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Postural orthostatic tachycardia syndrome
(section)
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==Treatment== A 2012 study [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390096/ Diagnosis and management of postural orthostatic tachycardia syndrome: A brief review]<ref name=":0" /> concluded: :"The pathophysiology of POTS is complex and the result of a number of separate mechanisms producing a common pattern of symptoms. The large number of clinical manifestations that characterize this disorder and the wide range of medications available, plus the clear evidence that certain medications and treatment strategies work in some, but not all POTS patients, demonstrates that POTS is a range of disorders requiring comprehensive investigation and characterisation to guide selection of the most appropriate treatment. The recent consensus statement will help to direct further research into the underlying conditions that lead to POTS." : When the cause of POTS is able to be identified and treated in certain individuals, their POTS symptoms may subside. However, there is currently no cure for POTS on the broader level. The following treatments have been identified to improve symptoms and quality of life: :* Increasing fluid intake (2-3 liters a day) :* Increasing salt intake :* Raising the head of the bed to conserve blood volume (less blood is turned into urine by the kidneys when reclining at an angle) :* Abdominal compression garments<ref>{{Cite journal|title=Abdominal Compression as a Treatment for Postural Tachycardia Syndrome|date=2020-07-21|url=https://www.ahajournals.org/doi/10.1161/JAHA.120.017610|journal=Journal of the American Heart Association|volume=9|issue=14|pages=e017610|last=Miller|first=Amanda J.|last2=Bourne|first2=Kate M.|language=en|doi=10.1161/JAHA.120.017610|pmc=PMC7660708|pmid=32673524|issn=2047-9980}}</ref> :* [[Diet]] :* Reclined exercise, such as rowing, biking, swimming (contraindicated in patients with co-morbid [[myalgic encephalomyelitis]]) :* [[saline|Sodium chloride]] 0.9% (Normal saline) :* Medications: :** [[:Category:Beta-blockers|Beta-blockers]] :** [[Fludrocortisone]] :** [[Ivabradine]] :** [[Erythropoietin]] :** [[Pyridostigmine|Pyridostigmine bromide]] (Mestinon) :** [[:Category:Vasoconstrictors|Vasoconstrictors]] :** [[Nonsteroidal anti-inflammatory drug|NSAIDs]] :** Others such as [[methyldopa]] and [[antidepressant]]s<ref name=":1" /><ref name=":0">{{Cite journal | last = Abed | first=Howraa | last2 = Ball | first2 = Patrick A | last3 = Wang | first3 = Le-Xin | date = 2012 | title = Diagnosis and management of postural orthostatic tachycardia syndrome: A brief review | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390096/|journal=Journal of Geriatric Cardiology : JGC|volume=9|issue=1 | pages = 61β67|doi=10.3724/SP.J.1263.2012.00061|issn=1671-5411|pmid=22783324|via=}}</ref> A small randomized crossover design trial found that patients with postural orthostatic tachychardia improved with Mestinon.<ref>{{Cite journal | last = Raj | first = S.R. | date = 2005-05-31 | title = Acetylcholinesterase Inhibition Improves Tachycardia in Postural Tachycardia Syndrome|url=https://www.ahajournals.org/doi/pdf/10.1161/circulationaha.104.497594|journal=Circulation|volume=111|issue=21|pages=2734β2740|doi=10.1161/circulationaha.104.497594|issn=0009-7322}}</ref>
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