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Post-exertional malaise
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=== Major Depressive disorder === In the 1996 study by Komaroff et al. (2006) only 19% of patients with major [[depression]] reported PEM.<ref name="Komaroff1996" /> A similar figure was found by Hawk et al., who found PEM in 3 patients in their sample of 15 with major depressive disorder.<ref name="Hawk2006">{{Cite journal | last = Hawk | first = Caroline | last2 = Jason | first2 = Leonard A. | authorlink2 = Leonard Jason | last3 = Torres-Harding | first3 = Susan | date = 2006 | title=Differential diagnosis of chronic fatigue syndrome and major depressive disorder |url = https://www.ncbi.nlm.nih.gov/pubmed/17078775|journal=International Journal of Behavioral Medicine|volume=13|issue=3|pages=244β251|doi=10.1207/s15327558ijbm1303_8|issn=1070-5503|pmid=17078775}}</ref>Β In contrast all of the 15 studied ME/CFS patients reported PEM, making it the largest discriminant function for all investigated symptoms. White et al. studied patients with persistent symptoms of fatigue and poor concentration after glandular fever. According to the authors "the complaint of post-exertional physical fatigue may help to differentiate post-viral fatigue states from psychiatric disorders."<ref name="White2018">{{Cite journal | url=https://www.ncbi.nlm.nih.gov/pubmed/8588010 | title = The validity and reliability of the fatigue syndrome that follows glandular fever | date = 1995 | volume =25|issue =5|pages =917-24|doi=10.1017/s0033291700037405 | last = White | first = PD | authorlink = Peter White |journal=Journal of Psychological Medicine |access-date=2018-10-24}}</ref>
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