Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Persistent infection hypothesis
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
{{stub}} The '''persistent infection hypothesis''' or '''persistent viral infection theory''' is the hypothesis that [[myalgic encephalomyelitis]] is triggered and/or maintained by one or more persistent [[Virus|viruses]] or infections. This is in contrast to the [[Hit and run hypothesis|"hit and run" hypothesis]], which is that the infection triggers a disease process that continues long after the [[immune system]] has eradicated the initial infection. ==Theory== ==Evidence== ==Treatment== == Notable studies == * 1992, [[Epstein-Barr virus|Epstein-Barr Virus]]-Related Persistent Erythema Multiforme in Chronic Fatigue Syndrome<ref>{{Cite journal | last =Rebora | first = Alfredo | last2 = Loi | first2 = Anna | last3 = Romagnoli | first3 = Marina | last4 = Drago | first4 = Francesco | date = 1992-02-01| title = Epstein-Barr Virus-Related Persistent Erythema Multiforme in Chronic Fatigue Syndrome|url=https://jamanetwork.com/journals/jamadermatology/fullarticle/553839|journal=Archives of Dermatology|language=en|volume=128|issue=2|pages=217โ222|doi=10.1001/archderm.1992.01680120089009|issn=0003-987X}}</ref> - [https://jamanetwork.com/journals/jamadermatology/article-abstract/553839 (Abstract)] * 1993, Persistence of enterovirus RNA in muscle biopsy samples suggests that some cases of chronic fatigue syndrome result from a previous, inflammatory viral myopathy<ref>{{Cite journal | last =Bowles | first = N. E. | last2 = Bayston | first2 = T.A. | last3 = Zhang | first3 = H.Y. | last4 = Doyle | first4 = D. | last5 = Lane | first5 = R.J. | last6 = Cunningham | first6 = L. | last7 = Archard | first7 = L.C. | date = 1993| title = Persistence of enterovirus RNA in muscle biopsy samples suggests that some cases of chronic fatigue syndrome result from a previous, inflammatory viral myopathy|url=https://www.ncbi.nlm.nih.gov/m/pubmed/8409778/|journal=Journal of Medicine|volume=24|issue=2-3|pages=145โ160|issn=0025-7850|pmid=8409778}}</ref> - [https://www.ncbi.nlm.nih.gov/m/pubmed/8409778/ (Abstract)] * 1999, Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA<ref>{{Cite journal | last =Cunningham | first = Louise | last2 = Bowles | first2 = N.E. | last3 = Lane | first3 = R. J.M. | last4 = Dubowitz | first4 = V. | last5 = Archard | first5 = L.C. | date = 1990| title = Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA|url=https://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-6-1399|journal=Journal of General Virology|volume=71|issue=6|pages=1399โ1402|doi=10.1099/0022-1317-71-6-1399}}</ref> - [https://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-6-1399 (Full text)] * 2010, Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence<ref>{{Cite journal | last =Chang | first = R. | authorlink = | last2 = Lee | first2 = T. | authorlink2 = | last3 = Voeller | first3 = M. | authorlink3 = | last4 = Chia | first4 = A. | authorlink4 = | last5 = Chia | first5 = J. | authorlink5 = John Chia | authorlink6 = | date = 2010-02-01| title = Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence|url=https://jcp.bmj.com/content/63/2/165|journal=Journal of Clinical Pathology|language=en|volume=63|issue=2|pages=165โ168|doi=10.1136/jcp.2009.070466|issn=0021-9746|pmid=19828908|quote=|via=}}</ref> - [https://jcp.bmj.com/content/63/2/165.full (Full text)] * 2012, Can persistent Epstein-Barr virus infection induce chronic fatigue syndrome as a Pavlov reflex of the immune response?<ref>{{Cite journal | last = Agliari | first = Elena | last2 = Barra | first2 = Adriano | last3 = Vidal | first3 = Kristian Gervasi | last4 = Guerra | first4 = Francesco | date = 2012-03-01| title = Can persistent EpsteinโBarr virus infection induce chronic fatigue syndrome as a Pavlov reflex of the immune response?|url=https://doi.org/10.1080/17513758.2012.704083|journal=Journal of Biological Dynamics|volume=6|issue=2 | pages = 740โ762|doi=10.1080/17513758.2012.704083|issn=1751-3758|pmid=22873615}}</ref> - [https://www.tandfonline.com/doi/full/10.1080/17513758.2012.704083 (Full text)] * 2016, Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence<ref name="Brooks2016">{{Cite journal | last =Brooks | first = David G. | authorlink = | last2 = Smale | first2 = Stephen T. | authorlink2 = | last3 = Bensinger | first3 = Steven J. | authorlink3 = | last4 = Horwitz | first4 = Marcus A. | authorlink4 = | last5 = Kitchen | first5 = Scott G. | authorlink5 = | last6 = Torre | first6 = Juan Carlos de la | authorlink6 = | last7 = Wilson | first7 = Elizabeth B. | last8 = Snell | first8 = Laura M. | last9 = Elsaesser | first9 = Heidi | date = 2016-01-25| title = Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence|url=https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005356|journal=PLOS Pathogens|language=en|volume=12|issue=1| pages = e1005356|doi=10.1371/journal.ppat.1005356|issn=1553-7374|pmc = 4726812|pmid=26808628|quote=|via=|access-date=}}</ref> - [https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005356 (Full text)] *2018, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the era of the human microbiome: persistent pathogens drive chronic symptoms by interfering with host metabolism, gene expression and immunity<ref>{{Cite journal | last = Proal | first = Amy | authorlink = Amy Proal | last2 = Marshall | first2 = Trevor | authorlink2 = Trevor Marshall | date = Nov 2018| title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the era of the human microbiome: persistent pathogens drive chronic symptoms by interfering with host metabolism, gene expression and immunity|url=https://www.frontiersin.org/articles/10.3389/fped.2018.00373/full|journal=Frontiers in Pediatrics|volume=|issue=|pages=|quote=|via=|doi=10.3389/fped.2018.00373}}</ref> - [https://www.frontiersin.org/articles/10.3389/fped.2018.00373/full (Full text)] ==See also== * [[Enteroviral infection hypothesis]] * [[Hit and run hypothesis]] * [[Viral onset hypothesis]] * [[Virus]] ==Learn more== == References == {{Reflist}} [[Category:Medical hypotheses]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Asbox
(
edit
)
Template:Cite journal
(
edit
)
Template:Full stop
(
edit
)
Template:Full stop character
(
edit
)
Template:GetFallback
(
edit
)
Template:Help improve text
(
edit
)
Template:LangSwitch
(
edit
)
Template:Main other
(
edit
)
Template:No fullstop
(
edit
)
Template:No fullstop/first
(
edit
)
Template:Reflist
(
edit
)
Template:Str crop
(
edit
)
Template:Str endswith
(
edit
)
Template:Stub
(
view source
) (semi-protected)
Template:Stub text
(
edit
)
Template:Talkpage text
(
edit
)
Template:Uselang
(
edit
)
Module:Arguments
(
edit
)
Module:Asbox
(
edit
)
Module:Buffer
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:Navbar
(
edit
)
Module:No globals
(
edit
)
Module:String
(
edit
)
This page is a member of 2 hidden categories:
Category:All stub articles
Category:Stub pages last edited in 2023
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs