Pentadecapeptide BPC 157

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Pentadecapeptide BPC 157, a fragment of gastric juice peptide BPC,[1] is derived from human stomach acid. It is an experimental compound used in research for its potential applications in wound healing, collagen repair and angiogenesis.[2]

BPC 157 improved wound healing in rats with muscle crush injury and contusions, and quadricep transection,[3][4] even in the presence of corticosteroids (which impair wound healing).[4] It has also demonstrated efficacy in experimental ulcer models[5] and models of traumatic nerve injury.[6]

It has been shown to increase expression of many types of growth factors[7][8][9] including growth hormone receptor[8] and vascular endothelial growth factor[9] (VEGF) expression on fibroblasts.

References

  1. ↑ Sikiric, Predrag; Seiwerth, Sven; Grabarevic, Zeljko; Petek, Marijan; Rucman, Rudolf; Turkovic, Branko; Rotkvic, Ivo; Jagic, Vjekoslav; Duvnjak, Marko (January 1, 1994). "The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides". Life Sciences. 54 (5): PL63–PL68. doi:10.1016/0024-3205(94)00796-9. ISSN 0024-3205.
  2. ↑ Seiwerth, Sven; Brcic, Luka; Batelja Vuletic, Lovorka; Kolenc, Danijela; Aralica, Gorana; Misic, Marija; Zenko, Anita; Drmic, Domagoj; Rucman, Rudolf (2014). "BPC 157 and Blood Vessels". ingentaconnect.com. Retrieved June 24, 2019.
  3. ↑ Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka (2006). "Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157". Journal of Orthopaedic Research. 24 (5): 1109–1117. doi:10.1002/jor.20089. ISSN 1554-527X.
  4. ↑ 4.0 4.1 Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka (2006). "Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157". Journal of Orthopaedic Research. 24 (5): 1109–1117. doi:10.1002/jor.20089. ISSN 1554-527X.
  5. ↑ Sikiric, Predrag; Seiwerth, Sven; Grabarevic, Zeljko; Petek, Marijan; Rucman, Rudolf; Turkovic, Branko; Rotkvic, Ivo; Jagic, Vjekoslav; Duvnjak, Marko (January 1, 1994). "The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides". Life Sciences. 54 (5): PL63–PL68. doi:10.1016/0024-3205(94)00796-9. ISSN 0024-3205.
  6. ↑ Gjurasin, Miroslav; Miklic, Pavle; Zupancic, Bozidar; Perovic, Darko; Zarkovic, Kamelija; Brcic, Luka; Kolenc, Danijela; Radic, Bozo; Seiwerth, Sven (February 25, 2010). "Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury". Regulatory Peptides. 160 (1): 33–41. doi:10.1016/j.regpep.2009.11.005. ISSN 0167-0115.
  7. ↑ Seiwerth, Sven; Rucman, Rudolf; Turkovic, Branko; Sever, Marko; Klicek, Robert; Radic, Bozo; Drmic, Domagoj; Stupnisek, Mirjana; Misic, Marija (2018). "BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing". ingentaconnect.com. Retrieved September 11, 2019.
  8. ↑ 8.0 8.1 Pang, Jong-Hwei Su; Hsu, Ya-Hui; Tsai, Wen-Chung; Chang, Chung-Hsun (November 2014). "Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts". Molecules. 19 (11): 19066–19077. doi:10.3390/molecules191119066.
  9. ↑ 9.0 9.1 Hsieh, Ming-Jer; Liu, Hsien-Ta; Wang, Chao-Nin; Huang, Hsiu-Yun; Lin, Yuling; Ko, Yu-Shien; Wang, Jong-Shyan; Chang, Vincent Hung-Shu; Pang, Jong-Hwei S. (March 1, 2017). "Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation". Journal of Molecular Medicine. 95 (3): 323–333. doi:10.1007/s00109-016-1488-y. ISSN 1432-1440.
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