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Positron emission tomography
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=== Nakatomi et al. 2014 === Nakatomi et al. (2014) was the first case-control study using PET to measure neuroinflammation through TSPO expression in ME. They used [[PK11195]], a first generation TSPO-binding radioligand. They found increased PK11195 in cingulate cortex, [[hippocampus]], [[amygdala]], thalamus, midbrain, and pons. PK11195 concentrations in certain regions were found to have positive correlations with cognitive impairment scores (related to brain fog), [[pain]] scores, and [[depression]] scores. The study concludes that neuroinflammation seems to be present in ME patients and is associated with neuropsychological symptoms.<ref name="Nakatomi2014" /> [[File:PK11195.gif|thumb|312x312px|center|Statistical parametric maps showing areas of significant contrast of PK11195 in brains of ME/CFS patients versus healthy controls.<ref name="Nakatomi2014">{{Cite journal | last = Nakatomi | first = Yasuhito | authorlink = Yasuhito Nakatomi | authorlink2 = Kei Mizuno | authorlink3 = Akira Ishii | authorlink4 = Yasuhiro Wada | authorlink5 = Masaaki Tanaka | authorlink6 = Shusaku Tazawa | authorlink7 = Kayo Onoe | authorlink8 = Sanae Fukuda | authorlink9 = Joji Kawabe | date = Jun 1, 2014|others=Kazuhiro Takahashi; Yosky Kataoka; Susuma Shiomi; Kouzi Yamaguti, Masaaki Inaba; Hirohiko Kuratsune; Yasuyoshi Watanabe | title = Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study|url=http://jnm.snmjournals.org/content/55/6/945.full|journal=The Journal of Nuclear Medicine|volume=555|issue=6 | pages = 945-950|quote=|via=SNM Journals}}</ref>''This image was originally published in JNM. Nakatomi, Yasuhito, et al. [https://jnm.snmjournals.org/content/55/6/945 Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study]. J Nucl Med. Mar 24, 2014; 55(6):945-950. Β© SNMMI (non-commercial reuse only)'']] {{See also|Neuroinflammation}}
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