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Pesticide exposure link to ME/CFS
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== The pesticide malathion multiplies its toxicity 1000-fold indoors == The household organophosphate pesticide malathion is particularly dangerous if a significant quantity is spilt in an indoor environment (in a house, workplace, garage or barn): although malathion itself is rated as "class III slightly toxic" in its pesticide toxicity class, the breakdown product of malathion called malaoxon is 33 times more toxic than malathion,<ref>{{Cite web|url=http://npic.orst.edu/factsheets/archive/malatech.html#mode | title = Malathion — Technical Fact Sheet. National Pesticide Information Center. | last = | first = | authorlink= | date = |website=|archive-url=|archive-date=|url-status=|access-date=}}</ref> and 1,000 times more toxic than malathion in terms of its acetylcholinesterase activity.<ref>{{Cite journal | last = Rodriguez | first = O. P. | last2 = Muth | first2 = G.W. | last3 = Berkman | first3 = C.E. | last4 = Kim | first4 = K. | last5 = Thompson | first5 = C.M. | date = Feb 1997 | title = Inhibition of various cholinesterases with the enantiomers of malaoxon | url =https://www.ncbi.nlm.nih.gov/pubmed/8975790|journal=Bulletin of Environmental Contamination and Toxicology|volume=58|issue=2|pages=171–176|doi=10.1007/s001289900316|issn=0007-4861|pmid=8975790|pmc=|quote=|access-date=|via=}}</ref> Thus when malathion is spilt indoors, because it is not dispersed by the wind or rain, it will remain indoors, and as it breaks down into malaoxon, the toxicty is increased by 1000 times, thereby becoming highly toxic to the inhabitants. Absorption or ingestion of malathion into the human body also results in its metabolism to malaoxon. The oxon breakdown products of malathion, parathion and chlorpyrifos (malaoxon, paraoxon and chloroxon) have also been shown to be 10 to 100 times more toxic than their parent compound to amphibians.<ref>{{Cite journal | last = Sparling | first = D. W. | last2 = Fellers | first2 = G. | date = Jun 2007 | title = Comparative toxicity of chlorpyrifos, diazinon, malathion and their oxon derivatives to larval Rana boylii|url=https://www.ncbi.nlm.nih.gov/pubmed/17218044|journal=Environmental Pollution (Barking, Essex: 1987)|volume=147|issue=3 | pages = 535–539|doi=10.1016/j.envpol.2006.10.036|issn=0269-7491|pmid=17218044|pmc=|quote=|access-date=|via=}}</ref>
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