 = Ben Z. | last3 = Shiraishi | first3 = Yukiko | last4 = Mears | first4 = Cynthia J. | last5 = Im | first5 = Young | last6 = Taylor | first6 = Renee R. | date = 2014-01-01 | title = Predictors of post-infectious chronic fatigue syndrome in adolescents|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956649/|journal=Health Psychology and Behavioral Medicine|volume=2|issue=1 | pages = 41β51|doi=10.1080/21642850.2013.869176|issn=2164-2850|pmc=3956649|pmid=24660116|quote= | author-link = Leonard Jason | authorlink2 = Ben Katz|via= | authorlink6 = Renee Taylor}}</ref> This confirmed the main conclusion of the Dubbo studies, namely that the severity of the acute infection is the main predictor of ME/CFS. In the Chicago study however, cytokine expression indicated differences in [[Th17]] function in patients with post-infectious ME/CFS.<ref>{{Cite journal | last = Broderick | first = Gordon | last2 = Katz | first2 = Ben Z. | last3 = Fernandes | first3 = Henrique | last4 = Fletcher | first4 = Mary Ann | last5 = Klimas | first5 = Nancy | last6 = Smith | first6 = Frederick A. | last7 = O'Gorman | first7 = Maurice R.G. | last8 = Vernon | first8 = Suzanne D. | last9 = Taylor | first9 = Renee | date = 2012-09-13 | title = Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue|url=https://www.ncbi.nlm.nih.gov/pubmed/22973830|journal=Journal of Translational Medicine|volume=10|pages=191|doi=10.1186/1479-5876-10-191|issn=1479-5876|pmc=3480896|pmid=22973830|issue=|quote= | author-link = Gordon Broderick | authorlink2 = Ben Katz | authorlink3 = | authorlink4 = Mary Ann Fletcher | authorlink5 = Nancy Klimas|via= | authorlink8 = Suzanne Vernon | authorlink9 = Renee Taylor}}</ref>
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